Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro

Experimental Cell Research

Volumn 318, Issue 8, 2012, Pages 944-954

  Yang, Wei ^a   Sun, Ting ^a   Cao, Jianping ^a   Liu, Fenju ^a   Tian, Ye ^a   Zhu, Wei ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

AIFM3; Hepatoma; Hypoxia; MiR 210; Radiosensitivity

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICRORNA 210; RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE TRANSFER; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIC CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY;

EID: 84862781979     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.02.010     Document Type: Article

References (34)

1. Moeller B.J., Dreher M.R., Rabbani Z.N., Schroeder T., Cao Y., Li C.Y., Dewhirst M.W. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 2005, 8:99-110.
2. Liu J.Y., Zhang J., Wang X.W., Li Y., Chen Y.B., Li K.C., Zhang J., Yao L.B., Guo G.Z. HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells. Exp. Cell Res. 2010, 316:1985-1993.
3. Moeller B.J., Dewhirst M.W. HIF-1 and tumour radiosensitivity. Br. J. Cancer 2006, 95:1-5.
4. Moeller B.J., Richardson R.A., Dewhirst M.W. Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev. 2007, 26:241-248.
5. Lan K.L., Lan K.H., Sheu M.L., Chen M.Y., Shih Y.S., Hsu F.C., Wang H.M., Liu R.S., Yen S.H. Honokiol inhibits hypoxia-inducible factor-1 pathway. Int. J. Radiat. Biol. 2011, 87:579-590.
6. Williams K.J., Telfer B.A., Xenaki D., Sheridan M.R., Desbaillets I., Peters H.J., Honess D., Harris A.L., Dachs G.U., van der Kogel A., Stratford I.J. Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiother. Oncol. 2005, 75:89-98.
7. Yang W., Sun T., Cao J.P., Fan S.J. Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells. Cancer Biother. Radiol. 2011, 6:565-571.
8. Marignol L., Coffey M., Lawler M., Hollywood D. Hypoxia in prostate cancer: a powerful shield against tumour destruction?. Cancer Treat. Rev. 2008, 34:313-327.
9. Crosby M.E., Devlin C.M., Glazer P.M., Calin G.A., Ivan M. Emerging roles of microRNAs in the molecular responses to hypoxia. Curr. Pharm. Design 2009, 15:3861-3866.
10. Huang X., Le Q.T., Giaccia A.J. MiR-210-micromanager of the hypoxia pathway. Trends Mol. Med. 2010, 16:230-237.
11. Bushati N., Cohen S.M. MicroRNA functions. Annu. Rev. Cell Dev. Biol. 2007, 23:175-205.
12. Ventura A., Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell 2009, 136:586-591.
13. Huang X., Ding L., Bennewith K.L., Tong R.T., Welford S.M., Ang K.K., Story M., Le Q.T., Giaccia A.J. Hypoxia-inducible miR-210 regulates normoxic gene expression involved in tumor initiation. Mol. Cell 2009, 35:856-867.
14. Kulshreshtha R., Ferracin M., Negrini M., Calin G.A., Davuluri R.V., Ivan M. Regulation of microRNA expression: the hypoxic component. Cell Cycle 2007, 6:1426-1431.
15. Giannakakis A., Sandaltaopoulos R., Greshock J., Liang S., Huang J., Hasegawa K., Li C., O'Brien-Jenkins A., Katsaros D., Weber B.L., Simon C., Coukos G., Zhang L. miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol. Ther. 2008, 7:255-264.
16. Zhang Z., Sun H., Dai H.Y., Walsh R.M., Imakura M., Schelter J., Burchard J., Dai X., Chang A.N., Diaz R.L., Marszalek J.R., Bartz S.R., Carleton M., Cleary M.A., Linsley P.S., Grandori C. MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle 2009, 8:2756-2768.
17. Chan S.Y., Zhang Y.Y., Hemann C., Mahoney C.E., Zweier J.L., Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009, 10:273-284.
18. Pulkkinen K., Malm T., Turunen M., Koistinaho J., Ylä-Herttuala S. Hypoxia induces microRNA miR-210 in vitro and in vivo Ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS Lett. 2008, 582:2397-2401.
19. Fasanaro P., D'Alessandra Y., Di Stefano V., Melchionna R., Romani S., Pompilio G., Capogrossi M.C., Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-A3. J. Biol. Chem. 2008, 283:15878-15883.
20. Lee D.C., Romero R., Kim J.S., Tarca A.L., Montenegro D., Pineles B.L., Kim E., Lee J., Kim S.Y., Draghici S., Mittal P., Kusanovic J.P., Chaiworapongsa T., Hassan S.S., Kim C.J. miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies. Am. J. Pathol. 2011, 179:590-602.
21. Wolf F., Li W.R., Li F., Li C.Y. Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy. Int. J. Radiat. Oncol. 2011, 79:233-238.
22. Yang W., Sun T., Cao J.P., Liu F.J. Survivin downregulation by siRNA/cationic liposome complex radiosensitizes human hepatoma cells in vitro and in vivo. Int. J. Radiat. Bio. 2010, 86:445-457.
23. Kirk G.D., Bah E., Montesano R. Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa. Carcinogenesis 2006, 27:2070-2082.
24. Mann C.D., Neal C.P., Garcea G., Manson M.M., Dennison A.R., Berry D.P. Prognostic molecular markers in hepatocellular carcinoma: a systematic review. Eur. J. Cancer 2007, 43:979-992.
25. Jakobs T.F., Hoffmann R.T., Tatsch K., Trumm C., Reiser M.F. Therapy response of liver tumors after selective internal radiation therapy. Radiologe 2008, 48:839-849.
26. Amellem O., Pettersen E.O. Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage. Cell Prolif. 1991, 24:127-141.
27. Kulshreshtha R., Ferracin M., Wojcik S.E., Garzon R., Alder H., Agosto-Perez F.J., Davuluri R., Liu C.G., Croce C.M., Negrini M., Calin G.A., Ivan M. A microRNA signature of hypoxia. Mol. Cell. Biol. 2007, 27:1859-1867.
28. Hurlin P.J., Queva C., Eisenman R.N. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 1997, 11:44-58.
29. Hurlin P.J., Huang J. The MAX-interacting transcription factor network. Semin. Cancer Biol. 2006, 16:265-274.
30. Kim H.W., Haider H.K., Jiang S., Ashraf M. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J. Biol. Chem. 2009, 284:33161-33168.
31. Zölzer F., Streffer C. Increased radiosensitivity with chronic hypoxia in four human tumor cell lines. Int. J. Radiat. Oncol. Biol. Phys. 2002, 54:910-920.
32. Quero L., Dubois L., Lieuwes N.G., Hennequin C., Lambin P. miR-210 as a marker of chronic hypoxia, but not a therapeutic target in prostate cancer. Radiother. Oncol. 2011, 101:203-208.
33. Xie Q., Lin T., Zhang Y., Zheng J., Bonanno J.A. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. J. Biol. Chem. 2005, 280:19673-19681.
34. Mutharasan R.K., Nagpal V., Ichikawa Y., Ardehali H. microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H1519-H1530.