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Volumn 12, Issue 2, 2015, Pages 216-222

Inflammation and HIV Transmission in Sub-Saharan Africa

Author keywords

Co infections; HIV transmission; Inflammation; Mucosal immunology; Sub Saharan Africa

Indexed keywords

AFRICA SOUTH OF THE SAHARA; CD4+ T LYMPHOCYTE; DISEASE TRANSMISSION; EPIDEMIOLOGY; FEMALE; FEMALE GENITAL SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; INFLAMMATION; ISOLATION AND PURIFICATION; MALE; MALE GENITAL SYSTEM; MUCOSAL IMMUNITY; SEXUALLY TRANSMITTED DISEASE; TRANSMISSION;

EID: 84937758976     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-015-0269-5     Document Type: Review
Times cited : (50)

References (94)
  • 2
    • 84866273459 scopus 로고    scopus 로고
    • PEPFAR’s past and future efforts to cut costs, improve efficiency, and increase the impact of global HIV programs
    • Holmes CB, Blandford JM, Sangrujee N, Stewart SR, DuBois A, Smith TR, et al. PEPFAR’s past and future efforts to cut costs, improve efficiency, and increase the impact of global HIV programs. Health Aff (Millwood). 2012;31:1553–60.
    • (2012) Health Aff (Millwood) , vol.31 , pp. 1553-1560
    • Holmes, C.B.1    Blandford, J.M.2    Sangrujee, N.3    Stewart, S.R.4    DuBois, A.5    Smith, T.R.6
  • 3
    • 44349159423 scopus 로고    scopus 로고
    • Setting the stage: host invasion by HIV
    • COI: 1:CAS:528:DC%2BD1cXmt1Ojtrg%3D, PID: 18469831
    • Hladik F, McElrath MJ. Setting the stage: host invasion by HIV. Nat Rev Immunol. 2008;8:447–57.
    • (2008) Nat Rev Immunol , vol.8 , pp. 447-457
    • Hladik, F.1    McElrath, M.J.2
  • 4
    • 79953836310 scopus 로고    scopus 로고
    • Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission
    • PID: 21471433, This was the first demonstration that the viral load in the genital tract is directly correlated with the risk of HIV transmission to a sexual partner
    • Baeten JM, Kahle E, Lingappa JR, Coombs RW, Delany-Moretlwe S, Nakku-Joloba E, et al. Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Sci Transl Med. 2011;3:77ra29. This was the first demonstration that the viral load in the genital tract is directly correlated with the risk of HIV transmission to a sexual partner.
    • (2011) Sci Transl Med , vol.3 , pp. 77
    • Baeten, J.M.1    Kahle, E.2    Lingappa, J.R.3    Coombs, R.W.4    Delany-Moretlwe, S.5    Nakku-Joloba, E.6
  • 5
    • 34547801371 scopus 로고    scopus 로고
    • Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    • PID: 17690570
    • Pilcher CD, Joaki G, Hoffman IF, Martinson FE, Mapanje C, Stewart PW, et al. Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection. AIDS. 2007;21:1723–30.
    • (2007) AIDS , vol.21 , pp. 1723-1730
    • Pilcher, C.D.1    Joaki, G.2    Hoffman, I.F.3    Martinson, F.E.4    Mapanje, C.5    Stewart, P.W.6
  • 6
  • 7
    • 16544377727 scopus 로고    scopus 로고
    • HIV and sexually transmitted diseases: lethal synergy
    • PID: 15516707
    • Cohen MS. HIV and sexually transmitted diseases: lethal synergy. Top HIV Med. 2004;12:104–7.
    • (2004) Top HIV Med , vol.12 , pp. 104-107
    • Cohen, M.S.1
  • 8
    • 0030604562 scopus 로고    scopus 로고
    • Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1
    • COI: 1:STN:280:DyaK2szmtVOqtw%3D%3D
    • Cohen MS, Hoffman IF, Royce RA, Kazembe P, Dyer JR, Daly CC, et al. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Res Group Lancet. 1997;349:1868–73.
    • (1997) AIDSCAP Malawi Res Group Lancet , vol.349 , pp. 1868-1873
    • Cohen, M.S.1    Hoffman, I.F.2    Royce, R.A.3    Kazembe, P.4    Dyer, J.R.5    Daly, C.C.6
  • 9
    • 0035701733 scopus 로고    scopus 로고
    • Human immunodeficiency virus in semen and plasma: investigation of sexual transmission risk behavioral correlates
    • COI: 1:STN:280:DC%2BD38%2FmtFGrsA%3D%3D, PID: 11788021
    • Kalichman SC, Cage M, Barnett T, Tharnish P, Rompa D, Austin J, et al. Human immunodeficiency virus in semen and plasma: investigation of sexual transmission risk behavioral correlates. AIDS Res Hum Retrovir. 2001;17:1695–703.
    • (2001) AIDS Res Hum Retrovir , vol.17 , pp. 1695-1703
    • Kalichman, S.C.1    Cage, M.2    Barnett, T.3    Tharnish, P.4    Rompa, D.5    Austin, J.6
  • 10
    • 84905397876 scopus 로고    scopus 로고
    • The semen microbiome and its relationship with local immunology and viral load in HIV infection
    • PID: 25058515
    • Liu CM, Osborne BJ, Hungate BA, Shahabi K, Huibner S, Lester R, et al. The semen microbiome and its relationship with local immunology and viral load in HIV infection. PLoS Pathog. 2014;10:e1004262.
    • (2014) PLoS Pathog , vol.10 , pp. 1004262
    • Liu, C.M.1    Osborne, B.J.2    Hungate, B.A.3    Shahabi, K.4    Huibner, S.5    Lester, R.6
  • 11
    • 84857362834 scopus 로고    scopus 로고
    • Quality and quantity: mucosal CD4+ T cells and HIV susceptibility
    • COI: 1:CAS:528:DC%2BC38XkvFynsb0%3D, PID: 22314505
    • McKinnon LR, Kaul R. Quality and quantity: mucosal CD4+ T cells and HIV susceptibility. Curr Opin HIV AIDS. 2012;7:195–202.
