Prolonged Local Hypothermia Has No Long-Term Adverse Effect on the Spinal Cord

Therapeutic Hypothermia and Temperature Management

Volumn 5, Issue 3, 2015, Pages 152-162

  Vipin, Ashwati ^a   Kortelainen, Jukka ^b   Al Nashash, Hasan ^c   Chua, Soo Min ^a   Thow, Xinyuan ^a   Manivannan, Janani ^a   Astrid, ^a   Thakor, Nitish V ^a,d   Kerr, Candace L ^e   All, Angelo H ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF OULU   (Finland)

^c AMERICAN UNIVERSITY OF SHARJAH   (United Arab Emirates)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORE TEMPERATURE; ELECTRIC CONDUCTIVITY; EVOKED SOMATOSENSORY RESPONSE; FEMALE; HISTOLOGY; INDUCED HYPOTHERMIA; INVASIVE PROCEDURE; LAMINECTOMY; LONG TERM CARE; MOTOR PERFORMANCE; NONHUMAN; PATIENT SAFETY; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD INJURY; SPINAL CORD PARENCHYMA; TREATMENT DURATION; ADVERSE DRUG REACTION; ADVERSE EFFECTS; ANIMAL; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; DISEASE MODEL; INJURIES; MOTOR ACTIVITY; NEUROPROTECTION; PATHOPHYSIOLOGY; PHYSIOLOGIC MONITORING; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; SOMATOSENSORY EVOKED POTENTIAL; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, SOMATOSENSORY; FEMALE; HYPOTHERMIA, INDUCED; LONG TERM ADVERSE EFFECTS; MONITORING, PHYSIOLOGIC; MOTOR ACTIVITY; NEUROPROTECTION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TIME FACTORS;

EID: 84937846710     PISSN: 21537658     EISSN: 21537933     Source Type: Journal    
DOI: 10.1089/ther.2015.0005     Document Type: Article

References (55)

