An energy theory of glaucoma

GLIA

Volumn 63, Issue 9, 2015, Pages 1537-1552

  Li, Ying ^a   Li, Daqing ^a   Ying, Xi ^b   Khaw, Peng T ^c   Raisman, Geoffrey ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

Glia; Intraocular pressure; Olfactory ensheathing cells; Optic nerve head; Posterior ciliary artery

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL TRANSPLANTATION; ENERGY RESOURCE; EXTRACELLULAR SPACE; FEMALE; FLUID TRANSPORT; GLAUCOMA; INTRAOCULAR PRESSURE; MITOCHONDRION; NERVE DEGENERATION; NERVE FIBER; NONHUMAN; OLFACTORY ENSHEATHING CELL; OPTIC NERVE; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; RETINA PIGMENT CELL; VASCULARIZATION; ANATOMY AND HISTOLOGY; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; DISEASE MODEL; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; RETINA; RETINA DEGENERATION; TRANSPLANTATION;

ANIMALS; ASTROCYTES; AXONS; DISEASE MODELS, ANIMAL; FEMALE; GLAUCOMA; INTRAOCULAR PRESSURE; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PATHOLOGIC; OPTIC NERVE; RATS; RETINA; RETINAL DEGENERATION; TRANSPLANTATION;

EID: 84938105592     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22825     Document Type: Article

References (66)

