-
1
-
-
84910682457
-
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
-
PID: 25027500
-
Alépée N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG (2014) State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX 31(4):441–477
-
(2014)
ALTEX
, vol.31
, Issue.4
, pp. 441-477
-
-
Alépée, N.1
Bahinski, T.2
Daneshian, M.3
De Wever, B.4
Fritsche, E.5
Goldberg, A.6
Hansmann, J.7
Hartung, T.8
Haycock, J.9
Hogberg, H.10
Hoelting, L.11
Kelm, J.M.12
Kadereit, S.13
McVey, E.14
Landsiedel, R.15
Leist, M.16
Lübberstedt, M.17
Noor, F.18
Pellevoisin, C.19
Petersohn, D.20
Pfannenbecker, U.21
Reisinger, K.22
Ramirez, T.23
Rothen-Rutishauser, B.24
Schäfer-Korting, M.25
Zeilinger, K.26
Zurich, M.G.27
more..
-
2
-
-
84902118292
-
Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development
-
COI: 1:CAS:528:DC%2BC2cXpsVektr4%3D, PID: 24476462
-
Balmer NV, Leist M (2014) Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development. Basic Clin Pharmacol Toxicol 115(1):59–68
-
(2014)
Basic Clin Pharmacol Toxicol
, vol.115
, Issue.1
, pp. 59-68
-
-
Balmer, N.V.1
Leist, M.2
-
3
-
-
84865776716
-
Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome
-
COI: 1:CAS:528:DC%2BC38Xht1yntrrK, PID: 22723015
-
Balmer NV, Weng M, Zimmer B, Ivanova VN, Chambers SM, Nikolaeva E, Jagtap S, Sachinidis A, Hescheler J, Waldmann T, Leist M (2012) Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet 21(18):4104–4114
-
(2012)
Hum Mol Genet
, vol.21
, Issue.18
, pp. 4104-4114
-
-
Balmer, N.V.1
Weng, M.2
Zimmer, B.3
Ivanova, V.N.4
Chambers, S.M.5
Nikolaeva, E.6
Jagtap, S.7
Sachinidis, A.8
Hescheler, J.9
Waldmann, T.10
Leist, M.11
-
4
-
-
84903439132
-
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects
-
COI: 1:CAS:528:DC%2BC2cXpvVehtrY%3D, PID: 24935251
-
Balmer NV, Klima S, Rempel E, Ivanova VN, Kolde R, Weng MK, Meganathan K, Henri M, Sachinidis A, Berthold MR, Hengstler JG, Rahnenführer J, Waldmann T, Leist M (2014) From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol 88(7):1451–1468
-
(2014)
Arch Toxicol
, vol.88
, Issue.7
, pp. 1451-1468
-
-
Balmer, N.V.1
Klima, S.2
Rempel, E.3
Ivanova, V.N.4
Kolde, R.5
Weng, M.K.6
Meganathan, K.7
Henri, M.8
Sachinidis, A.9
Berthold, M.R.10
Hengstler, J.G.11
Rahnenführer, J.12
Waldmann, T.13
Leist, M.14
-
5
-
-
84922032722
-
International STakeholder NETwork for Developmental Neurotoxicity (ISTNET): creating a developmental neurotoxicity (DNT) testing roadmap for regulatory purposes
-
COI: 1:CAS:528:DC%2BC2MXhsV2qur4%3D, PID: 25618548
-
Bal-Price A, Crofton K, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald R, Hartung T, Heinonen T, Hogberg H, Hougaard S, Lichtensteiger W, Oggier D, Paparella M, Axelstad Petersen M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Tschudi-Monnet F, Wilks M, Ylikomi T, Fritsche E (2015) International STakeholder NETwork for Developmental Neurotoxicity (ISTNET): creating a developmental neurotoxicity (DNT) testing roadmap for regulatory purposes. Arch Toxicol 89(2):269–287
-
(2015)
Arch Toxicol
, vol.89
, Issue.2
, pp. 269-287
-
-
Bal-Price, A.1
Crofton, K.2
Leist, M.3
Allen, S.4
Arand, M.5
Buetler, T.6
Delrue, N.7
FitzGerald, R.8
Hartung, T.9
Heinonen, T.10
Hogberg, H.11
Hougaard, S.12
Lichtensteiger, W.13
Oggier, D.14
Paparella, M.15
Axelstad Petersen, M.16
Piersma, A.17
Rached, E.18
Schilter, B.19
Schmuck, G.20
Stoppini, L.21
Tongiorgi, E.22
Tiramani, M.23
Tschudi-Monnet, F.24
Wilks, M.25
Ylikomi, T.26
Fritsche, E.27
more..
