Immunoglobulin A nephropathy: Current progress and future directions

Translational Research

Volumn 166, Issue 2, 2015, Pages 134-144

  Zhang, Chunlei ^a,b   Zeng, Xuehui ^a,b   Li, Zhongxin ^a,b   Wang, Zhe ^a,b   Li, Shunmin ^a,b  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; AZATHIOPRINE; BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GALACTOSE DEFICIENT IMMUNOGLOBULIN A1; GALACTOSE DEFICIENT IMMUNOGLOBULIN A1 DERIVATIVE; GLUCOCORTICOID; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN G; MICRORNA; PREDNISONE; PROTEIN KINASE INHIBITOR; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ALLELE; ANTIGEN ANTIBODY COMPLEX; BLOOD LEVEL; BLOOD PRESSURE; GENE LOCUS; GENETIC SUSCEPTIBILITY; GLOMERULONEPHRITIS; HISTOPATHOLOGY; HUMAN; IMMUNITY; IMMUNOGLOBULIN A NEPHROPATHY; INFLAMMATION; KIDNEY BIOPSY; KIDNEY INJURY; MAJOR HISTOCOMPATIBILITY COMPLEX; MESANGIUM CELL; NEMATODE; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEINURIA; PROTEOMICS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; URINALYSIS; ANIMAL; DISEASE COURSE; GENETICS; GLOMERULONEPHRITIS, IGA; KIDNEY; METABOLISM; PATHOLOGY;

ANIMALS; BIOLOGICAL MARKERS; DISEASE PROGRESSION; GLOMERULONEPHRITIS, IGA; HUMANS; INFLAMMATION; KIDNEY;

EID: 84937631868     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2015.02.007     Document Type: Review

References (78)

