-
1
-
-
67650874081
-
Cancer Statistics, 2009
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA Cancer J Clin. 2009;59(4):225-249.
-
(2009)
CA Cancer J Clin
, vol.59
, Issue.4
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
2
-
-
0242608613
-
The genetic basis of cancer of the kidney
-
Dec
-
Linehan WM WM, Zbar B. The genetic basis of cancer of the kidney. J Urol. 2003 Dec;170(6 Pt 1):2163-2172.
-
(2003)
J Urol
, vol.170
, Issue.6 Pt. 1
, pp. 2163-2172
-
-
Linehan, W.M.W.M.1
Zbar, B.2
-
3
-
-
16644373473
-
Role of VHL Gene Mutation in Human Cancer
-
Kim WY, Kaelin WG. Role of VHL Gene Mutation in Human Cancer. J Clin Oncol. 2004;22(24):4991-5004.
-
(2004)
J Clin Oncol
, vol.22
, Issue.24
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
4
-
-
0002688203
-
Cancer of the Kidney and Ureter
-
In: deVita VT HS, Rosenberg SA, editors, 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins
-
Linehan WM, Zbar B, Bates BE, Zelefsky MJ, Yang JC. Cancer of the Kidney and Ureter. In: deVita VT HS, Rosenberg SA, editors. Cancer Principles and Practice of Oncology, 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins. 2001:1362-1396.
-
(2001)
Cancer Principles and Practice of Oncology
, pp. 1362-1396
-
-
Linehan, W.M.1
Zbar, B.2
Bates, B.E.3
Zelefsky, M.J.4
Yang, J.C.5
-
5
-
-
28844484134
-
Renal-Cell Carcinoma
-
Cohen HT, McGovern FJ. Renal-Cell Carcinoma. N Engl J Med. 2005; 353(23):2477-2490.
-
(2005)
N Engl J Med
, vol.353
, Issue.23
, pp. 2477-2490
-
-
Cohen, H.T.1
McGovern, F.J.2
-
6
-
-
0033847587
-
Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma
-
Fisher RI RS, Fyfe G. Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J Sci Am. 2000; 6 Suppl 1:S55-S57.
-
(2000)
Cancer J Sci Am
, vol.6
, Issue.SUPPL. 1
-
-
Fisher, R.I.R.S.1
Fyfe, G.2
-
7
-
-
65949122058
-
Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma
-
Rini BI. Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer. 2009;115(S10):2306-2312.
-
(2009)
Cancer
, vol.115
, Issue.10
, pp. 2306-2312
-
-
Rini, B.I.1
-
9
-
-
0036154040
-
VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma
-
Schraml P, Struckmann K, Hatz F, et al. VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma. The Journal of Pathology. 2002; 196(2):186-193.
-
(2002)
The Journal of Pathology
, vol.196
, Issue.2
, pp. 186-193
-
-
Schraml, P.1
Struckmann, K.2
Hatz, F.3
-
10
-
-
0032970571
-
Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
-
Gallou C, Joly D, Méjean A, et al. Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC. Human Mutation. 1999;13(6):464-475.
-
(1999)
Human Mutation
, vol.13
, Issue.6
, pp. 464-475
-
-
Gallou, C.1
Joly, D.2
Méjean, A.3
-
11
-
-
73349121966
-
Impact of anti-angiogenic treatments on metastatic renal cell carcinoma
-
Ainsworth NL, Lee JS, Eisen T. Impact of anti-angiogenic treatments on metastatic renal cell carcinoma. Expert Rev Anticancer Ther. 2009;9(12):1793-805.
-
(2009)
Expert Rev Anticancer Ther
, vol.9
, Issue.12
, pp. 1793-1805
-
-
Ainsworth, N.L.1
Lee, J.S.2
Eisen, T.3
-
12
-
-
49249087039
-
Antitumor Activity and Biomarker Analysis of Sunitinib in Patients With Bevacizumab-Refractory Metastatic Renal Cell Carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, et al. Antitumor Activity and Biomarker Analysis of Sunitinib in Patients With Bevacizumab-Refractory Metastatic Renal Cell Carcinoma. J Clin Oncol. 2008;26(22):3743-3748.