-
6
-
-
84871013688
-
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
-
PID: 23138511
-
Blaauboer BJ, Boekelheide K, Clewell HJ, Daneshian M, Dingemans MML, Goldberg AM, Heneweer M, Jaworska J, Kramer NI, Leist M, Seibert H, Testai E, Vandebriel RJ, Yager J, Zurlo J (2012) The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX 29(4):411–425
-
(2012)
ALTEX
, vol.29
, Issue.4
, pp. 411-425
-
-
Blaauboer, B.J.1
Boekelheide, K.2
Clewell, H.J.3
Daneshian, M.4
Dingemans, M.M.L.5
Goldberg, A.M.6
Heneweer, M.7
Jaworska, J.8
Kramer, N.I.9
Leist, M.10
Seibert, H.11
Testai, E.12
Vandebriel, R.J.13
Yager, J.14
Zurlo, J.15
-
7
-
-
66049133721
-
The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
-
COI: 1:CAS:528:DC%2BD1MXmt1WitLk%3D, PID: 19416912
-
Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S, Tieu K (2009) The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc Natl Acad Sci USA 106(19):8043–8048
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.19
, pp. 8043-8048
-
-
Cui, M.1
Aras, R.2
Christian, W.V.3
Rappold, P.M.4
Hatwar, M.5
Panza, J.6
Jackson-Lewis, V.7
Javitch, J.A.8
Ballatori, N.9
Przedborski, S.10
Tieu, K.11
-
8
-
-
33645099728
-
The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune functions
-
COI: 1:CAS:528:DC%2BD28XjsFCmsr0%3D, PID: 16405499
-
Falsig J, Porzgen P, Lund S, Schrattenholz A, Leist M (2006) The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune functions. J Neurochem 96(3):893–907
-
(2006)
J Neurochem
, vol.96
, Issue.3
, pp. 893-907
-
-
Falsig, J.1
Porzgen, P.2
Lund, S.3
Schrattenholz, A.4
Leist, M.5
-
9
-
-
84903837546
-
Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity
-
COI: 1:CAS:528:DC%2BC2cXhtFShsLnI, PID: 24752500
-
Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, \de Graauw M, Meerman J, van de Water B (2014) Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity. Toxicol Sci 140(1):144–159
-
(2014)
Toxicol Sci
, vol.140
, Issue.1
, pp. 144-159
-
-
Fredriksson, L.1
Wink, S.2
Herpers, B.3
Benedetti, G.4
Hadi, M.5
de Bont, H.6
Groothuis, G.7
Luijten, M.8
Danen, E.9
de Graauw, M.10
Meerman, J.11
van de Water, B.12
-
10
-
-
0030601994
-
T-cell stimulus-induced crosstalk between lymphocytes and liver cells results in augmented cytokine-release
-
COI: 1:CAS:528:DyaK28Xntlegt7o%3D, PID: 8940257
-
Gantner F, Leist M, Küsters S, Vogt K, Volk H-D, Tiegs G (1996) T-cell stimulus-induced crosstalk between lymphocytes and liver cells results in augmented cytokine-release. Exp Cell Res 229(1):137–146
-
(1996)
Exp Cell Res
, vol.229
, Issue.1
, pp. 137-146
-
-
Gantner, F.1
Leist, M.2
Küsters, S.3
Vogt, K.4
Volk, H.-D.5
Tiegs, G.6
-
11
-
-
84912573844
-
Toxicogenomics directory of chemically exposed human hepatocytes
-
Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, D Arbo M, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JCS, Stierum RH, Leist M, Rahnenführer J, Hengstler JG (2014) Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol 88(12):2261–2278
-
(2014)
Arch Toxicol
, vol.88
, Issue.12
, pp. 2261-2278
-
-
Grinberg, M.1
Stöber, R.M.2
Edlund, K.3
Rempel, E.4
Godoy, P.5
Reif, R.6
Widera, A.7
Madjar, K.8
Schmidt-Heck, W.9
Marchan, R.10
Sachinidis, A.11
Spitkovsky, D.12
Hescheler, J.13
Carmo, H.14
D Arbo, M.15
van de Water, B.16
Wink, S.17
Vinken, M.18
Rogiers, V.19
Escher, S.20
Hardy, B.21
Mitic, D.22
Myatt, G.23
Waldmann, T.24
Mardinoglu, A.25
Damm, G.26
Seehofer, D.27
Nüssler, A.28
Weiss, T.S.29
Oberemm, A.30
Lampen, A.31
Schaap, M.M.32
Luijten, M.33
van Steeg, H.34
Thasler, W.E.35
Kleinjans, J.C.S.36
Stierum, R.H.37
Leist, M.38
Rahnenführer, J.39
Hengstler, J.G.40
more..
