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Volumn 19, Issue 8, 2015, Pages 1773-1782

Novel mechanism of cardiac protection by valsartan: Synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction

Author keywords

Fibrosis; Hif 1 ; Myocardial infarction; TGF 1; Valsartan

Indexed keywords

ANGIOTENSIN II; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VALSARTAN; CARDIOTONIC AGENT; COLLAGEN; GELATINASE A; GELATINASE B;

EID: 84938070440     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12551     Document Type: Article
Times cited : (55)

References (36)
  • 2
    • 79958830450 scopus 로고    scopus 로고
    • Fibrosis in endstage human heart failure: severe changes in collagen metabolism and mmp/timp profiles
    • Polyakova V, Loeffler I, Hein S, etal. Fibrosis in endstage human heart failure: severe changes in collagen metabolism and mmp/timp profiles. Int J Cardiol. 2011; 151: 18-33.
    • (2011) Int J Cardiol , vol.151 , pp. 18-33
    • Polyakova, V.1    Loeffler, I.2    Hein, S.3
  • 3
    • 70350575289 scopus 로고    scopus 로고
    • Il-17 induces myocardial fibrosis and enhances rankl/opg and mmp/timp signaling in isoproterenol-induced heart failure
    • Feng W, Li W, Liu W, etal. Il-17 induces myocardial fibrosis and enhances rankl/opg and mmp/timp signaling in isoproterenol-induced heart failure. Exp Mol Pathol. 2009; 87: 212-8.
    • (2009) Exp Mol Pathol , vol.87 , pp. 212-218
    • Feng, W.1    Li, W.2    Liu, W.3
  • 4
    • 77949768174 scopus 로고    scopus 로고
    • Tgf-beta1 expression and atrial myocardium fibrosis increase in atrial fibrillation secondary to rheumatic heart disease
    • Xiao H, Lei H, Qin S, etal. Tgf-beta1 expression and atrial myocardium fibrosis increase in atrial fibrillation secondary to rheumatic heart disease. Clin Cardiol. 2010; 33: 149-56.
    • (2010) Clin Cardiol , vol.33 , pp. 149-156
    • Xiao, H.1    Lei, H.2    Qin, S.3
  • 5
    • 27844536950 scopus 로고    scopus 로고
    • Differential role of tgf-beta1/bfgf and et-1 in graft fibrosis in heart failure patients
    • Aharinejad S, Krenn K, Paulus P, etal. Differential role of tgf-beta1/bfgf and et-1 in graft fibrosis in heart failure patients. Am J Transplant. 2005; 5: 2185-92.
    • (2005) Am J Transplant , vol.5 , pp. 2185-2192
    • Aharinejad, S.1    Krenn, K.2    Paulus, P.3
  • 6
    • 0033745462 scopus 로고    scopus 로고
    • Ctgf expression is induced by tgf- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis
    • Chen MM, Lam A, Abraham JA, etal. Ctgf expression is induced by tgf- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardiol. 2000; 32: 1805-19.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1805-1819
    • Chen, M.M.1    Lam, A.2    Abraham, J.A.3
  • 7
    • 0037083875 scopus 로고    scopus 로고
    • Ovarian hormones induce tgf-beta(3) and fibronectin mrnas but exhibit a disparate action on cardiac fibroblast proliferation
    • Mercier I, Colombo F, Mader S, etal. Ovarian hormones induce tgf-beta(3) and fibronectin mrnas but exhibit a disparate action on cardiac fibroblast proliferation. Cardiovasc Res. 2002; 53: 728-39.
    • (2002) Cardiovasc Res , vol.53 , pp. 728-739
    • Mercier, I.1    Colombo, F.2    Mader, S.3
  • 8
    • 78651104122 scopus 로고    scopus 로고
    • Valsartan decreases tgf-beta1 production and protects against chlorhexidine digluconate-induced liver peritoneal fibrosis in rats
    • Subeq YM, Ke CY, Lin NT, etal. Valsartan decreases tgf-beta1 production and protects against chlorhexidine digluconate-induced liver peritoneal fibrosis in rats. Cytokine. 2011; 53: 223-30.
    • (2011) Cytokine , vol.53 , pp. 223-230
    • Subeq, Y.M.1    Ke, C.Y.2    Lin, N.T.3
  • 9
    • 78649888294 scopus 로고    scopus 로고
