The current understanding of Ded1p/DDX3 homologs from yeast to human

RNA Biology

Volumn 6, Issue 1, 2009, Pages 17-20

  Tarn, Woan Yuh ^a   Chang, Tien Hsien ^b,c  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b OHIO STATE UNIVERSITY   (United States)

^c GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

DExD H box protein; Nuclear export; Post transcriptional gene regulation; RNA helicase; Splicing; Translation

Indexed keywords

DDX3 PROTEIN; DED1P PROTEIN; FUNGAL PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

HUMAN; METAZOON; NONHUMAN; NUCLEAR EXPORT SIGNAL; PROTEIN FUNCTION; REVIEW; RNA SPLICING; RNA TRANSLATION; TRANSLATION INITIATION; YEAST;

EUKARYOTA; MAMMALIA;

EID: 62549144414     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.6.1.7440     Document Type: Review

References (47)

1. Gorbalenya AE, Koonin EV. Helicases: amino acid sequence comparisons and structurefunction relationships. Curr Opin Struct Biol 1993; 3:419-29.
2. Bleichert F, Baserga SJ. The long unwinding road of RNA helicases. Mol Cell 2007; 27:339-52.
3. Linder P. Dead-box proteins: a family affair - active and passive players in RNP-remodeling. Nucleic Acids Res 2006; 34:4168-80.
4. Struhl K. Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region. Nucleic Acids Res 1985; 13:8587-601.
5. Chang T-H, Arenas J, Abelson J. Identification of five putative yeast RNA helicase genes. Proc Natl Acad Sci USA 1990; 87:1571-5.
6. Jamieson DJ, Rahe B, Pringle J, Beggs JD. A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase. Nature 1991; 349:715-9.
7. Chuang R-Y, Weaver PL, Liu Z, Chang T-H. Requirement of the DEAD-box protein Ded1p for messenger RNA translation. Science 1997; 275:1468-71.
8. Thuillier V, Stettler S, Sentenac A, Thuriaux P, Werner M. A mutation in the C31 subunit of Saccharomyces cerevisiae RNA polymerase III affects transcription initiation. EMBO J 1995; 14:351-9.
9. Hayashi N, Seino H, Irie K, Watanabe M, Clark KL, Matsumoto K, Nishimoto T. Genetic interaction of DED1 encoding a putative ATP-dependent RNA helicase with SRM1 encoding a mammalian RCC1 homolog in Saccharomyces cerevisiae. Mol Gen Genet 1996; 253:149-56.
10. de la Cruz J, Iost I, Kressler D, Linder P. The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1997; 94:5201-6.
11. Iost I, Dreyfus M, Linder P. Ded1p, a DEAD-box protein required for translation initiation in saccharomyces cerevisiae, is an RNA helicase. J Biol Chem 1999; 274:17677-83.
12. Yang Q, Jankowsky E. ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1. Biochemistry 2005; 44:13591-601.
13. Marsden S, Nardelli M, Linder P, McCarthy JE. Unwinding single RNA molecules using helicases involved in eukaryotic translation initiation. J Mol Biol 2006; 361:327-35.
14. Stevens SW, Ryan DE, Ge HY, Moore RE, Young MK, Lee TD, Abelson J. Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 2002; 9:31-44.
15. Burckin T, Nagel R, Mandel-Gutfreund Y, Shiue L, Clark T, Chong J-L, Chang T-H, Hartzog G, Ares M Jr. Gene expression phenotype analysis reveals functional relationships between components of the transcription, splicing and mRNA export machineries. Nature Struct Mol Biol 2004; 12:175-82.
16. Merz C, Urlaub H, Will CL, Luhrmann R. Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA 2007; 13:116-28.
17. Zhou Z, Licklider LJ, Gygi SP, Reed R. Comprehensive proteomic analysis of the human spliceosome. Nature 2002; 419:182-5.
18. Lai MC, Lee-Wu YH, Tarn WY. The DEAD-box RNA helicase DDX3 associates with export mRNPs as well as TAP and participates in translational control. Mol Biol Cell 2008; 19: 3847-58.
19. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev 2005; 19:1512-7.
20. Daneholt B. Assembly and transport of a premessenger RNP particle. Proc Natl Acad Sci USA 2001; 98:7012-7.
21. Askjaer P, Bachi A, Wilm M, Bischoff FR, Weeks DL, Ogniewski V, Ohno M, Niehrs C, Kjems J, Mattaj IW, Fornerod M. RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol 1999; 19:6276-85.
