Clinical Utility of Viscoelastic Tests of Coagulation (TEG/ROTEM) in Patients with Liver Disease and during Liver Transplantation

Seminars in Thrombosis and Hemostasis

Volumn 41, Issue 5, 2015, Pages 527-537

  Mallett, Susan V ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

coagulation; liver disease; viscoelastic tests

Indexed keywords

FIBRINOGEN; HEPARIN; HEPARINOID;

ACUTE LIVER DISEASE; ACUTE LIVER FAILURE; ARTICLE; BLOOD CELL; BLOOD CLOTTING; BLOOD CLOTTING TEST; CHRONIC LIVER DISEASE; CLINICAL EVALUATION; CORRELATIONAL STUDY; DIAGNOSTIC VALUE; ENDOTHELIAL DYSFUNCTION; FIBRINOLYSIS; HEMOSTASIS; HUMAN; HYPERCOAGULABILITY; INTERNATIONAL NORMALIZED RATIO; LIVER DISEASE; LIVER TRANSPLANTATION; ORTHOTOPIC TRANSPLANTATION; PLASMA; PRIORITY JOURNAL; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEPSIS; STANDARD; THROMBOCYTE COUNT; THROMBOELASTOGRAPHY; THROMBOELASTOMETRY; VASCULAR ENDOTHELIUM; DEVICES; LIVER DISEASES; PROCEDURES;

BLOOD COAGULATION TESTS; HUMANS; LIVER DISEASES; LIVER TRANSPLANTATION; THROMBELASTOGRAPHY;

EID: 84937813266     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0035-1550434     Document Type: Article

References (120)

