Role of macromolecular IgA in IgA nephropathy

Kidney International

Volumn 67, Issue 3, 2005, Pages 813-821

  Van Der Boog, Paul J M ^a   Van Kooten, Cees ^a   De Fijter, Johan W ^a   Daha, Mohamed R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

IgA; IgA nephropathy; Macromolecular IgA; Polymeric IgA

Indexed keywords

IMMUNOGLOBULIN A; FIBRONECTIN;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CIRCULATION; DISEASE ASSOCIATION; GLYCOSYLATION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; KIDNEY FAILURE; MACROMOLECULE; MESANGIUM CELL; PATHOGENESIS; PRIORITY JOURNAL; ANIMAL; BLOOD; IMMUNOLOGY; MESANGIUM; PHYSIOLOGY; REVIEW;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; FIBRONECTINS; GLOMERULAR MESANGIUM; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A;

EID: 20844460990     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00146.x     Document Type: Article

References (103)

1. D'AMICO G: The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 64:709-727, 1987
2. JOHNSTON PA, BROWN JS, BRAUMHOLTZ DA, DAVISON AM: Clinicopathological correlations and long-term follow-up of 253 United Kingdom patients with IgA nephropathy. A report from the MRC Glomerulonephritis Registry. Q J Med 84:619-627, 1992
3. VAN ES LA: Pathogenesis of IgA nephropathy. Kidney Int 41:1720-1729, 1992
4. NEELAKANTAPPA K, GALLO GR, BALDWIN DS: Proteinuria in IgA nephropathy. Kidney Int 33:716-721, 1988
5. OKADA H, SUZUKI H, KONISHI K, et al: Histological alterations in renal specimens as indicators of prognosis of IgA nephropathy. Clin Nephrol 37:235-238, 1992
6. IBELS LS, GYORY AZ: IgA nephropathy: Analysis of the natural history, important factors in the progression of renal disease, and a review of the literature. Medicine (Baltimore) 73:79-102, 1994
7. VAN DER BOOG PJ, DE FIJTER JW, BRUIJN JA, VAN ES LA: Recurrence of IgA nephropathy after renal transplantation. Ann Med Interne (Paris) 150:137-142, 1999
8. SANFILIPPO F, CROKER BP, BOLLINGER RR: Fate of four cadaveric donor renal allografts with mesangial IgA deposits. Transplantation 33:370-376, 1982
9. MONTEIRO RC, HALBWACHS-MECARELLI L, ROQUE-BARREIRA MC, et al: Charge and size of mesangial IgA in IgA nephropathy. Kidney Int 28:666-671, 1985
10. TOMINO Y, SAKAI H, MIURA M, et al. Detection of polymeric IgA in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49:419-425, 1982
11. CONLEY ME, DELACROIX DL: Intravascular and mucosal immunoglobulin A: Two separate but related systems of immune defense? Ann Intern Med 106:892-899, 1987
12. RUSSELL MW, LUE C, VAN DEN WALL BAKE AW, et al. Molecular heterogeneity of human IgA antibodies during an immune response. Clin Exp Immunol 87:1-6, 1992
13. CHEN N, NUSBAUM P, HALBWACHS-MECARELLI L, LESAVRE P: Light-chain composition of serum IgA1 and in vitro IgA1 production in IgA nephropathy. Nephrol Dial Transplant 6:846-850, 1991
14. CHUI SH, LAM CW, LEWIS WH, LAI KN: Light-chain ratio of serum IgA1 in IgA nephropathy. J Clin Immunol 11:219-223, 1991
15. DELACROIX DL, ELKOM KB, GEUBEL AP, et al: Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A. J Clin Invest 71:358-367, 1983
16. PETERMAN JH, JULIAN BA, KIRK KA, JACKSON S: Selective elevation of monomeric IgA1 in IgA nephropathy patients with normal renal function. Am J Kidney Dis 18:313-319, 1991
17. VAN DEN WALL BAKE AW, DAHA MR, VAN DER ARK A, et al: Serum levels and in vitro production of IgA subclasses in patients with primary IgA nephropathy. Clin Exp Immunol 74:115-120, 1988