-
12
-
-
84902897905
-
Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells
-
PID: 24964791
-
Hamon J, Jennings P, Bois FY (2014) Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells. BMC Syst Biol 8:76
-
(2014)
BMC Syst Biol
, vol.8
, pp. 76
-
-
Hamon, J.1
Jennings, P.2
Bois, F.Y.3
-
13
-
-
59849129394
-
Food for thought… on the evolution of toxicology and phasing out of animal testing
-
PID: 18551232
-
Hartung T, Leist M (2008) Food for thought… on the evolution of toxicology and phasing out of animal testing. ALTEX 25(2):91–102
-
(2008)
ALTEX
, vol.25
, Issue.2
, pp. 91-102
-
-
Hartung, T.1
Leist, M.2
-
14
-
-
0034659756
-
Phagocytosis of non-apoptotic cells dying by caspase-independent mechanisms
-
COI: 1:CAS:528:DC%2BD3cXktFWltbg%3D, PID: 10843710
-
Hirt U, Gantner F, Leist M (2000) Phagocytosis of non-apoptotic cells dying by caspase-independent mechanisms. J Immunol 164(12):6520–6529
-
(2000)
J Immunol
, vol.164
, Issue.12
, pp. 6520-6529
-
-
Hirt, U.1
Gantner, F.2
Leist, M.3
-
15
-
-
84890566643
-
Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants
-
COI: 1:CAS:528:DC%2BC3sXnsFSrsrk%3D, PID: 23670202
-
Krug A, Balmer NV, Matt F, Schoenenberger F, Merhof D, Leist M (2013a) Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants. Arch Toxicol 87(12):2215–2231
-
(2013)
Arch Toxicol
, vol.87
, Issue.12
, pp. 2215-2231
-
-
Krug, A.1
Balmer, N.V.2
Matt, F.3
Schoenenberger, F.4
Merhof, D.5
Leist, M.6
-
16
-
-
84872346334
-
Human embryonic stem cell derived test systems for developmental neurotoxicity: a transcriptomic approach
-
COI: 1:CAS:528:DC%2BC38XhslWrsLbO, PID: 23179753
-
Krug A, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans R, Stephanie Julien, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn L, Bremer S, van Thriel C, Krause KH, Hengstler JG, Rahnenführer J, Sacchinidis A, Leist M (2013b) Human embryonic stem cell derived test systems for developmental neurotoxicity: a transcriptomic approach. Arch Toxicol 87(1):123–143
-
(2013)
Arch Toxicol
, vol.87
, Issue.1
, pp. 123-143
-
-
Krug, A.1
Kolde, R.2
Gaspar, J.A.3
Rempel, E.4
Balmer, N.V.5
Meganathan, K.6
Vojnits, K.7
Baquié, M.8
Waldmann, T.9
Ensenat-Waser, R.10
Jagtap, S.11
Evans, R.12
Stephanie, J.13
Peterson, H.14
Zagoura, D.15
Kadereit, S.16
Gerhard, D.17
Sotiriadou, I.18
Heke, M.19
Natarajan, K.20
Henry, M.21
Winkler, J.22
Marchan, R.23
Stoppini, L.24
Bosgra, S.25
Westerhout, J.26
Verwei, M.27
Vilo, J.28
Kortenkamp, A.29
Hescheler, J.30
Hothorn, L.31
Bremer, S.32
van Thriel, C.33
Krause, K.H.34
Hengstler, J.G.35
Rahnenführer, J.36
Sacchinidis, A.37
Leist, M.38
more..
