Identification of new potential interaction partners for human cytoplasmic copper chaperone atox1: Roles in gene regulation?

International Journal of Molecular Sciences

Volumn 16, Issue 8, 2015, Pages 16728-16739

  Öhrvik, Helena ^a   Wittung Stafshede, Pernilla ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Atox1; Bioinformatics; Copper chaperone; Transcription factor; Two hybrid screen

Indexed keywords

COMPLEMENTARY DNA; CYTOPLASMIC COPPER CHAPERONE ATOX1; MESSENGER RNA; METALLOCHAPERONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ATOX1 PROTEIN, HUMAN; CHAPERONE; COPPER; PROTEIN BINDING;

ARTICLE; BIOINFORMATICS; CELL CYCLE REGULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; HUMAN; HUMAN CELL; PROTEIN FUNCTION; PROTEIN INTERACTION; TRANSCRIPTION REGULATION; BIOLOGY; CHEMISTRY; CYTOPLASM; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR MODEL; PROTEIN ANALYSIS; PROTEIN DATABASE; PROTEIN TERTIARY STRUCTURE; TWO HYBRID SYSTEM;

EUKARYOTA;

COMPUTATIONAL BIOLOGY; COPPER; CYTOPLASM; DATABASES, PROTEIN; GENE EXPRESSION REGULATION; HUMANS; METALLOCHAPERONES; MODELS, MOLECULAR; MOLECULAR CHAPERONES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84937943252     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160816728     Document Type: Article

References (41)

