Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

Journal of the American Medical Directors Association

Volumn 16, Issue 8, 2015, Pages 640-647

  Fabbri, Elisa ^a,b   Zoli, Marco ^b   Gonzalez Freire, Marta ^a   Salive, Marcel E ^a   Studenski, Stephanie A ^a   Ferrucci, Luigi ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Aging; Chronic disease; Multimorbidity; Multiple morbidities

Indexed keywords

AGING; CHRONIC DISEASE; COMORBIDITY; DEMENTIA; GERONTOLOGY; HUMAN; MEDICAL CARE; MEDICAL RESEARCH; MORBIDITY; MULTIMORBIDITY; REVIEW; RISK FACTOR; AGED; PHYSIOLOGY;

AGED; AGING; BIOMEDICAL RESEARCH; CHRONIC DISEASE; COMORBIDITY; HUMANS; RISK FACTORS;

EID: 84938210357     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2015.03.013     Document Type: Review

References (114)

1. Tinetti M.E., Fried T.R., Boyd C.M. Designing health care for the most common chronic condition-multimorbidity. JAMA 2012, 307:2493-2494.
2. Guiding principles for the care of older adults with multimorbidity: An approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. JAm Geriatr Soc 2012, 60:E1-E25.
3. Martin C.M., Félix-Bortolotti M. Person-centred health care: A critical assessment of current and emerging research approaches. JEval Clin Pract 2014, 20:1056-1064.
4. Banerjee S. Multimorbidity-older adults need health care that can count past one. Lancet 2015, 385:587-589.
5. Boyd C.M., Darer J., Boult C., et al. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: Implications for pay for performance. JAMA 2005, 294:716-724.
6. Fortin M., Dionne J., Pinho G., et al. Randomized clinical trials: Do they have external validity for patients with multiple comorbidities?. Ann Fam Med 2006, 4:104-108.
7. Campbell-Scherer D. Multimorbidity: A challenge for evidence-based medicine. Evid Based Med 2010, 15:165-166.
8. Boyd C.M., Vollenweider D., Puhan M.A. Informing evidence-based decision-making for patients with comorbidity: Availability of necessary information in clinical trials for chronic diseases. PLoS One 2012, 7:e41601.
9. Roland M., Paddison C. Better management of patients with multimorbidity. BMJ 2013, 346:f2510.
10. Boyd C.M., Kent D.M. Evidence-based medicine and the hard problem of multimorbidity. JGen Intern Med 2014, 29:552-553.
11. Boyd C.M., Wolff J.L., Giovannetti E., et al. Healthcare task difficulty among older adults with multimorbidity. Med Care 2014, 52:S118-S125.
12. Muth C., van den Akker M., Blom J.W., et al. The Ariadne principles: How to handle multimorbidity in primary care consultations. BMC Med 2014, 12:223.
13. Neale M.C., Kendler K.S. Models of comorbidity for multifactorial disorders. Am J Hum Genet 1995, 57:935-953.
14. Le Reste J.Y., Nabbe P., Manceau B., et al. The European General Practice Research Network presents a comprehensive definition of multimorbidity in family medicine and long term care, following a systematic review of relevant literature. JAm Med Dir Assoc 2013, 14:319-325.
15. Van den Akker M., Buntinx F., Knottnerus J.A. Comorbidity or multimorbidity: What's in a name. A review of literature. Eur J Gen Pract 1996, 2:65-70.
16. Yancik R., Ershler W., Satariano W., et al. Report of the national institute on aging task force on comorbidity. JGerontol A Biol Sci Med Sci 2007, 62:275-280.
17. Boyd C.M., Ritchie C.S., Tipton E.F., et al. From bedside to bench: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Comorbidity and Multiple Morbidity in Older Adults. Aging Clin Exp Res 2008, 20:181-188.
18. Fortin M., Stewart M., Poitras M.E., et al. Asystematic review of prevalence studies on multimorbidity: Toward a more uniform methodology. Ann Fam Med 2012, 10:142-151.
19. Salive M.E. Multimorbidity in older adults. Epidemiol Rev 2013, 35:75-83.
20. DuGoff E.H., Canudas-Romo V., Buttorff C., et al. Multiple chronic conditions and life expectancy: A life table analysis. Med Care 2014, 52:688-694.