-
17
-
-
84901008801
-
Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+
-
COI: 1:CAS:528:DC%2BC2cXntlOhsL8%3D, PID: 24810058
-
Krug AK, Gutbier S, Zhao L, Kullmann C, Pöltl D, Ivanova V, Förster S, Jagtap S, Meiser J, Leparc G, Schildknecht S, Adam M, Hiller K, Farhan H, Brunner T, Hartung T, Sachinidis A, Leist M (2014) Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+. Cell Death Dis 5:e1222
-
(2014)
Cell Death Dis
, vol.5
, pp. 1222
-
-
Krug, A.K.1
Gutbier, S.2
Zhao, L.3
Kullmann, C.4
Pöltl, D.5
Ivanova, V.6
Förster, S.7
Jagtap, S.8
Meiser, J.9
Leparc, G.10
Schildknecht, S.11
Adam, M.12
Hiller, K.13
Farhan, H.14
Brunner, T.15
Hartung, T.16
Sachinidis, A.17
Leist, M.18
-
18
-
-
77954696793
-
4)
-
PID: 20390237
-
4). ALTEX 27(1):17–42
-
(2010)
ALTEX
, vol.27
, Issue.1
, pp. 17-42
-
-
Kuegler, P.B.1
Zimmer, B.2
Waldmann, T.3
Baudis, B.4
Ilmjarv, S.5
Hescheler, J.6
Gaughwin, P.7
Brundin, P.8
Mundy, W.9
Bal-Price, A.K.10
Schrattenholz, A.11
Krause, K.H.12
van Thriel, C.13
Rao, M.14
Kadereit, S.15
Leist, M.16
-
19
-
-
0343618415
-
Metabolic depletion of adenosine triphosphate by fructose inversely controls CD95- and TNF-R1-mediated hepatic apoptosis
-
COI: 1:CAS:528:DC%2BD3cXjvFyntbo%3D, PID: 10839812
-
Latta M, Künstle G, Leist M, Wendel A (2000) Metabolic depletion of adenosine triphosphate by fructose inversely controls CD95- and TNF-R1-mediated hepatic apoptosis. J Exp Med 191(11):1975–1985
-
(2000)
J Exp Med
, vol.191
, Issue.11
, pp. 1975-1985
-
-
Latta, M.1
Künstle, G.2
Leist, M.3
Wendel, A.4
-
20
-
-
84876685425
-
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice
-
COI: 1:CAS:528:DC%2BC3sXktFCgt7w%3D, PID: 23503654
-
Leist M, Hartung T (2013) Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Arch Toxicol 87(4):563–567
-
(2013)
Arch Toxicol
, vol.87
, Issue.4
, pp. 563-567
-
-
Leist, M.1
Hartung, T.2
-
21
-
-
59849124092
-
The dawning of a new age of toxicology
-
PID: 18551234
-
Leist M, Hartung T, Nicotera P (2008) The dawning of a new age of toxicology. ALTEX 25(2):103–114
-
(2008)
ALTEX
, vol.25
, Issue.2
, pp. 103-114
-
-
Leist, M.1
Hartung, T.2
Nicotera, P.3
-
22
-
-
84870984610
-
Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics and drugs with animal-free methods
-
PID: 23138508
-
Leist M, Lidbury BA, Yang C, Hayden PJ, Kelm JM, Ringeissen S, Detroyer A, Meunier JR, Rathman JF, Jackson GR, Stolper G, Hasiwa N (2012) Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics and drugs with animal-free methods. ALTEX 29(4):373–388
-
(2012)
ALTEX
, vol.29
, Issue.4
, pp. 373-388
-
-
Leist, M.1
Lidbury, B.A.2
Yang, C.3
Hayden, P.J.4
Kelm, J.M.5
Ringeissen, S.6
Detroyer, A.7
Meunier, J.R.8
Rathman, J.F.9
Jackson, G.R.10
Stolper, G.11
Hasiwa, N.12
-
23
-
-
84904901979
-
Consensus report on the future of animal-free systemic toxicity testing
-
PID: 25061899
-
Leist M, Hasiwa N, Rovida C, Daneshian M, Basketter D, Kimber I, Clewell H, Gocht T, Goldberg A, Busquet F, Rossi AM, Schwarz M, Stephens M, Taalman R, Knudsen TB, McKim J, Harris G, Pamies D, Hartung T (2014) Consensus report on the future of animal-free systemic toxicity testing. ALTEX 31(3):341–356
-
(2014)
ALTEX
, vol.31
, Issue.3
, pp. 341-356
-
-
Leist, M.1
Hasiwa, N.2
Rovida, C.3
Daneshian, M.4
Basketter, D.5
Kimber, I.6
Clewell, H.7
Gocht, T.8