    • (2012) Curr Opin HIV AIDS , vol.7 , pp. 195-202
    • McKinnon, L.R.1    Kaul, R.2
  • 12
    • 79952264089 scopus 로고    scopus 로고
    • Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis
    • PID: 21358808
    • Low N, Chersich MF, Schmidlin K, Egger M, Francis SC, van de Wijgert JH, et al. Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis. PLoS Med. 2011;8:e1000416.
    • (2011) PLoS Med , vol.8 , pp. 1000416
    • Low, N.1    Chersich, M.F.2    Schmidlin, K.3    Egger, M.4    Francis, S.C.5    van de Wijgert, J.H.6
  • 13
    • 49849099241 scopus 로고    scopus 로고
    • Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies
    • PID: 18614873
    • Atashili J, Poole C, Ndumbe PM, Adimora AA, Smith JS. Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS. 2008;22:1493–501.
    • (2008) AIDS , vol.22 , pp. 1493-1501
    • Atashili, J.1    Poole, C.2    Ndumbe, P.M.3    Adimora, A.A.4    Smith, J.S.5
  • 14
    • 47049120441 scopus 로고    scopus 로고
    • More than their sum in your parts: the mechanisms that underpin the mutually advantageous relationship between HIV and sexually transmitted infections
    • Rebbapragada A, Kaul R. More than their sum in your parts: the mechanisms that underpin the mutually advantageous relationship between HIV and sexually transmitted infections. Drug Discov Today: Dis Mech. 2007;4:237–46.
    • (2007) Drug Discov Today: Dis Mech , vol.4 , pp. 237-246
    • Rebbapragada, A.1    Kaul, R.2
  • 15
    • 84155189092 scopus 로고    scopus 로고
    • Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study
    • PID: 21975269
    • Heffron R, Donnell D, Rees H, Celum C, Mugo N, Were E, et al. Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study. Lancet Infect Dis. 2012;12:19–26.
    • (2012) Lancet Infect Dis , vol.12 , pp. 19-26
    • Heffron, R.1    Donnell, D.2    Rees, H.3    Celum, C.4    Mugo, N.5    Were, E.6
  • 16
    • 84923849330 scopus 로고    scopus 로고
    • Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis
    • PID: 25612136, Short of a randomized clinical trial, this is the strongest form of evidence linking injectable DMPA use with an increased risk of HIV acquisition
    • Morrison CS, Chen PL, Kwok C, Baeten JM, Brown J, Crook AM, et al. Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis. PLoS Med. 2015;12:e1001778. Short of a randomized clinical trial, this is the strongest form of evidence linking injectable DMPA use with an increased risk of HIV acquisition.
    • (2015) PLoS Med , vol.12 , pp. 1001778
    • Morrison, C.S.1    Chen, P.L.2    Kwok, C.3    Baeten, J.M.4    Brown, J.5    Crook, A.M.6
  • 17
    • 84882699285 scopus 로고    scopus 로고
    • Use of hormonal contraceptives and HIV acquisition in women: a systematic review of the epidemiological evidence
    • PID: 23871397
    • Polis CB, Curtis KM. Use of hormonal contraceptives and HIV acquisition in women: a systematic review of the epidemiological evidence. Lancet Infect Dis. 2013;13:797–808.
    • (2013) Lancet Infect Dis , vol.13 , pp. 797-808
    • Polis, C.B.1    Curtis, K.M.2
  • 18
    • 58549113211 scopus 로고    scopus 로고
    • Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies
    • PID: 19179227, Metaanalysis demonstrating a four to ten-fold increase in the per-exposure risk of sexual HIV transmission in lower income countries
    • Boily MC, Baggaley RF, Wang L, Masse B, White RG, Hayes RJ, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis. 2009;9:118–29. Metaanalysis demonstrating a four to ten-fold increase in the per-exposure risk of sexual HIV transmission in lower income countries.
    • (2009) Lancet Infect Dis , vol.9 , pp. 118-129
    • Boily, M.C.1    Baggaley, R.F.2    Wang, L.3    Masse, B.4    White, R.G.5    Hayes, R.J.6
  • 19
    • 0034801698 scopus 로고    scopus 로고
    • Why do young women have a much higher prevalence of HIV than young men? A study in Kisumu, Kenya and Ndola, Zambia
    • PID: 11686466
    • Glynn JR, Carael M, Auvert B, Kahindo M, Chege J, Musonda R, et al. Why do young women have a much higher prevalence of HIV than young men? A study in Kisumu, Kenya and Ndola, Zambia. AIDS. 2001;15 Suppl 4:S51–60.
    • (2001) AIDS , vol.15 , pp. 51-60
    • Glynn, J.R.1    Carael, M.2    Auvert, B.3    Kahindo, M.4    Chege, J.5    Musonda, R.6
  • 20
    • 79551616146 scopus 로고    scopus 로고
    • Biological factors that may contribute to regional and racial disparities in HIV prevalence
    • PID: 21223426
    • Kaul R, Cohen CR, Chege D, Yi TJ, Tharao W, McKinnon LR, et al. Biological factors that may contribute to regional and racial disparities in HIV prevalence. Am J Reprod Immunol. 2011;65:317–24.
    • (2011) Am J Reprod Immunol , vol.65 , pp. 317-324
    • Kaul, R.1    Cohen, C.R.2    Chege, D.3    Yi, T.J.4    Tharao, W.5    McKinnon, L.R.6
  • 21
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • COI: 1:CAS:528:DC%2BC3cXhtV2hsr%2FI, PID: 20643915
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168–74.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3    Grobler, A.C.4    Baxter, C.5    Mansoor, L.E.6
  • 23
    • 38149074165 scopus 로고    scopus 로고
    • The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission
    • COI: 1:CAS:528:DC%2BD1cXovFOktA%3D%3D, PID: 17395270
    • Kaul R, Pettengell C, Sheth PM, Sunderji S, Biringer A, Macdonald K, et al. The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission. J Reprod Immunol. 2008;77:32–40.