21. Anderson G. Chronic Care: Making the Case for Ongoing Care 2010, 43. Robert Wood Johnson Foundation, Princeton, NJ.
22. Barnett K., Mercer S.W., Norbury M., et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study. Lancet 2012, 380:37-43.
23. Fabbri E., An Y., Zoli M., et al. Aging and the burden of multimorbidity: Associations with inflammatory and anabolic hormonal biomarkers. JGerontol A Biol Sci Med Sci 2015, 70:63-70.
24. Van den Akker M., Buntinx F., Metsemakers J.F., et al. Multimorbidity in general practice: Prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. JClin Epidemiol 1998, 51:367-375.
25. Wolff J.L., Starfield B., Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med 2002, 162:2269-2276.
26. Fortin M., Bravo G., Hudon C., et al. Prevalence of multimorbidity among adults seen in family practice. Ann Fam Med 2005, 3:223-228.
27. Walker A.E. Multiple chronic diseases and quality of life: Patterns emerging from a large national sample, Australia. Chronic Illn 2007, 3:202-218.
28. Schram M.T., Frijters D., van de Lisdonk E.H., et al. Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. JClin Epidemiol 2008, 61:1104-1112.
29. Marengoni A., Winblad B., Karp A., Fratiglioni L. Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden. Am J Public Health 2008, 98:1198-1200.
30. Uijen A.A., van de Lisdonk E.H. Multimorbidity in primary care: Prevalence and trend over the last 20 years. Eur J Gen Pract 2008, 14:28-32.
31. Britt H.C., Harrison C.M., Miller G.C., Knox S.A. Prevalence and patterns of multimorbidity in Australia. Med J Aust 2008, 189:72-77.
32. Schneider K.M., O'Donnel B.E., Dean D. Prevalence of multiple chronic conditions in the United States' Medicare population. Health Qual Life Outcomes 2009, 7:82.
33. Salisbury C., Johnson L., Purdy S., et al. Epidemiology and impact of multimorbidity in primary care: A retrospective cohort study. Br J Gen Pract 2011, 61:e12-e21.
34. Glynn L.G., Valderas J.M., Healy P., et al. The prevalence of multimorbidity in primary care and its effect on health care utilization and cost. Fam Pract 2011, 28:516-523.
35. Schafer I., Hansen H., Schon G., et al. The influence of age, gender and socioeconomic status on multimorbidity patterns in primary care. First results from the Multicare Cohort Study. BMC Health Serv Res 2012, 12:89.
36. Van Oostrom S.H., Picavet H.S., van Gelder B.M., et al. Multimorbidity and comorbidity in the Dutch population-data from general practices. BMC Public Health 2012, 12:715.
37. Nagel G., Peter R., Braig S., et al. The impact of education on risk factors and the occurrence of multimorbidity in the EPIC Heidelberg cohort. BMC Public Health 2008, 8:384.
38. Lochner K.A., Cox C.S. Prevalence of multiple chronic conditions among Medicare beneficiaries, United States, 2010. Prev Chronic Dis 2013, 10:e61.
39. Rocca W.A., Boyd C.M., Grossardt B.R., et al. Prevalence of multimorbidity in a geographically defined American population: Patterns by age, sex, and race/ethnicity. Mayo Clin Proc 2014, 89:1336-1349.
40. Melis R., Marengoni A., Angleman S., Fratiglioni L. Incidence and predictors of multimorbidity in the elderly: A population-based longitudinal study. PLoS One 2014, 9:e103120.
41. Marengoni A., Angleman S., Melis R., et al. Aging with multimorbidity: A systematic review of the literature. Ageing Res Rev 2011, 10:430-439.
42. Violan C., Foguet-Boreu Q., Flores-Mateo G., et al. Prevalence, determinants and patterns of multimorbidity in primary care: A systematic review of observational studies. PLoS One 2014, 9:e102149.
43. Quiñones A.R., Liang J., Bennett J.M., Xu X., Ye W. How does the trajectory of multimorbidity vary across Black, White, and Mexican Americans in middle and old age?. J Gerontol B Psychol Sci Soc Sci 2011, 66:739-749.
44. Cornell J.E., Pugh J.A., Williams J.W., et al. Multimorbidity clusters: Clustering binary data from a large administrative medical database. Applied Multivariate Research 2007, 12:163-182.
