Therapeutic hypothermia for acute severe spinal cord injury: Ready to start large clinical trials?

Critical Care Medicine

Volumn 40, Issue 2, 2012, Pages 691-692

  Dietrich, W Dalton ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

clinical trial; hypothermia; motor recovery; spinal cord injury

Indexed keywords

BRAIN INJURY; BRAIN ISCHEMIA; DISEASE SEVERITY; EDITORIAL; ELECTROPHYSIOLOGY; INDUCED HYPOTHERMIA; MOTOR PERFORMANCE; NEUROPROTECTION; PATIENT SAFETY; PRIORITY JOURNAL; SOMATOSENSORY STIMULATION; SPINAL CORD INJURY;

ANIMALS; EVOKED POTENTIALS, SOMATOSENSORY; FEMALE; HYPOTHERMIA, INDUCED; SPINAL CORD INJURIES;

EID: 84856167679     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318236eacb     Document Type: Editorial

References (14)

1. Maybhate A, Hu C, Bazley FA, et al: Potential long-term benefits of acute hypothermia after spinal cord injury: Assessments with somatosensory- evoked potentials. Crit Care Med 2012; 40:573-579
2. Dietrich WD 3rd: Therapeutic hypothermia for spinal cord injury. Crit Care Med 2009; 37:S238-S242
3. Dietrich WD, Atkins CM, Bramlett HM: Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia. J Neurotrauma 2009; 26:301-312
4. Yu CG, Jimenez O, Marcillo AE, et al: Beneficial effects of modest systemic hypothermia on locomotor function and histopathological damage following contusion-induced spinal cord injury in rats. J Neurosurg 2000; 93:85-93
5. Lo TP Jr, Cho KS, Garg MS, et al: Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats. J Comp Neurol 2009; 514: 433-448
6. Batchelor PE, Kerr NF, Gatt AM, et al: Hypothermia prior to decompression: Buying time for treatment of acute spinal cord injury. J Neurotrauma 2010; 27:1357-1368
7. Ha KY, Kim YH: Neuroprotective effect of moderate epidural hypothermia after spinal cord injury in rats. Spine 2008; 33:2059-2065
8. Morochovic R, Chudá M, Talánová J, et al: Local transcutaneous cooling of the spinal cord in the rat: Effects on long-term outcomes after compression spinal cord injury. Int J Neurosci 2008; 118:555-568
9. Horiuchi T, Kawaguchi M, Kurita N, et al: The long-term effects of mild to moderate hypothermia on gray and white matter injury after spinal cord ischemia in rats. Anesth Analg 2009; 109:559-566
10. Kang J, Albadawi H, Casey PJ, et al: The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion. J Vasc Surg 2010; 52:435-443
11. Levi AD, Green BA, Wang MY, et al: Clinical application of modest hypothermia after spinal cord injury. J Neurotrauma 2009; 26: 407-415
12. Levi AD, Casella A, Green BA, et al: Clinical outcomes using modest intravascular hypothermia after cervical spine injury. Neurosurgery 2010; 66:670-677
13. Kwon BK, Mann C, Sohn HM, et al: NASS Section on Biologics: Hypothermia for spinal cord injury. Spine J 2008; 8:859-874
14. Kwon BK, Sekhon LH, Fehlings MG: Emerging repair, regeneration, and translational research advances for spinal cord injury. Spine 2010; 35:S263-S270