-
2
-
-
28844484134
-
Renal-cell carcinoma
-
10.1056/NEJMra043172 1:CAS:528:DC%2BD2MXhtlShurnM 16339096
-
Cohen HT, McGovern FJ (2005) Renal-cell carcinoma. N Engl J Med 353(23):2477-2490. doi: 10.1056/NEJMra043172
-
(2005)
N Engl J Med
, vol.353
, Issue.23
, pp. 2477-2490
-
-
Cohen, H.T.1
McGovern, F.J.2
-
3
-
-
0034038518
-
Chemotherapy for renal cell carcinoma
-
1:CAS:528:DC%2BD3cXivFOgtbY%3D 10768596
-
Amato RJ (2000) Chemotherapy for renal cell carcinoma. Semin Oncol 27(2):177-186
-
(2000)
Semin Oncol
, vol.27
, Issue.2
, pp. 177-186
-
-
Amato, R.J.1
-
4
-
-
84891829996
-
Targeted therapy in metastatic renal carcinoma
-
10.1016/j.canlet.2013.09.038 1:CAS:528:DC%2BC3sXhvFOhu77E 24239667
-
Mattei J, da Silva RD, Sehrt D, Molina WR, Kim FJ (2014) Targeted therapy in metastatic renal carcinoma. Cancer Lett 343(2):156-160. doi: 10.1016/j.canlet.2013.09.038
-
(2014)
Cancer Lett
, vol.343
, Issue.2
, pp. 156-160
-
-
Mattei, J.1
Da Silva, R.D.2
Sehrt, D.3
Molina, W.R.4
Kim, F.J.5
-
5
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie
-
10.1056/nejm199804303381805 1:CAS:528:DyaK1cXivF2qt74%3D 9562581
-
Negrier S, Escudier B, Lasset C, Douillard JY, Savary J, Chevreau C, Ravaud A, Mercatello A, Peny J, Mousseau M, Philip T, Tursz T (1998) Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N Engl J Med 338(18):1272-1278. doi: 10.1056/nejm199804303381805
-
(1998)
N Engl J Med
, vol.338
, Issue.18
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
Douillard, J.Y.4
Savary, J.5
Chevreau, C.6
Ravaud, A.7
Mercatello, A.8
Peny, J.9
Mousseau, M.10
Philip, T.11
Tursz, T.12
-
6
-
-
23744456812
-
Immunotherapy in metastatic renal cell carcinoma
-
10.1007/s00345-004-0470-4 1:CAS:528:DC%2BD2MXmsFWmtb0%3D 15806434
-
Rohrmann K, Staehler M, Haseke N, Bachmann A, Stief CG, Siebels M (2005) Immunotherapy in metastatic renal cell carcinoma. World J Urol 23(3):196-201. doi: 10.1007/s00345-004-0470-4
-
(2005)
World J Urol
, vol.23
, Issue.3
, pp. 196-201
-
-
Rohrmann, K.1
Staehler, M.2
Haseke, N.3
Bachmann, A.4
Stief, C.G.5
Siebels, M.6
-
7
-
-
84880942539
-
Novel approaches targeting the vascular endothelial growth factor axis in renal cell carcinoma
-
10.1097/PPO.0b013e31829d5cff 1:CAS:528:DC%2BC3sXhtFCltrbJ
-
Voss MH, Hsieh JJ, Motzer RJ (2013) Novel approaches targeting the vascular endothelial growth factor axis in renal cell carcinoma. Cancer J (Sudbury, Mass) 19(4):299-306. doi: 10.1097/PPO.0b013e31829d5cff
-
(2013)
Cancer J (Sudbury, Mass)
, vol.19
, Issue.4
, pp. 299-306
-
-
Voss, M.H.1
Hsieh, J.J.2
Motzer, R.J.3
-
8
-
-
73349110096
-
The role of antiangiogenesis therapy: Bevacizumab and beyond
-
1:CAS:528:DC%2BD1MXnvVantbs%3D 19531449
-
Cortes-Funes H (2009) The role of antiangiogenesis therapy: bevacizumab and beyond. Clin Transl Oncol 11(6):349-355
-
(2009)
Clin Transl Oncol
, vol.11
, Issue.6
, pp. 349-355
-
-
Cortes-Funes, H.1
-
9
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
10.1038/nrd2062 1:CAS:528:DC%2BD28XnsFCkurk%3D 16883305
-
Faivre S, Kroemer G, Raymond E (2006) Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 5(8):671-688. doi: 10.1038/nrd2062
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.8
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
10
-
-
18144399578
-
MTOR-targeted therapy of cancer with rapamycin derivatives
-
10.1093/annonc/mdi113 1:STN:280:DC%2BD2M7kvVWmsQ%3D%3D 15728109
-
Vignot S, Faivre S, Aguirre D, Raymond E (2005) mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 16(4):525-537. doi: 10.1093/annonc/mdi113
-
(2005)
Ann Oncol
, vol.16
, Issue.4
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
Raymond, E.4
-
11
-
-
33646804507
-
Mechanisms of immune evasion by tumors
-
10.1016/s0065-2776(06)90002-9 1:CAS:528:DC%2BD1cXhsVCjur4%3D 16730261
-
Drake CG, Jaffee E, Pardoll DM (2006) Mechanisms of immune evasion by tumors. Adv Immunol 90:51-81. doi: 10.1016/s0065-2776(06)90002-9
-
(2006)
Adv Immunol
, vol.90
, pp. 51-81
-
-
Drake, C.G.1
Jaffee, E.2
Pardoll, D.M.3
-
12
-
-
84555218419
-
Cancer immunotherapy comes of age
-
10.1200/jco.2011.38.0899 1:CAS:528:DC%2BC38Xhslygs7k%3D 3255990 22042955
-
Topalian SL, Weiner GJ, Pardoll DM (2011) Cancer immunotherapy comes of age. J Clin Oncol 29(36):4828-4836. doi: 10.1200/jco.2011.38.0899
-
(2011)
J Clin Oncol
, vol.29
, Issue.36
, pp. 4828-4836
-
-
Topalian, S.L.1
Weiner, G.J.2
Pardoll, D.M.3
-
13
-
-
84874527525
-
Third generation tyrosine kinase inhibitors and their development in advanced renal cell carcinoma
-
10.3389/fonc.2012.00013 3356077 22655261
-
Bukowski RM (2012) Third generation tyrosine kinase inhibitors and their development in advanced renal cell carcinoma. Front Oncol 2:13. doi: 10.3389/fonc.2012.00013
-
(2012)
Front Oncol
, vol.2
, pp. 13
-
-
Bukowski, R.M.1
-
14
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
10.1158/0008-5472.can-04-1443 1:CAS:528:DC%2BD2cXotFalsbk%3D 15466206
-
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA (2004) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64(19):7099-7109. doi: 10.1158/0008-5472.can-04-1443
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
15
-
-
20344362911
-
Phase i safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
-
10.1038/sj.bjc.6602584 1:CAS:528:DC%2BD2MXkt1Sgsrw%3D 2361774 15870716
-
Awada A, Hendlisz A, Gil T, Bartholomeus S, Mano M, de Valeriola D, Strumberg D, Brendel E, Haase CG, Schwartz B, Piccart M (2005) Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 92(10):1855-1861. doi: 10.1038/sj.bjc.6602584
-
(2005)
Br J Cancer
, vol.92
, Issue.10
, pp. 1855-1861
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
Bartholomeus, S.4
Mano, M.5
De Valeriola, D.6
Strumberg, D.7
Brendel, E.8
Haase, C.G.9
Schwartz, B.10
Piccart, M.11
-
16
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
10.1200/jco.2005.03.6723 1:CAS:528:DC%2BD28XmtVOmtrk%3D 16636341
-
Ratain MJ, Eisen T, Stadler WM, Flaherty KT, Kaye SB, Rosner GL, Gore M, Desai AA, Patnaik A, Xiong HQ, Rowinsky E, Abbruzzese JL, Xia C, Simantov R, Schwartz B, O'Dwyer PJ (2006) Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 24(16):2505-2512. doi: 10.1200/jco.2005.03.6723
-
(2006)
J Clin Oncol
, vol.24
, Issue.16
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
17
-
-
62449186539
-
Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma
-
10.1200/jco.2008.19.3342 1:CAS:528:DC%2BD1MXktFKhsb8%3D 19171708
-
Escudier B, Szczylik C, Hutson TE, Demkow T, Staehler M, Rolland F, Negrier S, Laferriere N, Scheuring UJ, Cella D, Shah S, Bukowski RM (2009) Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma. J Clin Oncol 27(8):1280-1289. doi: 10.1200/jco.2008.19.3342
-
(2009)
J Clin Oncol
, vol.27
, Issue.8
, pp. 1280-1289
-
-
Escudier, B.1
Szczylik, C.2
Hutson, T.E.3
Demkow, T.4
Staehler, M.5
Rolland, F.6
Negrier, S.7
Laferriere, N.8
Scheuring, U.J.9
Cella, D.10
Shah, S.11
Bukowski, R.M.12
-
18
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
10.1056/NEJMoa060655 1:CAS:528:DC%2BD2sXksVKitg%3D%3D 17215530
-
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Freeman S, Schwartz B, Shan M, Simantov R, Bukowski RM (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356(2):125-134. doi: 10.1056/NEJMoa060655
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
19
-
-
70249097380
-
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
-
10.1200/jco.2008.19.5511 1:CAS:528:DC%2BD1MXpvFejt7w%3D 19451442
-
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, Negrier S, Chevreau C, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Anderson S, Hofilena G, Shan M, Pena C, Lathia C, Bukowski RM (2009) Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 27(20):3312-3318. doi: 10.1200/jco.2008.19.5511
-
(2009)
J Clin Oncol
, vol.27
, Issue.20
, pp. 3312-3318
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Staehler, M.6
Negrier, S.7
Chevreau, C.8
Desai, A.A.9
Rolland, F.10
Demkow, T.11
Hutson, T.E.12
Gore, M.13
Anderson, S.14
Hofilena, G.15
Shan, M.16
Pena, C.17
Lathia, C.18
Bukowski, R.M.19
-
20
-
-
67650069910
-
VEGF kinase inhibitors: How do they cause hypertension?