18. HARPER SJ, ALLEN AC, LAYWARD L, et al: Increased immunoglobulin A and immunoglobulin A1 cells in bone marrow trephine biopsy specimens in immunoglobulin A nephropathy. Am J Kidney Dis 24:888-892, 1994
19. VAN DEN WALL BAKE AW, DAHA MR, RADL J, et al: The bone marrow as production site of the IgA deposited in the kidneys of patients with IgA nephropathy. Clin Exp Immunol 72:321-325, 1988
20. VAN DEN WALL BAKE AW, DAHA MR, EVERS-SCHOUTEN J, VAN ES LA: Serum IgA and the production of IgA by peripheral blood and bone marrow lymphocytes in patients with primary IgA nephropathy: evidence for the bone marrow as the source of mesangial IgA. Am J Kidney Dis 12:410-414, 1988
21. VAN DEN WALL BAKE AW, DAHA MR, HAAIJMAN JJ, et al: Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy. Kidney Int 35:1400-1404, 1989
22. VAN DEN WALL BAKE AW, KIRK KA, GAY RE, et al: Binding of serum immunoglobulins to collagens in IgA nephropathy and HIV infection. Kidney Int 42:374-382, 1992
23. DAVIN JC, FOIDART JB, MAHIEU PR: Relation between biological IgA abnormalities and mesangial IgA deposits in isolated hematuria in childhood. Clin Nephrol 28:73-80, 1987
24. FEEHALLY J, BEATTIE TJ, BRENCHLEY PE, et al: Sequential study of the IgA system in relapsing IgA nephropathy. Kidney Int 30:924-931, 1986
25. DE FIJTER JW, EIJGENRAAM JW, BRAAM CA, et al: Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy. Kidney Int 50:952-961, 1996
26. BAENZIGER J, KORNFELD S: Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units. J Biol Chem 249:7270-7281, 1974
27. MATTU TS, PLEASS RJ, WILLIS AC, et al: The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. J Biol Chem 273:2260-2272, 1998
28. FRANGIONE B, WOLFENSTEIN-TODEL C: Partial duplication in the "hinge" region of IgA1 myeloma proteins. Proc Natl Acad Sci USA 69:3673-3676, 1972
29. ALLEN AC, HARPER SJ, FEEHALLY J: Galactosylation. Clin Exp Immunol 100:470-474, 1995
30. HIKI Y, IWASE H, SAITOH M, et al: Reactivity of glomerular and serum IgA1 to jacalin in IgA nephropathy. Nephron 72:429-435, 1996
31. MESTECKY J, TOMANA M, CROWLEY-NOWICK PA et al: Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 104:172-182, 1993
32. TOMANA M, MATOUSOVIC K, JULIAN BA, et al: Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 52:509-516, 1997
33. ALLEN AC, BAILEY EM, BARRATT J, et al: Analysis of IgA1 O-glycans in IgA nephropathy by fluorophore-assisted carbohydrate electrophoresis. J Am Soc Nephrol 10:1763-1771, 1999
34. HIKI Y, TANAKA A, KOKUBO T, et al: Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Am Soc Nephrol 9:577-582, 1998
35. ALLEN AC, WILLIS FR, BEATTIE TJ, FEEHALLY J: Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant 13:930-934, 1998
36. ALLEN AC, TOPHAM PS, HARPER SJ, FEEHALLY J: Leucocyte beta 1,3 galactosyltransferase activity in IgA nephropathy. Nephrol Dial Transplant 12:701-706, 1997
37. CHINTALACHARUVU SR, EMANCIPATOR SN: The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines. J Immunol 159:2327-2333, 1997
38. KOKUBO T, HIKI Y, IWASE H, et al: Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol 9:2048-2054, 1998
39. TOMANA M, NOVAK J, JULIAN BA, et al: Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104:73-81, 1999
40. COPPO R, AMORE A, GIANOGLIO B, et al: Serum IgA and macromolecular IgA reacting with mesangial matrix components. Contrib Nephrol 104:162-171, 1993
