Aging and the burden of multimorbidity: Associations with inflammatory and anabolic hormonal biomarkers

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 70, Issue 1, 2015, Pages 63-70

  Fabbri, Elisa ^a,b   An, Yang ^a   Zoli, Marco ^b   Simonsick, Eleanor M ^a   Guralnik, Jack M ^c   Bandinelli, Stefania ^d   Boyd, Cynthia M ^e   Ferrucci, Luigi ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Department of Geriatric Medicine ASF Firenze ^*  (Italy)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Chronic diseases; Inflammation; Interleukin 6; Multimorbidity

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; HORMONE; IL6 PROTEIN, HUMAN; INTERLEUKIN 6;

AGED; AGING; BLOOD; CHRONIC DISEASE; COMORBIDITY; CROSS-SECTIONAL STUDY; EPIDEMIOLOGY; FEMALE; HUMAN; ITALY; LONGITUDINAL STUDY; MALE; MIDDLE AGED; PROSPECTIVE STUDY; STATISTICAL MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BIOMARKERS; CHRONIC DISEASE; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; HORMONES; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; ITALY; LINEAR MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 84922470859     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu127     Document Type: Article

References (43)

1. Parekh AK, Barton MB. The challenge of multiple comorbidity for the US health care system. JAMA. 2010;303:1303-1304. doi:10.1370/ afm.1391
2. American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Guiding principles for the care of older adults with multimorbidity: an approach for clinicians. J Am Geriatr Soc. 2012;13:E1-E25. doi:10.1111/j.1532-5415.2012.04188.x. Epub 2012 Sep 19
3. Tinetti ME, Fried TR, Boyd CM. Designing health care for the most common chronic condition-multimorbidity. JAMA. 2012;307:2493-2494. doi:10.1001/jama.2012.5265
4. Van den Akker M, Buntinx F, Knottnerus JA. Comorbidity or multimorbidity: what's in a name? A review of literature. Eur J Gen Pract. 1996;2:65-70.
5. Burch JB, Augustine AD, Frieden LA, et al. Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci. 2014;69(suppl 1):S1-S3. doi:10.1093/gerona/glu041
6. Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, van den Bos GA. Causes and consequences of comorbidity: a review. J Clin Epidemiol. 2001;54:661-674.
7. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(suppl 1):S4-S9. doi:10.1093/gerona/glu057
8. Ferrucci L, Corsi A, Lauretani F, et al. The origins of age-related proinflammatory state. Blood. 2005;105:2294-2299.
9. Maggio M, Cattabiani C, Lauretani F, et al. The concept of multiple hormonal dysregulation. Acta Biomed. 2010;81:19-29.
10. Ferrucci L, Bandinelli S, Benvenuti E, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc. 2000;48:1618-1625.
11. Wallace RB, Salive ME. The dimensions of multiple chronic conditions: where do we go from here? A commentary on the special issue of preventing chronic disease. Prev Chronic Dis. 2013;10:E59. doi: 10.5888/pcd10.130104
12. Woodman R, Ferrucci L, Guralnik J. Anemia in older adults. Curr Opin Hematol. 2005;12:123-128.
13. Lamb EJ, Wood J, Stowe HJ, O'Riordan SE, Webb MC, Dalton RN. Susceptibility of glomerular filtration rate estimations to variations in creatinine methodology: a study in older patients. Ann Clin Biochem. 2005;42(Pt 1):11-18.
14. McDermott MM, Fried L, Simonsick E, Ling S, Guralnik JM. Asymptomatic peripheral arterial disease is independently associated with impaired lower extremity functioning: the women's health and aging study. Circulation. 2000;101:1007-1012.
15. Milaneschi Y, Bandinelli S, Penninx BW, et al. The relationship between plasma carotenoids and depressive symptoms in older persons. World J Biol Psychiatry. 2012;13:588-598. doi: 10.3109/15622975.2011.597876
16. Ferrucci L, Bandinelli S, Benvenuti E, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc. 2000;48:1618-1625.
17. Varadhan R, Yao W, Matteini A, et al. Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. J Gerontol A Biol Sci Med Sci. 2014;69:165-173. doi:10.1093/gerona/glt023