-
10.1152/ajpregu.90502.2008 1:CAS:528:DC%2BD1MXovVKitbY%3D 19439616
-
Bhargava P (2009) VEGF kinase inhibitors: How do they cause hypertension? Am J Physiol Regul Integr Comp Physiol 297(1):R1-R5. doi: 10.1152/ajpregu.90502.2008
-
(2009)
Am J Physiol Regul Integr Comp Physiol
, vol.297
, Issue.1
, pp. R1-R5
-
-
Bhargava, P.1
-
21
-
-
84896835575
-
Incidence and risk of sorafenib-induced hypertension: A systematic review and meta-analysis
-
10.1111/jch.12273 1:CAS:528:DC%2BC2cXktlCgtro%3D
-
Li Y, Li S, Zhu Y, Liang X, Meng H, Chen J, Zhang D, Guo H, Shi B (2014) Incidence and risk of sorafenib-induced hypertension: a systematic review and meta-analysis. J Clin Hypertens (Greenwich, Conn) 16(3):177-185. doi: 10.1111/jch.12273
-
(2014)
J Clin Hypertens (Greenwich, Conn)
, vol.16
, Issue.3
, pp. 177-185
-
-
Li, Y.1
Li, S.2
Zhu, Y.3
Liang, X.4
Meng, H.5
Chen, J.6
Zhang, D.7
Guo, H.8
Shi, B.9
-
22
-
-
84902277139
-
Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: A systematic review and meta-analysis of clinical trials
-
10.1002/ijc.28544 1:CAS:528:DC%2BC3sXhslygsLbK
-
Santoni M, Conti A, De Giorgi U, Iacovelli R, Pantano F, Burattini L, Muzzonigro G, Berardi R, Santini D, Cascinu S (2014) Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: a systematic review and meta-analysis of clinical trials. Int J Cancer J int du Cancer 135(4):763-773. doi: 10.1002/ijc.28544
-
(2014)
Int J Cancer J Int du Cancer
, vol.135
, Issue.4
, pp. 763-773
-
-
Santoni, M.1
Conti, A.2
De Giorgi, U.3
Iacovelli, R.4
Pantano, F.5
Burattini, L.6
Muzzonigro, G.7
Berardi, R.8
Santini, D.9
Cascinu, S.10
-
23
-
-
84899091849
-
Impairment of cognitive functioning during sunitinib or sorafenib treatment in cancer patients: A cross sectional study
-
10.1186/1471-2407-14-219 3987809 24661373
-
Mulder SF, Bertens D, Desar IM, Vissers KC, Mulders PF, Punt CJ, van Spronsen DJ, Langenhuijsen JF, Kessels RP, van Herpen CM (2014) Impairment of cognitive functioning during sunitinib or sorafenib treatment in cancer patients: a cross sectional study. BMC Cancer 14:219. doi: 10.1186/1471-2407-14-219
-
(2014)
BMC Cancer
, vol.14
, pp. 219
-
-
Mulder, S.F.1
Bertens, D.2
Desar, I.M.3
Vissers, K.C.4
Mulders, P.F.5
Punt, C.J.6
Van Spronsen, D.J.7
Langenhuijsen, J.F.8
Kessels, R.P.9
Van Herpen, C.M.10
-
24
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
1:CAS:528:DC%2BD3sXnt1OrtA%3D%3D 12538485
-
Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9(1):327-337
-
(2003)
Clin Cancer Res
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
25
-
-
0141653352
-
Final results of a phase i and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers
-
Raymond E, Faivre S, Vera C (2003) Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers. In: Proceedings of the American Society for Clinical Oncology 22 (192):abstr 769
-
(2003)
Proceedings of the American Society for Clinical Oncology
, vol.22
, Issue.192
-
-
Raymond, E.1
Faivre, S.2
Vera, C.3
-
26
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
10.1200/jco.2005.02.2574 1:CAS:528:DC%2BD28Xot1ChtA%3D%3D 16330672
-
Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE, Li JZ, Bello CL, Theuer CP, George DJ, Rini BI (2006) Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24(1):16-24. doi: 10.1200/jco.2005.02.2574
-
(2006)
J Clin Oncol
, vol.24
, Issue.1
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
Deprimo, S.E.10
Li, J.Z.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
27
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
10.1056/NEJMoa065044 1:CAS:528:DC%2BD2sXksVGqsw%3D%3D 17215529
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356(2):115-124. doi: 10.1056/NEJMoa065044
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
28
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
10.1200/jco.2008.20.1293 1:CAS:528:DC%2BD1MXhtVOnu7nI 3646307 19487381
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, Garcia-del-Muro X, Sosman JA, Solska E, Wilding G, Thompson JA, Kim ST, Chen I, Huang X, Figlin RA (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27(22):3584-3590. doi: 10.1200/jco.2008.20.1293
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Oudard, S.6
Negrier, S.7
Szczylik, C.8
Pili, R.9
Bjarnason, G.A.10
Garcia-Del-Muro, X.11
Sosman, J.A.12
Solska, E.13
Wilding, G.14
Thompson, J.A.15
Kim, S.T.16
Chen, I.17
Huang, X.18
Figlin, R.A.19
-
29
-
-
84883445852
-
Long-term response to sunitinib therapy for metastatic renal cell carcinoma
-
10.1016/j.clgc.2013.04.001 3959735 23707221
-
Molina AM, Jia X, Feldman DR, Hsieh JJ, Ginsberg MS, Velasco S, Patil S, Motzer RJ (2013) Long-term response to sunitinib therapy for metastatic renal cell carcinoma. Clin Genitourin Cancer 11(3):297-302. doi: 10.1016/j.clgc.2013.04.001
-
(2013)
Clin Genitourin Cancer
, vol.11
, Issue.3
, pp. 297-302
-
-
Molina, A.M.1
Jia, X.2
Feldman, D.R.3
Hsieh, J.J.4
Ginsberg, M.S.5
Velasco, S.6
Patil, S.7
Motzer, R.J.8
-
30
-
-
79955767772
-
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
10.1093/jnci/djr128 1:CAS:528:DC%2BC3MXlvVOqtLc%3D 3086879 21527770
-
Rini BI, Cohen DP, Lu DR, Chen I, Hariharan S, Gore ME, Figlin RA, Baum MS, Motzer RJ (2011) Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 103(9):763-773. doi: 10.1093/jnci/djr128
-
(2011)
J Natl Cancer Inst
, vol.103
, Issue.9
, pp. 763-773
-
-
Rini, B.I.1
Cohen, D.P.2
Lu, D.R.3
Chen, I.4
Hariharan, S.5
Gore, M.E.6
Figlin, R.A.7
Baum, M.S.8
Motzer, R.J.9
-
31
-
-
84875645855
-
Comparative efficacy of sunitinib versus sorafenib as first-line treatment for patients with metastatic renal cell carcinoma
-
10.1159/000346484 1:CAS:528:DC%2BC3sXms1entLY%3D 23548259
-
Park SJ, Lee JL, Park I, Park K, Ahn Y, Ahn JH, Lee DH, Ahn S, Song C, Hong JH, Kim CS, Ahn H (2012) Comparative efficacy of sunitinib versus sorafenib as first-line treatment for patients with metastatic renal cell carcinoma. Chemotherapy 58(6):468-474. doi: 10.1159/000346484
-
(2012)
Chemotherapy
, vol.58
, Issue.6
, pp. 468-474
-
-
Park, S.J.1
Lee, J.L.2
Park, I.3
Park, K.4
Ahn, Y.5
Ahn, J.H.6
Lee, D.H.7
Ahn, S.8
Song, C.9
Hong, J.H.10
Kim, C.S.11
Ahn, H.12
-
32
-
-
84866111387
-
Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: A national registry-based study
-