    • Fosinopril and valsartan intervention in gene expression of klotho, mmp-9, timp-1, and pai-1 in the kidney of spontaneously hypertensive rats
    • Cheng X, Zhou Q, Lin S, etal. Fosinopril and valsartan intervention in gene expression of klotho, mmp-9, timp-1, and pai-1 in the kidney of spontaneously hypertensive rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010; 35: 1048-56.
    • (2010) Zhong Nan Da Xue Xue Bao Yi Xue Ban , vol.35 , pp. 1048-1056
    • Cheng, X.1    Zhou, Q.2    Lin, S.3
  • 10
    • 84857634811 scopus 로고    scopus 로고
    • Comparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance: Nagoya heart study
    • Muramatsu T, Matsushita K, Yamashita K, etal. Comparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance: Nagoya heart study. Hypertension. 2012; 59: 580-6.
    • (2012) Hypertension , vol.59 , pp. 580-586
    • Muramatsu, T.1    Matsushita, K.2    Yamashita, K.3
  • 11
    • 34247379373 scopus 로고    scopus 로고
    • Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study
    • Mochizuki S, Dahlof B, Shimizu M, etal. Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study. Lancet. 2007; 369: 1431-9.
    • (2007) Lancet , vol.369 , pp. 1431-1439
    • Mochizuki, S.1    Dahlof, B.2    Shimizu, M.3
  • 12
    • 19444374007 scopus 로고    scopus 로고
    • Valsartan reduces morbidity in people with heart failure receiving a low dose of ace inhibitor and no beta-blocker. Commentary
    • Pierard LA. Valsartan reduces morbidity in people with heart failure receiving a low dose of ace inhibitor and no beta-blocker. Commentary. Evid Based Cardiovasc Med. 2005; 9: 115-6.
    • (2005) Evid Based Cardiovasc Med , vol.9 , pp. 115-116
    • Pierard, L.A.1
  • 13
    • 58149382068 scopus 로고    scopus 로고
    • Long-term treatment with valsartan improved cyclic variation of the myocardial integral backscatter signal and diastolic dysfunction in hypertensive patients: the echocardiographic assessment
    • Mizuta Y, Kai H, Mizoguchi M, etal. Long-term treatment with valsartan improved cyclic variation of the myocardial integral backscatter signal and diastolic dysfunction in hypertensive patients: the echocardiographic assessment. Hypertens Res. 2008; 31: 1835-42.
    • (2008) Hypertens Res , vol.31 , pp. 1835-1842
    • Mizuta, Y.1    Kai, H.2    Mizoguchi, M.3
  • 14
    • 35048904208 scopus 로고    scopus 로고
    • Valsartan in the treatment of heart failure or left ventricular dysfunction after myocardial infarction
    • Bissessor N, White H. Valsartan in the treatment of heart failure or left ventricular dysfunction after myocardial infarction. Vasc Health Risk Manag. 2007; 3: 425-30.
    • (2007) Vasc Health Risk Manag , vol.3 , pp. 425-430
    • Bissessor, N.1    White, H.2
  • 15
    • 0037061910 scopus 로고    scopus 로고
    • Valsartan in chronic heart failure
    • Cayley WE Jr. Valsartan in chronic heart failure. N Engl J Med. 2002; 346: 1173-4.
    • (2002) N Engl J Med , vol.346 , pp. 1173-1174
    • Cayley Jr, W.E.1
  • 16
    • 84864085352 scopus 로고    scopus 로고
    • Valsartan inhibited hif-1alpha pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats
    • Tang L, Yi R, Yang B, etal. Valsartan inhibited hif-1alpha pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats. Diabetes Res Clin Pract. 2012; 97: 125-31.
    • (2012) Diabetes Res Clin Pract , vol.97 , pp. 125-131
    • Tang, L.1    Yi, R.2    Yang, B.3
  • 17
    • 84901457818 scopus 로고    scopus 로고
    • Smooth muscle cell-specific hif-1alpha deficiency suppresses angiotensin II-induced vascular remodelling in mice
    • Imanishi M, Tomita S, Ishizawa K, etal. Smooth muscle cell-specific hif-1alpha deficiency suppresses angiotensin II-induced vascular remodelling in mice. Cardiovasc Res. 2014; 102: 460-8.
