Beneficial effects of calcium oral coadministration in gentamicin-induced nephrotoxicity in rats

Renal Failure

Volumn 34, Issue 5, 2012, Pages 622-627

  Stojiljkovic, Nenad ^a   Stoiljkovic, Milan ^a   Mihailovic, Dragan ^a   Randjelovic, Pavle ^a   Ilic, Sonja ^a   Gocmanac Ignjatovic, Marija ^a   Veljkovic, Milica ^a  

^a UNIVERSITY OF NI   (Serbia)

Author keywords

Calcium; Gentamicin; Morphometry; Nephrotoxicity; Rats

Indexed keywords

ALKALOID; CALCIUM CARBONATE; CREATININE; GENTAMICIN; POTASSIUM; SODIUM CHLORIDE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOPLASM; DIET SUPPLEMENTATION; GLOMERULAR STRUCTURE; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; HISTOPATHOLOGY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE NECROSIS; MALE; MORPHOMETRICS; NEPHROTOXICITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RAT; STATISTICAL SIGNIFICANCE; UREA BLOOD LEVEL; WISTAR RAT;

ACUTE KIDNEY INJURY; ADMINISTRATION, ORAL; ANIMALS; CALCIUM; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; GENTAMICINS; KIDNEY; MALE; RATS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 84860779705     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2012.664809     Document Type: Article

References (50)