10.1093/annonc/mds145 1:STN:280:DC%2BC38jitVWiug%3D%3D 22700990
-
Poprach A, Pavlik T, Melichar B, Puzanov I, Dusek L, Bortlicek Z, Vyzula R, Abrahamova J, Buchler T (2012) Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: a national registry-based study. Ann Oncol 23(12):3137-3143. doi: 10.1093/annonc/mds145
-
(2012)
Ann Oncol
, vol.23
, Issue.12
, pp. 3137-3143
-
-
Poprach, A.1
Pavlik, T.2
Melichar, B.3
Puzanov, I.4
Dusek, L.5
Bortlicek, Z.6
Vyzula, R.7
Abrahamova, J.8
Buchler, T.9
-
33
-
-
79952543555
-
Pazopanib: The newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma
-
1:CAS:528:DC%2BC3MXms1SntLg%3D 21395357
-
Keisner SV, Shah SR (2011) Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs 71(4):443-454. doi: 10.2165/11588960-000000000-00000
-
(2011)
Drugs
, vol.71
, Issue.4
, pp. 443-454
-
-
Keisner, S.V.1
Shah, S.R.2
-
34
-
-
78650387508
-
Pazopanib in renal cell carcinoma
-
10.1158/1078-0432.ccr-10-0728 1:CAS:528:DC%2BC3cXhsFOjsbfI 21059813
-
Ward JE, Stadler WM (2010) Pazopanib in renal cell carcinoma. Clin Cancer Res 16(24):5923-5927. doi: 10.1158/1078-0432.ccr-10-0728
-
(2010)
Clin Cancer Res
, vol.16
, Issue.24
, pp. 5923-5927
-
-
Ward, J.E.1
Stadler, W.M.2
-
35
-
-
78649356814
-
Pazopanib for the treatment of patients with advanced renal cell carcinoma
-
1:CAS:528:DC%2BC3cXht1KlsLjI 2956476 20981133
-
Lang JM, Harrison MR (2010) Pazopanib for the treatment of patients with advanced renal cell carcinoma. Clin Med Insights Oncol 4:95-105. doi: 10.4137/cmo.s4088
-
(2010)
Clin Med Insights Oncol
, vol.4
, pp. 95-105
-
-
Lang, J.M.1
Harrison, M.R.2
-
36
-
-
80955136942
-
Critical appraisal of pazopanib as treatment for patients with advanced metastatic renal cell carcinoma
-
10.2147/cmr.s15557 1:CAS:528:DC%2BC3MXhtFantbjP 3173017 21931501
-
Bukowski RM (2011) Critical appraisal of pazopanib as treatment for patients with advanced metastatic renal cell carcinoma. Cancer Manag Res 3:273-285. doi: 10.2147/cmr.s15557
-
(2011)
Cancer Manag Res
, vol.3
, pp. 273-285
-
-
Bukowski, R.M.1
-
37
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
10.1158/1535-7163.mct-07-0193 1:CAS:528:DC%2BD2sXnsV2jsrk%3D 17620431
-
Kumar R, Knick VB, Rudolph SK, Johnson JH, Crosby RM, Crouthamel MC, Hopper TM, Miller CG, Harrington LE, Onori JA, Mullin RJ, Gilmer TM, Truesdale AT, Epperly AH, Boloor A, Stafford JA, Luttrell DK, Cheung M (2007) Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 6(7):2012-2021. doi: 10.1158/1535-7163.mct-07-0193
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.7
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
Johnson, J.H.4
Crosby, R.M.5
Crouthamel, M.C.6
Hopper, T.M.7
Miller, C.G.8
Harrington, L.E.9
Onori, J.A.10
Mullin, R.J.11
Gilmer, T.M.12
Truesdale, A.T.13
Epperly, A.H.14
Boloor, A.15
Stafford, J.A.16
Luttrell, D.K.17
Cheung, M.18
-
38
-
-
67449164582
-
Phase i trial of pazopanib in patients with advanced cancer
-
10.1158/1078-0432.ccr-08-2740 1:CAS:528:DC%2BD1MXntlOitr4%3D 19509175
-
Hurwitz HI, Dowlati A, Saini S, Savage S, Suttle AB, Gibson DM, Hodge JP, Merkle EM, Pandite L (2009) Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res 15(12):4220-4227. doi: 10.1158/1078-0432.ccr-08-2740
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4220-4227
-
-
Hurwitz, H.I.1
Dowlati, A.2
Saini, S.3
Savage, S.4
Suttle, A.B.5
Gibson, D.M.6
Hodge, J.P.7
Merkle, E.M.8
Pandite, L.9
-
39
-
-
75749090050
-
Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
-
10.1200/jco.2008.21.6994 1:CAS:528:DC%2BC3cXivFartb0%3D 20008644
-
Hutson TE, Davis ID, Machiels JP, De Souza PL, Rottey S, Hong BF, Epstein RJ, Baker KL, McCann L, Crofts T, Pandite L, Figlin RA (2010) Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol 28(3):475-480. doi: 10.1200/jco.2008.21.6994
-
(2010)
J Clin Oncol
, vol.28
, Issue.3
, pp. 475-480
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.P.3
De Souza, P.L.4
Rottey, S.5
Hong, B.F.6
Epstein, R.J.7
Baker, K.L.8
McCann, L.9
Crofts, T.10
Pandite, L.11
Figlin, R.A.12
-
40
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
10.1200/jco.2009.23.9764 1:CAS:528:DC%2BC3cXktF2lt78%3D 20100962
-
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, Zarba JJ, Chen M, McCann L, Pandite L, Roychowdhury DF, Hawkins RE (2010) Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 28(6):1061-1068. doi: 10.1200/jco.2009.23.9764
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
Barrios, C.H.7
Salman, P.8
Gladkov, O.A.9
Kavina, A.10
Zarba, J.J.11
Chen, M.12
McCann, L.13
Pandite, L.14
Roychowdhury, D.F.15
Hawkins, R.E.16
-
41
-
-
84875690904
-
A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: Final overall survival results and safety update
-
10.1016/j.ejca.2012.12.010 1:CAS:528:DC%2BC3sXovFShtw%3D%3D
-
Sternberg CN, Hawkins RE, Wagstaff J, Salman P, Mardiak J, Barrios CH, Zarba JJ, Gladkov OA, Lee E, Szczylik C, McCann L, Rubin SD, Chen M, Davis ID (2013) A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update. Eur J Cancer (Oxford, England: 1990) 49(6):1287-1296. doi: 10.1016/j.ejca.2012.12.010
-
(2013)
Eur J Cancer (Oxford, England: 1990)
, vol.49
, Issue.6
, pp. 1287-1296
-
-
Sternberg, C.N.1
Hawkins, R.E.2
Wagstaff, J.3
Salman, P.4
Mardiak, J.5
Barrios, C.H.6
Zarba, J.J.7
Gladkov, O.A.8
Lee, E.9
Szczylik, C.10
McCann, L.11
Rubin, S.D.12
Chen, M.13
Davis, I.D.14
-
42
-
-
84882781441
-
Pazopanib versus sunitinib in metastatic renal-cell carcinoma
-
10.1056/NEJMoa1303989 1:CAS:528:DC%2BC3sXhtlCrsrbP 23964934
-
Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, de Souza P, Merchan JR, Boleti E, Fife K, Jin J, Jones R, Uemura H, De Giorgi U, Harmenberg U, Wang J, Sternberg CN, Deen K, McCann L, Hackshaw MD, Crescenzo R, Pandite LN, Choueiri TK (2013) Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369(8):722-731. doi: 10.1056/NEJMoa1303989
-
(2013)
N Engl J Med
, vol.369
, Issue.8
, pp. 722-731
-
-
Motzer, R.J.1
Hutson, T.E.2
Cella, D.3
Reeves, J.4
Hawkins, R.5
Guo, J.6
Nathan, P.7
Staehler, M.8
De Souza, P.9
Merchan, J.R.10
Boleti, E.11
Fife, K.12
Jin, J.13
Jones, R.14
Uemura, H.15
De Giorgi, U.16
Harmenberg, U.17
Wang, J.18
Sternberg, C.N.19
Deen, K.20
McCann, L.21
Hackshaw, M.D.22
Crescenzo, R.23
Pandite, L.N.24
Choueiri, T.K.25
more..