1. Anderson DR. 1969. Ultrastructure of human and monkey lamina cribrosa and optic nerve head. Arch Ophthal 82:801-814.
2. Anderson DR, Hendrickson A. 1974. Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest Ophthalmol 13:771-783.
3. Balaratnasingam, C, Morgan WH, Bass L, Matich G, Cringle SJ, Yu DY. 2007. Axonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure. Invest Ophthalmol Vis Sci 48:3632-3644.
4. Balaratnasingam C, Morgan WH, Bass L, Ye L, McKnight C, Cringle SJ, Yu DY. 2008. Elevated pressure induced astrocyte damage in the optic nerve. Brain Res 1244:142-154.
5. Band LR, Hall CL, Richardson G, Jensen OE, Siggers JH, Foss AJ. 2009. Intracellular flow in optic nerve axons: A mechanism for cell death in glaucoma. Invest Ophthalmol Vis Sci 50:3750-3758.
6. Barron MJ, Griffiths P, Turnbull DM, Bates D, Nichols P. 2004. The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head. Br J Ophthalmol 88:286-290.
7. Barros LF. 2013. Metabolic signaling by lactate in the brain. Trends Neurosci 36:396-404.
8. Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH. 2014. Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain. Glia 62:1486-1501.
9. Bloom W, Fawcett DW. 1969. A textbook of histology. Philadelphia: W. B. Saunders Company.
10. Bristow EA, Griffiths PG, Andrews RM, Johnson MA, Turnbull DM. 2002. The distribution of mitochondrial activity in relation to optic nerve structure. Arch Ophthalmol 120:791-796.
11. Burgoyne CF. 2011. A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma. Exp Eye Res 93:120-132.
12. Chauhan BC, Pan J, Archibald ML, LeVatte TL, Kelly ME, Tremblay F. 2002. Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage. Invest Ophthalmol Vis Sci 43:2969-2976.
13. Chung HS, Harris A, Evans DW, Kagemann L, Garzozi HJ, Martin B. 1999. Vascular aspects in the pathophysiology of glaucomatous optic neuropathy. Surv Ophthalmol 43(Suppl 1):S43-S50.
14. Dai C, Khaw PT, Yin Z-Q, Li D-Q, Raisman G, Li Y. 2012a. Olfactory ensheathing cells rescue optic nerve fibres in a rat glaucoma model. Transl Vis Sci Technol 1.2:1-12.
15. Dai C, Khaw PT, Yin ZQ, Li D, Raisman G, Li Y. 2012b. Structural basis of glaucoma: The fortified astrocytes of the optic nerve head are the target of raised intraocular pressure. Glia 60:13-28.
16. Deane BR, Lantos PL. 1981. The vasculature of experimental brain tumours. Part 1. A sequential light and electron microscope study of angiogenesis. J Neurol Sci 49:55-66.
17. Downs JC, Yang H, Girkin C, Sakata L, Bellezza A, Thompson H, Burgoyne CF. 2007. Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: Neural canal and subarachnoid space architecture. Invest Ophthalmol Vis Sci 48:3195-3208.
18. Elkington AR, Inman CB, Steart PV, Weller RO. 1990. The structure of the lamina cribrosa of the human eye: An immunocytochemical and electron microscopical study. Eye 4:42-57.
19. Evans DW, Harris A, Garrett M, Chung HS, Kagemann L. 1999. Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change. Br J Ophthalmol 83:809-813.
20. Fern R, Ransom BR, Stys PK, Waxman SG. 1993. Pharmacological protection of CNS white matter during anoxia: Actions of phenytoin, carbamazepine and diazepam. J Pharmacol Exp Ther 266:1549-1555.
21. Ffrench-Constant C, Miller RH, Burne JF, Raff MC. 1988. Evidence that migratory oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells are kept out of the rat retina by a barrier at the eye-end of the optic nerve. J Neurocytol 17:13-25.
22. Flage T. 1977. Permeability properties of the tissues in the optic nerve head region in the rabbit and the monkey. An ultrastructural study. Acta Ophthalmol (Copenh) 55:652-664.
23. Flammer J, Orgul S. 1998. Optic nerve blood-flow abnormalities in glaucoma. Prog Retin Eye Res 17:267-289.
24. Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, Stefansson E. 2002. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21:359-393.
25. Fujita Y, Imagawa T, Uehara M. 2000. Comparative study of the lamina cribrosa and the pial septa in the vertebrate optic nerve and their relationship to the myelinated axons. Tissue Cell 32:293-301.
26. Grant WM, Burke JF Jr. 1982. Why do some people go blind from glaucoma? Ophthalmology 89:991-998.
27. Hafez AS, Bizzarro RL, Lesk MR. 2003. Evaluation of optic nerve head and peripapillary retinal blood flow in glaucoma patients, ocular hypertensives, and normal subjects. Am J Ophthalmol 136:1022-1031.
28. Hains BC, Waxman SG. 2005. Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma. Invest Ophthalmol Vis Sci 46:4164-4169.
29. Hayreh SS. 2001. Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 20:595-624.
30. Hildebrand C, Remahl S, Waxman SG. 1985. Axo-glial relations in the retina-optic nerve junction of the adult rat: Electron-microscopic observations. J Neurocytol 14:597-617.
31. Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179:1523-1537.
32. Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW. 2012. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest 122:1246-1261.
