Thymoquinone Ameliorates Acute Renal Failure in Gentamicin-Treated Adult Male Rats

Pharmacology

Volumn 96, Issue 3-4, 2015, Pages 112-117

  Samarghandian, Saeed ^a   Azimi Nezhad, Mohsen ^a,b   Mehrad Majd, Hassan ^a   Mirhafez, Seyed Reza ^a  

^a NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute renal failure; Gentamicin; Rats; Thymoquinone

Indexed keywords

CREATININE; GENTAMICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; SUPEROXIDE DISMUTASE; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BENZOQUINONE DERIVATIVE; CYTOKINE; PROTEIN SYNTHESIS INHIBITOR;

ACUTE KIDNEY FAILURE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; KIDNEY FUNCTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RENAL PROTECTION; THERAPY EFFECT; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL; ACUTE KIDNEY INJURY; ANIMAL; BLOOD; CHEMICALLY INDUCED; METABOLISM; WISTAR RAT;

ACUTE KIDNEY INJURY; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BENZOQUINONES; BLOOD UREA NITROGEN; CREATININE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENTAMICINS; MALE; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, WISTAR;

EID: 84937783713     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000436975     Document Type: Article

References (38)

1. Sahu BD, Kuncha M, Putcha UK, Sistla R: Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation. Exp Toxicol Pathol 2013; 65: 933-940.
2. Parlakpinar H, Tasdemir S, Polat A, Bay-Karabulut A, Vardi N, Ucar M, et al: Protective role of caffeic acid phenethyl ester (CAPE) on gentamicin-induced acute renal toxicity in rats. Toxicology 2005; 207: 169-177.
3. Erdem A, Gundogan NU, Usubutun A, Kilinc K, Erdem SR, Kara A, et al: The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol Dial Transplant 2000; 15: 1175-1182.
4. Akcay A, Nguyen Q, Edelstein CL: Mediators of inflammation in acute kidney injury. Mediators Inflamm 2009; 2009: 137072.
5. Balakumar P, Rohilla A, Thangathirupathi A: Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it? Pharmacol Res 2010; 62: 179-186.
6. Samarghandian S, Azimi-Nezhad M, Samini F: Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. Biomed Res Int 2014; 2014: 920857.
7. Samarghandian S, Borji A, Delkhosh MB, Samini F: Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J Pharm Pharm Sci 2013; 16: 352-362.
8. Samarghandian S, Borji A, Tabasi SH: Effects of Cichorium intybus linn on blood glucose, lipid constituents and selected oxidative stress parameters in streptozotocin-induced diabetic rats. Cardiovasc Hematol Disord Drug Targets 2013; 13: 231-236.
9. Samarghandian S, Hadjzadeh MA, Amin Nya F, Davoodi S: Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats. Pharmacogn Mag 2012; 8: 65-72.
10. Al-Ghamdi MS: The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 2001; 76: 45-48.
11. Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH: Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 2003; 26: 87-98.
12. Genet S, Kale RK, Baquer NZ: Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonellafoenum graecum). Mol Cell Biochem 2002; 236: 7-12.
13. Gupta A, Gupta A, Nigam D, Shukla GS, Agarwal AK: Profile of reactive oxygen species generation and antioxidative mechanisms in the maturing rat kidney. J Appl Toxicol 1999; 19: 55-59.
14. Marklund S, Marklund G: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-474.
15. Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-169.
16. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1976; 72: 248-254.
17. Stojiljkovic N, Stoiljkovic M, Mihailovic D, Randjelovic P, Ilic S, Gocmanac-Ignjatovic M, Veljkovic M: Beneficial effects of calcium oral coadministration in gentamicin-induced nephrotoxicity in rats. Ren Fail 2012; 34: 622-627.
18. Balakumar P, Rohilla A, Thangathirupathi A: Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it? Pharmacol Res 2010; 62: 179-186.
19. Bledsoe G, Crickman S, Mao J, Xia CF, Murakami H, Chao L, Chao J: Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. Nephrol Dial Transplant 2006; 21: 624-633.
20. Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA: Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacol Res 2002; 46: 445-451.
21. Jia P, Teng J, Zou J, Fang Y, Jiang S, et al: Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. PLoS One 2013; 8:e64329.
22. Polat A, Parlakpinar H, Tasdemir S, Colak C, Vardi N, Ucar M, Emre MH, Acet A: Protective role of aminoguanidine on gentamicininduced acute renal failure in rats. Acta Histochem 2006; 108: 365-371.
23. Kalayarasan S, Prabhu PN, Sriram N, Manikandan R, Arumugam M, Sudhandiran G: Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats. Eur J Pharmacol 2009; 606: 162-171.
24. Mansour MA, Mostafa AM, Nagi MN, Khattab MM, Al-Shabanah OA: Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats. Comp Biochem Physiol C Toxicol Pharmacol 2002; 132: 123-128.
25. Ali BH, Al Za'abi M, Blunden G, Nemmar A: Experimental gentamicin nephrotoxicity and agents that modify it: A mini-review of recent research. Basic Clin Pharmacol Toxicol 2011; 109: 225-232.
26. Badary OA: Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol 1999; 67: 135-142.
27. Romero F, Perez M, Chavez M, Parra G, Durante P: Effect of uric acid on gentamicin-induced nephrotoxicity in rats-role of matrix metalloproteinases 2 and 9. Basic Clin Pharmacol Toxicol 2009; 105: 416-424.
28. Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH: Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 2003; 26: 87-98.
29. Simmons EM, Himmelfarb J, Sezer MT, et al: Plasma cytokine levels predict mortality in patients with acute renal failure. Kidney Int 2004; 65: 1357-1365.
30. Friedewald JJ, Rabb H: Inflammatory cells in ischemic acute renal failure. Kidney Int 2004; 66: 486-491.
31. Ramesh G, Reeves WB: TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 2002; 110: 835-842.
32. Donnahoo KK, et al: Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol 1999; 277(3 pt 2):R922-R929.
33. Sahu BD, Tatireddy S, Koneru M, Borkar RM, Kumar JM, Kuncha M, Srinivas R, Shyam Sunder R, Sistla R: Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol 2014; 277: 8-20.
34. Deng J, Kohda Y, Chiao H, et al: Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int 2001; 60: 2118-2128.
35. Sayed-Ahmed MM, Nagi MN: Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol 2007; 34: 399-405.
36. Nagi MN, Mansour MA: Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacol Res 2000; 41: 283-289.
37. Ragheb A, Attia A, Eldin WS, Elbarbry F, Gazarin S, Shoker A: The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review. Saudi J Kidney Dis Transpl 2009; 20: 741-752.
38. Al-Malki AL, Sayed AA: Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa-?. BMC Complement Altern Med 2014; 14: 282.