Goldberg, A.9
Busquet, F.10
Rossi, A.M.11
Schwarz, M.12
Stephens, M.13
Taalman, R.14
Knudsen, T.B.15
McKim, J.16
Harris, G.17
Pamies, D.18
Hartung, T.19
-
24
-
-
84922928503
-
Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing
-
PID: 25596134
-
Limonciel A, Mönks K, Stanzel S, Truisi GL, Parmentier C, Aschauer L, Wilmes A, Richert L, Hewitt P, Mueller SO, Lukas A, Kopp-Schneider A, Leonard MO, Jennings P (2015) Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. doi:10.1016/j.tiv.2014.12.011
-
(2015)
Toxicol In Vitro
-
-
Limonciel, A.1
Mönks, K.2
Stanzel, S.3
Truisi, G.L.4
Parmentier, C.5
Aschauer, L.6
Wilmes, A.7
Richert, L.8
Hewitt, P.9
Mueller, S.O.10
Lukas, A.11
Kopp-Schneider, A.12
Leonard, M.O.13
Jennings, P.14
-
25
-
-
84937763669
-
MPTP’s pathway of toxicity indicates central role of transcription factor SP1
-
PID: 25851821
-
Maertens A, Luechtefeld T, Kleensang A, Hartung T (2015) MPTP’s pathway of toxicity indicates central role of transcription factor SP1. Arch Toxicol. doi:10.1007/s00204-015-1509-6
-
(2015)
Arch Toxicol
-
-
Maertens, A.1
Luechtefeld, T.2
Kleensang, A.3
Hartung, T.4
-
26
-
-
4444368405
-
Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra
-
COI: 1:CAS:528:DC%2BD2cXnsVKgtr8%3D, PID: 15329391
-
Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff HJ (2004) Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J Neurosci 24(34):7445–7454
-
(2004)
J Neurosci
, vol.24
, Issue.34
, pp. 7445-7454
-
-
Miller, R.M.1
Callahan, L.M.2
Casaceli, C.3
Chen, L.4
Kiser, G.L.5
Chui, B.6
Kaysser-Kranich, T.M.7
Sendera, T.J.8
Palaniappan, C.9
Federoff, H.J.10
-
27
-
-
33644940123
-
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia
-
Penschuk S, Flagstad P, Didriksen M, Leist M, Michael-Titus AT (2006) Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. Eur J Neurosci 23(1):279–284
-
(2006)
Eur J Neurosci
, vol.23
, Issue.1
, pp. 279-284
-
-
Penschuk, S.1
Flagstad, P.2
Didriksen, M.3
Leist, M.4
Michael-Titus, A.T.5
-
28
-
-
84864510172
-
Uncoupling of ATP-depletion and cell death in human dopaminergic neurons
-
Pöltl D, Schildknecht S, Karreman C, Leist M (2012) Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. NeuroToxicol 33(4):769–779
-
(2012)
NeuroToxicol
, vol.33
, Issue.4
, pp. 769-779
-
-
Pöltl, D.1
Schildknecht, S.2
Karreman, C.3
Leist, M.4
-
29
-
-
84877593138
-
Metabolomics in toxicology and preclinical research, a t4 workshop report
-
PID: 23665807
-
Ramirez T, Daneshian M, Kamp H, Bois FY, Clench M, Coen M, Donley B, Fischer SM, Ekman DR, Fabian E, Guillou C, Heuer J, Hogberg H, Jungnickel H, Keun H, Krennrich G, Krupp E, Luch A, Noor F, Peter E, Riefke B, Seymour M, Skinner N, Smirnova L, Verheij E, Wagner S, van Raavenzway B, Hartung T, Leist M (2013) Metabolomics in toxicology and preclinical research, a t4 workshop report. ALTEX 30(2):209–225
-
(2013)
ALTEX
, vol.30
, Issue.2
, pp. 209-225
-
-
Ramirez, T.1
Daneshian, M.2
Kamp, H.3
Bois, F.Y.4
Clench, M.5
Coen, M.6
Donley, B.7
Fischer, S.M.8
Ekman, D.R.9
Fabian, E.10
Guillou, C.11
Heuer, J.12
Hogberg, H.13
Jungnickel, H.14
Keun, H.15
Krennrich, G.16
Krupp, E.17
Luch, A.18
Noor, F.19
Peter, E.20
Riefke, B.21
Seymour, M.22
Skinner, N.23
Smirnova, L.24
Verheij, E.25
Wagner, S.26
van Raavenzway, B.27
Hartung, T.28
Leist, M.29
more..
