Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration

Cellular and Molecular Life Sciences

Volumn 72, Issue 15, 2015, Pages 2973-2988

  Li, Na ^a,c   Parrish, Marcus ^b   Chan, Tze Khee ^a,d   Yin, Lu ^a   Rai, Prashant ^a,c   Yoshiyuki, Yamada ^a   Abolhassani, Nona ^b   Tan, Kong Bing ^d   Kiraly, Orsolya ^a   Chow, Vincent T K ^c   Engelward, Bevin P ^b  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Acute infection; Immunofluorescence; Nuclear foci; Repair deficiency

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CD45 ANTIGEN; CYCLINE; GAMMA HISTONE H2AX; HEMAGGLUTININ; HISTONE H2AX; KI 67 ANTIGEN; KU ANTIGEN; KU86 PROTEIN; NUCLEIC ACID BINDING PROTEIN; RAD51 PROTEIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CD8A+ T LYMPHOCYTE; CELL COUNT; CELL DIVISION; CELL POPULATION; CHROMATIN; CHROMATIN PHOSPHORYLATION; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; DNA STRAND BREAKAGE; HISTOLOGY; HISTONE PHOSPHORYLATION; HOST PATHOGEN INTERACTION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H1N1); LUNG ALVEOLUS EPITHELIUM CELL; LUNG ALVEOLUS MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN LOCALIZATION; TISSUE INJURY; TISSUE REGENERATION; VIRAL CLEARANCE; VIRUS LOAD; VIRUS REPLICATION; VIRUS TITRATION; WESTERN BLOTTING; ANIMAL; CELL LINE; DOG; GENETICS; INFLUENZA A VIRUS (H1N1); LUNG; MDCK CELL LINE; ORTHOMYXOVIRUS INFECTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PNEUMONIA; REGENERATION; VIROLOGY;

MUS; ORTHOMYXOVIRIDAE;

ANIMALS; CELL LINE; DNA DAMAGE; DNA REPAIR; DOGS; INFLUENZA A VIRUS, H1N1 SUBTYPE; LUNG; MADIN DARBY CANINE KIDNEY CELLS; ORTHOMYXOVIRIDAE INFECTIONS; OXIDATIVE STRESS; PNEUMONIA; REGENERATION;

EID: 84937726095     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1879-1     Document Type: Article

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