-
(2008)
J Clin Oncol
, vol.26
, Issue.22
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
-
13
-
-
0034778549
-
Impact of serum basic fibroblast growth factor on prognosis in human renal cell carcinoma
-
Rasmuson T, Grankvist K, Jacobsen J, Ljungberg B. Impact of serum basic fibroblast growth factor on prognosis in human renal cell carcinoma. European Journal of Cancer. 2001;37(17):2199-2203.
-
(2001)
European Journal of Cancer
, vol.37
, Issue.17
, pp. 2199-2203
-
-
Rasmuson, T.1
Grankvist, K.2
Jacobsen, J.3
Ljungberg, B.4
-
14
-
-
0033026356
-
Renal cell carcinoma: Relevance of angiogenetic factors
-
Mar-Apr
-
Wechsel HWBK, Feil G, Loeser W, Lahme S, Petri E. Renal cell carcinoma: relevance of angiogenetic factors. Anticancer Res. 1999 Mar-Apr; 19(2C):1537-1540.
-
(1999)
Anticancer Res
, vol.19
, Issue.2 C
, pp. 1537-1540
-
-
Wechsel, H.W.B.K.1
Feil, G.2
Loeser, W.3
Lahme, S.4
Petri, E.5
-
15
-
-
69849084521
-
Therapeutic potential of manipulating VEGF splice isoforms in oncology
-
Rennel ES, Harper SJ, Bates DO. Therapeutic potential of manipulating VEGF splice isoforms in oncology. Future Oncology. 2009;5(5):703-712.
-
(2009)
Future Oncology
, vol.5
, Issue.5
, pp. 703-712
-
-
Rennel, E.S.1
Harper, S.J.2
Bates, D.O.3
-
17
-
-
0042343801
-
A Randomized Trial of Bevacizumab, an Anti-Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer
-
Yang JC, Haworth L, Sherry RM, et al. A Randomized Trial of Bevacizumab, an Anti-Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer. N Engl J Med. 2003;349(5):427-434.
-
(2003)
N Engl J Med
, vol.349
, Issue.5
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
18
-
-
77952300540
-
Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival
-
Escudier B, Bellmunt J, Negrier S, et al. Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival. J Clin Oncol. 2010;28(13):2144-2150.
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Negrier, S.3
-
19
-
-
77952318310
-
Phase III Trial of Bevacizumab Plus Interferon Alfa Versus Interferon Alfa Monotherapy in Patients With Metastatic Renal Cell Carcinoma: Final Results of CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, et al. Phase III Trial of Bevacizumab Plus Interferon Alfa Versus Interferon Alfa Monotherapy in Patients With Metastatic Renal Cell Carcinoma: Final Results of CALGB 90206. J Clin Oncol. 2010;28(13):2137-2143.
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
20
-
-
0141653352
-
Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers
-
Raymond E, Faivre S, Vera K, et al. Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers. Proc Am Soc Clin Oncol. 2003;22:192.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 192
-
-
Raymond, E.1
Faivre, S.2
Vera, K.3
-
21
-
-
20044382799
-
Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors
-
Strumberg D, Richly H, Hilger RA, et al. Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors. J Clin Oncol. 2005;23(5):965-972.
-
(2005)
J Clin Oncol
, vol.23
, Issue.5
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
-
22
-
-
35549007093
-
Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib
-
2007 ASCO Annual Meeting Proceedings Part I, (Jun 20 Supplement):
-
Rini BI WG, Hudes G, Stadler WM, et al. Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib. J Clin Oncol. 2007; 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (Jun 20 Supplement):5032.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
, pp. 5032
-
-
Rini, B.I.W.G.1
Hudes, G.2
Stadler, W.M.3
-
23
-
-
67449164582
-
Phase I Trial of Pazopanib in Patients with Advanced Cancer
-
Hurwitz HI, Dowlati A, Saini S, et al. Phase I Trial of Pazopanib in Patients with Advanced Cancer. Clinical Cancer Research. 2009;15(12): 4220-4227.