    • (2008) J Reprod Immunol , vol.77 , pp. 32-40
    • Kaul, R.1    Pettengell, C.2    Sheth, P.M.3    Sunderji, S.4    Biringer, A.5    Macdonald, K.6
  • 24
    • 77949409948 scopus 로고    scopus 로고
    • Targeting early infection to prevent HIV-1 mucosal transmission
    • COI: 1:CAS:528:DC%2BC3cXjtFSmtrs%3D, PID: 20220840
    • Haase AT. Targeting early infection to prevent HIV-1 mucosal transmission. Nature. 2010;464:217–23.
    • (2010) Nature , vol.464 , pp. 217-223
    • Haase, A.T.1
  • 25
    • 84920972934 scopus 로고    scopus 로고
    • Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques
    • COI: 1:CAS:528:DC%2BC2MXltVyq, PID: 25550504, While similar human studies would be challenging to perform, in a primate model the probability of SIV acquisition after rectal challenge was directly correlated with the pre-existing frequency of mucosal CD4 + CCR5+ T cells
    • Carnathan DG, Wetzel KS, Yu J, Lee ST, Johnson BA, Paiardini M, et al. Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques. Proc Natl Acad Sci U S A. 2015;112:518–23. While similar human studies would be challenging to perform, in a primate model the probability of SIV acquisition after rectal challenge was directly correlated with the pre-existing frequency of mucosal CD4 + CCR5+ T cells.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 518-523
    • Carnathan, D.G.1    Wetzel, K.S.2    Yu, J.3    Lee, S.T.4    Johnson, B.A.5    Paiardini, M.6
  • 27
    • 84886078818 scopus 로고    scopus 로고
    • Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands
    • COI: 1:CAS:528:DC%2BC3sXhsVygtL3E, PID: 23903844
    • Alvarez Y, Tuen M, Shen G, Nawaz F, Arthos J, Wolff MJ, et al. Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands. J Virol. 2013;87:10843–54.
    • (2013) J Virol , vol.87 , pp. 10843-10854
    • Alvarez, Y.1    Tuen, M.2    Shen, G.3    Nawaz, F.4    Arthos, J.5    Wolff, M.J.6
  • 28
    • 82755190041 scopus 로고    scopus 로고
    • Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
    • COI: 1:CAS:528:DC%2BC3MXhsV2hsLjF, PID: 22048765
    • McKinnon LR, Nyanga B, Chege D, Izulla P, Kimani M, Huibner S, et al. Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility. J Immunol. 2011;187:6032–42.
    • (2011) J Immunol , vol.187 , pp. 6032-6042
    • McKinnon, L.R.1    Nyanga, B.2    Chege, D.3    Izulla, P.4    Kimani, M.5    Huibner, S.6
  • 29
    • 84908202620 scopus 로고    scopus 로고
    • Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract
    • COI: 1:CAS:528:DC%2BC2cXms1ajsrs%3D, PID: 24759207
    • Rodriguez-Garcia M, Barr FD, Crist SG, Fahey JV, Wira CR. Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract. Mucosal Immunol. 2014;7:1375–85.
    • (2014) Mucosal Immunol , vol.7 , pp. 1375-1385
    • Rodriguez-Garcia, M.1    Barr, F.D.2    Crist, S.G.3    Fahey, J.V.4    Wira, C.R.5
  • 31
    • 0033874108 scopus 로고    scopus 로고
    • Proinflammatory cytokines
    • COI: 1:CAS:528:DC%2BD3cXmtlSms7s%3D, PID: 10936147
    • Dinarello CA. Proinflammatory cytokines. Chest. 2000;118:503–8.
    • (2000) Chest , vol.118 , pp. 503-508
    • Dinarello, C.A.1
  • 32
    • 77954059792 scopus 로고    scopus 로고
    • Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
    • PID: 20386714
    • Nazli A, Chan O, Dobson-Belaire WN, Ouellet M, Tremblay MJ, Gray-Owen SD, et al. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog. 2010;6:e1000852.
    • (2010) PLoS Pathog , vol.6 , pp. 1000852
    • Nazli, A.1    Chan, O.2    Dobson-Belaire, W.N.3    Ouellet, M.4    Tremblay, M.J.5    Gray-Owen, S.D.6
  • 33
    • 84863176906 scopus 로고    scopus 로고
    • Associations between virologic and immunologic dynamics in blood and in the male genital tract
    • COI: 1:CAS:528:DC%2BC38XhsV2nsr8%3D, PID: 22114342
    • Gianella S, Strain MC, Rought SE, Vargas MV, Little SJ, Richman DD, et al. Associations between virologic and immunologic dynamics in blood and in the male genital tract. J Virol. 2012;86:1307–15.
    • (2012) J Virol , vol.86 , pp. 1307-1315
    • Gianella, S.1    Strain, M.C.2    Rought, S.E.3    Vargas, M.V.4    Little, S.J.5    Richman, D.D.6
  • 34
    • 84897374123 scopus 로고    scopus 로고
    • Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation, J Infect Dis:
    • Olivier AJ, Masson L, Ronacher K, Walzl G, Coetzee D, Lewis DA, et al. Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation. J Infect Dis. 2014.
    • (2014) et al
    • Olivier, A.J.1    Masson, L.2    Ronacher, K.3    Walzl, G.4    Coetzee, D.5    Lewis, D.A.6
  • 35
    • 25444498269 scopus 로고    scopus 로고
    • HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding
    • COI: 1:CAS:528:DC%2BD2MXhtVWltbbJ, PID: 16177128
    • Sheth PM, Danesh A, Shahabi K, Rebbapragada A, Kovacs C, Dimayuga R, et al. HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding. J Immunol. 2005;175:4789–96.