1. I.S. Roberts Pathology of IgA nephropathy Nat Rev Nephrol 10 2014 445 454
2. C.C. Geddes, V. Rauta, C. Gronhagen-Riska, and et al. A tricontinental view of IgA nephropathy Nephrol Dial Transplant 18 2003 1541 1548
3. Working Group of the International Ig ANN, the Renal Pathology Society D.C. Cattran, R. Coppo, H.T. Cook, and et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification Kidney Int 76 2009 534 545
4. Working Group of the International Ig ANN, the Renal Pathology Society I.S. Roberts, H.T. Cook, S. Troyanov, and et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility Kidney Int 76 2009 546 556
5. J.C. Davin Henoch-Schonlein purpura nephritis: pathophysiology, treatment, and future strategy Clin J Am Soc Nephrol 6 2011 679 689
6. P.J. van der Boog, C. van Kooten, J.W. de Fijter, and M.R. Daha Role of macromolecular IgA in IgA nephropathy Kidney Int 67 2005 813 821
7. K.N. Lai, S.C. Tang, J.Y. Guh, and et al. Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system J Am Soc Nephrol 14 2003 3127 3137
8. B.D. Oortwijn, A. Roos, L. Royle, and et al. Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy J Am Soc Nephrol 17 2006 3529 3539
9. T.J. Reterink, W.E. Schroeijers, L.A. Es, and M.R. Daha Dimeric and polymeric IgA, but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells Mediators inflamm 5 1996 191 195
10. J. Mestecky, M. Raska, B.A. Julian, and et al. IgA nephropathy: molecular mechanisms of the disease Annu Rev Pathol 8 2013 217 240
11. G.S. Li, H. Zhang, J.C. Lv, Y. Shen, and H.Y. Wang Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy Kidney Int 71 2007 448 453
12. D. Pirulli, S. Crovella, S. Ulivi, and et al. Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy J Nephrol 22 2009 152 159
13. L. Zhu, W. Tang, G. Li, and et al. Interaction between variants of two glycosyltransferase genes in IgA nephropathy Kidney Int 76 2009 190 198
14. H. Suzuki, Z. Moldoveanu, S. Hall, and et al. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1 J Clin Invest 118 2008 629 639
15. K.S. Buck, A.C. Smith, K. Molyneux, and et al. B-cell O-galactosyltransferase activity, and expression of O-glycosylation genes in bone marrow in IgA nephropathy Kidney Int 73 2008 1128 1136
16. H. Suzuki, R. Fan, Z. Zhang, and et al. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity J Clin Invest 119 2009 1668 1677
17. Z. Moldoveanu, I. Moro, J. Radl, and et al. Site of catabolism of autologous and heterologous IgA in non-human primates Scand J Immunol 32 1990 577 583
18. J. Novak, H.L. Vu, L. Novak, and et al. Interactions of human mesangial cells with IgA and IgA-containing immune complexes Kidney Int 62 2002 465 475
19. R.J. Wyatt, and B.A. Julian IgA nephropathy N Engl J Med 368 2013 2402 2414
20. J. Barratt, and J. Feehally IgA nephropathy J Am Soc Nephrol 16 2005 2088 2097
21. M.T. Vuong, M. Hahn-Zoric, S. Lundberg, and et al. Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy Kidney Int 78 2010 1281 1287
22. T. Kokubo, Y. Hiki, H. Iwase, and et al. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins J Am Soc Nephrol 9 1998 2048 2054
23. Y. Kaneko, T. Otsuka, Y. Tsuchida, F. Gejyo, and I. Narita Integrin alpha1/beta1 and alpha2/beta1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy Int Immunol 24 2012 219 232
24. I.C. Moura, M.N. Centelles, M. Arcos-Fajardo, and et al. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy J Exp Med 194 2001 417 425
25. J.C. Leung, S.C. Tang, M.F. Lam, T.M. Chan, and K.N. Lai Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy Kidney Int 59 2001 277 285
26. M. Matsuda, K. Shikata, J. Wada, and et al. Deposition of mannan binding protein and mannan binding protein-mediated complement activation in the glomeruli of patients with IgA nephropathy Nephron 80 1998 408 413
27. L.P. Yang, H.L. Sun, L.M. Wu, and et al. Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy Invest Ophthalmol Vis Sci 50 2009 2319 2327
28. Z. Wang, A. Sokolovska, R. Seymour, J.P. Sundberg, and H. Hogenesch SHARPIN is essential for cytokine production, NF-kappaB signaling, and induction of Th1 differentiation by dendritic cells PLoS One 7 2012 e31809
29. C.S. Potter, Z. Wang, K.A. Silva, and et al. Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling PLoS One 9 2014 e85666
30. A. Amore, G. Conti, P. Cirina, and et al. Aberrantly glycosylated IgA molecules downregulate the synthesis and secretion of vascular endothelial growth factor in human mesangial cells Am J Kidney Dis 36 2000 1242 1252
31. S.P. Berger, A. Roos, and M.R. Daha Complement and the kidney: what the nephrologist needs to know in 2006? Nephrol Dial Transplant 20 2005 2613 2619
32. A. Roos, M.P. Rastaldi, N. Calvaresi, and et al. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease J Am Soc Nephrol 17 2006 1724 1734
33. H.L. Sun, L. Sun, Y.Y. Li, and et al. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats Exp Clin Endocrinol Diabetes 117 2009 336 344
34. Y. Zeng, S. Li, J. Wu, and et al. Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model Apoptosis 19 2014 1215 1224
35. Z. Wang, C.S. Potter, J.P. Sundberg, and H. Hogenesch SHARPIN is a key regulator of immune and inflammatory responses J Cell Mol Med 16 2012 2271 2279
36. A.G. Gharavi, Z. Moldoveanu, R.J. Wyatt, and et al. Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy J Am Soc Nephrol 19 2008 1008 1014
37. J. Feehally, M. Farrall, A. Boland, and et al. HLA has strongest association with IgA nephropathy in genome-wide analysis J Am Soc Nephrol 21 2010 1791 1797
38. A.G. Gharavi, K. Kiryluk, M. Choi, and et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy Nat Genet 43 2011 321 327
39. K. Kiryluk, Y. Li, S. Sanna-Cherchi, and et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis PLoS Genet 8 2012 e1002765
40. X.Q. Yu, M. Li, H. Zhang, and et al. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy Nat Genet 44 2012 178 182