-
30
-
-
84923355252
-
Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
-
COI: 1:CAS:528:DC%2BC2cXhvFeitr%2FI, PID: 25370169
-
Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ, Tieu K (2014) Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo. Nat Commun 5:5244. doi:10.1038/ncomms6244
-
(2014)
Nat Commun
, vol.5
, pp. 5244
-
-
Rappold, P.M.1
Cui, M.2
Grima, J.C.3
Fan, R.Z.4
de Mesy-Bentley, K.L.5
Chen, L.6
Zhuang, X.7
Bowers, W.J.8
Tieu, K.9
-
31
-
-
70350031056
-
Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells
-
COI: 1:CAS:528:DC%2BD1MXhtlWitL7O, PID: 19647008
-
Schildknecht S, Poeltl D, Nagel DM, Matt F, Scholz D, Lotharius J, Salvo-Vargas A, Leist M (2009) Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicol Appl Pharmacol 241(1):23–35
-
(2009)
Toxicol Appl Pharmacol
, vol.241
, Issue.1
, pp. 23-35
-
-
Schildknecht, S.1
Poeltl, D.2
Nagel, D.M.3
Matt, F.4
Scholz, D.5
Lotharius, J.6
Salvo-Vargas, A.7
Leist, M.8
-
32
-
-
79953151438
-
Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite
-
COI: 1:CAS:528:DC%2BC3MXhvVeqtL4%3D, PID: 21081502
-
Schildknecht S, Pape R, Müller R, Robotta M, Marquardt A, Bürkle A, Drescher M, Leist M (2011) Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. J Biol Chem 286(7):4991–5002
-
(2011)
J Biol Chem
, vol.286
, Issue.7
, pp. 4991-5002
-
-
Schildknecht, S.1
Pape, R.2
Müller, R.3
Robotta, M.4
Marquardt, A.5
Bürkle, A.6
Drescher, M.7
Leist, M.8
-
33
-
-
36048983139
-
Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation
-
COI: 1:CAS:528:DC%2BD2sXht1ynt73E, PID: 17906685
-
Selenica ML, Jensen HS, Larsen AK, Pedersen ML, Helboe L, Leist M, Lotharius J (2007) Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol 152(6):959–979
-
(2007)
Br J Pharmacol
, vol.152
, Issue.6
, pp. 959-979
-
-
Selenica, M.L.1
Jensen, H.S.2
Larsen, A.K.3
Pedersen, M.L.4
Helboe, L.5
Leist, M.6
Lotharius, J.7
-
34
-
-
84901850014
-
Developmental neurotoxicity—challenges in the 21st century and in vitro opportunities
-
PID: 24687333
-
Smirnova L, Hogberg H, Leist M, Hartung T (2014) Developmental neurotoxicity—challenges in the 21st century and in vitro opportunities. ALTEX 31(2):129–156
-
(2014)
ALTEX
, vol.31
, Issue.2
, pp. 129-156
-
-
Smirnova, L.1
Hogberg, H.2
Leist, M.3
Hartung, T.4
-
35
-
-
84910608382
-
Current approaches and future role of high content imaging in safety sciences and drug discovery
-
van Vliet E, Daneshian M, Beilmann M, Davies A, Fava E, Fleck R, Julé Y, Kansy M, Kustermann S, Macko P, Mundy W, Roth A, Sachse C, Shah I, Uteng M, van de Water B, Hartung T, Leist M (2014) Current approaches and future role of high content imaging in safety sciences and drug discovery. ALTEX 31(4):479–493
-
(2014)
ALTEX
, vol.31
, Issue.4
, pp. 479-493
-
-
van Vliet, E.1
Daneshian, M.2
Beilmann, M.3
Davies, A.4
Fava, E.5
Fleck, R.6
Julé, Y.7
Kansy, M.8
Kustermann, S.9
