PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome

International Journal of Molecular Medicine

Volumn 36, Issue 3, 2015, Pages 839-844

  Cho, Kyung Ah ^a   Kang, Peter B ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Insulin resistance; NLRP3 inflammasome; PLIN2; Skeletal muscle

Indexed keywords

COMPLEMENTARY DNA; CRYOPYRIN; GLUCOSE; INFLAMMASOME; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PERILIPIN; PERILIPIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GLUCOSE TRANSPORT; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; MOUSE; MYOBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SKELETAL MUSCLE; WESTERN BLOTTING; ANIMAL; CELL LINE; GENETIC TRANSFECTION; GENETICS; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; UPREGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE; GLUCOSE; HUMANS; INFLAMMASOMES; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-1BETA; MEMBRANE PROTEINS; MICE; MYOBLASTS; TRANSFECTION; TRIGLYCERIDES; UP-REGULATION;

EID: 84938076057     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2276     Document Type: Article

References (29)

1. Rachek LI: Free fatty acids and skeletal muscle insulin resistance. Prog Mol Biol Transl Sci 121: 267-292, 2014.
2. Moors CC, van der Zijl NJ, Diamant M, Blaak EE and Goossens GH: Impaired insulin sensitivity is accompanied by disturbances in skeletal muscle fatty acid handling in subjects with impaired glucose metabolism. Int J Obes 36: 709-717, 2012.
3. Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI and Caprio S: Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51: 1022-1027, 2002.
4. Kaneko S, Iida RH, Suga T, Fukui T, Morito M and Yamane A: Changes in triacylglycerol-accumulated fiber type, fiber type composition, and biogenesis in the mitochondria of the soleus muscle in obese rats. Anat Rec (Hoboken) 294: 1904-1912, 2011.
5. Gray RE, Tanner CJ, Pories WJ, MacDonald KG and Houmard JA: Effect of weight loss on muscle lipid content in morbidly obese subjects. Am J Physiol Endocrinol Metab 284: E726-E732, 2003.
6. Ducharme NA and Bickel PE: Lipid droplets in lipogenesis and lipolysis. Endocrinology 149: 942-949, 2008.
7. Martin S and Parton RG: Lipid droplets: A unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7: 373-378, 2006.
8. Larigauderie G, Cuaz-Pérolin C, Younes AB, Furman C, Lasselin C, Copin C, Jaye M, Fruchart JC and Rouis M: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation. FEBS J 273: 3498-3510, 2006.
9. Fukushima M, Enjoji M, Kohjima M, Sugimoto R, Ohta S, Kotoh K, Kuniyoshi M, Kobayashi K, Imamura M, Inoguchi T, et al: Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells. In Vitro Cell Dev Biol Anim 41: 321-324, 2005.
10. Listenberger LL, Ostermeyer-Fay AG, Goldberg EB, Brown WJ and Brown DA: Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover. J Lipid Res 48: 2751-2761, 2007.
11. Minnaard R, Schrauwen P, Schaart G, Jorgensen JA, Lenaers E, Mensink M and Hesselink MK: Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus. J Clin Endocrinol Metab 94: 4077-4085, 2009.
12. Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM and Ahima RS: Inhibition of ADRP prevents diet-induced insulin resistance. Am J Physiol Gastrointest Liver Physiol 295: G621-G628, 2008.
13. Maury E and Brichard SM: Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 314: 1-16, 2010.
14. Sell H and Eckel J: Monocyte chemotactic protein-1 and its role in insulin resistance. Curr Opin Lipidol 18: 258-262, 2007.
15. Tack CJ, Stienstra R, Joosten LA and Netea MG: Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family. Immunol Rev 249: 239-252, 2012.
16. Strowig T, Henao-Mejia J, Elinav E and Flavell R: Inflammasomes in health and disease. Nature 481: 278-286, 2012.
17. Benetti E, Chiazza F, Patel NS and Collino M: The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators Inflamm 2013: 678627, 2013.
18. Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y and Tanti JF: Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148: 241-251, 2007.
19. Liu X, Xue R, Ji L, Zhang X, Wu J, Gu J, Zhou M and Chen S: Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction. Biochem Biophys Res Commun 450: 117-123, 2014.
20. Dalen KT, Schoonjans K, Ulven SM, Weedon-Fekjaer MS, Bentzen TG, Koutnikova H, Auwerx J and Nebb HI: Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes 53: 1243-1252, 2004.
21. Petrighi Polidori G, Lomax MA and Docherty K: Palmitate enhances the differentiation of mouse embryonic stem cells towards white adipocyte lineages. Mol Cell Endocrinol 361: 40-50, 2012.
22. Bartels ED, Ploug T, St?rling J, Mandrup-Poulsen T and Nielsen LB: Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation. Scand J Clin Lab Invest 74: 351-357, 2014.
23. Taniguchi CM, Emanuelli B and Kahn CR: Critical nodes in signalling pathways: Insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96, 2006.
24. Yang WM, Jeong HJ, Park SY and Lee W: Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes. FEBS Lett 588: 2170-2176, 2014.
25. Gao D, Madi M, Ding C, Fok M, Steele T, Ford C, Hunter L and Bing C: Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am J Physiol Endocrinol Metab 307: E289-E304, 2014.
26. Abdul-Ghani MA and DeFronzo RA: Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol 2010: 476279, 2010.
27. Kraegen EW and Cooney GJ: Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol 19: 235-241, 2008.
28. Rotter V, Nagaev I and Smith U: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278: 45777-45784, 2003.
29. Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM and Dixit VD: The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17: 179-188, 2011.