-
43
-
-
84902986833
-
Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study
-
10.1200/jco.2013.50.8267 1:CAS:528:DC%2BC2cXhtV2jsbvK 24687826
-
Escudier B, Porta C, Bono P, Powles T, Eisen T, Sternberg CN, Gschwend JE, De Giorgi U, Parikh O, Hawkins R, Sevin E, Negrier S, Khan S, Diaz J, Redhu S, Mehmud F, Cella D (2014) Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study. J Clin Oncol 32(14):1412-1418. doi: 10.1200/jco.2013.50.8267
-
(2014)
J Clin Oncol
, vol.32
, Issue.14
, pp. 1412-1418
-
-
Escudier, B.1
Porta, C.2
Bono, P.3
Powles, T.4
Eisen, T.5
Sternberg, C.N.6
Gschwend, J.E.7
De Giorgi, U.8
Parikh, O.9
Hawkins, R.10
Sevin, E.11
Negrier, S.12
Khan, S.13
Diaz, J.14
Redhu, S.15
Mehmud, F.16
Cella, D.17
-
44
-
-
58149337448
-
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
-
10.1158/1078-0432.ccr-08-0652 1:CAS:528:DC%2BD1cXhtlylur7I 19010843
-
Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR, Amundson K, Chen JH, Rewolinski DA, Yamazaki S, Wu EY, McTigue MA, Murray BW, Kania RS, O'Connor P, Shalinsky DR, Bender SL (2008) Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 14(22):7272-7283. doi: 10.1158/1078-0432.ccr-08-0652
-
(2008)
Clin Cancer Res
, vol.14
, Issue.22
, pp. 7272-7283
-
-
Hu-Lowe, D.D.1
Zou, H.Y.2
Grazzini, M.L.3
Hallin, M.E.4
Wickman, G.R.5
Amundson, K.6
Chen, J.H.7
Rewolinski, D.A.8
Yamazaki, S.9
Wu, E.Y.10
McTigue, M.A.11
Murray, B.W.12
Kania, R.S.13
O'Connor, P.14
Shalinsky, D.R.15
Bender, S.L.16
-
45
-
-
79959482485
-
Axitinib for the management of metastatic renal cell carcinoma
-
10.2165/11591240-000000000-00000
-
Escudier B, Gore M (2011) Axitinib for the management of metastatic renal cell carcinoma. Drugs R&D 11(2):113-126. doi: 10.2165/11591240-000000000-00000
-
(2011)
Drugs R&D
, vol.11
, Issue.2
, pp. 113-126
-
-
Escudier, B.1
Gore, M.2
-
46
-
-
24944453855
-
Phase i trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
-
10.1200/jco.2005.04.192 1:CAS:528:DC%2BD2MXhtVersr7F 16027439
-
Rugo HS, Herbst RS, Liu G, Park JW, Kies MS, Steinfeldt HM, Pithavala YK, Reich SD, Freddo JL, Wilding G (2005) Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 23(24):5474-5483. doi: 10.1200/jco.2005.04.192
-
(2005)
J Clin Oncol
, vol.23
, Issue.24
, pp. 5474-5483
-
-
Rugo, H.S.1
Herbst, R.S.2
Liu, G.3
Park, J.W.4
Kies, M.S.5
Steinfeldt, H.M.6
Pithavala, Y.K.7
Reich, S.D.8
Freddo, J.L.9
Wilding, G.10
-
47
-
-
35448934762
-
Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
-
10.1016/s1470-2045(07)70285-1 17959415
-
Rixe O, Bukowski RM, Michaelson MD, Wilding G, Hudes GR, Bolte O, Motzer RJ, Bycott P, Liau KF, Freddo J, Trask PC, Kim S, Rini BI (2007) Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 8(11):975-984. doi: 10.1016/s1470-2045(07)70285-1
-
(2007)
Lancet Oncol
, vol.8
, Issue.11
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
Wilding, G.4
Hudes, G.R.5
Bolte, O.6
Motzer, R.J.7
Bycott, P.8
Liau, K.F.9
Freddo, J.10
Trask, P.C.11
Kim, S.12
Rini, B.I.13
-
48
-
-
82755183572
-
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
-
10.1016/s0140-6736(11)61613-9 1:CAS:528:DC%2BC3MXhsFGqsL%2FP 22056247
-
Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, Negrier S, Ou YC, Castellano D, Lim HY, Uemura H, Tarazi J, Cella D, Chen C, Rosbrook B, Kim S, Motzer RJ (2011) Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 378(9807):1931-1939. doi: 10.1016/s0140-6736(11)61613-9
-
(2011)
Lancet
, vol.378
, Issue.9807
, pp. 1931-1939
-
-
Rini, B.I.1
Escudier, B.2
Tomczak, P.3
Kaprin, A.4
Szczylik, C.5
Hutson, T.E.6
Michaelson, M.D.7
Gorbunova, V.A.8
Gore, M.E.9
Rusakov, I.G.10
Negrier, S.11
Ou, Y.C.12
Castellano, D.13
Lim, H.Y.14
Uemura, H.15
Tarazi, J.16
Cella, D.17
Chen, C.18
Rosbrook, B.19
Kim, S.20
Motzer, R.J.21
more..
-
49
-
-
84876974877
-
Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial
-
10.1016/s1470-2045(13)70093-7 1:CAS:528:DC%2BC3sXmt1Ontbw%3D 23598172
-
Motzer RJ, Escudier B, Tomczak P, Hutson TE, Michaelson MD, Negrier S, Oudard S, Gore ME, Tarazi J, Hariharan S, Chen C, Rosbrook B, Kim S, Rini BI (2013) Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol 14(6):552-562. doi: 10.1016/s1470-2045(13)70093-7
-
(2013)
Lancet Oncol
, vol.14
, Issue.6
, pp. 552-562
-
-
Motzer, R.J.1
Escudier, B.2
Tomczak, P.3
Hutson, T.E.4
Michaelson, M.D.5
Negrier, S.6
Oudard, S.7
Gore, M.E.8
Tarazi, J.9
Hariharan, S.10
Chen, C.11
Rosbrook, B.12
Kim, S.13
Rini, B.I.14
-
50
-
-
84888132613
-
Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: A randomised open-label phase 3 trial
-
10.1016/s1470-2045(13)70465-0 1:CAS:528:DC%2BC3sXhslWltLjK 24206640
-
Hutson TE, Lesovoy V, Al-Shukri S, Stus VP, Lipatov ON, Bair AH, Rosbrook B, Chen C, Kim S, Vogelzang NJ (2013) Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial. Lancet Oncol 14(13):1287-1294. doi: 10.1016/s1470-2045(13)70465-0
-
(2013)
Lancet Oncol
, vol.14
, Issue.13
, pp. 1287-1294
-
-
Hutson, T.E.1
Lesovoy, V.2
Al-Shukri, S.3
Stus, V.P.4
Lipatov, O.N.5
Bair, A.H.6
Rosbrook, B.7
Chen, C.8
Kim, S.9
Vogelzang, N.J.10
-
51
-
-
70349388719
-
Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
-
10.1200/jco.2008.21.7034 1:CAS:528:DC%2BD1MXhtlCnsrfL 19652060
-
Rini BI, Wilding G, Hudes G, Stadler WM, Kim S, Tarazi J, Rosbrook B, Trask PC, Wood L, Dutcher JP (2009) Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J Clin Oncol 27(27):4462-4468. doi: 10.1200/jco.2008.21.7034
-
(2009)
J Clin Oncol
, vol.27
, Issue.27
, pp. 4462-4468
-
-
Rini, B.I.1
Wilding, G.2
Hudes, G.3
Stadler, W.M.4
Kim, S.5
Tarazi, J.6
Rosbrook, B.7
Trask, P.C.8
Wood, L.9
Dutcher, J.P.10
-
52
-
-
84879089369