-
(2009)
Clinical Cancer Research
, vol.15
, Issue.12
, pp. 4220-4227
-
-
Hurwitz, H.I.1
Dowlati, A.2
Saini, S.3
-
24
-
-
33846148701
-
Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma. N Engl J Med. 2007;356(2):125-134.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
25
-
-
33846181370
-
Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma. N Engl J Med. 2007;356(2):115-124.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
26
-
-
68949145218
-
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma. J Clin Oncol. 2009;27(22):3584-3590.
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
28
-
-
75749151307
-
Pazopanib for the treatment of renal cell carcinoma and other malignancies
-
Sonpavde G, Hutson TE, Sternberg CN. Pazopanib for the treatment of renal cell carcinoma and other malignancies. Drugs Today (Barc). 2009;45(9):651-661.
-
(2009)
Drugs Today (Barc)
, vol.45
, Issue.9
, pp. 651-661
-
-
Sonpavde, G.1
Hutson, T.E.2
Sternberg, C.N.3
-
29
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
Kumar R, Knick VB, Rudolph SK, et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Molecular Cancer Therapeutics. 2007;6(7):2012-2021.
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.7
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
-
30
-
-
84898698672
-
-
Note
-
Votrient (pazopanib) [package insert]. Research Triangle Park NG.
-
-
-
-
31
-
-
78650317831
-
A phase I and pharmacokinetic single agent study of pazopanib (P) in patients (Pts) with advanced malignancies and varying degrees of liver dysfunction (LD)
-
(Suppl; abstr 2571)
-
Shibata SLJ, Chung VM, Lenz H, et al. A phase I and pharmacokinetic single agent study of pazopanib (P) in patients (Pts) with advanced malignancies and varying degrees of liver dysfunction (LD). J Clin Oncol. 28:15s, (Suppl; abstr 2571). 2010.
-
(2010)
J Clin Oncol
, vol.28
-
-
Shibata, S.L.J.1
Chung, V.M.2
Lenz, H.3
-
32
-
-
34848857720
-
A phase I, open-label study of the safety and pharmacokinetics (PK) of pazopanib (P) and lapatinib (L) administered concurrently
-
(Suppl; abstr 3088)
-
Dejonge MSS, Verweij J, Collins TS, et al. A phase I, open-label study of the safety and pharmacokinetics (PK) of pazopanib (P) and lapatinib (L) administered concurrently. J Clin Onco. 24:142s, (Suppl; abstr 3088). 2006.
-
(2006)
J Clin Onco
, vol.24
-
-
Dejonge, M.S.S.1
Verweij, J.2
Collins, T.S.3
-
33
-
-
71949113673
-
Phase I study of the safety, tolerability, and pharmacokinetics (PK) of weekly paclitaxel administered in combination with pazopanib (GW786034)
-
(May 20 Suppl; abstr 3552)
-
Tan ARJS, Dowlati A, Levinson K, et al. Phase I study of the safety, tolerability, and pharmacokinetics (PK) of weekly paclitaxel administered in combination with pazopanib (GW786034). J Clin Oncol. 2008;26 (May 20 Suppl; abstr 3552).
-
(2008)
J Clin Oncol
, pp. 26
-
-
Tan, A.R.J.S.1
Dowlati, A.2
Levinson, K.3
-
34
-
-
75749090050
-
Efficacy and Safety of Pazopanib in Patients With Metastatic Renal Cell Carcinoma
-
Hutson TE, Davis ID, Machiels J-PH, et al. Efficacy and Safety of Pazopanib in Patients With Metastatic Renal Cell Carcinoma. J Clin Oncol. 2010;28(3):475-480.
-
(2010)
J Clin Oncol
, vol.28
, Issue.3
, pp. 475-480
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.-P.H.3
-
35
-
-
78650413534
-
Relationship between exposure to pazopanib (P) and efficacy in patients (pts) with advanced renal cell carcinoma (mRCC)
-
(Suppl; abstr 3048)
-
Suttle B, Ball HA, Molimard M, et al. Relationship between exposure to pazopanib (P) and efficacy in patients (pts) with advanced renal cell carcinoma (mRCC). J Clin Oncol. 2010; 28:15s, (Suppl; abstr 3048).
