Amplified transmission of HIV-1: Comparison of HIV-1 concentrations in semen and blood during acute and chronic infection

AIDS

Volumn 21, Issue 13, 2007, Pages 1723-1730

  Pilcher, Christopher D ^a,b   Joaki, George ^c   Hoffman, Irving F ^a,c   Martinson, Francis E A ^a,c   Mapanje, Clement ^c   Stewart, Paul W ^a   Powers, Kimberly A ^a   Galvin, Shannon ^a   Chilongozi, David ^a,c   Gama, Syze ^c   Price, Matthew A ^a   Fiscus, Susan A ^a   Cohen, Myron S ^a,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

Author keywords

Acute HIV infection; HIV transmission; Peak viral load; Semen

Indexed keywords

VIRUS RNA;

ADULT; ARTICLE; BLOOD ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCREENING; SEMEN ANALYSIS; VIRUS LOAD; VIRUS TRANSMISSION;

ACUTE DISEASE; ADOLESCENT; ADULT; CHRONIC DISEASE; DISEASE PROGRESSION; EPIDEMIOLOGIC METHODS; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; RNA, VIRAL; SEMEN; VIRAL LOAD; VIREMIA; VIRUS SHEDDING;

EID: 34547801371     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3281532c82     Document Type: Article

References (28)

1. Joint United Nations Programme on HIV/AIDS (UNAIDS). UNAIDS 2006 report on the global AIDS epidemic. http://www.unaids.org.
2. Galvin SR, Cohen MS. Sexual transmission of HIV. Nat Rev Microbiol 2004; 2:33-42.
3. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med 2000; 342:921-929.
4. Fideli US, Allen SA, Musonda R, Trask S, Hahn BH, Weiss H, et al. Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses 2001; 17:901-910.
5. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, Laeyendecker O, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005; 191:1403-1409.
6. Pilcher CD, Eron JJ Jr, Galvin S, Gay C, Cohen MS. Acute HIV revisited: new opportunities for treatment and prevention. J Clin Invest 2004; 113:937-945.
7. Pilcher CD, Fiscus SA, Nguyen TQ, Foust E, Wolf L, Williams D, et al. Detection of acute HIV infections during HIV testing in North Carolina. New Engl J Med 2005; 152:1873-1883.
8. Pilcher CD, Price MA, Hoffman IF, Galvin S, Martinson FE, Kazembe PN, et al. Frequent detection of acute primary HIV infection in men in Malawi. AIDS 2004; 18:517-524.
9. Fiscus SA, Pilcher CD, Miller WC, Powers KA, Hoffman IF, Price M, et al. Rapid real time detection of patients with acute HIV infection in Africa. J Infect Dis 195:416-424.
10. Stevens W, Akkers E, Myers M, Pilcher C, Venter F, et al. High Prevalence of undetected acute HIV infection in a South African primary care clinic. Third IAS Conference on HIV Pathogenesis and Treatment. Rio de Janeiro, August 2005 [abstract MoOa0108].
11. DeSouza R, Pilcher C, Fisus SA, Cachafenro A, Scherer L, Sperhacker RD, Silva M, et al. Rapid and efficient acute HIV detection by 4th generation Ag/Ab ELISA. XVI International Conference on AIDS. Toronto, August 2006 [abstract THLB0201].
12. Pilcher CD, McPherson JT, Leone PA, Smurzynski M, Owen-O'Dowd J, Peace-Brewer AL, et al. Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population. JAMA 2002; 288:216-221.
13. Quinn TC, Brookmeyer R, Kline et al. Feasibility of pooling sera for HIV-1 RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence. AIDS 2000; 14:2751-2757.
14. Stafford MA, Corel L, Gao Y, et al. Modeling plasma virus concentration during primary HIV infection. J Theor Biol 2000; 203:285-301.
15. Edwards LJ, Stewart PW, MacDougall JE, Helmsa R. A method for fitting regression splines with varying polynomial order in the linear mixed model. Stat Med 2006; 15:513-527.
16. Royce AR, Seña A, Cates W, Cohen MS. Sexual transmission of HIV. N Engl J Med 1997; 336:1072-1078.
17. Cohen MS, Pilcher C. Amplified HIV transmission and new approaches to HIV prevention. J Infect Dis 2005; 191:1391-1393.
18. Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. SexTrans Infect 1999; 75:3-17.
19. Cohen MS, Hoffman IF, Royce RA, Kazembe P, Dyer JR, Daly CC, et al. Reduction of concentration of HIV-1 in semen after treatment of urethritis: Implications for prevention of sexual transmission of HIV-1. Lancet 1997; 349:1868-1873.
20. Bollinger RC, Brookmeyer RS, Mehendale SM, Paranjape RS, Shepherd ME, Gadkari DA, et al. Risk factors and clinical presentation of acute primary HIV infection in India. JAMA 1997; 278:2085-2089.
21. Pilcher CD, Tien HC, Eron JJ Jr, Vernazza PL, Leu SY, Stewart PW, et al. Brief but efficient: Acute HIV infection and the sexual transmission of HIV. J Infect Dis 2004; 189:1785-1792.
22. Coombs RW, Speck CE, Hughes JP, Lee W, Sampoleo R, Ross SO, et al. Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood. J Infect Dis 1998; 177:320-330.
23. Pullium JK, Adams DR, Jackson E, Kim CN, Smith DK, Janssen R, et al. Pig-tailed macaques infected with human immunodeficiency virus (HIV) type 2GB122 or simian/HIV89.6p express virus in semen during primary infection: new model for genital tract shedding and transmission. J Infect Dis 2001; 183:1023-1030.
24. Pilcher CD, Shugars DC, Fiscus SA, Miller WC, Menezes P, Giner J, et al. HIV in body fluids during primary HIV infection: implications for pathogenesis, treatment and public health. AIDS 2001; 15:837-845.
25. Stekler J, Syckr BJ, Holte S, Mgenza J, Stevens C, Dragavon J, et al. Semen HIV dynamics and effect of antiretrovirals following primary HIV infection. Thirteenth Conference on Retroviruses and Opportunistic Infections. Denver, CO, February 2006 [abstract 396].
26. Dyer JR, Vernazza PL, Gilliam B, et al. High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa. J Infect Dis 1998; 177:1742-1746.
27. Koopman JS, Jacquez JA, Welch GW, et al. The role of early HIV infection in the spread of HIV through populations. J Acquired Immune Defic Syndr Hum Retrovirol 1997; 14:249-258.
28. Fraser C, Hollingsworth T, Chapman R, Anderson R. Quantitating the impact of primary HIV on HIV transmission and control. Thirteenth Conference on Retroviruses and Opportunistic Infections. Denver, CO, February 2006 [abstract 62].