1. Mannucci P. M. Abnormal hemostasis tests and bleeding in chronic liver disease: are they related? No. J Thromb Haemost: 2006; 4 4 721 723
2. Tripodi A., Mannucci P. M. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol: 2007; 46 4 727 733
3. Caldwell S. H., Hoffman M., Lisman T., et al. Coagulation in Liver Disease Group. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology: 2006; 44 4 1039 1046
4. Lisman T., Porte R. J. Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences. Blood: 2010; 116 6 878 885
5. Tripodi A., Salerno F., Chantarangkul V., et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology: 2005; 41 3 553 558
6. Sogaard K. K., Horváth-Puhó E., Gronbaek H., Jepsen P., Vilstrup H., Sorensen H. T. Risk of venous thromboembolism in patients with liver disease: a nationwide population-based case-control study. Am J Gastroenterol: 2009; 104 1 96 101
7. Massicotte L., Beaulieu D., Thibeault L., et al. Coagulation defects do not predict blood product requirements during liver transplantation. Transplantation: 2008; 85 7 956 962
8. Ben-Ari Z., Panagou M., Patch D., et al. Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosing cholangitis evaluated by thrombelastography. J Hepatol: 1997; 26 3 554 559
9. Kargili A., Cipil H., Karakurt F., et al. Hemostatic alterations in fatty liver disease. Blood Coagul Fibrinolysis: 2010; 21 4 325 327
10. Shore-Lesserson L., Manspeizer H. E., DePerio M., Francis S., Vela-Cantos F., Ergin M. A. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg: 1999; 88 2 312 319
11. Schöchl H., Frietsch T., Pavelka M., Jámbor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma: 2009; 67 1 125 131
12. Kashuk J. L., Moore E. E., Sabel A., et al. Rapid thrombelastography (r-TEG) identifies hypercoagulability and predicts thromboembolic events in surgical patients. Surgery: 2009; 146 4 764 772, discussion 772-774
13. Kang Y. G., Martin D. J., Marquez J., et al. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg: 1985; 64 9 888 896
14. Tripodi A., Primignani M., Chantarangkul V., et al. The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters. Thromb Res: 2009; 124 1 132 136
15. Stravitz R. T. Potential applications of thromboelastography in patients with acute and chronic liver disease. Gastroenterol Hepatol (N Y): 2012; 8 8 513 520
16. Tripodi A., Chantarangkul V., Mannucci P. M. Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing. Br J Haematol: 2009; 147 1 77 82
17. Mann K. G., Butenas S., Brummel K. The dynamics of thrombin formation. Arterioscler Thromb Vasc Biol: 2003; 23 1 17 25
18. Kamal A. H., Tefferi A., Pruthi R. K. How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults. Mayo Clin Proc: 2007; 82 7 864 873
19. Roberts H. R., Monroe D. M., Escobar M. A. Current concepts of hemostasis: implications for therapy. Anesthesiology: 2004; 100 3 722 730
20. Hoffman M., Monroe D. M. III. A cell-based model of hemostasis. Thromb Haemost: 2001; 85 6 958 965
21. Wolberg A. S. Thrombin generation and fibrin clot structure. Blood Rev: 2007; 21 3 131 142
22. Hartert H. [Not Available]. Klin Wochenschr: 1948; 26 37-38 577 583
23. Ganter M. T., Hofer C. K. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg: 2008; 106 5 1366 1375
24. Whiting D., DiNardo J. A. TEG and ROTEM: technology and clinical applications. Am J Hematol: 2014; 89 2 228 232
25. Coakley M., Reddy K., Mackie I., Mallett S. Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. J Cardiothorac Vasc Anesth: 2006; 20 4 548 553
26. Kitchen D. P., Kitchen S., Jennings I., Woods T., Walker I. Quality assurance and quality control of thrombelastography and rotational Thromboelastometry: the UK NEQAS for blood coagulation experience. Semin Thromb Hemost: 2010; 36 7 757 763
27. Karon B. S. Why is everyone so excited about thromboelastrography (TEG)? Clin Chim Acta: 2014; 436 143 148
28. Roullet S., Pillot J., Freyburger G., et al. Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation. Br J Anaesth: 2010; 104 4 422 428
