Docosahexaenoic acid alleviates atopic dermatitis by generating tregs and IL-10/TGF-β-modified macrophages via a TGF-β-dependent mechanism

Journal of Investigative Dermatology

Volumn 135, Issue 6, 2015, Pages 1556-1564

  Han, Sang Chul ^a   Koo, Dong Hwan ^b   Kang, Na Jin ^b   Yoon, Weon Jong ^c   Kang, Gyeoung Jin ^d   Kang, Hee Kyoung ^a,b   Yoo, Eun Sook ^a,b  

^a Jeju National University School of Medicine   (South Korea)

^b Jeju National University   (South Korea)

^c Jeju Biodiversity Research Institute   (South Korea)

^d Dongguk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DOCOSAHEXAENOIC ACID; GAMMA INTERFERON; HISTAMINE; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 31; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOTOXIN; MESSENGER RNA; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; CD4+ T LYMPHOCYTE; CELL CONTACT; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HISTAMINE BLOOD LEVEL; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; INFLAMMATORY CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REGULATORY T LYMPHOCYTE; SKINFOLD THICKNESS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL; TISSUE STRUCTURE; TREATMENT DURATION; TREATMENT RESPONSE; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL DIFFERENTIATION; CHEMISTRY; DERMATITIS, ATOPIC; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOLOGY; INFLAMMATION; METABOLISM;

ANIMALS; CELL DIFFERENTIATION; DERMATITIS, ATOPIC; DOCOSAHEXAENOIC ACIDS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-10; MACROPHAGES; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84938074943     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.488     Document Type: Article

References (37)

1. Bailes JE, Mills JD (2010) Docosahexaenoic acid reduces traumatic axonal injury in a rodent head injury model. J Neurotrauma 27:1617-24
2. Bogiatzi SI, Fernandez I, Bichet JC et al. (2007) Cutting edge: proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J Immunol 178:3373-7
3. Bousquet M, Saint-Pierre M, Julien C et al. (2008) Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of parkinson's disease. FASEB J 22:1213-25
4. Cao Q, Wang Y, Zheng D et al. (2010) IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol 21:933-42
5. de Vries IJ, Langeveld-Wildschut EG, van Reijsen FC et al. (1997) Nonspecific T-cell homing during inflammation in atopic dermatitis: expression of cutaneous lymphocyte-associated antigen and integrin alphaE beta7 on skin-infiltrating T cells. J Allergy Clin Immunol 100:694-701
6. Debes GF, Bonhagen K, Wolff T et al. (2004) CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J Virol 78:7528-35
7. Dokmeci E, Herrick CA (2008) The immune system and atopic dermatitis. Semin Cutan Med Surg 27:138-43
8. Elhelu MA (1983) The role of macrophages in immunology. J Natl Med Assoc 75:314-7
9. Fu S, Zhang N, Yopp AC et al. (2004) TGF-beta induces Foxp3+T-regulatory cells from CD4+CD25-precursors. Am J Transplant 4:1614-27
10. Hijnen D, Haeck I, van Kraats AA et al. (2009) Cyclosporin A reduces CD4(+)CD25(+) regulatory T-cell numbers in patients with atopic dermatitis. J Allergy Clin Immunol 124:856-8
11. Huang FP, Platt N, Wykes M et al. (2000) A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 191:435-44
12. Huehn J, Hamann A (2005) Homing to suppress: Address codes for treg migration. Trends Immunol 26:632-6
13. Ikezumi Y, Hurst LA, Masaki T et al. (2003) Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation. Kidney Int 63:83-95
14. Ito Y, Adachi Y, Makino T et al. (2009) Expansion of FOXP3-positive CD4 + CD25+ T cells associated with disease activity in atopic dermatitis. Ann Allergy Asthma Immunol 103:160-5
15. Jakasa I, Koster ES, Calkoen F et al. (2011) Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin loss-of-function mutations. J Invest Dermatol 131:540-2
16. Koch C, Dolle S, Metzger M et al. (2008) Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, double-blind, controlled trial. Br J Dermatol 158:786-92
17. Kremmyda LS, Vlachava M, Noakes PS et al. (2011) Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review. Clin Rev Allergy Immunol 41:36-66
18. Leung DY, Boguiewicz M, Howell MD et al. (2004) New insights into atopic dermatitis. J Clin Invest 113:651-7
19. Levin TA, Ownby DR, Smith PH et al. (2006) Relationship between extremely low total serum IgE levels and rhinosinusitis. Ann Allergy Asthma Immunol 97:650-2
20. Li C, Lasse S, Lee P et al. (2010) Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc Natl Acad Sci USA 107:22249-54
21. Lin W, Truong N, Grossman WJ et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116:1106-15
22. Lopez-Vales R, Redensek A, Skinner TA et al. (2010) Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice. J Neurosci 30:3220-6
23. Martinez FO, Sica A, Mantovani A et al. (2008) Macrophage activation and polarization. Front Biosci 13:453-61
24. Ou LS, Goleva E, Hall C et al. (2004) T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 113:756-63
25. Saito K, Torii M, Ma N et al. (2008) Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammation. J Immunol 181:6889-97
26. Sakaguchi S, Wing K, Onishi Y et al. (2009) Regulatory T cells: how do they suppress immune responses? Int Immunol 21:1105-11
27. Savage ND, de Boer T, Walburg KV et al. (2008) Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J Immunol 181:2220-6
28. Shevach EM (2002) CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2:389-400
29. Shevach EM, DiPaolo RA, Andersson J et al. (2006) The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev 212:60-73
30. Soumelis V, Reche PA, Kanzler H et al. (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673-80
31. Storey A, McArdle F, Friedmann PS et al. (2005) Eicosapentaenoic acid and docosahexaenoic acid reduce UVB-and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. J Invest Dermatol 124:248-55
32. Tiemessen MM, Mitchell TJ, Hendry L et al. (2006) Lack of suppressive CD4+ CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma. J Invest Dermatol 126:2217-23
33. Tjiu JW, Chen JS, Shun CT et al. (2009) Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction. J Invest Dermatol 129:1016-25
34. Vignali DA, Collison LW, Workman CJ (2008) How regulatory T cells work. Nat Rev Immunol 8:523-32
35. Wahlgren CF (1999) Itch and atopic dermatitis: an overview. J Dermatol 26:770-9
36. Zheng Y, Rudensky AY (2007) Foxp3 in control of the regulatory T cell lineage. Nat Immunol 8:457-62
37. Ziegler SF (2006) FOXP3: Of mice and men. Annu Rev Immunol 24:209-26