1. Sundin DP, Sandoval R, Molitoris BA. Gentamicin inhibits renal protein and phospholipid metabolism in rats. J Am Soc Nephrol. 2001;12(1):114-123.
2. Mingeot-Leclercq MP, Tulkens PM. Aminoglycosides: Nephrotoxicity. Antimicrob Agents Chemother. 1999;43(5):1003-1012. (Pubitemid 29214718)
3. Ali BH. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: Some recent research. Food Chem Toxicol. 2003;41(11):1447-1452. (Pubitemid 37088099)
4. Halliwell B, Chirico S. Lipid peroxidation: Its mechanism, measurement and significance. Am J Clin Nutr. 1993; 57(5 Suppl.):715-725.
5. Stojiljkovic N, Stoiljkovic M, Randjelovic P, Veljkovic S, Mihailovic D. Cytoprotective effect of vitamin C against gentamicin-induced acute kidney injury in rats. Exp Toxicol Pathol. 2012;64(1-2):69-74.
6. Stojiljkovic N, Mihailovic D, Veljkovic S, Stoiljkovic M, Jovanovic I. Glomerular basement membrane alterations induced by gentamicin administration in rats. Exp Toxicol Pathol. 2008;60(1):69-75.
7. Servais H, Jossin Y, Van Bambeke F, Tulkens PM, Mingeot- Leclercq MP. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrob Agents Chemother. 2006;50(4):1213-1221.
8. Ozaki N, Matheis KA, Gamber M, et al. Identification of genes involved in gentamicin-induced nephrotoxicity in rats- A toxicogenomic investigation. Exp Toxicol Pathol. 2010;62(5): 555-566.
9. Humes HD, Sastrasinh M, Weinberg JM. Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. J Clin Invest. 1984;73(1):134-141.
10. Ali BH, Al-Qarawi AA, Mousa HM. The effect of calcium load and the calcium channel blocker verapamil on gentamicin nephrotoxicity in rats. Food Chem Toxicol. 2002;40(12): 1843-1847. (Pubitemid 35284155)
11. Whiting PH, Brown PA. The relationship between enzymuria and kidney enzyme activities in experimental gentamicin nephrotoxicity. Ren Fail. 1996;18(6):899-909. (Pubitemid 26399128)
12. Martinez-Salgado C, Lopez-Hernandez FJ, Lopez-Novoa JM. Glomerular nephrotoxicity of aminoglycosides. Toxicol Appl Pharmacol. 2007;223(1):86-98. (Pubitemid 47211265)
13. Elfarra AA, Duescher RJ, Sausen PJ, O'Hara TM, Cooley AJ. Methimazole protection of rats against gentamicininduced nephrotoxicity. Can J Physiol Pharmacol. 1994;72(10): 1238-1244.
14. Geleilete TJ, Melo GC, Costa RS, Volpini RA, Soares TJ, Coimbra TM. Role of myofibroblasts, macrophages, transforming growth factor-beta endothelin, angiotensin-II and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin. J Nephrol. 2002;15(6):633-642. (Pubitemid 36040563)
15. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull. 2009;32(1):61-67.
16. Balakumar P, Rohilla A, Thangathirupathi A. Gentamicininduced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res. 2010;62(3):179-186.
17. De Broe ME, Paulus GJ, Verpooten GA, et al. Early effects of gentamicin, tobramycin and amikacin on the human kidney. Kidney Int. 1984;25(4):643-652. (Pubitemid 14079959)
18. Giuliano RA, Paulus GJ, Verpooten GA, et al. Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats. Kidney Int. 1984;26(6):838-847. (Pubitemid 15197005)
19. Nonclercq D, Wrona S, Toubeau G, et al. Tubular injury and regeneration in the rat kidney following acute exposure to gentamicin: A time-course study. Ren Fail. 1992;14(4):507-521.
20. Mingeot-Leclercq MP, Brasseur R, Schanck A. Molecular parameters involved in aminoglycoside nephrotoxicity. J Toxicol Environ Health. 1995;44(3):263-300.
21. Laurent G, Carlier MB, Rollman B, van Hoof F, Tulkens P. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: In vitro and in vivo studies with gentamicin and amikacin. Biochem Pharmacol. 1982;31(23):3861-3870. (Pubitemid 13218461)
22. Ramsammy LS, Josepovitz C, Lane B, Kaloyanides GJ. Effect of gentamicin on phospholipid metabolism in cultured rabbit proximal tubular cells. Am J Physiol. 1989;256(1 Pt 1): C204-C213.
23. Abdel-Gayoum AA, Ali BH, Ghawarsha K, Bashir AA. Plasma lipid profile in rats with gentamicin-induced nephrotoxicity. Hum Exp Toxicol. 1993;12(5):371-375. (Pubitemid 23269410)
24. Tulkens PM. Nephrotoxicity of aminoglycoside antibiotics. Toxicol Lett. 1989;46(1-3):107-123. (Pubitemid 19084006)
25. Kaloyanides GJ. Drug-phospholipid interactions: Role in aminoglycoside nephrotoxicity. Ren Fail. 1992;14(3):351-357.
26. Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez- Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity: An integrative point of view. Kidney Int. 2011;79(1):33-45.
27. Priuska EM, Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol. 1995;50(11):1749-1752. (Pubitemid 26011387)
28. Yanagida C, Ito K, Komiya I, Horie T. Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem Biol Interact. 2004;148(3):139-147. (Pubitemid 38987831)
29. Karakoyun B, Yuksel M, Turan P, Arbak S, Alican I. Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats. Drug Chem Toxicol. 2009;32(4):312-318.
30. Kays SE, Crowell WA, Johnson MA. Iron supplementation increases gentamicin nephrotoxicity in rats. J Nutr. 1991;121(11):1869-1875.
31. Trollfors B, Alestig K, Krantz I, Norrby R. Quantitative nephrotoxicity of gentamicin in nontoxic doses. J Infect Dis. 1980;141(3):306-309. (Pubitemid 10147499)
32. Klastersky J, Hensgens C, Henri A, Daneau D. Comparative clinical study of tobramycin and gentamicin. Antimicrob Agents Chemother. 1974;5(2):133-138.
33. Parsons PP, Garland HO, Harpur ES, Old S. Acute gentamicin-induced hypercalciuria and hypermagnesiuria in the rat: Dose-response relationship and role of renal tubular injury. Br J Pharmacol. 1997;122(3):570-576. (Pubitemid 27429735)
34. Banday AA, Farooq N, Priyamvada S, Yusufi AN, Khan F. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci. 2008;82(9-10):450-459.
35. Bledsoe G, Crickman S, Mao J, et al. Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. Nephrol Dial Transplant. 2006;21(3):624-633. (Pubitemid 43372907)
36. Abdel-Naim AB, Abdel-Wahab MH, Attia FF. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rats. Pharmacol Res. 1999;40(2):183-187. (Pubitemid 29378100)
37. Shirwaikar A, Malini S, Kumari SC. Protective effect of Pongamia pinnata flowers against cisplatin and gentamicininduced nephrotoxicity in rats. Ind J Exp Biol. 2003;41(1): 58-62. (Pubitemid 36052889)
38. Atessahin A, Karahan I, Yilmaz S, Ceribasi AO, Princci I. The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats. Pharmacol Res. 2003;48(6):637-642. (Pubitemid 38352783)
39. Polat A, Parlakpinar H, Tasdemir S, et al. Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem. 2006;108(5):365-371. (Pubitemid 44584348)
40. Ozbek E, Cekmen M, Ilbey YO, Simsek A, Polat EC, Somay A. Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF kappaB pathways. Ren Fail. 2009;31(5):382-392.
41. Abdel-Raheem IT, El-Sherbiny GA, Taye A. Green tea ameliorates renal oxidative damage induced by gentamicin in rats. Pak J Pharm Sci. 2010;23(1):21-28.
42. Lakshmi BVS, Sudhakar M. Protective effect of zingiber officinale on gentamicin-induced nephrotoxicity in rats. Int J Pharmacol. 2010;6(1):58-62.
43. Stojiljkovic N, Veljkovic S, Mihailovic D, et al. Protective effects of pentoxifylline treatment on gentamicin-induced nephrotoxicity in rats. Ren Fail. 2009;31(1):54-61.
44. Ermak G, Davies KJ. Calcium and oxidative stress: From cell signaling to cell death. Mol Immunol. 2001;38(10): 713-721.
45. Bennett WM, Elliott WC, Houghton DC, Gilbert DN, DeFehr J, McCarron DA. Reduction of experimental gentamicin nephrotoxicity in rats by dietary calcium loading. Antimicrob Agents Chemother. 1982;22(3):508-512. (Pubitemid 13241716)
46. Perez de la Cruz MJ, Cadorniga R, Ochoa MC, Albarran I, Herrero-Vanrell R, Pastoriza P. Chronopharmacokinetics and calcium in the prevention of gentamicin-induced nephrotoxicity in rabbits. Biopharm Drug Dispos. 1998;19(6):407-412. (Pubitemid 28393861)
47. Pannu N, Nadim MK. An overview of drug-induced acute kidney injury. Crit Care Med. 2008;36(4 Suppl.): S216-S223. (Pubitemid 351483055)
48. Weinberg JM, Humes HD.Mechanisms of gentamicin-induced dysfunction of renal cortical mitochondria. Effects on mitochondrial respiration. Arch Biochem Biophys. 1980;205(1): 222-231. (Pubitemid 11114633)
49. Knauss TC, Weinberg JM, Humes HD. Alterations in renal cortical phospholipid content induced by gentamicin: Time course, specificity and subcellular localization. Am J Physiol. 1983;244(5):F535-F546. (Pubitemid 13084053)
50. Goldberg M, Agus ZS, Goldfarb S. Renal handling of phosphate, calcium, and magnesium. In: Brenner BM, Rector FC, eds. The Kidney. Philadelphia, PA: WB Saunders Co.; 1976:344-390.