1. Agrawal G, Kerr C, Thakor NV, All AH. Characterization of Graded MASCIS Contusion Spinal Cord Injury using Somatosensory Evoked Potentials. Spine (Phila Pa 1976), 2010a;35:1122-1127.
2. Agrawal G, Sherman D, Maybhate A, Gorelik M, Kerr DA, Thakor NV, All AH. Slope analysis of somatosensory evoked potentials in spinal cord injury for detecting contusion injury and focal demyelination. J Clin Neurosci 2010b;17: 159-164.
3. Agrawal G, Thakor NV, All AH. Evoked potential versus behavior to detect minor insult to spinal cord in rat model. J Clin Neurosci 2009;16:1052-1055.
4. Arrich J. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007;35:1041-1047.
5. Auriat AM, Klahr AC, Silasi G, Maclellan CL, Penner M, Clark DL, Colbourne F. Prolonged hypothermia in rat: A safety study using brain-selective and systemic treatments. Ther Hypothermia Temp Manag 2012;2:37-43.
6. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996;139:244-256.
7. Basso DM, Beattie MS, Bresnahan, JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995;12:1-21.
8. Batchelor PE, Kerr NF, Gatt AM, Aleksoska E, Cox SF, Ghasem-Zadeh A, Wills TE, Howells DW. Hypothermia prior to decompression: buying time for treatment of acute spinal cord injury. J Neurotrauma 2010;27:1357-1368.
9. Batista LM, Lima FO, Januzzi Jr., JL, Donahue V, Snydeman C, Greer DM. Feasibility and safety of combined percutaneous coronary intervention and therapeutic hypothermia following cardiac arrest. Resuscitattion 2010;81: 398-403.
10. Bazley FA, All AH, Thakor NV, Maybhate A. Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats. Conf Proc IEEE Eng Med Biol Soc 2011;2011:2005-2008.
11. Bazley FA, Hu A, Maybhate A, Pourmorteza A, Pashai N, Thakor NV, Kerr C, All AH. Electrophysiologal evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusion. J Neurosurg Spine 2012;16: 414-423.
12. Bazley FA, Maybhate A, Tan CS, Thakor NV, Kerr C, All AH. Enhancement of bilateral cortical somatosensory evoked potentials to intact forelimb stimulation following thoracic contusion spinal cord injury in rats. IEEE Trans Neural Syst Rehabil Eng 2014a;22:953-964.
13. Bazley FA, Pashai N, Kerr C, Thakor N, All AH. A simple and effective semi-invasive method for inducing local hypothermia in rat spinal cord. Proc IEEE Eng Med Biol Soc 2013;2013:6321-6324.
14. Bazley FA, Pashai N, Kerr CL, All AH. The effects of local and general hypothermia on temperature profiles of the central nervous system following SCI in rats. Ther Hypothermia Temp Manag 2014b;4:115-124.
15. Beddingfield E, Clark AP. Therapeutic hypothermia after cardiac arrest: improving adherence to national guidelines. Clin Nurse Spec 2012;26:12-18.
16. Belliard G, Catez E, Charron C, Caille V, Aegerter P, Dubourg O, Jardin F, Vieillard-Baron A. Efficacy of therapeutic hypothermia after out-of-hospital cardiac arrest due to ventricular fibrillation. Resuscitattion 2007;75:252-259.
17. Bro-Jeppesen J, Kjaergaard J, Horsted TI, Wanscher MC, Nielsen SL, Rasmussen LS, Hassager C. The impact of therapeutic hypothermia on neurological function and quality of life after cardiac arrest. Resuscitattion 2009;80: 171-176.
18. Castillo-Abrego Guadalupe A. Hypothermia in spinal cord injury. Crit Care 2012;16(Suppl 2):A12:10.1186/cc11270.
19. Chang M, Marshall J. Therapeutic hypothermia for acute air embolic stroke. West J Emerg Med 2012;13:111-113.
20. Dietrich WD. Therapeutic hypothermia for acute severe spinal cord injury: ready to start large clinical trials? Crit Care Med 2012;40:691-692.
21. Dietrich WD. Therapeutic hypothermia for spinal cord injury. Crit Care Med 2009;37:S238-S242.
22. Dietrich WD, Atkins CM, Bramlett HM. Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia. J Neurotrauma 2009;26:301-312.
23. Dietrich WD, Cappuccino A, Cappuccino H. Systemic hypothermia for the treatment of acute cervical spinal cord injury in sports. Curr Sports Med Rep 2011a;10:50-54.
24. Dietrich WD, Levi AD, Wang M, Green BA. Hypothermic treatment for acute spinal cord injury. Neurotherapeutics 2011b;8:229-239.
25. Faridar A, Bershad EM, Emiru T, Iaizzo PA, Suarez JI, Divani AA. Therapeutic hypothermia in stroke and traumatic brain injury. Front Neurol 2011;2:80.
26. Grulova I, Slovinska L, Nagyova M, Cizek M, Cizkova D. The effect of hypothermia on sensory-motor function and tissue sparing after spinal cord injury. Spine J 2013;13: 1881-1891.
27. Gupta R, Bathen ME, Smith JS, Levi AD, Bhatia NN, Steward O. Advances in the management of spinal cord injury. J Am Acad Ortho Surg 2010;18:210-222.