45. Agborsangaya C.B., Ngwakongnwi E., Lahtinen M., et al. Multimorbidity prevalence in the general population: The role of obesity in chronic disease clustering. BMC Public Health 2013, 13:1161.
46. Booth H.P., Prevost A.T., Gulliford M.C. Impact of body mass index on prevalence of multimorbidity in primary care: Cohort study. Fam Pract 2014, 31:38-43.
47. Fortin M., Haggerty J., Almirall J., et al. Lifestyle factors and multimorbidity: A cross sectional study. BMC Public Health 2014, 14:686.
48. Hudon C., Soubhi H., Fortin M. Relationship between multimorbidity and physical activity: Secondary analysis from the Quebec health survey. BMC Public Health 2008, 8:304.
49. Cimarras-Otal C., Calderón-Larrañaga A., Poblador-Plou B., et al. Association between physical activity, multimorbidity, self-rated health and functional limitation in the Spanish population. BMC Public Health 2014, 14:1170.
50. Prados-Torres A., Calderón-Larrañaga A., Hancco-Saavedra J., et al. Multimorbidity patterns: A systematic review. JClin Epidemiol 2014, 67:254-266.
51. Marengoni A., Rizzuto D., Wang H.X., et al. Patterns of chronic multimorbidity in the elderly population. JAm Geriatr Soc 2009, 57:225-230.
52. Marengoni A., Bonometti F., Nobili A., et al. In-hospital death and adverse clinical events in elderly patients according to disease clustering: The REPOSI study. Rejuvenation Res 2010, 13:469-477.
53. Schafer I., von Leitner E.C., Schon G., et al. Multimorbidity patterns in theelderly: A new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS One 2010, 5:e15941.
54. Newcomer S.R., Steiner J.F., Bayliss E.A. Identifying subgroups of complex patients with cluster analysis. Am J Manag Care 2011, 17:e324-e332.
55. Van den Bussche H., Koller D., Kolonko T., et al. Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Public Health 2011, 11:101.
56. Wong A., Boshuizen H.C., Schellevis F.G., et al. Longitudinal administrative data can be used to examine multimorbidity, provided false discoveries are controlled for. JClin Epidemiol 2011, 64:1109-1117.
57. Prados-Torres A., Poblador-Plou B., Calderon-Larranaga A., et al. Multimorbidity patterns in primary care: Interactions among chronic diseases using factor analysis. PLoS One 2012, 7:e32190.
58. Kirchberger I., Meisinger C., Heier M., et al. Patterns of multimorbidity in the aged population. Results from the KORA-age study. PLoS One 2012, 7:e30556.
59. Freund T., Kunz C.U., Ose D., et al. Patterns of multimorbidity in primary care patients at high risk of future hospitalization. Popul Health Manag 2012, 15:119-124.
60. Garcia-Olmos L., Salvador C.H., Alberquilla A., et al. Comorbidity patterns in patients with chronic diseases in general practice. PLoS One 2012, 7:e32141.
61. Sinnige J., Braspenning J., Schellevis F., et al. The prevalence of disease clusters in older adults with multiple chronic diseases-a systematic literature review. PLoS One 2013, 8:e79641.
62. Poblador-Plou B., van den Akker M., Vos R., et al. Similar multimorbidity patterns in primary care patients from two European regions: Results of a factor analysis. PLoS One 2014, 9:e100375.
63. Hidalgo C.A., Blumm N., Barabási A.L., Christakis N.A. Adynamic network approach for the study of human phenotypes. PLoS Comput Biol 2009, 5:e1000353.
64. Barabasi A.L., Gulbahce N., Loscalzo J. Network medicine: A network-based approach to human disease. Nat Rev Genet 2011, 12:56-68.
65. Divo M.J., Martinez C.H., Mannino D.M. Ageing and the epidemiology of multimorbidity. Eur Respir J 2014, 44:1055-1068.
66. Schäfer I., Kaduszkiewicz H., Wagner H.O., et al. Reducing complexity: A visualisation of multimorbidity by combining disease clusters and triads. BMC Public Health 2014, 14:1285.
67. Strauss V.Y., Jones P.W., Kadam U.T., Jordan K.P. Distinct trajectories of multimorbidity in primary care were identified using latent class growth analysis. JClin Epidemiol 2014, 67:1163-1171.
