Pig kidney graft survival in a baboon for 136 days: Longest life-supporting organ graft survival to date

Xenotransplantation

Volumn 22, Issue 4, 2015, Pages 302-309

  Iwase, Hayato ^a   Liu, Hong ^a,b   Wijkstrom, Martin ^a   Zhou, Huidong ^a,c   Singh, Jagjit ^a   Hara, Hidetaka ^a   Ezzelarab, Mohamed ^a   Long, Cassandra ^a   Klein, Edwin ^d   Wagner, Robert ^d   Phelps, Carol ^e   Ayares, David ^e   Shapiro, Ron ^a   Humar, Abhinav ^a   Cooper, David K C ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b SHANXI MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SOUTH CHINA   (China)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e REVIVICOR INC   (United States)

Author keywords

anti IL 6R antagonist; costimulation blockade; genetically engineered; kidney; pig; xenotransplantation

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 1,3 GALACTOSYLTRANSFERASE; ANTIINFLAMMATORY AGENT; CD20 ANTIBODY; CD40 ANTIBODY; CELL ANTIBODY; COBROTOXIN; COMPLEMENT; CORTICOSTEROID; CREATININE; ETANERCEPT; FIBRINOGEN; INTERLEUKIN 6 RECEPTOR ANTIBODY; LOW MOLECULAR WEIGHT HEPARIN; METHYLPREDNISOLONE; RAPAMYCIN; RECEPTOR ANTIBODY; REGULATOR PROTEIN; RITUXIMAB; THYMOCYTE ANTIBODY; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; GALACTOSYLTRANSFERASE; HETEROPHILE ANTIGEN; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BABOON; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEATH; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG DOSE REDUCTION; GENE INACTIVATION; GENETIC ENGINEERING; GRAFT SURVIVAL; HISTOPATHOLOGY; HYPOFIBRINOGENEMIA; IMMUNE INJURY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DISEASE; KIDNEY GRAFT; KIDNEY STRUCTURE; KIDNEY TRANSPLANTATION; MAINTENANCE THERAPY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; THROMBOCYTOPENIA; TRANSGENIC PIG; XENOTRANSPLANTATION; ADVERSE EFFECTS; ANIMAL; DEFICIENCY; GENETICS; HUMAN; IMMUNOLOGY; KIDNEY; PATHOLOGY; PIG; PROCEDURES; TIME FACTOR; TRANSGENIC ANIMAL; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, HETEROPHILE; COMPLEMENT SYSTEM PROTEINS; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; GENETIC ENGINEERING; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY TRANSPLANTATION; PAPIO; SWINE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84938056310     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12174     Document Type: Article

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