miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression

International Journal of Molecular Medicine

Volumn 32, Issue 1, 2013, Pages 51-58

  Kang, Min ^a   Li, Yumei ^a   Liu, Wenqi ^a   Wang, Rensheng ^a   Tang, Anzhou ^a   Hao, Hong ^b   Liu, Zhenguo ^b   Ou, Hesheng ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Esophageal cancer; Migration; miR 129 2; Proliferation; SOX4

Indexed keywords

MICRORNA; MIR 129 2; TRANSCRIPTION FACTOR SOX4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SIZE; CARCINOMA CELL; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DISTANT METASTASIS; DOWN REGULATION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS CANCER; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ADULT; AGED; CARCINOMA; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM STAGING; RNA INTERFERENCE; SOXC TRANSCRIPTION FACTORS;

EID: 84878224991     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1384     Document Type: Article

References (40)

1. Dawsey SP, Tonui S, Parker RK, Fitzwater JW, Dawsey SM, White RE and Abnet CC: Esophageal cancer in young people: a case series of 109 cases and review of the literature. PLoS One 5: e14080, 2010.
2. Pramoonjago P, Baras AS and Moskaluk CA: Knockdown of Sox4 expression by RNAi induces apoptosis in ACC3 cells. Oncogene 25: 5626-5639, 2006. (Pubitemid 44387618)
3. Medina PP, Castillo SD, Blanco S, et al: The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. Hum Mol Genet 18: 1343-1352, 2009.
4. Liao YL, Sun YM, Chau GY, et al: Identification of SOX4 target genes using phylogenetic footprinting based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma. Oncogene 27: 5578-5589, 2008.
5. Liu P, Ramachandran S, Ali Seyed M, et al: Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Res 66: 4011-4019, 2006.
6. Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML and Moreno CS: Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells. Cancer Res 69: 709-717, 2009.
7. Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB and Lefebvre V: The three SoxC proteins - Sox4, Sox11 and Sox12 - exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res 36: 3101-3117, 2008. (Pubitemid 351737202)
8. Tavazoie SF, Alarcon C, Oskarsson T, et al: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152, 2008.
9. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
10. Saito Y, Liang G, Egger G, et al: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9: 435-443, 2006. (Pubitemid 43832188)
11. Huang YW, Liu JC, Deatherage DE, et al: Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer Res 69: 9038-9046, 2009.
12. Kulkarni S, Savan R, Qi Y, et al: Differential microRNA regulation of HLA- C expression and its association with HIV control. Nature 472: 495-498, 2011.
13. Wang LH, Kim SH, Lee JH, et al: Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression. Clin Cancer Res 13: 102-110, 2007. (Pubitemid 46121858)
14. Chern CJ and Beutler E: Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans. Am J Hum Genet 28: 9-17, 1976.
15. Aaboe M, Birkenkamp-Demtroder K, Wiuf C, et al: SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Cancer Res 66: 3434-3442, 2006.
16. Lee SH, Kunz J, Lin SH and Yu-Lee LY: 16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway. Cancer Res 67: 11045-11053, 2007.
17. van de Wetering M, Oosterwegel M, van Norren K and Clevers H: Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J 12: 3847-3854, 1993.
18. van Beest M, Dooijes D, van De Wetering M, et al: Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs. J Biol Chem 275: 27266-27273, 2000.
19. Wotton D, Lake RA, Farr CJ and Owen MJ: The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. J Biol Chem 270: 7515-7522, 1995.
20. Mu L, Berti L, Masserdotti G, et al: SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. J Neurosci 32: 3067-3080, 2012.
21. Zhang J, Liang Q, Lei Y, et al: SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Res 72: 4597-4608, 2012.
22. Kuwahara M, Yamashita M, Shinoda K, et al: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation. Nat Immunol 13: 778-786, 2012.
23. Mavropoulos A, Devos N, Biemar F, et al: sox4b is a key player of pancreatic α cell differentiation in zebrafish. Dev Biol 285: 211-223, 2005. (Pubitemid 41242826)
24. Pan X, Zhao J, Zhang WN, et al: Induction of SOX4 by DNA damage is critical for p53 stabilization and function. Proc Natl Acad Sci USA 106: 3788-3793, 2009.
25. Ahn SG, Kim HS, Jeong SW, et al: Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and Δ(12)-PGJ(2). Exp Mol Med 34: 243-249, 2002.
26. Hur EH, Hur W, Choi JY, et al: Functional identification of the pro-apoptotic effector domain in human Sox4. Biochem Biophys Res Commun 325: 59-67, 2004. (Pubitemid 39441160)
27. Mikkers H, Allen J, Knipscheer P, et al: High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 32: 153-159, 2002. (Pubitemid 34977211)
28. Suzuki T, Shen H, Akagi K, et al: New genes involved in cancer identified by retroviral tagging. Nat Genet 32: 166-174, 2002. (Pubitemid 34977213)
29. 2 in Hep3B cells. Biochem Biophys Res Commun 260: 216-221, 1999.
30. Graham JD, Hunt SM, Tran N and Clarke CL: Regulation of the expression and activity by progestins of a member of the SOX gene family of transcriptional modulators. J Mol Endocrinol 22: 295-304, 1999. (Pubitemid 29281838)
31. Lee CJ, Appleby VJ, Orme AT, et al: Differential expression of SOX4 and SOX11 in medulloblastoma. J Neurooncol 57: 201-214, 2002. (Pubitemid 34692628)
32. Bangur CS, Switzer A, Fan L, et al: Identification of genes over-expressed in small cell lung carcinoma using suppression subtractive hybridization and cDNA microarray expression analysis. Oncogene 21: 3814-3825, 2002. (Pubitemid 34620545)
33. Frierson HF Jr, El-Naggar AK, Welsh JB, et al: Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol 161: 1315-1323, 2002.
34. Allegra A, Alonci A, Campo S, et al: Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review). Int J Oncol 41: 1897-1912, 2012.
35. Mo MH, Chen L, Fu Y, Wang W and Fu SW: Cell-free circulating miRNA biomarkers in cancer. J Cancer 3: 432-448, 2012.
36. Garzon R and Marcucci G. Potential of microRNAs for cancer diagnostics, prognostication and therapy. Curr Opin Oncol 24: 655-659, 2012.
37. Zhao JJ, Yang J, Lin J, et al: Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis. Childs Nerv Syst 25: 13-20, 2009.
38. Shen R, Pan S, Qi S, Lin X and Cheng S: Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer. Biochem Biophys Res Commun 394: 1047-1052, 2010.
39. Tsai KW, Wu CW, Hu LY, et al: Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. Int J Cancer 129: 2600-2610, 2011.
40. Bandres E, Agirre X, Bitarte N, et al: Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 125: 2737-2743, 2009.