68. Kennedy B.K., Berger S.L., Brunet A., et al. Geroscience: Linking aging to chronic disease. Cell 2014, 159:709-713.
69. Burch J.B., Augustine A.D., Frieden L.A., et al. Advances in geroscience: Impact on healthspan and chronic disease. JGerontol A Biol Sci Med Sci 2014, 69:S1-S3.
70. López-Otín C., Blasco M.A., Partridge L., et al. The hallmarks of aging. Cell 2013, 153:1194-1217.
71. Ferrucci L., Studenski S. Clinical problems of aging. Harrison's Principles of Internal Medicine 2012, McGraw-Hill, New York, NY. D.L. Longo, A.S. Fauci, D.L. Kasper (Eds.).
72. Fabbri E, An Y, Schrack JA, etal. Energy metabolism and the burden of multimorbidity in older adults: Results from the Baltimore Longitudinal Study of Aging [published online ahead of print November 18, 2014]. J Gerontol A Biol Sci Med Sci.
73. Fabbri E, Tanaka T, An Y, et al. Loss of weight in obese older adults: a biomarker of impending expansion of multi-morbidity? J Am Geriatr Soc. In press.
74. Schubert C.C., Boustani M., Callahan C.M., et al. Comorbidity profile of dementia patients in primary care: Are they sicker?. JAm Geriatr Soc 2006, 54:104-109.
75. Melis R.J., Marengoni A., Rizzuto D., et al. The influence of multimorbidity on clinical progression of dementia in a population-based cohort. PLoS One 2013, 8:e84014.
76. Leoutsakos J.M., Han D., Mielke M.M., et al. Effects of general medical health on Alzheimer's progression: The Cache County Dementia Progression Study. Int Psychogeriatr 2012, 24:1561-1570.
77. Biessels G.J., Strachan M.W., Visseren F.L., et al. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: Towards targeted interventions. Lancet Diabetes Endocrinol 2014, 2:246-255.
78. Song X., Mitnitski A., Rockwood K. Nontraditional risk factors combine to predict Alzheimer disease and dementia. Neurology 2011, 77:227-234.
79. Fortin M., Bravo G., Hudon C., et al. Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res 2006, 15:83-91.
80. Guralnik J.M., LaCroix A.Z., Abbott R.D., et al. Maintaining mobility in late life. I. Demographic characteristics and chronic conditions. Am J Epidemiol 1993, 137:845-857.
81. Kriegsman D.M.W., Deeg D.J.H., Stalman W.A.B. Comorbidity of somatic chronic diseases and decline in physical functioning: The Longitudinal Aging Study Amsterdam. JClin Epidemiol 2004, 57:55-65.
82. Marengoni A., von Strauss E., Rizzuto D., et al. The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. JIntern Med 2009, 265:288-295.
83. Wolff J.L., Boult C., Boyd C., Anderson G. Newly reported chronic conditions and onset of functional dependency. JAm Geriatr Soc 2005, 53:851-855.
84. Marventano S., Ayala A., Gonzalez N., et al. Multimorbidity and functional status in community-dwelling older adults. Eur J Intern Med 2014, 25:610-616. Spanish Research Group of Quality of Life and Ageing.
85. Newman A.B., Haggerty C.L., Goodpaster B., et al. Strength and muscle quality in a well-functioning cohort of older adults: The health, aging and body composition study. JAm Geriatr Soc 2003, 51:323-330.
86. Welmer A.K., Kareholt I., Angleman S., et al. Can chronic multimorbidity explain the age-related differences in strength, speed, and balance in older adults?. Aging Clin Exp Res 2012, 24:480-489.
87. Yorke A.M., Curtis A.B., Shoemaker M., Vangsnes E. Grip strength values stratified by age, gender, and chronic disease status in adults aged 50 years and older. J Geriatr Phys Ther 2015, 38:115-121.
88. Menotti A., Mulder I., Nissinen A., et al. Prevalence of morbidity and multimorbidity in elderly male populations and their impact on 10-year all-cause mortality: The FINE study (Finland, Italy, Netherlands, Elderly). JClin Epidemiol 2001, 54:680-686.
89. St John P.D., Tyas S.L., Menec V., Tate R. Multimorbidity, disability, and mortality in community-dwelling older adults. Can Fam Physician 2014, 60:e272-e280.
90. Calderón-Larrañaga A., Poblador-Plou B., González-Rubio F., et al. Multimorbidity, polypharmacy, referrals, and adverse drug events: Are we doing things well?. Br J Gen Pract 2012, 62:e821-e826.