33. Jia L, Cepurna WO, Johnson EC, Morrison JC. 2000. Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest Ophthalmol Vis Sci 41:3415-3419.
34. Jonas JB. 2011. Role of cerebrospinal fluid pressure in the pathogenesis of glaucoma. Acta Ophthalmol 89:505-514.
35. Kistler HB Jr, LaVail JH. 1981. Penetration of horseradish peroxidase into the optic nerve after vitreal or vascular injections in the developing chick. Invest Ophthalmol Vis Sci 20:705-716.
36. Kuffler SW, Fitzhugh R, Barlow HB. 1957. Maintained activity in the cat's retina in light and darkness. J Gen Physiol 40:683-702.
37. Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD. 2012. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 487:443-448.
38. Malone P, Miao H, Parker A, Juarez S, Hernandez MR. 2007. Pressure induces loss of gap junction communication and redistribution of connexin 43 in astrocytes. Glia 55:1085-1098.
39. May CA, Lutjen-Drecoll E. 2002. Morphology of the murine optic nerve. Invest Ophthalmol Vis Sci 43:2206-2212.
40. Morgan JE. 2000. Optic nerve head structure in glaucoma: Astrocytes as mediators of axonal damage. Eye (Lond) 14:437-444.
41. Morrison JC. 2005. Elevated intraocular pressure and optic nerve injury models in the rat. J Glaucoma 14:315-317.
42. Morrison JC, Johnson E, Cepurna WO. 2008. Rat models for glaucoma research. Prog Brain Res 173:285-301.
43. Morrison JC, Johnson EC, Cepurna W, Jia L. 2005. Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res 24:217-240.
44. Morrison JC, Johnson EC, Cepurna WO, Funk RH. 1999. Microvasculature of the rat optic nerve head. Invest Ophthalmol Vis Sci 40:1702-1709.
45. Nagelhus EA, Veruki ML, Torp R, Haug FM, Laake JH, Nielsen S, Agre P, Ottersen OP. 1998. Aquaporin-4 water channel protein in the rat retina and optic nerve: Polarized expression in muller cells and fibrous astrocytes. J Neurosci 18:2506-2519.
46. Nickells RW, Howell GR, Soto I, John SW. 2012. Under pressure: Cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu Rev Neurosci 35:153-179.
47. Quigley HA. 1977. Gap junctions between optic nerve head astrocytes. Invest Ophthalmol Vis Sci 16:582-585.
48. Quigley HA. 2011. Glaucoma. Lancet 377:1367-1377.
49. Quigley HA, Addicks EM. 1981. Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol 99:137-143.
50. Quigley HA, Addicks EM, Green WR, Maumenee AE. 1981. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol 99:635-649.
51. Quigley HA, Hohman RM, Addicks EM, Massof RW, Green WR. 1983. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. Am J Ophthalmol 95:673-691.
52. Robson JG, Troy JB. 1987. Nature of the maintained discharge of Q, X, and Y retinal ganglion cells of the cat. J Opt Soc Am A 4:2301-2307.
53. Samsel PA, Kisiswa L, Erichsen JT, Cross SD, Morgan JE. 2011. A novel method for the induction of experimental glaucoma using magnetic microspheres. Invest Ophthalmol Vis Sci 52:1671-1675.
54. Schwartz B, Rieser JC, Fishbein SL. 1977. Fluorescein angiographic defects of the optic disc in glaucoma. Arch Ophthalmol 95:1961-1974.
55. Stys PK. 2005. General mechanisms of axonal damage and its prevention. J Neurol Sci 233:3-13.
56. Stys PK, Ransom BR, Waxman SG. 1992a. Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability. J Neurophysiol 67:236-240.
57. Stys PK, Waxman SG, Ransom BR. 1992b. Ionic mechanisms of anoxic injury in mammalian CNS white matter: Role of Na+ channels and Na(+)-Ca2+ exchanger. J Neurosci 12:430-439.
58. Sun D, Lye-Barthel M, Masland RH, Jakobs TC. 2009. The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse. J Comp Neurol 516:1-19.
59. Sun D, Qu J, Jakobs TC. 2013. Reversible reactivity by optic nerve astrocytes. Glia 61:1218-1235.
60. Tsacopoulos M, Magistretti PJ. 1996. Metabolic coupling between glia and neurons. J Neurosci 16:877-885.
61. Whitmore AV, Libby RT, John SW. 2005. Glaucoma: Thinking in new ways-A role for autonomous axonal self-destruction and other compartmentalised processes? Prog Retin Eye Res 24:639-662.
62. Wu X, Hammer JA. 2014. Melanosome transfer: It is best to give and receive. Curr Opin Cell Biol 29C:1-7.
63. Yamamoto T, Kitazawa Y. 1998. Vascular pathogenesis of normal-tension glaucoma: A possible pathogenetic factor, other than intraocular pressure, of glaucomatous optic neuropathy. Prog Retin Eye Res 17:127-143.
64. Yang H, Downs JC, Bellezza A, Thompson H, Burgoyne CF. 2007a. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Prelaminar neural tissues and cupping. Invest Ophthalmol Vis Sci 48:5068-5084.
65. Yang H, Downs JC, Girkin C, Sakata L, Bellezza A, Thompson H, Burgoyne CF. 2007b. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Lamina cribrosa and peripapillary scleral position and thickness. Invest Ophthalmol Vis Sci 48:4597-4607.
66. Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. 2015. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell 160:161-176.