Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa

AIDS

Volumn 24, Issue 13, 2010, Pages 2069-2074

  Cohen, Craig R ^a   Moscicki, Anna Barbara ^a   Scott, Mark E ^a   Ma, Yifei ^a   Shiboski, Stephen ^a   Bukusi, Elizabeth ^b   Daud, Ibrahim ^b   Rebbapragada, Anu ^c   Brown, Joelle ^d   Kaul, Rupert ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD4 + T cells; female genital tract; HIV transmission; mucosal immunology; secretory leukocyte protease inhibitor; sub Saharan Africa

Indexed keywords

CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; INTERLEUKIN 8; MICROBICIDE; PLACEBO; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; VIRUS RECEPTOR;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ASSAY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CRYOPRESERVATION; FEMALE; FLOW CYTOMETRY; GENITAL SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; KENYA; LYMPHOCYTE PRESERVATION; LYMPHOCYTE SUBPOPULATION; NORMAL HUMAN; POPULATION DIFFERENTIATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; UNITED STATES; UTERINE CERVIX CYTOLOGY;

ADOLESCENT; AFRICA SOUTH OF THE SAHARA; CERVIX UTERI; CROSS-SECTIONAL STUDIES; FEMALE; GENITALIA, FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, MUCOSAL; MALE; RISK FACTORS; SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR; UNITED STATES; VIRUS SHEDDING; YOUNG ADULT;

EID: 77955430749     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32833c323b     Document Type: Article

References (24)

1. Centers for Disease Control and Prevention. Subpopulation estimates from the HIV incidence surveillance system: United States, 2006. MMWR Morb Mortal Wkly Rep 2008; 57:985-989.
2. Barnighausen T, Wallrauch C, Welte A, McWalter TA, Mbizana N, Viljoen J, et al. HIV incidence in rural South Africa: comparison of estimates from longitudinal surveillance and cross-sectional cBED assay testing. PLoS One 2008; 3: e3640.
3. Morrison CS, Richardson BA, Mmiro F, Chipato T, Celentano DD, Luoto J, et al. Hormonal contraception and the risk of HIV acquisition. AIDS 2007; 21:85-95.
4. Bearinger LH, Sieving RE, Ferguson J, Sharma V. Global perspectives on the sexual and reproductive health of adolescents: patterns, prevention, and potential. Lancet 2007; 369:1220-1231.
5. Pettifor AE, van der Straten A, Dunbar MS, Shiboski SC, Padian NS. Early age of first sex: a risk factor for HIV infection among women in Zimbabwe. AIDS 2004; 18:1435-1442.
6. Poles MA, Elliott J, Taing P, Anton PA, Chen IS. A preponderance of CCR5(R) CXCR4(R) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection. J Virol 2001; 75:8390-8399.
7. Patterson BK, Landay A, Siegel JN, Flener Z, Pessis D, Chaviano A, Bailey RC. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am J Pathol 2002; 161:867-873.
8. Zhu J, Hladik F, Woodward A, Klock A, Peng T, Johnston C, et al. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med 2009; 15:886-892.
9. Cohen CR, Plummer FA, MugoN,MacleanI,ShenC,BukusiEA, et al. Increased interleukin-10 in the endocervical secretions of women with nonulcerative sexually transmitted diseases: a mechanism for enhanced HIV-1 transmission? AIDS 1999; 13:327-332.
10. Fichorova RN, Tucker LD, Anderson DJ. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis 2001; 184:418-428.
11. Clerici M, Butto S, Lukwiya M, Saresella M, Declich S, Trabattoni D, et al. Immune activation in Africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project. AIDS 2000; 14:2083-2092.
12. Novak RM, Donoval BA, Graham PJ, Boksa LA, Spear G, Hershow RC, et al. Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection. Clin Vaccine Immunol 2007; 14: 1102-1107.
13. Chen MP, Macaluso M, Blackwell R, Galvao L, Kulczycki A, Diaz J, et al. Self-reported mechanical problems during condom use and semen exposure. Comparison of two randomized trials in the United States of America and Brazil. Sex Transm Dis 2007; 34:557-562.
14. Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlee F, Hildesheim A, et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol 2000; 38:357-361.
15. Rebbapragada A, Wachihi C, Pettengell C, Sunderji S, Huibner S, Jaoko W, et al. Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract. AIDS 2007; 21:589-598.
16. Moscicki AB, Hills N, Shiboski S, Powell K, Jay N, Hanson E, et al. Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. JAMA 2001; 285:2995-3002.
17. Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, Southern PJ, et al. Glycerol monolaurate prevents mucosal SIV transmission. Nature 2009; 458:1034-1038.
18. Abu-Raddad LJ, Magaret AS, Celum C, Wald A, Longini IM Jr, Self SG, Corey L. Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS One 2008; 3:e2230.
19. van de Wijgert JH, Morrison CS, Brown J, Kwok C, Van Der Pol B, Chipato T, et al. Disentangling contributions of reproductive tract infections to HIV acquisition in African Women. Sex Transm Dis 2009; 36:357-364.
20. Trifonova RT, Bajpai M, Pasicznyk JM, Chandra N, Doncel GF, Fichorova RN. Biomarkers of leukocyte traffic and activation in the vaginal mucosa. Biomarkers 2007; 12:608-622.
21. McNeely TB, Dealy M, Dripps DJ, Orenstein JM, Eisenberg SP, Wahl SM. Secretory leukocyte protease inhibitor: a human saliva protein exhibiting antihuman immunodeficiency virus 1 activity in vitro. J Clin Invest 1995; 96:456-464.
22. Stuckler D, King L, Robinson H, McKee M. WHO's budgetary allocations and burden of disease: a comparative analysis. Lancet 2008; 372:1563-1569.
23. Arthos J, Cicala C, Martinelli E, Macleod K, Van Ryk D, Wei D, et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 2008; 9:301-309.
24. 7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to HIV-1 infection. Proc Natl Acad Sci\USA 2009; 106:20877-20882.