-
The risk of hand-foot skin reaction to axitinib, a novel VEGF inhibitor: A systematic review of literature and meta-analysis
-
10.1007/s10637-013-9927-x 1:CAS:528:DC%2BC3sXnt12ltb8%3D 23345001
-
Fischer A, Wu S, Ho AL, Lacouture ME (2013) The risk of hand-foot skin reaction to axitinib, a novel VEGF inhibitor: a systematic review of literature and meta-analysis. Invest New Drugs 31(3):787-797. doi: 10.1007/s10637-013-9927-x
-
(2013)
Invest New Drugs
, vol.31
, Issue.3
, pp. 787-797
-
-
Fischer, A.1
Wu, S.2
Ho, A.L.3
Lacouture, M.E.4
-
53
-
-
84882578238
-
Incidence and risk of hypertension with a novel multi-targeted kinase inhibitor axitinib in cancer patients: A systematic review and meta-analysis
-
10.1111/bcp.12149 1:CAS:528:DC%2BC3sXhtlaitLvN 3769663 23617405
-
Qi WX, He AN, Shen Z, Yao Y (2013) Incidence and risk of hypertension with a novel multi-targeted kinase inhibitor axitinib in cancer patients: a systematic review and meta-analysis. Br J Clin Pharmacol 76(3):348-357. doi: 10.1111/bcp.12149
-
(2013)
Br J Clin Pharmacol
, vol.76
, Issue.3
, pp. 348-357
-
-
Qi, W.X.1
He, A.N.2
Shen, Z.3
Yao, Y.4
-
54
-
-
84894625038
-
Hypertension among patients with renal cell carcinoma receiving axitinib or sorafenib: Analysis from the randomized phase III AXIS trial
-
4363524 24595903
-
Rini BI, Quinn DI, Baum M, Wood LS, Tarazi J, Rosbrook B, Arruda LS, Cisar L, Roberts WG, Kim S, Motzer RJ (2014) Hypertension among patients with renal cell carcinoma receiving axitinib or sorafenib: analysis from the randomized phase III AXIS trial. Target Oncol. doi: 10.1007/s11523-014-0307-z
-
(2014)
Target Oncol
-
-
Rini, B.I.1
Quinn, D.I.2
Baum, M.3
Wood, L.S.4
Tarazi, J.5
Rosbrook, B.6
Arruda, L.S.7
Cisar, L.8
Roberts, W.G.9
Kim, S.10
Motzer, R.J.11
-
55
-
-
84879346616
-
Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma
-
10.2147/dddt.s31442 1:CAS:528:DC%2BC3sXhtVGqtbnN
-
Cowey CL (2013) Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma. Drug Des Dev Ther 7:519-527. doi: 10.2147/dddt.s31442
-
(2013)
Drug des Dev Ther
, vol.7
, pp. 519-527
-
-
Cowey, C.L.1
-
56
-
-
33749503264
-
KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties
-
10.1158/0008-5472.can-05-4290 1:CAS:528:DC%2BD28Xps1aiurY%3D 16982756
-
Nakamura K, Taguchi E, Miura T, Yamamoto A, Takahashi K, Bichat F, Guilbaud N, Hasegawa K, Kubo K, Fujiwara Y, Suzuki R, Kubo K, Shibuya M, Isae T (2006) KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res 66(18):9134-9142. doi: 10.1158/0008-5472.can-05-4290
-
(2006)
Cancer Res
, vol.66
, Issue.18
, pp. 9134-9142
-
-
Nakamura, K.1
Taguchi, E.2
Miura, T.3
Yamamoto, A.4
Takahashi, K.5
Bichat, F.6
Guilbaud, N.7
Hasegawa, K.8
Kubo, K.9
Fujiwara, Y.10
Suzuki, R.11
Kubo, K.12
Shibuya, M.13
Isae, T.14
-
57
-
-
38949178751
-
Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model
-
10.1111/j.1349-7006.2007.00724.x 1:CAS:528:DC%2BD1cXjt1ehsLg%3D 18201272
-
Taguchi E, Nakamura K, Miura T, Shibuya M, Isoe T (2008) Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci 99(3):623-630. doi: 10.1111/j.1349-7006.2007.00724.x
-
(2008)
Cancer Sci
, vol.99
, Issue.3
, pp. 623-630
-
-
Taguchi, E.1
Nakamura, K.2
Miura, T.3
Shibuya, M.4
Isoe, T.5
-
58
-
-
81255128983
-
Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1, -2, and -3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors
-
10.1158/1078-0432.ccr-11-0411 1:CAS:528:DC%2BC3MXhsVKht7bJ 21976547
-
Eskens FA, de Jonge MJ, Bhargava P, Isoe T, Cotreau MM, Esteves B, Hayashi K, Burger H, Thomeer M, van Doorn L, Verweij J (2011) Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1, -2, and -3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors. Clin Cancer Res 17(22):7156-7163. doi: 10.1158/1078-0432.ccr-11-0411
-
(2011)
Clin Cancer Res
, vol.17
, Issue.22
, pp. 7156-7163
-
-
Eskens, F.A.1
De Jonge, M.J.2
Bhargava, P.3
Isoe, T.4
Cotreau, M.M.5
Esteves, B.6
Hayashi, K.7
Burger, H.8
Thomeer, M.9
Van Doorn, L.10
Verweij, J.11
-
59
-
-
84863755452
-
Antitumor activity and safety of tivozanib (AV-951) in a phase II randomized discontinuation trial in patients with renal cell carcinoma
-
10.1200/jco.2011.35.3524 1:CAS:528:DC%2BC38XpsVKjtrY%3D 22493422
-
Nosov DA, Esteves B, Lipatov ON, Lyulko AA, Anischenko AA, Chacko RT, Doval DC, Strahs A, Slichenmyer WJ, Bhargava P (2012) Antitumor activity and safety of tivozanib (AV-951) in a phase II randomized discontinuation trial in patients with renal cell carcinoma. J Clin Oncol 30(14):1678-1685. doi: 10.1200/jco.2011.35.3524
-
(2012)
J Clin Oncol
, vol.30
, Issue.14
, pp. 1678-1685
-
-
Nosov, D.A.1
Esteves, B.2
Lipatov, O.N.3
Lyulko, A.A.4
Anischenko, A.A.5
Chacko, R.T.6
Doval, D.C.7
Strahs, A.8
Slichenmyer, W.J.9
Bhargava, P.10
-
60
-
-
84891713447
-
Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: Results from a phase III trial
-
10.1200/jco.2012.47.4940 1:CAS:528:DC%2BC3sXhvVWgtrvK 24019545
-
Motzer RJ, Nosov D, Eisen T, Bondarenko I, Lesovoy V, Lipatov O, Tomczak P, Lyulko O, Alyasova A, Harza M, Kogan M, Alekseev BY, Sternberg CN, Szczylik C, Cella D, Ivanescu C, Krivoshik A, Strahs A, Esteves B, Berkenblit A, Hutson TE (2013) Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol 31(30):3791-3799. doi: 10.1200/jco.2012.47.4940
-
(2013)
J Clin Oncol
, vol.31
, Issue.30
, pp. 3791-3799
-
-
Motzer, R.J.1
Nosov, D.2
Eisen, T.3
Bondarenko, I.4
Lesovoy, V.5
Lipatov, O.6
Tomczak, P.7
Lyulko, O.8
Alyasova, A.9
Harza, M.10
Kogan, M.11
Alekseev, B.Y.12
Sternberg, C.N.13
Szczylik, C.14
Cella, D.15
Ivanescu, C.16
Krivoshik, A.17
Strahs, A.18
Esteves, B.19
Berkenblit, A.20
Hutson, T.E.21
more..