22. Lee CS, Dias AP, Jedrychowski M, Patel AH, Hsu JL, Reed R. Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Res 2008; 36:4708-18.
23. Snay-Hodge CA, Colot HV, Goldstein AL, Cole CN. Dbp5p/Rat8p is a yeast nuclear poreassociated DEAD-box protein essential for RNA export. EMBO J 1998; 17:2663-76.
24. Tseng SS, Weaver PL, Liu Y, Hitomi M, Tartakoff AM, Chang T-H. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J 1998; 17:2651-62.
25. Askjaer P, Rosendahl R, Kjems J. Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity. J Biol Chem 2000; 275:11561-8.
26. Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Cell 2004; 119:381-92.
27. Sekiguchi T, Iida H, Fukumura J, Nishimoto T. Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. Exp Cell Res 2004; 300:213-22.
28. Hodge CA, Colot HV, Stafford P, Cole CN. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells. EMBO J 1999; 18:5778-88.
29. Fukumura J, Noguchi E, Sekiguchi T, Nishimoto T. A temperature-sensitive mutant of the mammalian RNA helicase, DEAD-BOX X isoform, DBX, defective in the transition from G1 to S phase. J Biochem 2003; 134:71-82.
30. Shih JW, Tsai TY, Chao CH, Wu Lee YH. Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein. Oncogene 2008; 27:700-14.
31. Jamieson DJ, Beggs JD. A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase. Mol Microbiol 1991; 5:805-12.
32. Noueiry AO, Chen J, Ahlquist P. A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA. Proc Natl Acad Sci USA 2000; 97:12985-90.
33. Daga RR, Jimenez J. Translational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth. J Cell Sci 1999; 112:3137-46.
34. Grallert B, Kearsey SE, Lenhard M, Carlson CR, Nurse P, Boye E, Labib K. A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. J Cell Sci 2000; 113:1447-58.
35. Berthelot K, Muldoon M, Rajkowitsch L, Hughes J, McCarthy JE. Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Mol Microbiol 2004; 51:987-1001.
36. Anderson P, Kedersha N. Stress granules: the Tao of RNA triage. Trends Biochem Sci 2008; 33:141-50.
37. Botlagunta M, Vesuna F, Mironchik Y, Raman A, Lisok A, Winnard P Jr, Mukadam S, Van Diest P, Chen JH, Farabaugh P, Patel AH, Raman V. Oncogenic role of DDX3 in breast cancer biogenesis. Oncogene 2008; 27:3912-22.
38. Krishnan V, Zeichner SL. Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication. Retrovirology 2004; 1:42.
39. Oveland E, Gjertsen BT, Wergeland L, Selheim F, Fladmark KE, Hovland R. Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Leuk Res 2008.
40. Mamiya N, Worman HJ. Hepatitis C virus core protein binds to a DEAD box RNA helicase. J Biol Chem 1999; 274:15751-6.
41. Owsianka AM, Patel AH. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. Virology 1999; 257:330-40.
42. You LR, Chen CM, Yeh TS, Tsai TY, Mai RT, Lin CH, Lee YH. Hepatitis C virus core protein interacts with cellular putative RNA helicase. J Virol 1999; 73:2841-53.
43. Boni S, Lavergne JP, Boulant S, Cahour A. Hepatitis C virus core protein acts as a transmodulating factor on internal translation initiation of the viral RNA. J Biol Chem 2005; 280:17737-48.
44. Shimoike T, Koyama C, Murakami K, Suzuki R, Matsuura Y, Miyamura T, Suzuki T. Downregulation of the internal ribosome entry site (IRES)-mediated translation of the hepatitis C virus: critical role of binding of the stem-loop IIId domain of IRES and the viral core protein. Virology 2006; 345:434-45.
45. Ohlmann T, Prevot D, Decimo D, Roux F, Garin J, Morley SJ, Darlix JL. In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system. J Mol Biol 2002; 318:9-20.
46. Huang JS, Chao CC, Su TL, Yeh SH, Chen DS, Chen CT, Chen PJ, Jou YS. Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma. Biochem Biophys Res Commun 2004; 315:950-8.
47. Holcik M. Targeting translation for treatment of cancer - A novel role for IRES? Curr Cancer Drug Targets 2004; 4:299-311.