-
(2010)
J Clin Oncol
, vol.28
-
-
Suttle, B.1
Ball, H.A.2
Molimard, M.3
-
36
-
-
77949890945
-
Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
-
Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial. J Clin Oncol. 2010;28(6):1061-1068.
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
37
-
-
77954060790
-
Pazopanib in renal cell carcinoma
-
Apr
-
Sternberg CN. Pazopanib in renal cell carcinoma. Clin Adv Hematol Oncol. 2010 Apr;8(4):232-233.
-
(2010)
Clin Adv Hematol Oncol
, vol.8
, Issue.4
, pp. 232-233
-
-
Sternberg, C.N.1
-
38
-
-
77951666852
-
Pazopanib-induced hyperbilirubinemia is associated with gilbert's syndrome ugt1a1 polymorphism
-
Xu C-F, Reck BH, Xue Z, et al. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. 2010;102(9): 1371-1377.
-
(2010)
, vol.102
, Issue.9
, pp. 1371-1377
-
-
Xu, C.-F.1
Reck, B.H.2
Xue, Z.3
-
39
-
-
0032772880
-
Survival and Prognostic Stratification of 670 Patients with Advanced Renal Cell Carcinoma
-
Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and Prognostic Stratification of 670 Patients with Advanced Renal Cell Carcinoma. J Clin Oncol. 1999;17(8):2530.
-
J Clin Oncol
, vol.17
, Issue.8
, pp. 1999
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
Berg, W.4
Amsterdam, A.5
Ferrara, J.6
-
40
-
-
14144252047
-
Validation and Extension of the Memorial Sloan-Kettering Prognostic Factors Model for Survival in Patients with Previously Untreated Metastatic Renal Cell Carcinoma
-
Mekhail TM, Abou-Jawde RM, BouMerhi G, et al. Validation and Extension of the Memorial Sloan-Kettering Prognostic Factors Model for Survival in Patients with Previously Untreated Metastatic Renal Cell Carcinoma. J Clin Oncol. 2005;23(4):832-841.
-
(2005)
J Clin Oncol
, vol.23
, Issue.4
, pp. 832-841
-
-
Mekhail, T.M.1
Abou-Jawde, R.M.2
BouMerhi, G.3
-
41
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. The Lancet. 2008;372(9637):449-456.
-
(2008)
The Lancet
, vol.372
, Issue.9637
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
42
-
-
34249779568
-
Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma. New England Journal of Medicine. 2007;356(22):2271-2281.
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
43
-
-
26844552759
-
Soluble protein biomarkers of pharmacodynamic activity of the multi-targeted kinase inhibitor SU11248 in patients with metastatic renal cell cancer
-
DePrimo S, Bello C, Smeraglia J, et al. Soluble protein biomarkers of pharmacodynamic activity of the multi-targeted kinase inhibitor SU11248 in patients with metastatic renal cell cancer. Proc Am Assoc Cancer Res. 2005;46:108.
-
(2005)
Proc Am Assoc Cancer Res
, vol.46
, pp. 108
-
-
Deprimo, S.1
Bello, C.2
Smeraglia, J.3
-
44
-
-
62449186539
-
Randomized Phase II Trial of First-Line Treatment with Sorafenib Versus Interferon Alfa-2a in Patients with Metastatic Renal Cell Carcinoma
-
Escudier B, Szczylik C, Hutson TE, et al. Randomized Phase II Trial of First-Line Treatment with Sorafenib Versus Interferon Alfa-2a in Patients with Metastatic Renal Cell Carcinoma. J Clin Oncol. 2009;27(8):1280-1289.
-
(2009)
J Clin Oncol
, vol.27
, Issue.8
, pp. 1280-1289
-
-
Escudier, B.1
Szczylik, C.2
Hutson, T.E.3
|