28. Kang J, Albadawi H, Casey PJ, Abbruzzese TA, Patel VI, Yoo HJ, Cambria RP, Watkins MT. The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion. J Vasc Surg 2010;52:435-443.
29. Kawamura N, Schmeichel AM, Wang Y, Schmelzer JD, Low PA. Multiple effects of hypothermia on inflammatory response following ischemia-reperfusion injury in experimental ischemic neuropathy. Exp Neurol 2006;202:487-496.
30. Khan S, Plummer M, Martinez-Arizala A, Banovac K. Hypothermia in patients with chronic spinal cord injury. J Spinal Cord Med 2007;30:27-30.
31. Kortelainen J, Koskinen M, Mustola S, Seppänen T. Timefrequency properties of electroencephalogram during induction of anesthesia. Neurosci Lett 2008;446:70-74.
32. Kortelainen J, Vipin A, Thow X, Mir H, Thakor N, Al-Nashash H, All A. Effect of isoflurane on somatosensory evoked potentials in a rat model. Conf Proc IEEE Eng Med Biol Soc 2014;4286-4289.
33. Kwon BK, Mann C, Sohn HM, Hilibrand AS, Phillips FM, Wang JC, Fehlings MG, the NASS Section on Biologics. Hypothermia for spinal cord injury. Spine J 2008;8:859-874.
34. Kwon BK, Sekhon LH, Fehlings MG. Emerging repair, regeneration and translational research advances for spinal cord injury. Spine 2010;35:S263-S70.
35. Lakhan SE, Pamplona F. Application of mild therapeutic hypothermia on stroke: A systematic review and metaanalysis. Stroke Res Treat 2012;2012:295906.
36. Lenhardt R. The effect of anesthesia on body temperature. Front Biosci (Schol Ed) 2010;2:1145-1154.
37. Levi AD, Casella G, Green BA, Dietrich WD, Vanni S, Jagid J, Wang MY. Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury. Neurosurgery 2010;66:670-677.
38. Li N, Tian L, Wu W, Lu H, Zhou Y, Zhang L, Xu X, Zhang X, Cheng H. Regional hypothermia inhibits spinal cord somatosensory-evoked potentials without neural damages in uninjured rats. J Neurotrauma 2013;30:1325-1333.
39. Lo TP, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD. Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats. J Comp Neurol 2009;514:433-448.
40. Lotocki G, de Rivero Vaccari J, Alonso O, Molano JS, Nixon R, Dietrich WD, Bramlett HM. Oligodendrocyte vulnerability following traumatic brain injury in rats: effect of moderate hypothermia. Ther Hypothermia Temp Manag 2011;5:43-51.
41. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med 1997;336:540-546.
42. Martinez-Arizala A, Green BA. Hypothermia in spinal cord injury. J Neurotrauma 1992;9:S497-S505.
43. Maybhate A, Hu C, Bazley FA, Yu Q, Thakor NV, Kerr CL, All AH. Potential long-term benefits of acute hypothermia after spinal cord injury: Assessments with somatosensory-evoked potentials. Crit Care Med 2012;40:573-579.
44. McKinley WO, Seel RT, Hardman JT. Nontraumatic spinal cord injury: incidence, epidemiology, and functional outcome. Arch Phys Med Rehabil 1999;80:619-623.
45. Melhuish T. Linking hypothermia and hyperglycemia. Nurs Manage 2009;40:42-45.
46. Morizane K, Ogata T, Morino T, Horiuchi H, Yamaoka G, Hino M, Miura H. A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord: The effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats. Neurosci Res 2012;72:279-282.
47. Piironen K, Tiainen M, Mustanoja S, Kaukonen KM, Meretoja A, Tatlisumak T, Kaste M. Mild hypothermia after intravenous thrombolysis in patients with acute stroke: A randomized controlled trial. Stroke 2014;45:486-491.
48. Polderman KH, Herold I. Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical consideratotions, side effects, and cooling methods. Crit Care Med 2009;37:1101-1120.
49. Saito T, Saito S, Yamamoto H, Tsuchida M. Neuroprotection following mild hypothermia after spinal cord ischemia in rats. J Vasc Surg 2013;57:173-181.
50. The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549-556.
51. van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis. Brain 2007; 130:3063-3074.
52. Yenari MA, Hans HS. Neuroprotective mechanisms of hypothermia in brain ischemia. Nat Rev Neurosci 2012;13: 267-278.
53. Yoshitake A, Mori A, Shimizu H, Ueda T, Kabei N, Hachiya T, Okano H, Yozu R. Use of an epidural cooling catheter with a closed countercurrent lumen to protect against ischemic spinal cord injury in pigs. J Thorac Cardiovasc Surg 2007; 134:1220-1226.
54. Yu CG, Jimenez O, Marcillo AE, Weider B, Bangerter K, Dietrich WD, Castro S, Yezierski RP. Beneficial effects of modest systemic hypothermia on locomotor function and histopathological damage following contusion-induced spinal cord injury in rats. J Neurosurg 2000;93:85-93.
55. Zhang L, Cheng H, Shi J, Chen J. Focal epidural cooling reduces the infarction volume of permanent middle cerebral artery occlusion in swine. Surg Neurol 2007;67:117-121.