Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis

Journal of Molecular Biology

Volumn 427, Issue 9, 2015, Pages 1779-1796

  Epling, Leslie B ^a   Grace, Christy R ^a   Lowe, Brandon R ^a,b   Partridge, Janet F ^a,b   Enemark, Eric J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

biochemistry; crystallography; genetics; NMR

Indexed keywords

ADENOSINE TRIPHOSPHATE; DDX3X PROTEIN, HUMAN; DEAD BOX PROTEIN; RNA;

BINDING SITE; CEREBELLUM TUMOR; CHEMICAL STRUCTURE; CHEMISTRY; CHILD; CRYSTALLIZATION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; HYDROLYSIS; MEDULLOBLASTOMA; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; PROTEIN SYNTHESIS; SCHIZOSACCHAROMYCES; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CEREBELLAR NEOPLASMS; CHILD; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEAD-BOX RNA HELICASES; GENETIC COMPLEMENTATION TEST; HUMANS; HYDROLYSIS; MEDULLOBLASTOMA; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; RNA; SCHIZOSACCHAROMYCES;

EID: 84937769292     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.02.015     Document Type: Article

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