29. Nascimento B., Al Mahoos M., Callum J., et al. Vitamin K-dependent coagulation factor deficiency in trauma: a comparative analysis between international normalized ratio and thromboelastography. Transfusion: 2012; 52 1 7 13
30. Esch J. S., Jurk K., Knoefel W. T., et al. Platelet activation and increased tissue factor expression on monocytes in reperfusion injury following orthotopic liver transplantation. Platelets: 2010; 21 5 348 359
31. Rautou P. E., Vion A. C., Luyendyk J. P., Mackman N. Circulating microparticle tissue factor activity is increased in patients with cirrhosis. Hepatology: 2014; 60 5 1793 1795
32. Fries D., Haas T., Klingler A., et al. Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy--a porcine model. Br J Anaesth: 2006; 97 4 460 467
33. Alexander D. C., Butt W. W., Best J. D., Donath S. M., Monagle P. T., Shekerdemian L. S. Correlation of thromboelastography with standard tests of anticoagulation in paediatric patients receiving extracorporeal life support. Thromb Res: 2010; 125 5 387 392
34. Gunduz E., Akay O. M., Bal C., Gulbas Z. Can thrombelastography be a new tool to assess bleeding risk in patients with idiopathic thrombocytopenic purpura? Platelets: 2011; 22 7 516 520
35. Kim W. H., Park J. B., Jung C. W., Kim G. S. Rebalanced hemostasis in patients with idiopathic thrombocytopenic purpura. Platelets: 2015; 26 1 38 42
36. Görlinger K., Dirkmann D., Hanke A. A., et al. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology: 2011; 115 6 1179 1191
37. Fenger-Eriksen C., Moore G. W., Rangarajan S., Ingerslev J., Sorensen B. Fibrinogen estimates are influenced by methods of measurement and hemodilution with colloid plasma expanders. Transfusion: 2010; 50 12 2571 2576
38. Molinaro R. J., Szlam F., Levy J. H., Fantz C. R., Tanaka K. A. Low plasma fibrinogen levels with the Clauss method during anticoagulation with bivalirudin. Anesthesiology: 2008; 109 1 160 161
39. Harr J. N., Moore E. E., Ghasabyan A., et al. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock: 2013; 39 1 45 49
40. Haase N., Ostrowski S. R., Wetterslev J., et al. Thromboelastography in patients with severe sepsis: a prospective cohort study. Intensive Care Med: 2015; 41 1 77 85
41. Yang Lu S., Tanaka K. A., Abuelkasem E., Planinsic R. M., Sakai T. Clinical applicability of rapid thrombelastography and functional fibrinogen thrombelastography to adult liver transplantation. Liver Transpl: 2014; 20 9 1097 1105
42. Thalheimer U., Triantos C. K., Samonakis D. N., et al. A comparison of kaolin-activated versus nonkaolin-activated thromboelastography in native and citrated blood. Blood Coagul Fibrinolysis: 2008; 19 6 495 501
43. Kleinegris M. C., Bos M. H., Roest M., et al. Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity. J Thromb Haemost: 2014; 12 10 1647 1657
44. Rockey D. C., Caldwell S. H., Goodman Z. D., Nelson R. C., Smith A. D.; American Association for the Study of Liver Diseases. Liver biopsy. Hepatology: 2009; 49 3 1017 1044
45. Herbstreit F., Winter E. M., Peters J., Hartmann M. Monitoring of haemostasis in liver transplantation: comparison of laboratory based and point of care tests. Anaesthesia: 2010; 65 1 44 49
46. Afdhal N. H., Giannini E. G., Tayyab G., et al. ELEVATE Study Group. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med: 2012; 367 8 716 724
47. Lisman T., Porte R. J. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med: 2012; 367 21 2055 2056
48. Tripodi A., Primignani M., Chantarangkul V., et al. Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion. Liver Int: 2013; 33 3 362 367
49. Weeder P. D., Porte R. J., Lisman T. Hemostasis in liver disease: implications of new concepts for perioperative management. Transfus Med Rev: 2014; 28 3 107 113
50. Coppell J. A., Thalheimer U., Zambruni A., et al. The effects of unfractionated heparin, low molecular weight heparin and danaparoid on the thromboelastogram (TEG): an in-vitro comparison of standard and heparinase-modified TEGs with conventional coagulation assays. Blood Coagul Fibrinolysis: 2006; 17 2 97 104
51. White H., Sosnowski K., Bird R., Jones M., Solano C. The utility of thromboelastography in monitoring low molecular weight heparin therapy in the coronary care unit. Blood Coagul Fibrinolysis: 2012; 23 4 304 310