    • (2005) J Immunol , vol.175 , pp. 4789-4796
    • Sheth, P.M.1    Danesh, A.2    Shahabi, K.3    Rebbapragada, A.4    Kovacs, C.5    Dimayuga, R.6
  • 36
    • 0030798648 scopus 로고    scopus 로고
    • Factors associated with increased levels of human immunodeficiency virus type 1 DNA in semen
    • COI: 1:STN:280:DyaK2svnt1ehtQ%3D%3D, PID: 9333152
    • Xu C, Politch JA, Tucker L, Mayer KH, Seage 3rd GR, Anderson DJ. Factors associated with increased levels of human immunodeficiency virus type 1 DNA in semen. J Infect Dis. 1997;176:941–7.
    • (1997) J Infect Dis , vol.176 , pp. 941-947
    • Xu, C.1    Politch, J.A.2    Tucker, L.3    Mayer, K.H.4    Seage, G.R.5    Anderson, D.J.6
  • 37
    • 50149090179 scopus 로고    scopus 로고
    • Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection
    • COI: 1:CAS:528:DC%2BD1cXhtVClt77K, PID: 18562528
    • Gumbi PP, Nkwanyana NN, Bere A, Burgers WA, Gray CM, Williamson AL, et al. Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection. J Virol. 2008;82:8529–36.
    • (2008) J Virol , vol.82 , pp. 8529-8536
    • Gumbi, P.P.1    Nkwanyana, N.N.2    Bere, A.3    Burgers, W.A.4    Gray, C.M.5    Williamson, A.L.6
  • 38
    • 53549115621 scopus 로고    scopus 로고
    • Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility
    • PID: 18784472
    • Kaul R, Rebbapragada A, Hirbod T, Wachihi C, Ball TB, Plummer FA, et al. Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility. AIDS. 2008;22:2049–51.
    • (2008) AIDS , vol.22 , pp. 2049-2051
    • Kaul, R.1    Rebbapragada, A.2    Hirbod, T.3    Wachihi, C.4    Ball, T.B.5    Plummer, F.A.6
  • 39
    • 68249133729 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract
    • PID: 19740336
    • Nkwanyana NN, Gumbi PP, Roberts L, Denny L, Hanekom W, Soares A, et al. Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract. Immunology. 2009;128:e746–757.
    • (2009) Immunology , vol.128 , pp. 746-757
    • Nkwanyana, N.N.1    Gumbi, P.P.2    Roberts, L.3    Denny, L.4    Hanekom, W.5    Soares, A.6
  • 41
    • 84865168164 scopus 로고    scopus 로고
    • Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya
    • COI: 1:CAS:528:DC%2BC38Xht1GqsLnK, PID: 22928014
    • Chege D, Chai Y, Huibner S, Kain T, Wachihi C, Kimani M, et al. Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya. PLoS One. 2012;7:e43670.
    • (2012) PLoS One , vol.7 , pp. 43670
    • Chege, D.1    Chai, Y.2    Huibner, S.3    Kain, T.4    Wachihi, C.5    Kimani, M.6
  • 42
    • 84859824979 scopus 로고    scopus 로고
    • A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
    • COI: 1:CAS:528:DC%2BC38XitVWqur8%3D, PID: 22318497
    • Lajoie J, Juno J, Burgener A, Rahman S, Mogk K, Wachihi C, et al. A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers. Mucosal Immunol. 2012;5:277–87.
    • (2012) Mucosal Immunol , vol.5 , pp. 277-287
    • Lajoie, J.1    Juno, J.2    Burgener, A.3    Rahman, S.4    Mogk, K.5    Wachihi, C.6
  • 43
    • 78049448608 scopus 로고    scopus 로고
    • HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
    • COI: 1:CAS:528:DC%2BC3cXhsFSnsb3F, PID: 20887221
    • McLaren PJ, Ball TB, Wachihi C, Jaoko W, Kelvin DJ, Danesh A, et al. HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors. J Infect Dis. 2010;202 Suppl 3:S339–344.
    • (2010) J Infect Dis , vol.202 , pp. 339-344
    • McLaren, P.J.1    Ball, T.B.2    Wachihi, C.3    Jaoko, W.4    Kelvin, D.J.5    Danesh, A.6
  • 44
    • 84897464454 scopus 로고    scopus 로고
    • Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda
    • COI: 1:CAS:528:DC%2BC3sXhs1Grt77E, PID: 24150258, In this rigorously blinded study, repeated sexual exposure to HIV without infection was associated with reduced levels of T cell activation in the foreskin of uncircumcised men
    • Prodger JL, Hirbod T, Kigozi G, Nalugoda F, Reynolds SJ, Galiwango R, et al. Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda. Mucosal Immunol. 2014;7:634–44. In this rigorously blinded study, repeated sexual exposure to HIV without infection was associated with reduced levels of T cell activation in the foreskin of uncircumcised men.
    • (2014) Mucosal Immunol , vol.7 , pp. 634-644
    • Prodger, J.L.1    Hirbod, T.2    Kigozi, G.3    Nalugoda, F.4    Reynolds, S.J.5    Galiwango, R.6
  • 45
    • 84908141673 scopus 로고    scopus 로고
    • Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers
    • COI: 1:CAS:528:DC%2BC3sXhtVSht77J, PID: 23801306
    • Yao XD, Omange RW, Henrick BM, Lester RT, Kimani J, Ball TB, et al. Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers. Mucosal Immunol. 2014;7:268–79.
    • (2014) Mucosal Immunol , vol.7 , pp. 268-279
    • Yao, X.D.1    Omange, R.W.2    Henrick, B.M.3    Lester, R.T.4    Kimani, J.5    Ball, T.B.6
  • 46
    • 84928923391 scopus 로고    scopus 로고
    • Plasma cytokine levels and risk of HIV type 1 (HIV-1) transmission and acquisition: a nested case-control study among HIV-1-serodiscordant couples
    • Kahle EM, Bolton M, Hughes JP, Donnell D, Celum C, Lingappa JR, et al. Plasma cytokine levels and risk of HIV type 1 (HIV-1) transmission and acquisition: a nested case-control study among HIV-1-serodiscordant couples. J Infect Dis. 2014.
