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Volumn 22, Issue 1, 2009, Pages 152-159

Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy

(22)  Pirulli, Doroti a   Crovella, Sergio a   Ulivi, Sheila a   Zadro, Cristina a   Bertok, Sara a   Rendine, Sabina b   Scolari, Francesco c   Foramitti, Marina c   Ravani, Pietro d   Roccatello, Dario b   Savoldi, Silvana e   Cerullo, Giuseppina f   Lanzilotta, Salvatore Giovanni f   Bisceglia, Luigi g   Zelante, Leopoldo g   Floege, Jurgen h   Alexopoulos, Epstathios i   Kirmizis, Dimitrios i   Ghiggeri, Gian Marco j   Frascà, Giovanni k   more..


Author keywords

C1Ga T1; Genetic association; IgA nephropathy; Polymorphisms

Indexed keywords

CORE 1 BETA 1,3 GALACTOSYLTRANSFERASE 1; GALACTOSYLTRANSFERASE; UNCLASSIFIED DRUG; C1GALT1 PROTEIN, HUMAN; IMMUNOGLOBULIN A;

EID: 66349083640     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (34)

References (29)
  • 2
    • 24944496919 scopus 로고    scopus 로고
    • Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy
    • Xu LX, Zhao MH. Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int. 2005;68:167-172.
    • (2005) Kidney Int , vol.68 , pp. 167-172
    • Xu, L.X.1    Zhao, M.H.2
  • 3
    • 0032588650 scopus 로고    scopus 로고
    • Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy
    • Hiki Y, Kokubo T, Iwase H, et al. Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy. J Am Soc Nephrol. 1999;10:760-769.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 760-769
    • Hiki, Y.1    Kokubo, T.2    Iwase, H.3
  • 4
    • 0030882005 scopus 로고    scopus 로고
    • Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy
    • Kokubo T, Hiki Y, Iwase H, et al. Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy. J Am Soc Nephrol. 1997;8:915-919.
    • (1997) J Am Soc Nephrol , vol.8 , pp. 915-919
    • Kokubo, T.1    Hiki, Y.2    Iwase, H.3
  • 5
    • 0034728771 scopus 로고    scopus 로고
    • Direct evidence for decreased sialylation and galactosylation of human serum IgA1 Fc O-glycosylated hinge peptides in IgA nephropathy by mass spectrometry
    • Odani H, Hiki Y, Takahashi M, et al. Direct evidence for decreased sialylation and galactosylation of human serum IgA1 Fc O-glycosylated hinge peptides in IgA nephropathy by mass spectrometry. Biochem Biophys Res Commun. 2000;271:268-274.
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 268-274
    • Odani, H.1    Hiki, Y.2    Takahashi, M.3
  • 7
    • 0034863147 scopus 로고    scopus 로고
    • Glycosylation of circulating IgA in patients with IgA Nephropathy modulates proliferation and apoptosis of mesangial cells
    • Amore A, Cirina P, Conti G, et al. Glycosylation of circulating IgA in patients with IgA Nephropathy modulates proliferation and apoptosis of mesangial cells. J Am Soc Nephrol. 2001;12:1862-1871.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1862-1871
    • Amore, A.1    Cirina, P.2    Conti, G.3
  • 8
    • 0031787449 scopus 로고    scopus 로고
    • Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins
    • Kokubo T, Hiki Y, Iwase H, et al. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 1998;9:2048-2054.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 2048-2054
    • Kokubo, T.1    Hiki, Y.2    Iwase, H.3
  • 9
    • 0027355459 scopus 로고
    • Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy
    • Mestecky J, Tomana M, Crowley-Nowick PA, et al. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol. 1993;104:172-182.
    • (1993) Contrib Nephrol , vol.104 , pp. 172-182
    • Mestecky, J.1    Tomana, M.2    Crowley-Nowick, P.A.3
  • 10
    • 0030894229 scopus 로고    scopus 로고
    • Leucocyte beta 1,3 galactosyltransferase activity in IgA nephropathy
    • Allen AC, Topham PS, Harper SJ, et al. Leucocyte beta 1,3 galactosyltransferase activity in IgA nephropathy. Nephrol Dial Transplant. 1997;12:701-706.
    • (1997) Nephrol Dial Transplant , vol.12 , pp. 701-706
    • Allen, A.C.1    Topham, P.S.2    Harper, S.J.3
  • 11
    • 0037458698 scopus 로고    scopus 로고
    • Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
    • Iwasaki H, Zhang Y, Tachibana K, et al. Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. J Biol Chem. 2003;278:5613-5621.
    • (2003) J Biol Chem , vol.278 , pp. 5613-5621
    • Iwasaki, H.1    Zhang, Y.2    Tachibana, K.3
  • 12
    • 0037016720 scopus 로고    scopus 로고
    • Cloning and expression of human core 1 beta1,3-galactosyltransferase
    • Ju T, Brewer K, D'Souza A, et al. Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem. 2002;277:178-186.
    • (2002) J Biol Chem , vol.277 , pp. 178-186
    • Ju, T.1    Brewer, K.2    D'Souza, A.3
  • 13
    • 0037033072 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel UDP-Gal:GalNAc (alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan
    • Kudo T, Iwai T, Kubota T, et al. Molecular cloning and characterization of a novel UDP-Gal:GalNAc (alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan. J Biol Chem. 2002;277:47724-47731.
    • (2002) J Biol Chem , vol.277 , pp. 47724-47731
    • Kudo, T.1    Iwai, T.2    Kubota, T.3
  • 14
    • 0028291625 scopus 로고
    • Differential expression of five sialyltransferase genes in human tissues