41. COPPO R, BASOLO B, MARTINA G, et al: Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schönlein nephritis. Correlation with clinical and histologic signs of activity. Clin Nephrol 18:230-239, 1982
42. CZERKINSKY C, KOOPMAN WJ, JACKSON S, et al: Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies. J Clin Invest 77:1931-1938, 1986
43. SCHENA FP, PASTORE A, LUDOVICO N, et al: Increased serum levels of IgA1-IgG immune complexes and anti-F(ab')2 antibodies in patients with primary IgA nephropathy. Clin Exp Immunol 77:15-20, 1989
44. KANATSU K, DOI T, SEKITA K, et al: A comparative immunologic study of IgA nephropathy. Am J Kidney Dis 2:618-625, 1983
45. CONLEY ME, COOPER MD, MICHAEL AF: Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66:1432-1436, 1980
46. NOVAK J, VU HL, NOVAK L, et al: Interactions of human mesangial cells with IgA and IgA-containing immune complexes. Kidney Int 62:465-475, 2002
47. ALLEN AC, BAILEY EM, BRENCHLEY PE, et al: Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients. Kidney Int 60:969-973, 2001
48. HIKI Y, ODANI H, TAKAHASHI M, et al: Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 59:1077-1085, 2001
49. SINICO RA, FORNASIERI A, MALDIFASSI P, et al: The clinical significance of IgA rheumatoid factor in idiopathic IgA mesangial nephropathy (Berger's disease). Clin Nephrol 30:182-186, 1988
50. LAI KN, TO WY, LEUNG JC, et al: Serologic study of immunoglobulin A-fibronectin aggregates in immunoglobulin A nephropathy. Am J Kidney Dis 27:622-630, 1996
51. DAVIN JC, LI VM, NAGY J, et al: Evidence that the interaction between circulating IgA and fibronectin is a normal process enhanced in primary IgA nephropathy. J Clin Immunol 11:78-94, 1991
52. EITNER F, SCHULZE M, BRUNKHORST R et al: On the specificity of assays to detect circulating immunoglobulin A-fibronectin complexes: Implications for the study of serologic phenomena in patients with immunoglobulin A nephropathy. J Am Soc Nephrol 5:1400-1406, 1994
53. JENNETTE JC, WIESLANDER J, TUTTLE R, FALK RJ: Serum IgA-fibronectin aggregates in patients with IgA nephropathy and Henoch-Schönlein purpura: Diagnostic value and pathogenic implications. The Glomerular Disease Collaborative Network. Am J Kidney Dis 18:466-471, 1991
54. WAGA S, SUGIMOTO K, TANAKA H, et al: IgA interaction with carboxy-terminal 43-kD fragment of fibronectin in IgA nephropathy. J Am Soc Nephrol 10:256-263, 1999
55. ZHENG F, KUNDU GC, ZHANG Z, et al: Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. Nat Med 5:1018-1025, 1999
56. COPPO R, CHIESA M, CIRINA P, et al: In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice. Am J Kidney Dis 40:495-503, 2002
57. VAN DER BOOG PJ, VAN ZANDBERGEN G, DE FIJTER JW, et al: Fc alpha RI/CD89 circulates in human serum covalently linked to IgA in a polymeric state. J Immunol 168:1252-1258, 2002
58. LAUNAY P, GROSSETETE B, ARCOS-FAJARDO M, et al: Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med 191:1999-2009, 2000
59. GROSSETETE B, LAUNAY P, LEHUEN A, et al: Down-regulation of Fc alpha receptors on blood cells of IgA nephropathy patients: Evidence for a negative regulatory role of serum IgA. Kidney Int 53:1321-1335, 1998
60. ROCCATELLO D, PICCIOTTO G, TORCHIO M, et al: Removal systems of immunoglobulin A and immunoglobulin A containing complexes in IgA nephropathy and cirrhosis patients. The role of asialoglycoprotein receptors. Lab Invest 69:714-723, 1993