    • (2014) J Infect Dis
    • Kahle, E.M.1    Bolton, M.2    Hughes, J.P.3    Donnell, D.4    Celum, C.5    Lingappa, J.R.6
  • 47
    • 84866137168 scopus 로고    scopus 로고
    • Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel
    • COI: 1:CAS:528:DC%2BC38XhtlCru7bL, PID: 22829639, In references #46 and #47, increased systemic inflammation and immune activation was directly associated with in vivo HIV acquisition
    • Naranbhai V, Abdool Karim SS, Altfeld M, Samsunder N, Durgiah R, Sibeko S, et al. Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis. 2012;206:993–1001. In references #46 and #47, increased systemic inflammation and immune activation was directly associated with in vivo HIV acquisition.
    • (2012) J Infect Dis , vol.206 , pp. 993-1001
    • Naranbhai, V.1    Abdool Karim, S.S.2    Altfeld, M.3    Samsunder, N.4    Durgiah, R.5    Sibeko, S.6
  • 48
    • 59849116233 scopus 로고    scopus 로고
    • Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition
    • COI: 1:CAS:528:DC%2BD1MXht1Gmtrc%3D, PID: 19114868
    • Levinson P, Kaul R, Kimani J, Ngugi E, Moses S, MacDonald KS, et al. Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. AIDS. 2009;23:309–17.
    • (2009) AIDS , vol.23 , pp. 309-317
    • Levinson, P.1    Kaul, R.2    Kimani, J.3    Ngugi, E.4    Moses, S.5    MacDonald, K.S.6
  • 49
    • 84937768268 scopus 로고    scopus 로고
    • Passmore JS. Genital tract inflammation and susceptibility to HIV infection in women from the CAPRISA 004 microbicide trial of tenofovir gel (Webcast at:). In: Boston, MA: AIDS Vaccine; 2012.
    • Passmore JS. Genital tract inflammation and susceptibility to HIV infection in women from the CAPRISA 004 microbicide trial of tenofovir gel (Webcast at: http://aidsvac.capitalreach.com/console/player/19096?mediaType=audio). In: Boston, MA: AIDS Vaccine; 2012.
  • 50
    • 21644455339 scopus 로고    scopus 로고
    • Elevation of immune activation in Kenyan women is associated with alterations in immune function: implications for vaccine development
    • COI: 1:CAS:528:DC%2BD2MXhtFSlsA%3D%3D, PID: 15622455
    • Koesters SA, Matu L, Kiama P, Anzala O, Embree J, Plummer FA, et al. Elevation of immune activation in Kenyan women is associated with alterations in immune function: implications for vaccine development. J Clin Immunol. 2004;24:702–9.
    • (2004) J Clin Immunol , vol.24 , pp. 702-709
    • Koesters, S.A.1    Matu, L.2    Kiama, P.3    Anzala, O.4    Embree, J.5    Plummer, F.A.6
  • 51
    • 0033791524 scopus 로고    scopus 로고
    • Immune activation in Africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project
    • COI: 1:CAS:528:DC%2BD3cXotVOgtL4%3D, PID: 11061648
    • Clerici M, Butto S, Lukwiya M, Saresella M, Declich S, Trabattoni D, et al. Immune activation in Africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project. AIDS. 2000;14:2083–92.
    • (2000) AIDS , vol.14 , pp. 2083-2092
    • Clerici, M.1    Butto, S.2    Lukwiya, M.3    Saresella, M.4    Declich, S.5    Trabattoni, D.6
  • 52
    • 77955430749 scopus 로고    scopus 로고
    • Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa
    • COI: 1:CAS:528:DC%2BC3cXps1Wmsr8%3D, PID: 20588163, This cross-sectional study demonstrated substantially increased T cell activation in the cervical mucosa of Kenyan vs. US women, independent of genital co-infections
    • Cohen CR, Moscicki AB, Scott ME, Ma Y, Shiboski S, Bukusi E, et al. Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa. AIDS. 2010;24:2069–74. This cross-sectional study demonstrated substantially increased T cell activation in the cervical mucosa of Kenyan vs. US women, independent of genital co-infections.
    • (2010) AIDS , vol.24 , pp. 2069-2074
    • Cohen, C.R.1    Moscicki, A.B.2    Scott, M.E.3    Ma, Y.4    Shiboski, S.5    Bukusi, E.6
  • 53
    • 0037108418 scopus 로고    scopus 로고
    • Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review
    • PID: 12353183
    • Smith JS, Robinson NJ. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. J Infect Dis. 2002;186 Suppl 1:S3–28.
    • (2002) J Infect Dis , vol.186 , pp. 3-28
    • Smith, J.S.1    Robinson, N.J.2
  • 54
    • 84880577824 scopus 로고    scopus 로고
    • Prevalence of Chlamydia trachomatis and herpes simplex virus type 2: results from the 2009 to 2011 Canadian health measures survey
    • Rotermann M, Langlois KA, Severini A, Totten S. Prevalence of Chlamydia trachomatis and herpes simplex virus type 2: results from the 2009 to 2011 Canadian health measures survey. Health Rep. 2013;24:10–5.
    • (2013) Health Rep , vol.24 , pp. 10-15
    • Rotermann, M.1    Langlois, K.A.2    Severini, A.3    Totten, S.4
  • 55
    • 29144444035 scopus 로고    scopus 로고
    • Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies
    • PID: 16327322
    • Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS. 2006;20:73–83.