    • (2014) Cardiovasc Res , vol.102 , pp. 460-468
    • Imanishi, M.1    Tomita, S.2    Ishizawa, K.3
  • 18
    • 77956364637 scopus 로고    scopus 로고
    • Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes
    • Chiu CZ, Wang BW, Chung TH, etal. Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes. Clin Sci. 2010; 119: 273-82.
    • (2010) Clin Sci , vol.119 , pp. 273-282
    • Chiu, C.Z.1    Wang, B.W.2    Chung, T.H.3
  • 19
    • 34250870604 scopus 로고    scopus 로고
    • Prolonged hypoxia concomitant with serum deprivation induces massive human mesenchymal stem cell death
    • Potier E, Ferreira E, Meunier A, etal. Prolonged hypoxia concomitant with serum deprivation induces massive human mesenchymal stem cell death. Tissue Eng. 2007; 13: 1325-31.
    • (2007) Tissue Eng , vol.13 , pp. 1325-1331
    • Potier, E.1    Ferreira, E.2    Meunier, A.3
  • 20
    • 77955709587 scopus 로고    scopus 로고
    • Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive chitosan hydrogel
    • Wang H, Zhang X, Li Y, etal. Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive chitosan hydrogel. J Heart Lung Transplant. 2010; 29: 881-7.
    • (2010) J Heart Lung Transplant , vol.29 , pp. 881-887
    • Wang, H.1    Zhang, X.2    Li, Y.3
  • 21
    • 84862784201 scopus 로고    scopus 로고
    • The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment
    • Liu Z, Wang H, Wang Y, etal. The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment. Biomaterials. 2012; 33: 3093-106.
    • (2012) Biomaterials , vol.33 , pp. 3093-3106
    • Liu, Z.1    Wang, H.2    Wang, Y.3
  • 22
    • 77950809834 scopus 로고    scopus 로고
    • Both the transplantation of somatic cell nuclear transfer- and fertilization-derived mouse embryonic stem cells with temperature-responsive chitosan hydrogel improve myocardial performance in infarcted rat hearts
    • Lu S, Wang H, Lu W, etal. Both the transplantation of somatic cell nuclear transfer- and fertilization-derived mouse embryonic stem cells with temperature-responsive chitosan hydrogel improve myocardial performance in infarcted rat hearts. Tissue Eng Part A. 2010; 16: 1303-15.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1303-1315
    • Lu, S.1    Wang, H.2    Lu, W.3
  • 23
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    • Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012; 18: 1028-40.
    • (2012) Nat Med , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 24
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol. 2003; 200: 500-3.
    • (2003) J Pathol , vol.200 , pp. 500-503
    • Gabbiani, G.1
  • 26
    • 33745843718 scopus 로고    scopus 로고
    • Effects of perindopril and valsartan on expression of transforming growth factor-beta-smads in experimental hepatic fibrosis in rats
    • Xu W, Song S, Huang Y, etal. Effects of perindopril and valsartan on expression of transforming growth factor-beta-smads in experimental hepatic fibrosis in rats. J Gastroenterol Hepatol. 2006; 21: 1250-6.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 1250-1256
    • Xu, W.1    Song, S.2    Huang, Y.3
  • 27
    • 22144453935 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker inhibits pulmonary injury
    • Mancini GB, Khalil N. Angiotensin II type 1 receptor blocker inhibits pulmonary injury. Clin Invest Med. 2005; 28: 118-26.
    • (2005) Clin Invest Med , vol.28 , pp. 118-126
    • Mancini, G.B.1    Khalil, N.2
  • 28
    • 34447326418 scopus 로고    scopus 로고
    • Cardioprotective effect of angiotensin II type 1 receptor antagonist associated with bradykinin-endothelial nitric oxide synthase and oxidative stress in Dahl salt-sensitive hypertensive rats