52. McKee R. F., Hodson S., Dawes J., Garden O. J., Carter D. C. Plasma concentrations of endogenous heparinoids in portal hypertension. Gut: 1992; 33 11 1549 1552
53. Nelson A., Berkestedt I., Schmidtchen A., Ljunggren L., Bodelsson M. Increased levels of glycosaminoglycans during septic shock: relation to mortality and the antibacterial actions of plasma. Shock: 2008; 30 6 623 627
54. Ostrowski S. R., Johansson P. I. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg: 2012; 73 1 60 66
55. Kettner S. C., Gonano C., Seebach F., et al. Endogenous heparin-like substances significantly impair coagulation in patients undergoing orthotopic liver transplantation. Anesth Analg: 1998; 86 4 691 695
56. Montalto P., Vlachogiannakos J., Cox D. J., Pastacaldi S., Patch D., Burroughs A. K. Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study. J Hepatol: 2002; 37 4 463 470
57. Papatheodoridis G. V., Patch D., Webster G. J., Brooker J., Barnes E., Burroughs A. K. Infection and hemostasis in decompensated cirrhosis: a prospective study using thrombelastography. Hepatology: 1999; 29 4 1085 1090
58. Thalheimer U., Triantos C., Samonakis D., et al. Endogenous heparinoids in acute variceal bleeding. Gut: 2005; 54 2 310 311
59. Chau T. N., Chan Y. W., Patch D., Tokunaga S., Greenslade L., Burroughs A. K. Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. Gut: 1998; 43 2 267 271
60. Triantos C., Louvros E., Kalafateli M., et al. Endogenous heparinoids detected by anti-Xa activity are present in blood during acute variceal bleeding in cirrhosis. A prospective study. J Gastrointestin Liver Dis: 2014; 23 2 187 194
61. Thalheimer U., Triantos C., Samonakis D., Patch D., Burroughs A. K. Heparin effect on thromboelastography after transjugular intrahepatic portosystemic shunt procedure. Scand J Gastroenterol: 2009; 44 12 1463 1470
62. Northup P. G. Hypercoagulation in liver disease. Clin Liver Dis: 2009; 13 1 109 116
63. Tsochatzis E. A., Senzolo M., Germani G., Gatt A., Burroughs A. K. Systematic review: portal vein thrombosis in cirrhosis. Aliment Pharmacol Ther: 2010; 31 3 366 374
64. Hoekstra J., Janssen H. L. Vascular liver disorders (II): portal vein thrombosis. Neth J Med: 2009; 67 2 46 53
65. Tripodi A., Primignani M., Chantarangkul V., et al. An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology: 2009; 137 6 2105 2111
66. Tripodi A., Anstee Q. M., Sogaard K. K., Primignani M., Valla D. C. Hypercoagulability in cirrhosis: causes and consequences. J Thromb Haemost: 2011; 9 9 1713 1723
67. Pihusch R., Rank A., Göhring P., Pihusch M., Hiller E., Beuers U. Platelet function rather than plasmatic coagulation explains hypercoagulable state in cholestatic liver disease. J Hepatol: 2002; 37 5 548 555
68. Hickman I. J., Sullivan C. M., Flight S., et al. Altered clot kinetics in patients with non-alcoholic fatty liver disease. Ann Hepatol: 2009; 8 4 331 338
69. Cakir T., Cingi A., Yeʇen C. Coagulation dynamics and platelet functions in obstructive jaundiced patients. J Gastroenterol Hepatol: 2009; 24 5 748 751
70. McCrath D. J., Cerboni E., Frumento R. J., Hirsh A. L., Bennett-Guerrero E. Thromboelastography maximum amplitude predicts postoperative thrombotic complications including myocardial infarction. Anesth Analg: 2005; 100 6 1576 1583
71. Toukh M., Siemens D. R., Black A., et al. Thromboelastography identifies hypercoagulablilty and predicts thromboembolic complications in patients with prostate cancer. Thromb Res: 2014; 133 1 88 95
72. Dai Y., Lee A., Critchley L. AH, White P. F. Does thromboelastography predict postoperative thromboembolic events? A systematic review of the literature. Anesth Analg: 2009; 108 3 734 742
73. Munoz S. J., Rajender Reddy K., Lee W.; Acute Liver Failure Study Group. The coagulopathy of acute liver failure and implications for intracranial pressure monitoring. Neurocrit Care: 2008; 9 1 103 107
74. Stravitz R. T., Lisman T., Luketic V. A., et al. Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography. J Hepatol: 2012; 56 1 129 136
