Primary Sequence Confirmation of a Protein Therapeutic Using Top Down MS/MS and MS3

Analytical Chemistry

Volumn 87, Issue 14, 2015, Pages 6995-6999

  Levy, Michaella J ^a   Gucinski, Ashley C ^a   Boyne, Michael T ^a,b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b MTB: Biotechlogic Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; DISSOCIATION; DRUG PRODUCTS; MASS SPECTROMETERS; MASS SPECTROMETRY; SULFUR COMPOUNDS;

AMINO ACID SEQUENCE; COLLISION INDUCED DISSOCIATION; COLLISIONAL DISSOCIATION; ELECTRON-TRANSFER DISSOCIATION; GRANULOCYTE-COLONY STIMULATING FACTOR; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN THERAPEUTICS; REGULATORY APPROVALS;

PROTEINS;

GRANULOCYTE COLONY STIMULATING FACTOR; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; TANDEM MASS SPECTROMETRY;

EID: 84937716031     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.5b01113     Document Type: Article

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