-
61
-
-
21044443128
-
In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
-
10.1158/1078-0432.ccr-04-2129 1:CAS:528:DC%2BD2MXktFyrsb4%3D 15897558
-
Lee SH, Lopes de Menezes D, Vora J, Harris A, Ye H, Nordahl L, Garrett E, Samara E, Aukerman SL, Gelb AB, Heise C (2005) In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 11(10):3633-3641. doi: 10.1158/1078-0432.ccr-04-2129
-
(2005)
Clin Cancer Res
, vol.11
, Issue.10
, pp. 3633-3641
-
-
Lee, S.H.1
Lopes De Menezes, D.2
Vora, J.3
Harris, A.4
Ye, H.5
Nordahl, L.6
Garrett, E.7
Samara, E.8
Aukerman, S.L.9
Gelb, A.B.10
Heise, C.11
-
62
-
-
81055124256
-
Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer
-
10.1158/1535-7163.mct-11-0312 1:CAS:528:DC%2BC3MXhsVeltLfL 21885862
-
Taeger J, Moser C, Hellerbrand C, Mycielska ME, Glockzin G, Schlitt HJ, Geissler EK, Stoeltzing O, Lang SA (2011) Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Mol Cancer Ther 10(11):2157-2167. doi: 10.1158/1535-7163.mct-11-0312
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.11
, pp. 2157-2167
-
-
Taeger, J.1
Moser, C.2
Hellerbrand, C.3
Mycielska, M.E.4
Glockzin, G.5
Schlitt, H.J.6
Geissler, E.K.7
Stoeltzing, O.8
Lang, S.A.9
-
63
-
-
84874851836
-
Phase i study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma
-
10.1158/1078-0432.ccr-12-2885 1:CAS:528:DC%2BC3sXjsFektLg%3D 23339124
-
Angevin E, Lopez-Martin JA, Lin CC, Gschwend JE, Harzstark A, Castellano D, Soria JC, Sen P, Chang J, Shi M, Kay A, Escudier B (2013) Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Clin Cancer Res 19(5):1257-1268. doi: 10.1158/1078-0432.ccr-12-2885
-
(2013)
Clin Cancer Res
, vol.19
, Issue.5
, pp. 1257-1268
-
-
Angevin, E.1
Lopez-Martin, J.A.2
Lin, C.C.3
Gschwend, J.E.4
Harzstark, A.5
Castellano, D.6
Soria, J.C.7
Sen, P.8
Chang, J.9
Shi, M.10
Kay, A.11
Escudier, B.12
-
64
-
-
84901804554
-
Phase II results of Dovitinib (TKI258) in patients with metastatic renal cell cancer
-
10.1158/1078-0432.ccr-13-3006 1:CAS:528:DC%2BC2cXpt1Kkt7w%3D 24691021
-
Escudier B, Grunwald V, Ravaud A, Ou YC, Castellano D, Lin CC, Gschwend JE, Harzstark A, Beall S, Pirotta N, Squires M, Shi M, Angevin E (2014) Phase II results of Dovitinib (TKI258) in patients with metastatic renal cell cancer. Clin Cancer Res 20(11):3012-3022. doi: 10.1158/1078-0432.ccr-13-3006
-
(2014)
Clin Cancer Res
, vol.20
, Issue.11
, pp. 3012-3022
-
-
Escudier, B.1
Grunwald, V.2
Ravaud, A.3
Ou, Y.C.4
Castellano, D.5
Lin, C.C.6
Gschwend, J.E.7
Harzstark, A.8
Beall, S.9
Pirotta, N.10
Squires, M.11
Shi, M.12
Angevin, E.13
-
65
-
-
84896713052
-
Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: An open-label, randomised phase 3 trial
-
10.1016/s1470-2045(14)70030-0 1:CAS:528:DC%2BC2cXis1Cks7c%3D 24556040
-
Motzer RJ, Porta C, Vogelzang NJ, Sternberg CN, Szczylik C, Zolnierek J, Kollmannsberger C, Rha SY, Bjarnason GA, Melichar B, De Giorgi U, Grunwald V, Davis ID, Lee JL, Esteban E, Urbanowitz G, Cai C, Squires M, Marker M, Shi MM, Escudier B (2014) Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial. Lancet Oncol 15(3):286-296. doi: 10.1016/s1470-2045(14)70030-0
-
(2014)
Lancet Oncol
, vol.15
, Issue.3
, pp. 286-296
-
-
Motzer, R.J.1
Porta, C.2
Vogelzang, N.J.3
Sternberg, C.N.4
Szczylik, C.5
Zolnierek, J.6
Kollmannsberger, C.7
Rha, S.Y.8
Bjarnason, G.A.9
Melichar, B.10
De Giorgi, U.11
Grunwald, V.12
Davis, I.D.13
Lee, J.L.14
Esteban, E.15
Urbanowitz, G.16
Cai, C.17
Squires, M.18
Marker, M.19
Shi, M.M.20
Escudier, B.21
more..
-
66
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
10.1002/ijc.25864 1:CAS:528:DC%2BC3MXltFGlu7c%3D
-
Wilhelm SM, Dumas J, Adnane L, Lynch M, Carter CA, Schutz G, Thierauch KH, Zopf D (2011) Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer J int du Cancer 129(1):245-255. doi: 10.1002/ijc.25864
-
(2011)
Int J Cancer J Int du Cancer
, vol.129
, Issue.1
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
Lynch, M.4
Carter, C.A.5
Schutz, G.6
Thierauch, K.H.7
Zopf, D.8
-
67
-
-
84860531989
-
A phase i dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors
-
10.1158/1078-0432.ccr-11-1900 1:CAS:528:DC%2BC38XmsFeisLk%3D 22421192
-
Mross K, Frost A, Steinbild S, Hedbom S, Buchert M, Fasol U, Unger C, Kratzschmar J, Heinig R, Boix O, Christensen O (2012) A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. Clin Cancer Res 18(9):2658-2667. doi: 10.1158/1078-0432.ccr-11-1900
-
(2012)
Clin Cancer Res
, vol.18
, Issue.9
, pp. 2658-2667
-
-
Mross, K.1
Frost, A.2
Steinbild, S.3
Hedbom, S.4
Buchert, M.5
Fasol, U.6
Unger, C.7
Kratzschmar, J.8
Heinig, R.9
Boix, O.10
Christensen, O.11
-
68
-
-
84866888498
-
Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: A single-group phase 2 trial
-
10.1016/s1470-2045(12)70364-9 1:CAS:528:DC%2BC38XhsVCjsbvM 22959186
-
Eisen T, Joensuu H, Nathan PD, Harper PG, Wojtukiewicz MZ, Nicholson S, Bahl A, Tomczak P, Pyrhonen S, Fife K, Bono P, Boxall J, Wagner A, Jeffers M, Lin T, Quinn DI (2012) Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: a single-group phase 2 trial. Lancet Oncol 13(10):1055-1062. doi: 10.1016/s1470-2045(12)70364-9
-
(2012)
Lancet Oncol
, vol.13
, Issue.10
, pp. 1055-1062
-
-
Eisen, T.1
Joensuu, H.2
Nathan, P.D.3
Harper, P.G.4
Wojtukiewicz, M.Z.5
Nicholson, S.6
Bahl, A.7
Tomczak, P.8
Pyrhonen, S.9
Fife, K.10
Bono, P.11
Boxall, J.12
Wagner, A.13
Jeffers, M.14
Lin, T.15
Quinn, D.I.16
-
69
-
-
20144370978
-
AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
10.1158/0008-5472.can-04-4409 1:CAS:528:DC%2BD2MXktlSmtLs%3D 15899831
-
Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO, Chester R, Jackson JA, Boffey SJ, Kilburn LL, Barnett S, Richmond GH, Wadsworth PF, Walker M, Bigley AL, Taylor ST, Cooper L, Beck S, Jurgensmeier JM, Ogilvie DJ (2005) AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 65(10):4389-4400. doi: 10.1158/0008-5472.can-04-4409
-
(2005)
Cancer Res
, vol.65
, Issue.10
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
Valentine, P.J.4
Barry, S.T.5
Brave, S.R.6
Smith, N.R.7
James, N.H.8
Dukes, M.9
Curwen, J.O.10
Chester, R.11
Jackson, J.A.12
Boffey, S.J.13
Kilburn, L.L.14
Barnett, S.15
Richmond, G.H.16
Wadsworth, P.F.17
Walker, M.18
Bigley, A.L.19
Taylor, S.T.20
Cooper, L.21
Beck, S.22
Jurgensmeier, J.M.23
Ogilvie, D.J.24
more..
