MiR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

Biochemical and Biophysical Research Communications

Volumn 464, Issue 1, 2015, Pages 161-167

  Zhai, Jian ^a   Qu, Shuping ^a   Li, Xiaowei ^a   Zhong, Jiaming ^a   Chen, Xiaoxia ^a   Qu, Zengqiang ^a   Wu, Dong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; Invasion; miR 129; PAK5; Proliferation

Indexed keywords

MICRORNA; MICRORNA 129; P21 ACTIVATED KINASE 5; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MIRN129 MICRORNA, HUMAN; P21 ACTIVATED KINASE; PAK7 PROTEIN, HUMAN; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL INVASION; CELL PROLIFERATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG TARGETING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN PROCESSING; RECEPTOR DOWN REGULATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; BLOOD VESSEL; CANCER STAGING; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR INVASION; TUMOR MICROENVIRONMENT; VASCULARIZATION;

3' UNTRANSLATED REGIONS; APOPTOSIS; BINDING SITES; BLOOD VESSELS; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; P21-ACTIVATED KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

EID: 84937627831     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.06.108     Document Type: Article

References (23)

1. J.C. Nault, A. De Reyniès, A. Villanueva, J. Calderaro, S. Rebouissou, G. Couchy, T. Decaens, D. Franco, S. Imbeaud, and F. Rousseau A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection Gastroenterology 145 2013 176 187
2. K. Hao, J.M. Luk, N.P. Lee, M. Mao, C. Zhang, M.D. Ferguson, J. Lamb, H. Dai, I.O. Ng, and P.C. Sham Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters BMC Cancer 9 2009 389
3. H. Xia, L.L.P. Ooi, and K.M. Hui MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer Hepatology 58 2013 629 641
4. G. Hu, H. Fang, X. Tang, K. Ouyang, X. Yang, F. Xie, K. Wang, Y. Zhang, Z. Jiang, and L. Zhang Generation and characterization of a sorafenib-resistant hepatocellular carcinoma model from patient-derived tumor xenografts Cancer Res. 74 2014 1225-1225
5. D.F. Quail, and J.A. Joyce Microenvironmental regulation of tumor progression and metastasis Nat. Med. 19 2013 1423 1437
6. F. Wang, T. Li, B. Zhang, H. Li, Q. Wu, L. Yang, Y. Nie, K. Wu, Y. Shi, and D. Fan MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN Biochem. Biophys. Res. Commun. 434 2013 688 694
7. J.-Y. Sun, Y. Huang, J.-P. Li, X. Zhang, L. Wang, Y.-L. Meng, B. Yan, Y.-Q. Bian, J. Zhao, and W.-Z. Wang MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin Biochem. Biophys. Res. Commun. 420 2012 787 792
8. J. Yao, L. Liang, S. Huang, J. Ding, N. Tan, Y. Zhao, M. Yan, C. Ge, Z. Zhang, and T. Chen MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma Hepatology 51 2010 846 856
9. W. Yang, T. Sun, J. Cao, F. Liu, Y. Tian, and W. Zhu Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro Exp. Cell Res. 318 2012 944 954
10. Z.-B. Han, H.-Y. Chen, J.-W. Fan, J.-Y. Wu, H.-M. Tang, and Z.-H. Peng Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation J. Cancer Res. Clin. Oncol. 138 2012 153 161
11. L.C. Sanders, F. Matsumura, G.M. Bokoch, and P. de Lanerolle Inhibition of myosin light chain kinase by p21-activated kinase Science 283 1999 2083 2085
12. D. Li, X. Yao, and P. Zhang The overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer Mol. Cell. Biochem. 383 2013 191 199
13. Z.-X. Han, X.-X. Wang, S.-N. Zhang, J.-X. Wu, H.-y. Qian, Y.-y. Wen, H. Tian, D.-S. Pei, and J.-N. Zheng Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway Brain Tumor Pathol. 31 2014 234 241
14. Z.-p. Fang, B.-g. Jiang, X.-f. Gu, B. Zhao, R.-l. Ge, and F.-b. Zhang P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma Acta Pharmacol. Sin. 35 2014 82 88
15. K.W. Tsai, C.W. Wu, L.Y. Hu, S.C. Li, Y.L. Liao, C.H. Lai, H.W. Kao, W.L. Fang, K.H. Huang, and W.C. Chan Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer Int. J. Cancer 129 2011 2600 2610
16. M. Boeri, C. Verri, D. Conte, L. Roz, P. Modena, F. Facchinetti, E. Calabrò, C.M. Croce, U. Pastorino, and G. Sozzi MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer Proc. Natl. Acad. Sci. 108 2011 3713 3718
17. M. Karaayvaz, H. Zhai, and J. Ju miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer Cell Death Dis. 4 2013 e659
18. J. Wu, J. Qian, C. Li, L. Kwok, F. Cheng, P. Liu, C. Perdomo, D. Kotton, C. Vaziri, and C. Anderlind miR-129 regulates cell proliferation by downregulating Cdk6 expression Cell. Cycle 9 2010 1809 1818
19. M. Kang, Y. Li, W. Liu, R. Wang, A. Tang, H. Hao, Z. Liu, and H. Ou miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression Int. J. Mol. Med. 32 2013 51 58
20. R. Shen, S. Pan, S. Qi, X. Lin, and S. Cheng Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer Biochem. Biophys. Res. Commun. 394 2010 1047 1052
21. D. Wang, L. Luo, and J. Guo miR-129-1-3p inhibits cell migration by targeting BDKRB2 in gastric cancer Med. Oncol. 31 2014 1 6
22. R. Kumar, A.E. Gururaj, and C.J. Barnes p21-activated kinases in cancer Nat. Rev. Cancer 6 2006 459 471
23. K.B. Dossing, T. Binderup, B. Kaczkowski, A. Jacobsen, M. Rossing, O. Winther, B. Federspiel, U. Knigge, A. Kjær, and L. Friis-Hansen Down-regulation of miR-129-5p and the let-7 family in neuroendocrine tumors and metastases leads to up-regulation of their targets Egr1, G3bp1, Hmga2 and Bach1 Genes 6 2014 1 21