Fibrosis in endstage human heart failure: Severe changes in collagen metabolism and MMP/TIMP profiles

International Journal of Cardiology

Volumn 151, Issue 1, 2011, Pages 18-33

  Polyakova, Victoria ^a   Loeffler, Ivo ^a   Hein, Stefan ^b   Miyagawa, Shigeru ^b,c   Piotrowska, Izabela ^d   Dammer, Sebastian ^a   Risteli, Juha ^e   Schaper, Jutta ^a   Kostin, Sawa ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b KERCKHOFF HEART CENTER   (Germany)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF OULU   (Finland)

Author keywords

Collagen; Fibrosis; Heart failure; Immunoconfocal microscopy; MMP; TIMP

Indexed keywords

ACTIVIN A; ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYTOKINE; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 19; MESSENGER RNA; NEUTROPHIL COLLAGENASE; PROCOLLAGEN C PROTEINASE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ADULT; ARTICLE; CARDIOMYOPATHY; CLINICAL ARTICLE; COLLAGEN DEGRADATION; COLLAGEN METABOLISM; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE FIBROSIS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IN SITU HYBRIDIZATION; ISCHEMIC CARDIOMYOPATHY; MALE; MYOCARDITIS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

ADULT; COLLAGEN TYPE I; COLLAGEN TYPE III; FEMALE; FIBROSIS; HEART FAILURE; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MYOCARDITIS; MYOCARDIUM; SEVERITY OF ILLNESS INDEX; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TISSUE INHIBITOR OF METALLOPROTEINASES; UP-REGULATION;

EID: 79958830450     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.04.053     Document Type: Article

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