-
70
-
-
34547681379
-
Phase i clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
-
10.1200/jco.2006.07.2066 1:CAS:528:DC%2BD2sXptlGrsbo%3D 17634482
-
Drevs J, Siegert P, Medinger M, Mross K, Strecker R, Zirrgiebel U, Harder J, Blum H, Robertson J, Jurgensmeier JM, Puchalski TA, Young H, Saunders O, Unger C (2007) Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J Clin Oncol 25(21):3045-3054. doi: 10.1200/jco.2006.07.2066
-
(2007)
J Clin Oncol
, vol.25
, Issue.21
, pp. 3045-3054
-
-
Drevs, J.1
Siegert, P.2
Medinger, M.3
Mross, K.4
Strecker, R.5
Zirrgiebel, U.6
Harder, J.7
Blum, H.8
Robertson, J.9
Jurgensmeier, J.M.10
Puchalski, T.A.11
Young, H.12
Saunders, O.13
Unger, C.14
-
71
-
-
84857052966
-
Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study
-
10.1016/j.ejca.2011.12.022 1:CAS:528:DC%2BC38XislSktb0%3D
-
Mulders P, Hawkins R, Nathan P, de Jong I, Osanto S, Porfiri E, Protheroe A, van Herpen CM, Mookerjee B, Pike L, Jurgensmeier JM, Gore ME (2012) Cediranib monotherapy in patients with advanced renal cell carcinoma: results of a randomised phase II study. Eur J Cancer (Oxford, England: 1990) 48(4):527-537. doi: 10.1016/j.ejca.2011.12.022
-
(2012)
Eur J Cancer (Oxford, England: 1990)
, vol.48
, Issue.4
, pp. 527-537
-
-
Mulders, P.1
Hawkins, R.2
Nathan, P.3
De Jong, I.4
Osanto, S.5
Porfiri, E.6
Protheroe, A.7
Van Herpen, C.M.8
Mookerjee, B.9
Pike, L.10
Jurgensmeier, J.M.11
Gore, M.E.12
-
72
-
-
79851489474
-
Renal cell carcinoma: Focus on safety and efficacy of temsirolimus
-
10.4137/cmo.s4482 1:CAS:528:DC%2BC3MXhsFSm 3018897 21234295
-
Hadoux J, Vignot S, De La Motte Rouge T (2010) Renal cell carcinoma: focus on safety and efficacy of temsirolimus. Clin Med Insights Oncol 4:143-154. doi: 10.4137/cmo.s4482
-
(2010)
Clin Med Insights Oncol
, vol.4
, pp. 143-154
-
-
Hadoux, J.1
Vignot, S.2
De La Motte, R.T.3
-
73
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
10.1200/jco.2004.08.116 1:CAS:528:DC%2BD2cXpsVWltbc%3D 15136596
-
Raymond E, Alexandre J, Faivre S, Vera K, Materman E, Boni J, Leister C, Korth-Bradley J, Hanauske A, Armand JP (2004) Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 22(12):2336-2347. doi: 10.1200/jco.2004.08.116
-
(2004)
J Clin Oncol
, vol.22
, Issue.12
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
Leister, C.7
Korth-Bradley, J.8
Hanauske, A.9
Armand, J.P.10
-
74
-
-
33750321673
-
A phase i and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
-
10.1158/1078-0432.ccr-06-0118 1:CAS:528:DC%2BD28XhtVartbvK 17020981
-
Hidalgo M, Buckner JC, Erlichman C, Pollack MS, Boni JP, Dukart G, Marshall B, Speicher L, Moore L, Rowinsky EK (2006) A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin Cancer Res 12(19):5755-5763. doi: 10.1158/1078-0432.ccr-06-0118
-
(2006)
Clin Cancer Res
, vol.12
, Issue.19
, pp. 5755-5763
-
-
Hidalgo, M.1
Buckner, J.C.2
Erlichman, C.3
Pollack, M.S.4
Boni, J.P.5
Dukart, G.6
Marshall, B.7
Speicher, L.8
Moore, L.9
Rowinsky, E.K.10
-
75
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
10.1200/jco.2004.08.185 1:CAS:528:DC%2BD2cXpsVKisr0%3D 14990647
-
Atkins MB, Hidalgo M, Stadler WM, Logan TF, Dutcher JP, Hudes GR, Park Y, Liou SH, Marshall B, Boni JP, Dukart G, Sherman ML (2004) Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22(5):909-918. doi: 10.1200/jco.2004.08.185
-
(2004)
J Clin Oncol
, vol.22
, Issue.5
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
Park, Y.7
Liou, S.H.8
Marshall, B.9
Boni, J.P.10
Dukart, G.11
Sherman, M.L.12
-
76
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
10.1056/NEJMoa066838 1:CAS:528:DC%2BD2sXmtVKkurs%3D 17538086
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, Staroslawska E, Sosman J, McDermott D, Bodrogi I, Kovacevic Z, Lesovoy V, Schmidt-Wolf IG, Barbarash O, Gokmen E, O'Toole T, Lustgarten S, Moore L, Motzer RJ (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356(22):2271-2281. doi: 10.1056/NEJMoa066838
-
(2007)
N Engl J Med
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
77
-
-
77951729433
-
FDA approval summary: Temsirolimus as treatment for advanced renal cell carcinoma
-
10.1634/theoncologist.2009-0178 1:CAS:528:DC%2BC3cXmsFynsLg%3D 3227966 20332142
-
Kwitkowski VE, Prowell TM, Ibrahim A, Farrell AT, Justice R, Mitchell SS, Sridhara R, Pazdur R (2010) FDA approval summary: temsirolimus as treatment for advanced renal cell carcinoma. Oncologist 15(4):428-435. doi: 10.1634/theoncologist.2009-0178
-
(2010)
Oncologist
, vol.15
, Issue.4
, pp. 428-435
-
-
Kwitkowski, V.E.1
Prowell, T.M.2
Ibrahim, A.3
Farrell, A.T.4
Justice, R.5
Mitchell, S.S.6
Sridhara, R.7
Pazdur, R.8
-
78
-
-
84884167903
-
MTOR inhibitors in advanced renal cell carcinomas: From biology to clinical practice
-
10.1016/j.critrevonc.2013.02.006 23523056
-
Barthelemy P, Hoch B, Chevreau C, Joly F, Laguerre B, Lokiec F, Duclos B (2013) mTOR inhibitors in advanced renal cell carcinomas: from biology to clinical practice. Crit Rev Oncol Hematol 88(1):42-56. doi: 10.1016/j.critrevonc.2013.02.006
-
(2013)
Crit Rev Oncol Hematol
, vol.88
, Issue.1
, pp. 42-56
-
-
Barthelemy, P.1
Hoch, B.2
Chevreau, C.3
Joly, F.4
Laguerre, B.5
Lokiec, F.6
Duclos, B.7
-
79
-
-
43249086546
-
Phase i pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
-
10.1200/jco.2007.14.0988 18332470
-
O'Donnell A, Faivre S, Burris HA 3rd, Rea D, Papadimitrakopoulou V, Shand N, Lane HA, Hazell K, Zoellner U, Kovarik JM, Brock C, Jones S, Raymond E, Judson I (2008) Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 26(10):1588-1595. doi: 10.1200/jco.2007.14.0988
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1588-1595
-
-
O'Donnell, A.1
Faivre, S.2
Burris, H.A.3
Rea, D.4
Papadimitrakopoulou, V.5
Shand, N.6
Lane, H.A.7
Hazell, K.8
Zoellner, U.9
Kovarik, J.M.10
Brock, C.11
Jones, S.12
Raymond, E.13
Judson, I.14
-
80
-
-
66649133114
-
A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer
-
10.1002/cncr.24280 1:CAS:528:DC%2BD1MXmvVyhsrc%3D 19306412
-
Amato RJ, Jac J, Giessinger S, Saxena S, Willis JP (2009) A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer. Cancer 115(11):2438-2446. doi: 10.1002/cncr.24280
-
(2009)
Cancer
, vol.115
, Issue.11
, pp. 2438-2446
-
-
Amato, R.J.1
Jac, J.2
Giessinger, S.3
Saxena, S.4
Willis, J.P.5
-
81
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
10.1016/s0140-6736(08)61039-9 1:CAS:528:DC%2BD1cXps1GmsLY%3D 18653228
-
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grunwald V, Thompson JA, Figlin RA, Hollaender N, Urbanowitz G, Berg WJ, Kay A, Lebwohl D, Ravaud A (2008) Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372(9637):449-456. doi: 10.1016/s0140-6736(08)61039-9
-
(2008)
Lancet
, vol.372
, Issue.9637
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Grunwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
Urbanowitz, G.11
Berg, W.J.12
Kay, A.13
Lebwohl, D.14
Ravaud, A.15
-
82
-
-
77956227464
-
Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
-
10.1002/cncr.25219 1:CAS:528:DC%2BC3cXhtF2rtrrF 20549832
-
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grunwald V, Thompson JA, Figlin RA, Hollaender N, Kay A, Ravaud A (2010) Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 116(18):4256-4265. doi: 10.1002/cncr.25219
-
(2010)
Cancer
, vol.116
, Issue.18
, pp. 4256-4265
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Grunwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
Kay, A.11
Ravaud, A.12
-
83
-
-
0035253739
-
Phase i safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
-
1:CAS:528:DC%2BD3MXhtlGrt7k%3D 11157038
-
Gordon MS, Margolin K, Talpaz M, Sledge GW Jr, Holmgren E, Benjamin R, Stalter S, Shak S, Adelman D (2001) Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 19(3):843-850
-
(2001)
J Clin Oncol
, vol.19
, Issue.3
, pp. 843-850
-
-
Gordon, M.S.1
Margolin, K.2
Talpaz, M.3
Sledge, G.W.4
Holmgren, E.5
Benjamin, R.6
Stalter, S.7
Shak, S.8
Adelman, D.9
-
84
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
10.1056/NEJMoa021491 1:CAS:528:DC%2BD3sXms1Klu7w%3D 2275324 12890841
-
Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, Steinberg SM, Chen HX, Rosenberg SA (2003) A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349(5):427-434. doi: 10.1056/NEJMoa021491
-
(2003)
N Engl J Med
, vol.349
, Issue.5
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
Steinberg, S.M.7
Chen, H.X.8
Rosenberg, S.A.9
-
85
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
10.1016/s0140-6736(07)61904-7 18156031
-
Escudier B, Pluzanska A, Koralewski P, Ravaud A, Bracarda S, Szczylik C, Chevreau C, Filipek M, Melichar B, Bajetta E, Gorbunova V, Bay JO, Bodrogi I, Jagiello-Gruszfeld A, Moore N (2007) Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 370(9605):2103-2111. doi: 10.1016/s0140-6736(07)61904-7
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
Ravaud, A.4
Bracarda, S.5
Szczylik, C.6
Chevreau, C.7
Filipek, M.8
Melichar, B.9
Bajetta, E.10
Gorbunova, V.11
Bay, J.O.12
Bodrogi, I.13
Jagiello-Gruszfeld, A.14
Moore, N.15
-
86
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
-
10.1200/jco.2009.26.5561 1:CAS:528:DC%2BC3cXpsFSgsbw%3D 2860433 20368558
-
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ (2010) Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 28(13):2137-2143. doi: 10.1200/jco.2009.26.5561
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
Stadler, W.M.4
Vaena, D.A.5
Archer, L.6
Atkins, J.N.7
Picus, J.8
Czaykowski, P.9
Dutcher, J.10
Small, E.J.11
-
87
-
-
77649213706
-
Phase i pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
-
10.1200/jco.2009.23.7537 1:CAS:528:DC%2BC3cXksVyrtr0%3D 2834394 20048182
-
Spratlin JL, Cohen RB, Eadens M, Gore L, Camidge DR, Diab S, Leong S, O'Bryant C, Chow LQ, Serkova NJ, Meropol NJ, Lewis NL, Chiorean EG, Fox F, Youssoufian H, Rowinsky EK, Eckhardt SG (2010) Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 28(5):780-787. doi: 10.1200/jco.2009.23.7537
-
(2010)
J Clin Oncol
, vol.28
, Issue.5
, pp. 780-787
-
-
Spratlin, J.L.1
Cohen, R.B.2
Eadens, M.3
Gore, L.4
Camidge, D.R.5
Diab, S.6
Leong, S.7
O'Bryant, C.8
Chow, L.Q.9
Serkova, N.J.10
Meropol, N.J.11
Lewis, N.L.12
Chiorean, E.G.13
Fox, F.14
Youssoufian, H.15
Rowinsky, E.K.16
Eckhardt, S.G.17
-
88
-
-
84892852372
-
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial
-
10.1016/s0140-6736(13)61719-5 1:CAS:528:DC%2BC3sXhsFOns77J 24094768
-
Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, Safran H, dos Santos LV, Aprile G, Ferry DR, Melichar B, Tehfe M, Topuzov E, Zalcberg JR, Chau I, Campbell W, Sivanandan C, Pikiel J, Koshiji M, Hsu Y, Liepa AM, Gao L, Schwartz JD, Tabernero J (2014) Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 383(9911):31-39. doi: 10.1016/s0140-6736(13)61719-5
-
(2014)
Lancet
, vol.383
, Issue.9911
, pp. 31-39
-
-
Fuchs, C.S.1
Tomasek, J.2
Yong, C.J.3
Dumitru, F.4
Passalacqua, R.5
Goswami, C.6
Safran, H.7
Dos Santos, L.V.8
Aprile, G.9
Ferry, D.R.10
Melichar, B.11
Tehfe, M.12
Topuzov, E.13
Zalcberg, J.R.14
Chau, I.15
Campbell, W.16
Sivanandan, C.17
Pikiel, J.18
Koshiji, M.19
Hsu, Y.20
Liepa, A.M.21
Gao, L.22
Schwartz, J.D.23
Tabernero, J.24
more..