91. Fortin M., Bravo G., Hudon C., et al. Psychological distress and multimorbidity in primary care. Ann Fam Med 2006, 4:417-422.
92. Smith D.J., Court H., McLean G., et al. Depression and multimorbidity: A cross-sectional study of 1,751,841 patients in primary care. JClin Psychiatry 2014, 75:1202-1208.
93. Vogeli C., Shields A.E., Lee T.A., et al. Multiple chronic conditions: Prevalence, health consequences, and implications for quality, care management, and costs. JGen Intern Med 2007, 22:391-395.
94. Bähler C., Huber C.A., Brüngger B., Reich O. Multimorbidity, health care utilization and costs in an elderly community-dwelling population: A claims data based observational study. BMC Health Serv Res 2015, 15:23.
95. Smith S.M., Soubhi H., Fortin M., et al. Managing patients with multimorbidity: Systematic review of interventions in primary care and community settings. BMJ 2012, 345:e5205.
96. Smith S.M., O'Kelly S., O'Dowd T. GPs' and pharmacists' experiences of managing multimorbidity: A Pandora's box. Br J Gen Pract 2010, 60:285-294.
97. Uhlig K., Leff B., Kent D., et al. Aframework for crafting clinical practice guidelines that are relevant to the care and management of people with multimorbidity. JGen Intern Med 2014, 29:670-679.
98. Blozik E., van den Bussche H., Gurtner F., et al. Epidemiological strategies for adapting clinical practice guidelines to the needs of multimorbid patients. BMC Health Serv Res 2013, 13:352.
99. Weiss C.O., Varadhan R., Puhan M.A., et al. Multimorbidity and evidence generation. JGen Intern Med 2014, 29:653-660.
100. Doos L., Roberts E.O., Corp N., Kadam U.T. Multi-drug therapy in chronic condition multimorbidity: A systematic review. Fam Pract 2014, 31:654-663.
101. Veehof L.J., Stewart R.E., Meyboom-de Jong B., Haaijer-Ruskamp F.M. Adverse drug reactions and polypharmacy in the elderly in general practice. Eur J Clin Pharmacol 1999, 55:533-536.
102. Kadam U.T. Potential health impacts of multiple drug prescribing for older people: A case-control study. Br J Gen Pract 2011, 61:128-130.
103. Lorgunpai S.J., Grammas M., Lee D.S., et al. Potential therapeutic competition in community-living older adults in the US: Use of medications that may adversely affect a coexisting condition. PLoS One 2014, 9:e89447.
104. Holmes H.M., Min L.C., Yee M., et al. Rationalizing prescribing for older patients with multimorbidity: Considering time to benefit. Drugs Aging 2013, 30:655-666.
105. Schuling J., Gebben H., Veehof L.J., Haaijer-Ruskamp F.M. Deprescribing medication in very elderly patients with multimorbidity: The view of Dutch GPs. A qualitative study. BMC Fam Pract 2012, 13:56.
106. Scott I.A., Gray L.C., Martin J.H., et al. Deciding when to stop: Towards evidence-based deprescribing of drugs in older populations. Evid Based Med 2013, 18:121-124.
107. Reeve E., Wiese M.D. Benefits of deprescribing on patients' adherence to medications. Int J Clin Pharm 2014, 36:26-29.
108. Tannenbaum C., Martin P., Tamblyn R., et al. Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: The EMPOWER cluster randomized trial. JAMA Intern Med 2014, 174:890-898.
109. Bayliss E.A. Simplifying care for complex patients. Ann Fam Med 2012, 10:3-5.
110. Sampalli T., Fox R.A., Dickson R., Fox J. Proposed model of integrated care to improve health outcomes for individuals with multimorbidities. Patient Prefer Adherence 2012, 6:757-764.
111. Fried L.P., Ferrucci L., Darer J., et al. Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. JGerontol A Biol Sci Med Sci 2004, 59:255-263.
112. Fried L.P., Tangen C.M., Walston J., et al. Frailty in older adults: Evidence for a phenotype. JGerontol A Biol Sci Med Sci 2001, 56A:M146-M156.
113. Rockwood K., Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med 2011, 27:17-26.
114. Abellan van Kan G., Rolland Y.M., Morley J.E., Vellas B. Frailty: Toward a clinical definition. JAm Med Dir Assoc 2008, 9:71-72.