    • (2006) AIDS , vol.20 , pp. 73-83
    • Freeman, E.E.1    Weiss, H.A.2    Glynn, J.R.3    Cross, P.L.4    Whitworth, J.A.5    Hayes, R.J.6
  • 56
    • 84862756838 scopus 로고    scopus 로고
    • Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin
    • PID: 22516874
    • Prodger JL, Gray R, Kigozi G, Nalugoda F, Galiwango R, Nehemiah K, et al. Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin. AIDS. 2012;26:1319–22.
    • (2012) AIDS , vol.26 , pp. 1319-1322
    • Prodger, J.L.1    Gray, R.2    Kigozi, G.3    Nalugoda, F.4    Galiwango, R.5    Nehemiah, K.6
  • 57
    • 33847219957 scopus 로고    scopus 로고
    • Negative mucosal synergy between herpes simplex type 2 and HIV in the female genital tract
    • PID: 17314521
    • Rebbapragada A, Wachihi C, Pettengell C, Sunderji S, Huibner S, Jaoko W, et al. Negative mucosal synergy between herpes simplex type 2 and HIV in the female genital tract. AIDS. 2007;21:589–98.
    • (2007) AIDS , vol.21 , pp. 589-598
    • Rebbapragada, A.1    Wachihi, C.2    Pettengell, C.3    Sunderji, S.4    Huibner, S.5    Jaoko, W.6
  • 58
    • 84901257569 scopus 로고    scopus 로고
    • Impact of asymptomatic herpes simplex virus type 2 infection on mucosal homing and immune cell subsets in the blood and female genital tract
    • COI: 1:CAS:528:DC%2BC2cXotFGisL4%3D, PID: 24760150
    • Shannon B, Yi TJ, Thomas-Pavanel J, Chieza L, Janakiram P, Saunders M, et al. Impact of asymptomatic herpes simplex virus type 2 infection on mucosal homing and immune cell subsets in the blood and female genital tract. J Immunol. 2014;192:5074–82.
    • (2014) J Immunol , vol.192 , pp. 5074-5082
    • Shannon, B.1    Yi, T.J.2    Thomas-Pavanel, J.3    Chieza, L.4    Janakiram, P.5    Saunders, M.6
  • 59
    • 84901267036 scopus 로고    scopus 로고
    • Valacyclovir therapy does not reverse herpes-associated alterations in cervical immunology: a randomized, placebo-controlled crossover trial
    • Yi TJ, Shannon B, Chieza L, Su D, Saunders M, Tharao W, et al. Valacyclovir therapy does not reverse herpes-associated alterations in cervical immunology: a randomized, placebo-controlled crossover trial. J Infect Dis. 2014.
    • (2014) J Infect Dis
    • Yi, T.J.1    Shannon, B.2    Chieza, L.3    Su, D.4    Saunders, M.5    Tharao, W.6
  • 60
    • 45249108765 scopus 로고    scopus 로고
    • Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD1cXnsFGjurY%3D, PID: 18572080
    • Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delany-Moretlwe S, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:2109–19.
    • (2008) Lancet , vol.371 , pp. 2109-2119
    • Celum, C.1    Wald, A.2    Hughes, J.3    Sanchez, J.4    Reid, S.5    Delany-Moretlwe, S.6
  • 61
    • 42049102191 scopus 로고    scopus 로고
    • Effect of herpes simplex suppression on incidence of HIV among women in Tanzania
    • COI: 1:CAS:528:DC%2BD1cXksF2hs7w%3D, PID: 18337596
    • Watson-Jones D, Weiss HA, Rusizoka M, Changalucha J, Baisley K, Mugeye K, et al. Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. N Engl J Med. 2008;358:1560–71.
    • (2008) N Engl J Med , vol.358 , pp. 1560-1571
    • Watson-Jones, D.1    Weiss, H.A.2    Rusizoka, M.3    Changalucha, J.4    Baisley, K.5    Mugeye, K.6
  • 62
    • 84857233459 scopus 로고    scopus 로고
    • Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
    • COI: 1:CAS:528:DC%2BC38XisFWjsrY%3D, PID: 22225814
    • Johnston C, Saracino M, Kuntz S, Magaret A, Selke S, Huang ML, et al. Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials. Lancet. 2012;379:641–7.
    • (2012) Lancet , vol.379 , pp. 641-647
    • Johnston, C.1    Saracino, M.2    Kuntz, S.3    Magaret, A.4    Selke, S.5    Huang, M.L.6
  • 63
    • 48449099125 scopus 로고    scopus 로고
    • Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
    • PID: 18493617
    • Abu-Raddad LJ, Magaret AS, Celum C, Wald A, Longini Jr IM, Self SG, et al. Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS One. 2008;3:e2230.
    • (2008) PLoS One , vol.3 , pp. 2230
    • Abu-Raddad, L.J.1    Magaret, A.S.2    Celum, C.3    Wald, A.4    Longini, I.M.5    Self, S.G.6
  • 64
    • 67049098800 scopus 로고    scopus 로고
    • Disentangling contributions of reproductive tract infections to HIV acquisition in African women
    • PID: 19434010
    • van de Wijgert JH, Morrison CS, Brown J, Kwok C, Van Der Pol B, Chipato T, et al. Disentangling contributions of reproductive tract infections to HIV acquisition in African women. Sex Transm Dis. 2009;36:357–64.
    • (2009) Sex Transm Dis , vol.36 , pp. 357-364
    • van de Wijgert, J.H.1    Morrison, C.S.2    Brown, J.3    Kwok, C.4    Van Der Pol, B.5    Chipato, T.6
  • 65
    • 84911409001 scopus 로고    scopus 로고
    • Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study
    • PID: 25107710
    • Masson L, Mlisana K, Little F, Werner L, Mkhize NN, Ronacher K, et al. Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study. Sex Transm Infect. 2014;90:580–7.