75. Agarwal B., Wright G., Gatt A., et al. Evaluation of coagulation abnormalities in acute liver failure. J Hepatol: 2012; 57 4 780 786
76. Herriman D. J., Mallett S. A comparison of baseline international normalised ratio (INR) and thromboelastography (TEG) R times, and transfusion requirements for patients with fulminant hepatic failure undergoing orthotopic liver transplant (OLT). Liver Transpl: 2011; 17 6 S120
77. Agarwal S., Senzolo M., Melikian C., Burroughs A., Mallett S. V. The prevalence of a heparin-like effect shown on the thromboelastograph in patients undergoing liver transplantation. Liver Transpl: 2008; 14 6 855 860
78. Senzolo M., Riddell A., Tuddenham E., Burroughs A. K. Endogenous heparinoids contribute to coagulopathy in patients with liver disease. J Hepatol: 2008; 48 2 371 372, author reply 372-373
79. Massicotte L., Lenis S., Thibeault L., Sassine M. P., Seal R. F., Roy A. Reduction of blood product transfusions during liver transplantation. Can J Anaesth: 2005; 52 5 545 546
80. Ozier Y., Pessione F., Samain E., Courtois F.; French Study Group on Blood Transfusion in Liver Transplantation. Institutional variability in transfusion practice for liver transplantation. Anesth Analg: 2003; 97 3 671 679
81. Schumann R. Intraoperative resource utilization in anesthesia for liver transplantation in the United States: a survey. Anesth Analg: 2003; 97 1 21 28 table of contents.
82. Steib A., Freys G., Lehmann C., Meyer C., Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can J Anaesth: 2001; 48 11 1075 1079
83. McCluskey S. A., Karkouti K., Wijeysundera D. N., et al. Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation. Liver Transpl: 2006; 12 11 1584 1593
84. Massicotte L., Beaulieu D., Roy J. D., et al. MELD score and blood product requirements during liver transplantation: no link. Transplantation: 2009; 87 11 1689 1694
85. Massicotte L., Denault A. Y., Thibeault L., Hevesi Z., Nozza A., Roy A. Relationship between conventional coagulation tests and bleeding for 600 consecutive liver transplantations. Transplantation: 2014; 98 2 e13 e15
86. Lopez-Plaza I. Transfusion guidelines and liver transplantation: time for consensus. Liver Transpl: 2007; 13 12 1630 1632
87. Massicotte L., Sassine M. P., Lenis S., Seal R. F., Roy A. Survival rate changes with transfusion of blood products during liver transplantation. Can J Anaesth: 2005; 52 2 148 155
88. Trentino K. M., Farmer S. L., Swain S. G., et al. Increased hospital costs associated with red blood cell transfusion. Transfusion: 2014
89. Trzebicki J., Flakiewicz E., Kosieradzki M., et al. The use of thromboelastometry in the assessment of hemostasis during orthotopic liver transplantation reduces the demand for blood products. Ann Transplant: 2010; 15 3 19 24
90. Gorlinger K., Dirkmann D., Muller-Beissenhirtz H., Paul A., Hartmann M., Saner F. Thromboelastometry-based perioperative coagulation management in visceral surgery and liver transplantation: experience of 10 tears and 1105 LTX. Liver Transpl: 2010; 16 6 S86
91. Kozek-Langenecker S. A., Afshari A., Albaladejo P., et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol: 2013; 30 6 270 382
92. Haas T., Spielmann N., Mauch J., et al. Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgery. Br J Anaesth: 2012; 108 1 36 41
93. Kirchner C., Dirkmann D., Treckmann J. W., et al. Coagulation management with factor concentrates in liver transplantation: a single-center experience. Transfusion: 2014; 54 10 Pt 2 2760 2768
94. Larsen O. H., Fenger-Eriksen C., Christiansen K., Ingerslev J., Sorensen B. Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology: 2011; 115 2 294 302
95. Pereboom I. TA, de Boer M. T., Haagsma E. B., Hendriks H. GD, Lisman T., Porte R. J. Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury. Anesth Analg: 2009; 108 4 1083 1091
96. Schöchl H., Voelckel W., Maegele M., Kirchmair L., Schlimp C. J. Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: a 7-day observational study of trauma patients. Crit Care: 2014; 18 4 R147
97. Arshad F., Ickx B., van Beem R. T., et al. Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial. BMC Surg: 2013; 13 22