    • Kitagawa H, Paulson JC. Differential expression of five sialyltransferase genes in human tissues. J Biol Chem. 1994;269:17872-17878.
    • (1994) J Biol Chem , vol.269 , pp. 17872-17878
    • Kitagawa, H.1    Paulson, J.C.2
  • 15
    • 27544431952 scopus 로고    scopus 로고
    • Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression
    • Qin W, Zhou Q, Yang LC, et al. Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression. J Intern Med. 2005;258:467-477.
    • (2005) J Intern Med , vol.258 , pp. 467-477
    • Qin, W.1    Zhou, Q.2    Yang, L.C.3
  • 16
    • 33745051675 scopus 로고    scopus 로고
    • Updated March 21, 2008. Available at:, Accessed January 12, 2009
    • The AceView genes. Updated March 21, 2008. Available at: http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly. Accessed January 12, 2009.
    • The AceView genes
  • 17
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983;11:1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 19
    • 67649317669 scopus 로고    scopus 로고
    • Schneider S, Roessli D, Excoffier L. Arlequin: a software for population genetics data analysis. Version 2.00. Geneva: Genetics and Biometry Lab, Department of Anthropology and Ecology, University of Geneva; 2000. Available at:, Accessed January 12, 2009
    • Schneider S, Roessli D, Excoffier L. Arlequin: a software for population genetics data analysis. Version 2.00. Geneva: Genetics and Biometry Lab, Department of Anthropology and Ecology, University of Geneva; 2000. Available at: http://lgb.unige.ch/arlequin/. Accessed January 12, 2009.
  • 20
    • 0042360262 scopus 로고    scopus 로고
    • IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy
    • Horie A, Hiki Y, Odani H, et al. IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy. Am J Kidney Dis. 2003;42:486-496.
    • (2003) Am J Kidney Dis , vol.42 , pp. 486-496
    • Horie, A.1    Hiki, Y.2    Odani, H.3
  • 21
    • 0030836018 scopus 로고    scopus 로고
    • Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG
    • Tomana M, Matousovic K, Julian BA, et al. Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int. 1997;52:509-516.
    • (1997) Kidney Int , vol.52 , pp. 509-516
    • Tomana, M.1    Matousovic, K.2    Julian, B.A.3
  • 22
    • 0029150074 scopus 로고
    • A comparison of linkage disequilibrium measures for fine-scale mapping
    • Devlin B, Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics. 1995;29:311-322.
    • (1995) Genomics , vol.29 , pp. 311-322
    • Devlin, B.1    Risch, N.2
  • 23
    • 0032695357 scopus 로고    scopus 로고
    • Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies
    • Tomana M, Novak J, Julian BA, et al. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest. 1999;104:73-81.
    • (1999) J Clin Invest , vol.104 , pp. 73-81
    • Tomana, M.1    Novak, J.2    Julian, B.A.3
  • 24
    • 0037231850 scopus 로고    scopus 로고
    • Polymeric IgA increases the synthesis of macrophage migration inhibitory factor by human mesangial cells in IgA nephropathy
    • Leung JC, Tang SC, Chan LY, et al. Polymeric IgA increases the synthesis of macrophage migration inhibitory factor by human mesangial cells in IgA nephropathy. Nephrol Dial Transplant. 2003;18:36-45.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 36-45
    • Leung, J.C.1    Tang, S.C.2    Chan, L.Y.3
  • 25
    • 0037335613 scopus 로고    scopus 로고
    • Downstream elements of mammalian pre-mRNA polyadenylation signals: Primary, secondary and higher-order structures
    • Zarudnaya MI, Kolomiets IM, Potyahaylo AL, et al. Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures. Nucleic Acids Res. 2003;31:1375-1386.
    • (2003) Nucleic Acids Res , vol.31 , pp. 1375-1386
    • Zarudnaya, M.I.1    Kolomiets, I.M.2    Potyahaylo, A.L.3
  • 26
    • 33847213133 scopus 로고    scopus 로고
    • Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy
    • Li G-S, Zhang H, Lv J-C, et al. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int. 2007;71:448-453.
    • (2007) Kidney Int , vol.71 , pp. 448-453
    • Li, G.-S.1    Zhang, H.2    Lv, J.-C.3
  • 27
    • 33847239862 scopus 로고    scopus 로고
    • The genetic susceptibility to IgA nephropathy: A novel functional candidate gene for incomplete O-glycosylation of IgA1
    • Narita I, Kaneko Y, Kondo D, Goto S, Sakatsume M, Gejyo F. The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1. Kidney Int. 2007;71:379-381.
    • (2007) Kidney Int , vol.71 , pp. 379-381
    • Narita, I.1    Kaneko, Y.2    Kondo, D.3    Goto, S.4    Sakatsume, M.5    Gejyo, F.6
  • 28
    • 27644442375 scopus 로고    scopus 로고
    • Protein glycosylation: Chaperone mutation in Tn syndrome [brief communication]
    • Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome [brief communication]. Nature. 2005;437:1252.
    • (2005) Nature , vol.437 , pp. 1252
    • Ju, T.1    Cummings, R.D.2
  • 29
    • 0037168608 scopus 로고    scopus 로고
    • A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase
    • Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci U S A. 2002;99:16613-16618.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16613-16618
    • Ju, T.1    Cummings, R.D.2


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