Macko, P.10
Mundy, W.11
Roth, A.12
Sachse, C.13
Shah, I.14
Uteng, M.15
van de Water, B.16
Hartung, T.17
Leist, M.18
-
36
-
-
84896349339
-
Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells
-
COI: 1:CAS:528:DC%2BC2cXitFKisw%3D%3D, PID: 24383497
-
Waldmann T, Rempel E, Balmer NV, König A, Kolde R, Gaspar JA, Henry M, Hescheler J, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M (2014) Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol 27(3):408–420
-
(2014)
Chem Res Toxicol
, vol.27
, Issue.3
, pp. 408-420
-
-
Waldmann, T.1
Rempel, E.2
Balmer, N.V.3
König, A.4
Kolde, R.5
Gaspar, J.A.6
Henry, M.7
Hescheler, J.8
Sachinidis, A.9
Rahnenführer, J.10
Hengstler, J.G.11
Leist, M.12
-
37
-
-
84973558678
-
Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics
-
Wilmes A, Bielow C, Ranninger C, Bellwon P, Aschauer L, Limonciel A, Chassaigne H, Kristl T, Aiche S, Huber CG, Guillou C, Hewitt P, Leonard MO, Dekant W, Bois F, Jennings P (2014) Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. doi:10.1016/j.tiv.2014.10.006
-
(2014)
Toxicol In Vitro
-
-
Wilmes, A.1
Bielow, C.2
Ranninger, C.3
Bellwon, P.4
Aschauer, L.5
Limonciel, A.6
Chassaigne, H.7
Kristl, T.8
Aiche, S.9
Huber, C.G.10
Guillou, C.11
Hewitt, P.12
Leonard, M.O.13
Dekant, W.14
Bois, F.15
Jennings, P.16
-
38
-
-
79951678616
-
Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
-
COI: 1:CAS:528:DC%2BC3MXhvV2nsrg%3D, PID: 20865013
-
Zimmer B, Kuegler PB, Baudis B, Genewsky A, Tanavde V, Koh W, Tan B, Waldmann T, Kadereit S, Leist M (2011) Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death Differ 18(3):383–395
-
(2011)
Cell Death Differ
, vol.18
, Issue.3
, pp. 383-395
-
-
Zimmer, B.1
Kuegler, P.B.2
Baudis, B.3
Genewsky, A.4
Tanavde, V.5
Koh, W.6
Tan, B.7
Waldmann, T.8
Kadereit, S.9
Leist, M.10
-
39
-
-
84864758119
-
Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells
-
COI: 1:CAS:528:DC%2BC38XhtlCqtLbP
-
Zimmer B, Lee G, Balmer NV, Meganathan K, Sacchinidis A, Studer L, Leist M (2012) Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells. Env Health Perspect 120(8):1116–1122
-
(2012)
Env Health Perspect
, vol.120
, Issue.8
, pp. 1116-1122
-
-
Zimmer, B.1
Lee, G.2
Balmer, N.V.3
Meganathan, K.4
Sacchinidis, A.5
Studer, L.6
Leist, M.7
-
40
-
-
84901307535
-
Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery
-
COI: 1:CAS:528:DC%2BC2cXlt1CgsLk%3D, PID: 24691702
-
Zimmer B, Pallocca G, Dreser N, Foerster S, Waldmann T, Westerhout J, Julien S, Krause KH, van Thriel C, Hengstler J, Sachinidis A, Bosgra S, Leist M (2014) Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery. Arch Toxicol 88(5):1109–1126
-
(2014)
Arch Toxicol
, vol.88
, Issue.5
, pp. 1109-1126
-
-
Zimmer, B.1
Pallocca, G.2
Dreser, N.3
Foerster, S.4
Waldmann, T.5
Westerhout, J.6
Julien, S.7
Krause, K.H.8
van Thriel, C.9
Hengstler, J.10
Sachinidis, A.11
Bosgra, S.12
Leist, M.13
|