    • Yoshida K, Kobayashi N, Ohno T, etal. Cardioprotective effect of angiotensin II type 1 receptor antagonist associated with bradykinin-endothelial nitric oxide synthase and oxidative stress in Dahl salt-sensitive hypertensive rats. J Hypertens. 2007; 25: 1633-42.
    • (2007) J Hypertens , vol.25 , pp. 1633-1642
    • Yoshida, K.1    Kobayashi, N.2    Ohno, T.3
  • 29
    • 0030924446 scopus 로고    scopus 로고
    • Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target?
    • Noble NA, Border WA. Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target? Semin Nephrol. 1997; 17: 455-66.
    • (1997) Semin Nephrol , vol.17 , pp. 455-466
    • Noble, N.A.1    Border, W.A.2
  • 30
    • 0141792887 scopus 로고    scopus 로고
    • Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients
    • el-Agroudy AE, Hassan NA, Foda MA, etal. Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients. Am J Nephrol. 2003; 23: 300-6.
    • (2003) Am J Nephrol , vol.23 , pp. 300-306
    • el-Agroudy, A.E.1    Hassan, N.A.2    Foda, M.A.3
  • 31
    • 84864320125 scopus 로고    scopus 로고
    • Angiotensin II increases CTGF expression via mapks/tgf-beta1/traf6 pathway in atrial fibroblasts
    • Gu J, Liu X, Wang QX, etal. Angiotensin II increases CTGF expression via mapks/tgf-beta1/traf6 pathway in atrial fibroblasts. Exp Cell Res. 2012; 318: 2105-15.
    • (2012) Exp Cell Res , vol.318 , pp. 2105-2115
    • Gu, J.1    Liu, X.2    Wang, Q.X.3
  • 32
    • 34247473874 scopus 로고    scopus 로고
    • [Activation of transforming growth factor-beta1/smads signal pathway in diabetic cardiomyopathy and effects of valsartan thereon: experiment with rats]
    • Miao Y, Zhang W, Zhong M, etal. [Activation of transforming growth factor-beta1/smads signal pathway in diabetic cardiomyopathy and effects of valsartan thereon: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2007; 87: 366-70.
    • (2007) Zhonghua Yi Xue Za Zhi , vol.87 , pp. 366-370
    • Miao, Y.1    Zhang, W.2    Zhong, M.3
  • 33
    • 84860335047 scopus 로고    scopus 로고
    • Rsume is implicated in hif-1-induced vegf-a production in pituitary tumour cells
    • Shan B, Gerez J, Haedo M, etal. Rsume is implicated in hif-1-induced vegf-a production in pituitary tumour cells. Endocr Relat Cancer. 2012; 19: 13-27.
    • (2012) Endocr Relat Cancer , vol.19 , pp. 13-27
    • Shan, B.1    Gerez, J.2    Haedo, M.3
  • 34
    • 84911032637 scopus 로고    scopus 로고
    • Activation of the AT1R/HIF-1 α/ACE axis mediates angiotensin II-induced VEGF synthesis in mesenchymal stem cells
    • Liu C, Zhang JW, Hu L, etal. Activation of the AT1R/HIF-1 α/ACE axis mediates angiotensin II-induced VEGF synthesis in mesenchymal stem cells. Biomed Res Int. 2014; 2014: 627380.
    • (2014) Biomed Res Int , vol.2014 , pp. 627380
    • Liu, C.1    Zhang, J.W.2    Hu, L.3
  • 35
    • 79959968571 scopus 로고    scopus 로고
    • Molecular mechanism of hif-1-independent vegf expression in a hepatocellular carcinoma cell line
    • Choi SB, Park JB, Song TJ, etal. Molecular mechanism of hif-1-independent vegf expression in a hepatocellular carcinoma cell line. Int J Mol Med. 2011; 28: 449-54.
    • (2011) Int J Mol Med , vol.28 , pp. 449-454
    • Choi, S.B.1    Park, J.B.2    Song, T.J.3
  • 36
    • 84864699868 scopus 로고    scopus 로고
    • Decreased vegf expression and microvascular density, but increased hif-1 and 2alpha accumulation and epo expression in chronic moderate hyperoxia in the mouse brain
    • Benderro GF, Sun X, Kuang Y, etal. Decreased vegf expression and microvascular density, but increased hif-1 and 2alpha accumulation and epo expression in chronic moderate hyperoxia in the mouse brain. Brain Res. 2012; 1471: 46-55.
    • (2012) Brain Res , vol.1471 , pp. 46-55
    • Benderro, G.F.1    Sun, X.2    Kuang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.