Phase i combination of pazopanib and everolimus in PIK3CA mutation positive/PTEN loss patients with advanced solid tumors refractory to standard therapy

Investigational New Drugs

Volumn 33, Issue 3, 2015, Pages 700-709

  Rodrigues, Heloisa Veasey ^a   Ke, Danxia ^b   Lim, Joann ^b   Stephen, Bettzy ^b   Bellido, Jorge ^b   Janku, Filip ^b   Zinner, Ralph ^b   Tsimberidou, Apostolia ^b   Hong, David ^b   Piha Paul, Sarina ^b   Fu, Siqing ^b   Naing, Aung ^b   Subbiah, Vivek ^b   Karp, Daniel ^b   Falchook, Gerald ^c   Kurzrock, Razelle ^d   Wheler, Jennifer ^b  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c HealthOne   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Everolimus; Pazopanib; PIK3CA mutation; PTEN loss

Indexed keywords

ANTINEOPLASTIC AGENT; EVEROLIMUS; PAZOPANIB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

ADOLESCENT; ADULT; AGED; CANCER STAGING; CLINICAL TRIAL; DOSE RESPONSE; DRUG RESISTANCE; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MUTATION; NEOPLASMS; PATHOLOGY; PHASE 1 CLINICAL TRIAL; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; EVEROLIMUS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM STAGING; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; PYRIMIDINES; SULFONAMIDES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84937758561     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-015-0238-2     Document Type: Article

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