98. Mannucci P. M., Franchini M. Recombinant factor VIIa as haemostatic therapy in advanced liver disease. Blood Transfus: 2013; 11 4 487 490
99. Ferraris V. A., Brown J. R., Despotis G. J., et al. Society of Thoracic Surgeons Blood Conservation Guideline Task Force; Society of Cardiovascular Anesthesiologists Special Task Force on Blood Transfusion; International Consortium for Evidence Based Perfusion. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg: 2011; 91 3 944 982
100. Noval-Padillo J. A., León-Justel A., Mellado-Miras P., et al. Introduction of fibrinogen in the treatment of hemostatic disorders during orthotopic liver transplantation: implications in the use of allogenic blood. Transplant Proc: 2010; 42 8 2973 2974
101. Wang S. C., Shieh J. F., Chang K. Y., et al. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proc: 2010; 42 7 2590 2593
102. Roullet S., Freyburger G., Cruc M., et al. Management of bleeding and transfusion during liver transplantation before and after the introduction of a ROTEM -based algorithm. Liver Transpl: 2014
103. Hevesi Z. G., Lopukhin S. Y., Mezrich J. D., Andrei A. C., Lee M. Designated liver transplant anesthesia team reduces blood transfusion, need for mechanical ventilation, and duration of intensive care. Liver Transpl: 2009; 15 5 460 465
104. Wang S. C., Lin H. T., Chang K. Y., et al. Use of higher thromboelastogram transfusion values is not associated with greater blood loss in liver transplant surgery. Liver Transpl: 2012; 18 10 1254 1258
105. Ferro D., Celestini A., Violi F. Hyperfibrinolysis in liver disease. Clin Liver Dis: 2009; 13 1 21 31
106. Porte R. J., Bontempo F. A., Knot E. A., Lewis J. H., Kang Y. G., Starzl T. E. Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation: 1989; 47 6 978 984
107. Homatas J., Wasantapruek S., Von Kaulla E., Von Kaulla K. N., Eiseman B. Clotting abnormalities following orthotopic and heterotopic transplantation of marginally preserved pig livers. Acta Hepatosplenol: 1971; 18 1 14 26
108. Porte R. J., Blauw E., Knot E. A., et al. Role of the donor liver in the origin of platelet disorders and hyperfibrinolysis in liver transplantation. J Hepatol: 1994; 21 4 592 600
109. Görlinger K. [Coagulation management during liver transplantation]. Hamostaseologie: 2006; 26 3 01 S64 S76
110. Schofield N., Sugavanam A., Thompson K., Mallett S. V. No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin. Liver Transpl: 2014; 20 5 584 590
111. Kang Y. Coagulation and liver transplantation. Transplant Proc: 1993; 25 2 2001 2005
112. Kang Y. Thromboelastography in liver transplantation. Semin Thromb Hemost: 1995; 21 04 34 44
113. Harding S. A., Mallett S. V., Peachey T. D., Cox D. J. Use of heparinase modified thrombelastography in liver transplantation. Br J Anaesth: 1997; 78 2 175 179
114. Bezeaud A., Denninger M. H., Dondero F., et al. Hypercoagulability after partial liver resection. Thromb Haemost: 2007; 98 6 1252 1256
115. Krzanicki D., Sugavanam A., Mallett S. Intraoperative hypercoagulability during liver transplantation as demonstrated by thromboelastography. Liver Transpl: 2013; 19 8 852 861
116. Schöchl H., Solomon C., Schulz A., et al. Thromboelastometry (TEM) findings in disseminated intravascular coagulation in a pig model of endotoxinemia. Mol Med: 2011; 17 3-4 266 272
117. Warnaar N., Molenaar I. Q., Colquhoun S. D., et al. Intraoperative pulmonary embolism and intracardiac thrombosis complicating liver transplantation: a systematic review. J Thromb Haemost: 2008; 6 2 297 302
118. Xia V. W., Ho J. K., Nourmand H., Wray C., Busuttil R. W., Steadman R. H. Incidental intracardiac thromboemboli during liver transplantation: incidence, risk factors, and management. Liver Transpl: 2010; 16 12 1421 1427
119. Lerner A. B., Sundar E., Mahmood F., Sarge T., Hanto D. W., Panzica P. J. Four cases of cardiopulmonary thromboembolism during liver transplantation without the use of antifibrinolytic drugs. Anesth Analg: 2005; 101 6 1608 1612
120. Tripodi A., Mannucci P. M. The coagulopathy of chronic liver disease. N Engl J Med: 2011; 365 2 147 156