-
89
-
-
84906903314
-
Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial
-
10.1016/s0140-6736(14)60845-x 1:CAS:528:DC%2BC2cXpslCntrc%3D 24933332
-
Garon EB, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Gorbunova V, Kowalyszyn RD, Pikiel J, Czyzewicz G, Orlov SV, Lewanski CR, Thomas M, Bidoli P, Dakhil S, Gans S, Kim JH, Grigorescu A, Karaseva N, Reck M, Cappuzzo F, Alexandris E, Sashegyi A, Yurasov S, Perol M (2014) Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 384(9944):665-673. doi: 10.1016/s0140-6736(14)60845-x
-
(2014)
Lancet
, vol.384
, Issue.9944
, pp. 665-673
-
-
Garon, E.B.1
Ciuleanu, T.E.2
Arrieta, O.3
Prabhash, K.4
Syrigos, K.N.5
Goksel, T.6
Park, K.7
Gorbunova, V.8
Kowalyszyn, R.D.9
Pikiel, J.10
Czyzewicz, G.11
Orlov, S.V.12
Lewanski, C.R.13
Thomas, M.14
Bidoli, P.15
Dakhil, S.16
Gans, S.17
Kim, J.H.18
Grigorescu, A.19
Karaseva, N.20
Reck, M.21
Cappuzzo, F.22
Alexandris, E.23
Sashegyi, A.24
Yurasov, S.25
Perol, M.26
more..
-
90
-
-
84904044814
-
Ramucirumab: First global approval
-
10.1007/s40265-014-0244-2 1:CAS:528:DC%2BC2cXhtVagtrrN 24916147
-
Poole RM, Vaidya A (2014) Ramucirumab: first global approval. Drugs 74(9):1047-1058. doi: 10.1007/s40265-014-0244-2
-
(2014)
Drugs
, vol.74
, Issue.9
, pp. 1047-1058
-
-
Poole, R.M.1
Vaidya, A.2
-
91
-
-
77955873586
-
Phase II study of IMC-1121B in patients with metastatic renal cancer (mRCC) following VEGFR-2 tyrosine kinase inhibitor (TKI) therapy (IMCL CP12-0605/NCT00515697).
-
Garcia JA, Hudes GR, Choueiri TK, Stadler WM, Wood LS, Bhatia S, Youssoufian H, Rowinsky EK, Schwartz JD, Thompson JA (2010) Phase II study of IMC-1121B in patients with metastatic renal cancer (mRCC) following VEGFR-2 tyrosine kinase inhibitor (TKI) therapy (IMCL CP12-0605/NCT00515697). Genitourin Cancers Symposium:Abstr. 326
-
(2010)
Genitourin Cancers Symposium
-
-
Garcia, J.A.1
Hudes, G.R.2
Choueiri, T.K.3
Stadler, W.M.4
Wood, L.S.5
Bhatia, S.6
Youssoufian, H.7
Rowinsky, E.K.8
Schwartz, J.D.9
Thompson, J.A.10
-
92
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
10.1056/NEJMoa1200690 1:CAS:528:DC%2BC38XhtV2rs7fN 3544539 22658127
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366(26):2443-2454. doi: 10.1056/NEJMoa1200690
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
Leming, P.D.11
Spigel, D.R.12
Antonia, S.J.13
Horn, L.14
Drake, C.G.15
Pardoll, D.M.16
Chen, L.17
Sharfman, W.H.18
Anders, R.A.19
Taube, J.M.20
McMiller, T.L.21
Xu, H.22
Korman, A.J.23
Jure-Kunkel, M.24
Agrawal, S.25
McDonald, D.26
Kollia, G.D.27
Gupta, A.28
Wigginton, J.M.29
Sznol, M.30
more..
-
93
-
-
84859158384
-
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
-
10.1016/j.coi.2011.12.009 1:CAS:528:DC%2BC38XltValu7o%3D 3319479 22236695
-
Topalian SL, Drake CG, Pardoll DM (2012) Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 24(2):207-212. doi: 10.1016/j.coi.2011.12.009
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.2
, pp. 207-212
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
94
-
-
84883050318
-
Drug of the year: Programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies
-
10.1016/j.ejca.2013.07.001 1:CAS:528:DC%2BC3sXhtF2itLbN
-
Robert C, Soria JC, Eggermont AM (2013) Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies. Eur J Cancer (Oxford, England: 1990) 49(14):2968-2971. doi: 10.1016/j.ejca.2013.07.001
-
(2013)
Eur J Cancer (Oxford, England: 1990)
, vol.49
, Issue.14
, pp. 2968-2971
-
-
Robert, C.1
Soria, J.C.2
Eggermont, A.M.3
-
95
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
10.1056/NEJMoa1305133 1:CAS:528:DC%2BC3sXht1emsbjP 4126516 23724846
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, Dronca R, Gangadhar TC, Patnaik A, Zarour H, Joshua AM, Gergich K, Elassaiss-Schaap J, Algazi A, Mateus C, Boasberg P, Tumeh PC, Chmielowski B, Ebbinghaus SW, Li XN, Kang SP, Ribas A (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369(2):134-144. doi: 10.1056/NEJMoa1305133
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
Wolchok, J.D.7
Hersey, P.8
Joseph, R.W.9
Weber, J.S.10
Dronca, R.11
Gangadhar, T.C.12
Patnaik, A.13
Zarour, H.14
Joshua, A.M.15
Gergich, K.16
Elassaiss-Schaap, J.17
Algazi, A.18
Mateus, C.19
Boasberg, P.20
Tumeh, P.C.21
Chmielowski, B.22
Ebbinghaus, S.W.23
Li, X.N.24
Kang, S.P.25
Ribas, A.26
more..
-
96
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
10.1200/jco.2009.26.7609 1:CAS:528:DC%2BC3cXpslajtLw%3D 20516446
-
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28(19):3167-3175. doi: 10.1200/jco.2009.26.7609
-
(2010)
J Clin Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
Stankevich, E.7
Pons, A.8
Salay, T.M.9
McMiller, T.L.10
Gilson, M.M.11
Wang, C.12
Selby, M.13
Taube, J.M.14
Anders, R.15
Chen, L.16
Korman, A.J.17
Pardoll, D.M.18
Lowy, I.19
Topalian, S.L.20
more..
|