41. J.K. Boyd, and J. Barratt Inherited IgA glycosylation pattern in IgA nephropathy and HSP nephritis: where do we go next? Kidney Int 80 2011 8 10
42. K. Kiryluk, Y. Li, F. Scolari, and et al. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens Nat Genet 46 2014 1187 1196
43. A.J. Macpherson, K.D. McCoy, F.E. Johansen, and P. Brandtzaeg The immune geography of IgA induction and function Mucosal Immunol 1 2008 11 22
44. R.L. Pullan, J.L. Smith, R. Jasrasaria, and S.J. Brooker Global numbers of infection and disease burden of soil transmitted helminth infections in 2010 Parasit Vectors 7 2014 37
45. A. Franke, D.P. McGovern, J.C. Barrett, and et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nat Genet 42 2010 1118 1125
46. D.P. McGovern, A. Gardet, L. Torkvist, and et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci Nat Genet 42 2010 332 337
47. J.M. Ambruzs, P.D. Walker, and C.P. Larsen The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease Clin J Am Soc Nephrol 9 2014 265 270
48. R. Camilla, H. Suzuki, V. Dapra, and et al. Oxidative stress and galactose-deficient IgA1 as markers of progression in IgA nephropathy Clin J Am Soc Nephrol 6 2011 1903 1911
49. G.Y. Cheng, D.W. Liu, N. Zhang, and et al. Clinical and prognostic implications of serum uric acid levels on IgA nephropathy: a cohort study of 348 cases with a mean 5-year follow-up Clin Nephrol 80 2013 40 46
50. J. Zwirner, M. Burg, M. Schulze, and et al. Activated complement C3: a potentially novel predictor of progressive IgA nephropathy Kidney Int 51 1997 1257 1264
51. R. Machii, M. Sakatume, R. Kubota, and et al. Examination of the molecular diversity of alpha1 antitrypsin in urine: deficit of an alpha1 globulin fraction on cellulose acetate membrane electrophoresis J Clin Lab Anal 19 2005 16 21
52. H. Mitsuhashi, Y. Tsukada, K. Ono, S. Yano, and T. Naruse Urine glycosaminoglycans and heparan sulfate excretions in adult patients with glomerular diseases Clin Nephrol 39 1993 231 238
53. K. Dohi, M. Iwano, A. Muraguchi, and et al. The prognostic significance of urinary interleukin 6 in IgA nephropathy Clin Nephrol 35 1991 1 5
54. D.D. Torres, M. Rossini, C. Manno, and et al. The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy Kidney Int 73 2008 327 333
55. H.P. Peters, J.A. van den Brand, and J.F. Wetzels Urinary excretion of low-molecular-weight proteins as prognostic markers in IgA nephropathy Neth J Med 67 2009 54 61
56. L.L. Liu, Y. Jiang, L.N. Wang, and N. Liu Urinary mannose-binding lectin is a biomarker for predicting the progression of immunoglobulin (Ig)A nephropathy Clin Exp Immunol 169 2012 148 155
57. M. Haubitz, S. Wittke, E.M. Weissinger, and et al. Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy Kidney Int 67 2005 2313 2320
58. B.A. Julian, S. Wittke, J. Novak, and et al. Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases Electrophoresis 28 2007 4469 4483
59. B.A. Julian, S. Wittke, M. Haubitz, and et al. Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases World J Urol 25 2007 467 476
60. C.C. Szeto, and P.K. Li MicroRNAs in IgA nephropathy Nat Rev Nephrol 10 2014 249 256
61. K. Tan, J. Chen, W. Li, and et al. Genome-wide analysis of microRNAs expression profiling in patients with primary IgA nephropathy Genome 56 2013 161 169
62. G. Serino, F. Sallustio, S.N. Cox, F. Pesce, and F.P. Schena Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy J Am Soc Nephrol 23 2012 814 824
63. Y. Fang, X. Yu, Y. Liu, and et al. miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation Am J Physiol Renal Physiol 304 2013 F1274 F1282
64. G. Wang, B.C. Kwan, F.M. Lai, and et al. Intrarenal expression of microRNAs in patients with IgA nephropathy Lab Invest 90 2010 98 103
65. G. Wang, B.C. Kwan, F.M. Lai, and et al. Elevated levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy Dis Markers 30 2011 171 179
66. G. Wang, B.C. Kwan, F.M. Lai, and et al. Urinary miR-21, miR-29, and miR-93: novel biomarkers of fibrosis Am J Nephrol 36 2012 412 418
67. H. Yanagawa, H. Suzuki, Y. Suzuki, and et al. A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases PLoS One 9 2014 e98081
68. L. He, and G.J. Hannon MicroRNAs: small RNAs with a big role in gene regulation Nat Rev Genet 5 2004 522 531
69. P. Kalliakmani, L. Nakopoulou, S. Tsakas, and et al. Urinary interleukin-6 (IL-6) and transforming growth factor (TGF-beta) levels in corticosteroidtreated patients with IgA nephropathy Clin Nephrol 76 2011 144 150
70. W. Wu, X.Y. Jiang, Q.L. Zhang, and et al. Expression and significance of TGF-beta1/Smad signaling pathway in children with IgA nephropathy World J Pediatr 5 2009 211 215
71. A.C. Chung, X. Yu, and H.Y. Lan MicroRNA and nephropathy: emerging concepts Int J Nephrol Renovasc Dis 6 2013 169 179
72. C.C. Szeto, K.B. Ching-Ha, L. Ka-Bik, and et al. Micro-RNA expression in the urinary sediment of patients with chronic kidney diseases Dis Markers 33 2012 137 144
73. G. Wang, B.C. Kwan, F.M. Lai, and et al. Expression of microRNAs in the urinary sediment of patients with IgA nephropathy Dis Markers 28 2010 79 86
74. A. Yasin, D. Liu, L. Chau, J. Madrenas, and G. Filler Fibroblast growth factor-23 and calcium phosphate product in young chronic kidney disease patients: a cross-sectional study BMC Nephrol 14 2013 39
75. S.E. Delanghe, M.M. Speeckaert, H. Segers, and et al. Soluble transferrin receptor in urine, a new biomarker for IgA nephropathy and Henoch-Schonlein purpura nephritis Clin Biochem 46 2013 591 597
76. J. Floege, and F. Eitner Current therapy for IgA nephropathy J Am Soc Nephrol 22 2011 1785 1794
77. F. Berthoux, S. El Deeb, C. Mariat, and et al. Antithymocyte globulin (ATG) induction therapy and disease recurrence in renal transplant recipients with primary IgA nephropathy Transplantation 85 2008 1505 1507
78. P. Clayton, S. McDonald, and S. Chadban Steroids and recurrent IgA nephropathy after kidney transplantation Am J Transplant 11 2011 1645 1649