Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 11, 2015, Pages 2680-2694

  Lüthy, Monique ^a   Wheldon, Mary C ^a   Haji Cheteh, Chehasnah ^a   Atobe, Masakazu ^a,b   Bond, Paul S ^a   O'Brien, Peter ^a   Hubbard, Roderick E ^a,c   Fairlamb, Ian J S ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b ASAHI KASEI PHARMA CORPORATION   (Japan)

^c Vernalis PLC   (United Kingdom)

Author keywords

3 D shape analysis; Lead like library; Lead oriented synthesis; Nitrogen heterocycles; Organolithium mediated synthesis

Indexed keywords

HETEROCYCLIC COMPOUND; LITHIUM; MOLECULAR LIBRARY; ORGANOMETALLIC COMPOUND; PIPERAZINE; PIPERAZINE DERIVATIVE; PIPERIDINE; PIPERIDINE DERIVATIVE; PYRROLIDINE; PYRROLIDINE DERIVATIVE;

CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG DEVELOPMENT; MOLECULAR LIBRARY; PROCEDURES; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS; LITHIUM; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PIPERAZINES; PIPERIDINES; PYRROLIDINES; SMALL MOLECULE LIBRARIES;

EID: 84937764358     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.005     Document Type: Article

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