18. Maggio M, Lauretani F, Ceda GP, et al. Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Arch Intern Med. 2007;167:2249-2254.
19. Maggio M, Ceda GP, Lauretani F, et al. SHBG, sex hormones, and inflammatory markers in older women. J Clin Endocrinol Metab. 2011;96:1053-1059. doi:10.1210/jc.2010-1902
20. Schellevis FG, van der Velden J, van de Lisdonk E, van Eijk JT, van Weel C. Comorbidity of chronic diseases in general practice. J Clin Epidemiol. 1993;46:469-473.
21. van den Akker M, Buntinx F, Metsemakers JF, Roos S, Knottnerus JA. Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. J Clin Epidemiol. 1998;51:367-375.
22. Walker AE. Multiple chronic diseases and quality of life: patterns emerging from a large national sample, Australia. Chronic Illn. 2007;3:202-218.
23. Marengoni A, Winblad B, Karp A, Fratiglioni L. Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden. Am J Public Health. 2008;98:1198-1200. doi:10.2105/ AJPH.2007.121137
24. Uijen AA, van de Lisdonk EH. Multimorbidity in primary care: prevalence and trend over the last 20 years. Eur J Gen Pract. 2008;14(suppl 1):28-32. doi:10.1080/13814780802436093
25. Scher I, Hansen H, Sch G, et al. The influence of age, gender and socioeconomic status on multimorbidity patterns in primary care. First results from the multicare cohort study. BMC Health Serv Res. 2012;12:89. doi:10.1186/1472-6963-12-89
26. van Oostrom SH, Picavet HS, van Gelder BM, et al. Multimorbidity and comorbidity in the Dutch population - data from general practices. BMC Public Health. 2012;12:715. doi:10.1186/1471-2458-12-715
27. Fortin M, Stewart M, Poitras ME, Almirall J, Maddocks H. A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med. 2012;10:142-151. doi: 10.1370/afm.1337.
28. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104:2263-2268.
29. Ferrucci L, Ble A, Bandinelli S, Lauretani F, Suthers K, Guralnik JM. A flame burning within. Aging Clin Exp Res. 2004;16:240-243.
30. Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009;8:18-30. doi:10.1016/j.arr.2008.07.002
31. Prasad S, Sung B, Aggarwal BB. Age-associated chronic diseases require age-old medicine: role of chronic inflammation. Prev Med. 2012;54(suppl):S29-S37. doi:10.1016/j.ypmed.2011.11.011
32. Howcroft TK, Campisi J, Louis GB, et al. The role of inflammation in age-related disease. Aging (Albany NY). 2013;5:84-93.
33. Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation. 2001;103:947-953.
34. Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jgensen T, Pedersen BK. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol. 2003;132:24-31.
35. Baune BT, Rothermundt M, Ladwig KH, Meisinger C, Berger K. Systemic inflammation (Interleukin 6) predicts all-cause mortality in men: results from a 9-year follow-up of the MEMO Study. Age (Dordr). 2011;33:209-217. doi:10.1007/s11357-010-9165-5
36. Salanitro AH, Ritchie CS, Hovater M, et al. Inflammatory biomarkers as predictors of hospitalization and death in communitydwelling older adults. Arch Gerontol Geriatr. 2012;54:e387-e391. doi:10.1016/j.archger.2012.01.006
37. Nafziger AN, Bowlin SJ, Jenkins PL, Pearson TA. Longitudinal changes in dehydroepiandrosterone concentrations in men and women. J Lab Clin Med. 1998;131:316-323.
38. Cappola AR, Xue QL, Fried LP. Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the women's health and aging studies. J Gerontol A Biol Sci Med Sci. 2009;64:243-248. doi:10.1093/gerona/gln026
39. Cappola AR, O'Meara ES, Guo W, Bartz TM, Fried LP, Newman AB. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol A Biol Sci Med Sci. 2009;64:1268-1274. doi:10.1093/gerona/glp129
40. Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187:728-735. doi:10.1164/rccm.201209-1665OC
41. Akbaraly TN, Hamer M, Ferrie JE, et al. Chronic inflammation as a determinant of future aging phenotypes. CMAJ. 2013;185:E763-E770. doi:10.1503/cmaj.122072
42. Weiss CO, Boyd CM, Yu Q, Wolff JL, Leff B. Patterns of prevalent major chronic disease among older adults in the United States. JAMA. 2007;298:1160-1162.
43. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380:37-43. doi:10.1016/S0140-6736(12)60240-2