1. Huffman, D.L.; O'Halloran, T.V. Function, structure, and mechanism of intracellular copper trafficking proteins. Annu. Rev. Biochem. 2001, 70, 677-701.
2. Puig, S.; Thiele, D.J. Molecular mechanisms of copper uptake and distribution. Curr. Opin. Chem. Biol. 2002, 6, 171-180.
3. Harris, E.D. Basic and clinical aspects of copper. Crit. Rev. Clin. Lab. Sci. 2003, 40, 547-586.
4. O'Halloran, T.V.; Culotta, V.C. Metallochaperones, an intracellular shuttle service for metal ions. J. Biol. Chem. 2000, 275, 25057-25060.
5. Festa, R.A.; Thiele, D.J. Copper: An essential metal in biology. Curr. Biol. 2011, 21, R877-R883.
6. Robinson, N.J.; Winge, D.R. Copper metallochaperones. Annu. Rev. Biochem. 2010, 79, 537.
7. Arnesano, F.; Banci, L.; Bertini, I.; Ciofi-Baffoni, S.; Molteni, E.; Huffman, D.L.; O'Halloran, T.V. Metallochaperones and metal-transporting ATPases: A comparative analysis of sequences and structures. Genome Res. 2002, 12, 255-271.
8. Hamza, I.; Schaefer, M.; Klomp, L.W.; Gitlin, J.D. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc. Natl. Acad. Sci. USA 1999, 96, 13363-13368.
9. Banci, L.; Bertini, I.; Cantini, F.; Rosenzweig, A.C.; Yatsunyk, L.A. Metal binding domains 3 and 4 of the Wilson disease protein: Solution structure and interaction with the copper(I) chaperone HAH1. Biochemistry 2008, 47, 7423-7429.
10. Achila, D.; Banci, L.; Bertini, I.; Bunce, J.; Ciofi-Baffoni, S.; Huffman, D.L. Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake. Proc. Natl. Acad. Sci. USA 2006, 103, 5729-5734.
11. Wernimont, A.K.; Huffman, D.L.; Lamb, A.L.; O'Halloran, T.V.; Rosenzweig, A.C. Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. Nat. Struct. Biol. 2000, 7, 766-771.
12. Pufahl, R.A.; Singer, C.P.; Peariso, K.L.; Lin, S.J.; Schmidt, P.J.; Fahrni, C.J.; Cizewski Culotta, V.; Penner-Hahn, J.E.; O'halloran, T.V. Metal ion chaperone function of the soluble Cu(I) receptor Atx1. Science 1997, 278, 853-856.
13. Banci, L. The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat. Chem. Biol. 2006, 2, 367-368.
14. Banci, L.; Bertini, I.; Calderone, V.; Della-Malva, N.; Felli, I.; Neri, S.; Pavelkova, A.; Rosato, A. Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces. Biochem. J. 2009, 422, 37-42.
15. Rodriguez-Granillo, A.; Crespo, A.; Estrin, D.A.; Wittung-Stafshede, P. Copper-transfer mechanism from the human chaperone Atox1 to a metal-binding domain of Wilson disease protein. J. Phys. Chem. B 2010, 114, 3698-3706.
16. Niemiec, M.S.; Weise, C.F.; Wittung-Stafshede, P. In vitro thermodynamic dissection of human copper transfer from chaperone to target protein. PLoS ONE 2012, 7, e36102.
17. Yamamoto, T.; Ebisuya, M.; Ashida, F.; Okamoto, K.; Yonehara, S.; Nishida, E. Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. Curr. Biol. 2006, 16, 1171-1182.
18. Itoh, S.; Kim, H.W.; Nakagawa, O.; Ozumi, K.; Lessner, S.M.; Aoki, H.; Akram, K.; McKinney, R.D.; Ushio-Fukai, M.; Fukai, T. Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. J. Biol. Chem. 2008, 283, 9157-9167.
19. Itoh, S.; Ozumi, K.; Kim, H.W.; Nakagawa, O.; McKinney, R.D.; Folz, R.J.; Zelko, I.N.; Ushio-Fukai, M.; Fukai, T. Novel mechanism for regulation of extracellular SOD transcription and activity by copper: Role of antioxidant-1. Free Radic. Biol. Med. 2009, 46, 95-104.
20. Ozumi, K.; Sudhahar, V.; Kim, H.W.; Chen, G.F.; Kohno, T.; Finney, L.; Vogt, S.; McKinney, R.D.; Ushio-Fukai, M.; Fukai, T. Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: A key regulator of extracellular superoxide dismutase. Hypertension 2012, 60, 476-486.
21. Beaino, W.; Guo, Y.; Chang, A.J.; Anderson, C.J. Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: Implications for cancer therapy. J. Biol. Inorg. Chem. 2014, 19, 427-438.
22. Kahra, D.; Mondol, T.; Niemiec, M.S.; Wittung-Stafshede, P. Human copper chaperone Atox1 translocates to the nucleus but does not bind DNA in vitro. Protein Pept. Lett. 2015, 22, 532-538.
23. Rain, J.C.; Selig, L.; de Reuse, H.; Battaglia, V.; Reverdy, C.; Simon, S.; Lenzen, G.; Petel. F.; Wojcik, J.; Schächter, V.; et al. The protein-protein interaction map of Helicobacter pylori. Nature 2001, 409, 211-215.
24. Banci, L.; Bertini, I.; Cantini, F.; Massagni, C.; Migliardi, M.; Rosato, A. An NMR study of the interaction of the N-terminal cytoplasmic tail of the Wilson disease protein with copper(I)-HAH1. J. Biol. Chem. 2009, 284, 9354-9360.
25. Chang, C.Y.; Lin, S.C.; Su, W.H.; Ho, C.M.; Jou, Y.S. Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma. Oncogene 2012, 31, 2640-2652.
26. Callebaut, I.; Courvalin, J.C.; Mornon, J.P. The BAH (bromo-adjacent homology) domain: A link between DNA methylation, replication and transcriptional regulation. FEBS Lett. 1999, 446, 189-193.
27. Kimura, H.; Nakamura, T.; Ogawa, T.; Tanaka, S.; Shiota, K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res. 2003, 31, 3101-3113.
28. Jurkowska, R.Z.; Jurkowski, T.P.; Jeltsch, A. Structure and function of mammalian DNA methyltransferases. Chembiochem 2011, 12, 206-222.
29. Afroz, T.; Skrisovska, L.; Belloc, E.; Guillén-Boixet, J.; Méndez, R.; Allain, F.H.T. A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins. Genes Dev. 2014, 28, 1498-1514.
30. Ortiz-Zapater, E.; Pineda, D.; Martínez-Bosch, N.; Fernández-Miranda, G.; Iglesias, M.; Alameda, F.; Moreno, M.; Eliscovich C.; Eyras, E.; Real, F.X. Key contribution of CPEB4-mediated translational control to cancer progression. Nat. Med. 2012, 18, 83-90.
31. Maris, C.; Dominguez, C.; Allain, F.H. The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression. FEBS J. 2005, 272, 2118-2131.
32. Ozato, K.; Shin, D.M.; Chang, T.H.; Morse, H.C. TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol. 2008, 8, 849-860.
33. Shi, Y. Serine/threonine phosphatases: Mechanism through structure. Cell 2009, 139, 468-484.
34. Li, Z.; Liu, G.; Sun, L.; Teng, Y.; Guo, X.; Jia, J.; Sha, J.; Yang, X.; Chen, D.; Sun, Q. PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation. PLoS Pathog. 2015, 11, e1004783.
35. Das, A.K.; Helps, N.R.; Cohen, P.T.; Barford, D. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J. 1996, 15, 6798-6809.
36. Lu, D.; Klug, A. Invariance of the zinc finger module: A comparison of the free structure with those in nucleic-acid complexes. Proteins 2007, 67, 508-512.
37. Vojtek, A.B.; Hollenberg, S.M. Ras-Raf interaction: Two-hybrid analysis. Methods Enzymol. 1995, 255, 331-342.
38. Fromont-Racine, M.; Rain, J.C.; Legrain, P. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat. Genet. 1997, 16, 277-282.
39. Das, A.K.; Helps, N.R.; Cohen, P.T.; Barford, D. Protein interaction mapping: A Drosophila case study. Genome Res. 2005, 15, 376-384.
40. Wojcik, J.; Boneca, I.G.; Legrain, P. Prediction, assessment and validation of protein interaction maps in bacteria. J. Mol. Biol. 2002, 323, 763-770.
41. Hasan, N.M.; Lutsenko, S. Regulation of copper transporters in human cells. Curr. Top. Membr. 2012, 69, 137-161.