    • (2014) Sex Transm Infect , vol.90 , pp. 580-587
    • Masson, L.1    Mlisana, K.2    Little, F.3    Werner, L.4    Mkhize, N.N.5    Ronacher, K.6
  • 66
    • 84861558518 scopus 로고    scopus 로고
    • Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa
    • PID: 22517910
    • Mlisana K, Naicker N, Werner L, Roberts L, van Loggerenberg F, Baxter C, et al. Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa. J Infect Dis. 2012;206:6–14.
    • (2012) J Infect Dis , vol.206 , pp. 6-14
    • Mlisana, K.1    Naicker, N.2    Werner, L.3    Roberts, L.4    van Loggerenberg, F.5    Baxter, C.6
  • 67
    • 84888638983 scopus 로고    scopus 로고
    • The global epidemiology of bacterial vaginosis: a systematic review
    • PID: 23659989
    • Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 2013;209:505–23.
    • (2013) Am J Obstet Gynecol , vol.209 , pp. 505-523
    • Kenyon, C.1    Colebunders, R.2    Crucitti, T.3
  • 68
    • 33646942950 scopus 로고    scopus 로고
    • High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
    • PID: 16652274
    • Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis. 2006;193:1478–86.
    • (2006) J Infect Dis , vol.193 , pp. 1478-1486
    • Bradshaw, C.S.1    Morton, A.N.2    Hocking, J.3    Garland, S.M.4    Morris, M.B.5    Moss, L.M.6
  • 69
    • 33846163146 scopus 로고    scopus 로고
    • Bacterial vaginosis: resistance, recurrence, and/or reinfection?
    • COI: 1:CAS:528:DC%2BD2sXhsVKmt7s%3D, PID: 17173220
    • Eschenbach DA. Bacterial vaginosis: resistance, recurrence, and/or reinfection? Clin Infect Dis. 2007;44:220–1.
    • (2007) Clin Infect Dis , vol.44 , pp. 220-221
    • Eschenbach, D.A.1
  • 70
    • 84864703034 scopus 로고    scopus 로고
    • Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples
    • PID: 22745608
    • Cohen CR, Lingappa JR, Baeten JM, Ngayo MO, Spiegel CA, Hong T, et al. Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. PLoS Med. 2012;9:e1001251.
    • (2012) PLoS Med , vol.9 , pp. 1001251
    • Cohen, C.R.1    Lingappa, J.R.2    Baeten, J.M.3    Ngayo, M.O.4    Spiegel, C.A.5    Hong, T.6
  • 71
    • 84901218191 scopus 로고    scopus 로고
    • Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US
    • PID: 24817204
    • Benning L, Golub ET, Anastos K, French AL, Cohen M, Gilbert D, et al. Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US. PLoS One. 2014;9:e96844.
    • (2014) PLoS One , vol.9 , pp. 96844
    • Benning, L.1    Golub, E.T.2    Anastos, K.3    French, A.L.4    Cohen, M.5    Gilbert, D.6
  • 75
    • 84902440757 scopus 로고    scopus 로고
    • Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract
    • PID: 24896815
    • Kleppa E, Ramsuran V, Zulu S, Karlsen GH, Bere A, Passmore JA, et al. Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract. PLoS One. 2014;9:e98593.
    • (2014) PLoS One , vol.9 , pp. 98593
    • Kleppa, E.1    Ramsuran, V.2    Zulu, S.3    Karlsen, G.H.4    Bere, A.5    Passmore, J.A.6
  • 76
    • 56149127456 scopus 로고    scopus 로고
    • Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure
    • PID: 18648516
    • Chenine AL, Shai-Kobiler E, Steele LN, Ong H, Augostini P, Song R, et al. Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure. PLoS Negl Trop Dis. 2008;2:e265.
    • (2008) PLoS Negl Trop Dis , vol.2 , pp. 265
    • Chenine, A.L.1    Shai-Kobiler, E.2    Steele, L.N.3    Ong, H.4    Augostini, P.5    Song, R.6
  • 78
    • 0037388893 scopus 로고    scopus 로고
    • Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians
    • COI: 1:STN:280:DC%2BD3s7mslarsg%3D%3D, PID: 12653845
    • Kassu A, Tsegaye A, Wolday D, Petros B, Aklilu M, Sanders EJ, et al. Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians. Clin Exp Immunol. 2003;132:113–9.
    • (2003) Clin Exp Immunol , vol.132 , pp. 113-119
    • Kassu, A.1    Tsegaye, A.2    Wolday, D.3    Petros, B.4    Aklilu, M.5    Sanders, E.J.6
  • 79
    • 21544438177 scopus 로고    scopus 로고
    • Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients
    • COI: 1:CAS:528:DC%2BD2MXlsFant78%3D, PID: 15980685
    • Wolday D, Tegbaru B, Kassu A, Messele T, Coutinho R, van Baarle D, et al. Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients. J Acquir Immune Defic Syndr. 2005;39:265–71.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 265-271
    • Wolday, D.1    Tegbaru, B.2    Kassu, A.3    Messele, T.4    Coutinho, R.5    van Baarle, D.6
  • 80
    • 84898749264 scopus 로고    scopus 로고
    • Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae
    • COI: 1:CAS:528:DC%2BC2cXmsVKjtbo%3D, PID: 24256632
    • Chege D, Higgins SJ, McDonald CR, Shahabi K, Huibner S, Kain T, et al. Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. J Acquir Immune Defic Syndr. 2014;65:517–25.
    • (2014) J Acquir Immune Defic Syndr , vol.65 , pp. 517-525
    • Chege, D.1    Higgins, S.J.2    McDonald, C.R.3    Shahabi, K.4    Huibner, S.5    Kain, T.6
  • 81
    • 84925235420 scopus 로고    scopus 로고
    • Brief report: HIV-1 transmissions during asymptomatic infection: exploring the impact of changes in HIV-1 viral load due to coinfections
    • COI: 1:CAS:528:DC%2BC2MXksVegs7k%3D, PID: 25585299
    • Baggaley RF, Hollingsworth TD. Brief report: HIV-1 transmissions during asymptomatic infection: exploring the impact of changes in HIV-1 viral load due to coinfections. J Acquir Immune Defic Syndr. 2015;68:594–8.