61. VAN ZANDBERGEN G, WESTERHUIS R, MOHAMAD NK, et al: Crosslinking of the human Fc receptor for IgA (FcalphaRI/CD89) triggers FcR gamma-chain-dependent shedding of soluble CD89. J Immunol 163:5806-5812, 1999
62. VAN DER BOOG PJ, DE FIJTER JW, VAN KOOTEN C, et al: Complexes of IgA with FcalphaRI/CD89 are not specific for primary IgA nephropathy. Kidney Int 63:514-521, 2003
63. HARPER SJ, ALLEN AC, BENE MC, et al: Increased dimeric IgA-producing B cells in tonsils in IgA nephropathy determined by in situ hybridization for J chain mRNA. Clin Exp Immunol 101:442-448, 1995
64. HARPER SJ, ALLEN AC, PRINGLE JH, FEEHALLY J: Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA. J Clin Pathol 49:38-42, 1996
65. BARRATT J, BAILEY EM, BUCK KS, et al: Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy. Am J Kidney Dis 33:1049-1057, 1999
66. LOMAX-SMITH JD, ZABROWARNY LA, HOWARTH GS, et al: The immunochemical characterization of mesangial IgA deposits. Am J Pathol 113:359-364, 1983
67. HISANO S, MATSUSHITA M, FUJITA T, et al: Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 38:1082-1088, 2001
68. LAI KN, CHUI SH, LAI FM, LAM CW: Predominant synthesis of IgA with lambda light chain in IgA nephropathy. Kidney Int 33:584-589, 1988
69. BENE MC, FAURE G, DUHEILLE J: IgA nephropathy: Characterization of the polymeric nature of mesangial deposits by in vitro binding of free secretory component. Clin Exp Immunol 47:527-534, 1982
70. EGIDO J, SANCHO J, MAMPASO F, et al. A possible common pathogenesis of the mesangial IgA glomerulonephritis in patients with Berger's disease and Schönlein-Henoch syndrome. Proc Eur Dial Transplant Assoc 17:660-666, 1980
71. SANCHO J, EGIDO J, SANCHEZ-CRESPO M, BLASCO R: Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease. Clin Exp Immunol 47:327-335, 1982
72. DONINI U, CASANOVA S, ZINI N, ZUCCHELLI P: The presence of J chain in mesangial immune deposits of IgA nephropathy. Proc Eur Dial Transplant Assoc 19:655-662, 1983
73. KOMATSU N, NAGURA H, WATANABE K, et al: Mesangial deposition of J chain-linked polymeric IgA in IgA nephropathy. Nephron 33:61-64, 1983
74. MALISZEWSKI CR, MARCH CJ, SCHOENBORN MA, et al: Expression cloning of a human Fc receptor for IgA. J Exp Med 172:1665-1672, 1990
75. MOSTOV KE: Transepithelial transport of immunoglobulins. Annu Rev Immunol 12:63-84, 1994
76. MOURA IC, CENTELLES MN, ARCOS-FAJARDO M, et al: Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J Exp Med 194:417-425, 2001
77. SHIBUYA A, SAKAMOTO N, SHIMIZU Y, et al: Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol 1:441-446, 2000
78. STOCKERT RJ, KRESSNER MS, COLLINS JC, et al: IgA interaction with the asialoglycoprotein receptor. Proc Natl Acad Sci USA 79:6229-6231, 1982
79. BARRATT J, GREER MR, PAWLUCZYK IZ, et al: Identification of a novel Fc alpha receptor expressed by human mesangial cells. Kidney Int 57:1936-1948, 2000
80. KITAMURA T, GAROFALO RP, KAMIJO A, et al: Human intestinal epithelial cells express a novel receptor for IgA. J Immunol 164:5029-5034, 2000
81. MILLET I, BRIERE F, VINCENT C, et al: Spontaneous expression of a low affinity Fc receptor for IgA (Fc alpha R) on human B cell lines. Clin Exp Immunol 76:268-273, 1989
82. WESTERHUIS R, VAN ZANDBERGEN G, VERHAGEN NA, et al: Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89). J Am Soc Nephrol 10:770-778, 1999
83. DIVEN SC, CAFLISCH CR, HAMMOND DK, et al: IgA induced activation of human mesangial cells: independent of Fc alphaR1 (CD 89). Kidney Int 54:837-847, 1998
84. LEUNG JC, TSANG AW, CHAN DT, LAI KN: Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol 11:241-249, 2000
85. MCDONALD KJ, CAMERON AJ, ALLEN JM, JARDINE AG: Expression of Fc alpha/mu receptor by human mesangial cells: A candidate receptor for immune complex deposition in IgA nephropathy. Biochem Biophys Res Commun 290:438-442, 2002
86. MOURA IC, ARCOS-FAJARDO M, SADAKA C, et al: Glycosylation and size of IgA1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy. J Am Soc Nephrol 15:622-634, 2004
87. CEDERHOLM B, WIESLANDER J, BYGREN P, HEINEGARD D: Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy. Proc Natl Acad Sci USA 85:4865-4868, 1988
88. SHINKAI Y, KARAI M, OSAWA G, et al: Antimouse laminin antibodies in IgA nephropathy and various glomerular diseases. Nephron 56:285-296, 1990
89. CHEN A, CHEN WP, SHEU LF, LIN CY: Pathogenesis of IgA nephropathy: In vitro activation of human mesangial cells by IgA immune complex leads to cytokine secretion. J Pathol 173:119-126, 1994
90. GOMEZ-GUERRERO C, LOPEZ-ARMADA MJ, GONZALEZ E, EGIDO J: Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation. J Immunol 153:5247-5255, 1994
91. VAN DEN DOBBELSTEEN ME, VAN DER WOUDE FJ, SCHROEIJERS WE, et al: Binding of dimeric and polymeric IgA to rat renal mesangial cells enhances the release of interleukin 6. Kidney Int 46:512-519, 1994
92. LOPEZ-ARMADA MJ, GOMEZ-GUERRERO C, EGIDO J: Receptors for immune complexes activate gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: Role of TGF-beta. J Immunol 157:2136-2142, 1996
93. RUSSELL MW, KILIAN M, LAMM ME: Biological activity of IgA, in Mucosal Immunology, edited by Ogra PLO, Mestecky J, San Diego, Academic Press, 1999, p 225
94. HIEMSTRA PS, BIEWENGA J, GORTER A, et al: Activation of complement by human serum IgA, secretory IgA and IgA1 fragments. MoI Immunol 25:527-533, 1988
95. JANOFF EN, FASCHING C, ORENSTEIN JM, et al: Killing of Streptococcus pneumoniae by capsular polysaccharide-specific polymeric IgA, complement, and phagocytes. J Clin Invest 104:1139-1147, 1999
96. ROOS A, BOUWMAN LH, GIJLSWIJK-JANSSEN DJ, et al: Human IgA activates the complement system via the mannan-binding lectin pathway. J Immunol 167:2861-2868, 2001
97. SCHAAPHERDER AF, GOOSZEN HG, TE BULTE MT, DAHA MR: Human complement activation via the alternative pathway on porcine endothelium initiated by IgA antibodies. Transplantation 60:287-291, 1995
98. ENDO M, OHI H, OHSAWA I, et al: Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol Dial Transplant 13:1984-1990, 1998
99. MATSUDA M, SHIKATA K, WADA J, et al: Deposition of mannan binding protein and mannan binding protein-mediated complement activation in the glomeruli of patients with IgA nephropathy. Nephron 80:408-413, 1998
100. ENDO M, OHI H, OHSAWA I, et al: Complement activation through the lectin pathway in patients with Henoch-Schönlein purpura nephritis. Am J Kidney Dis 35:401-407, 2000
101. HIEMSTRA PS, GORTER A, STUURMAN ME, et al: Activation of the alternative pathway of complement by human serum IgA. Eur J Immunol 17:321-326, 1987
102. AMORE A, COPPO R: Modulation of mesangial cell reactivity by aberrantly glycosylated IgA. Nephron 86:255-259, 2000
103. AMORE A, CIRINA P, CONTI G, et al: Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells. J Am Soc Nephrol 12:1862-1871, 2001