    • (2015) J Acquir Immune Defic Syndr , vol.68 , pp. 594-598
    • Baggaley, R.F.1    Hollingsworth, T.D.2
  • 82
    • 84921027231 scopus 로고    scopus 로고
    • Hormonal contraceptive use and women’s risk of HIV acquisition: a meta-analysis of observational studies
    • PID: 25578825
    • Ralph LJ, McCoy SI, Shiu K, Padian NS. Hormonal contraceptive use and women’s risk of HIV acquisition: a meta-analysis of observational studies. Lancet Infect Dis. 2015;15:181–9.
    • (2015) Lancet Infect Dis , vol.15 , pp. 181-189
    • Ralph, L.J.1    McCoy, S.I.2    Shiu, K.3    Padian, N.S.4
  • 84
    • 84904492810 scopus 로고    scopus 로고
    • Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells
    • COI: 1:CAS:528:DC%2BC2cXhtlSrurrF, PID: 24652495
    • Mitchell CM, McLemore L, Westerberg K, Astronomo R, Smythe K, Gardella C, et al. Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells. J Infect Dis. 2014;210:651–5.
    • (2014) J Infect Dis , vol.210 , pp. 651-655
    • Mitchell, C.M.1    McLemore, L.2    Westerberg, K.3    Astronomo, R.4    Smythe, K.5    Gardella, C.6
  • 85
    • 84884886414 scopus 로고    scopus 로고
    • Differential binding of IgG and IgA to mucus of the female reproductive tract
    • COI: 1:CAS:528:DC%2BC3sXhsFyrur7L, PID: 24098437
    • Fahrbach KM, Malykhina O, Stieh DJ, Hope TJ. Differential binding of IgG and IgA to mucus of the female reproductive tract. PLoS One. 2013;8:e76176.
    • (2013) PLoS One , vol.8 , pp. 76176
    • Fahrbach, K.M.1    Malykhina, O.2    Stieh, D.J.3    Hope, T.J.4
  • 86
    • 84874051662 scopus 로고    scopus 로고
    • Human cervicovaginal mucus contains an activity that hinders HIV-1 movement
    • COI: 1:CAS:528:DC%2BC38XhtlKku7jI, PID: 22990624
    • Shukair SA, Allen SA, Cianci GC, Stieh DJ, Anderson MR, Baig SM, et al. Human cervicovaginal mucus contains an activity that hinders HIV-1 movement. Mucosal Immunol. 2013;6:427–34.
    • (2013) Mucosal Immunol , vol.6 , pp. 427-434
    • Shukair, S.A.1    Allen, S.A.2    Cianci, G.C.3    Stieh, D.J.4    Anderson, M.R.5    Baig, S.M.6
  • 87
    • 84884500073 scopus 로고    scopus 로고
    • Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: implications for HIV transmission
    • PID: 23660575
    • van de Wijgert JH, Verwijs MC, Turner AN, Morrison CS. Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: implications for HIV transmission. AIDS. 2013;27:2141–53.
    • (2013) AIDS , vol.27 , pp. 2141-2153
    • van de Wijgert, J.H.1    Verwijs, M.C.2    Turner, A.N.3    Morrison, C.S.4
  • 88
    • 0026625698 scopus 로고
    • Vaginal inflammation in Africa
    • COI: 1:STN:280:DyaK38zkt1WqsQ%3D%3D, PID: 1635585
    • Brown RC, Brown JE, Ayowa OB. Vaginal inflammation in Africa. N Engl J Med. 1992;327:572.
    • (1992) N Engl J Med , vol.327 , pp. 572
    • Brown, R.C.1    Brown, J.E.2    Ayowa, O.B.3
  • 90
    • 33847104829 scopus 로고    scopus 로고
    • Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
    • PID: 17321311
    • Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, Nalugoda F, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007;369:657–66.
    • (2007) Lancet , vol.369 , pp. 657-666
    • Gray, R.H.1    Kigozi, G.2    Serwadda, D.3    Makumbi, F.4    Watya, S.5    Nalugoda, F.6
  • 91
    • 33847151707 scopus 로고    scopus 로고
    • Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial
    • PID: 17321310
    • Bailey RC, Moses S, Parker CB, Agot K, Maclean I, Krieger JN, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007;369:643–56.
    • (2007) Lancet , vol.369 , pp. 643-656
    • Bailey, R.C.1    Moses, S.2    Parker, C.B.3    Agot, K.4    Maclean, I.5    Krieger, J.N.6
  • 92
    • 28444460441 scopus 로고    scopus 로고
    • Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial
    • PID: 16231970
    • Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2:e298.
    • (2005) PLoS Med , vol.2 , pp. 298
    • Auvert, B.1    Taljaard, D.2    Lagarde, E.3    Sobngwi-Tambekou, J.4    Sitta, R.5    Puren, A.6
  • 93
    • 77949420120 scopus 로고    scopus 로고
    • Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters)
    • PID: 19770623
    • Kigozi G, Wawer M, Ssettuba A, Kagaayi J, Nalugoda F, Watya S, et al. Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters). AIDS. 2009;23:2209–13.
    • (2009) AIDS , vol.23 , pp. 2209-2213
    • Kigozi, G.1    Wawer, M.2    Ssettuba, A.3    Kagaayi, J.4    Nalugoda, F.5    Watya, S.6
  • 94
    • 84884196029 scopus 로고    scopus 로고
    • Programme science research on medical male circumcision scale-up in sub-Saharan Africa
    • PID: 23698513
    • Gray RH, Wawer MJ, Kigozi G. Programme science research on medical male circumcision scale-up in sub-Saharan Africa. Sex Transm Infect. 2013;89:345–9.
    • (2013) Sex Transm Infect , vol.89 , pp. 345-349
    • Gray, R.H.1    Wawer, M.J.2    Kigozi, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.