Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer

Biochemical and Biophysical Research Communications

Volumn 394, Issue 4, 2010, Pages 1047-1052

  Shen, Ruizhe ^a   Pan, Shen ^b   Qi, Shengjian ^a   Lin, Xiaolin ^a   Cheng, Shidan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Gastric cancer; Methylation; MicroRNA 129 2; SOX4

Indexed keywords

MICRORNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX4;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER DIAGNOSIS; CONTROLLED STUDY; DOWN REGULATION; ENDOMETRIUM CANCER; EPIGENETICS; FEMALE; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METHYLATION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; UPREGULATION;

APOPTOSIS; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM METASTASIS; PROGNOSIS; SOXC TRANSCRIPTION FACTORS; STOMACH NEOPLASMS; UP-REGULATION;

EID: 77950861247     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.03.121     Document Type: Article

References (20)

1. Moreno C.S. The sex-determining region Y-Box 4 and homeobox C6 transcriptional networks in prostate cancer progression. Crosstalk with the Wnt, notch, and PI3K pathways. Am. J. Pathol. 176 (2010) 518-527
2. Liu P., Ramachandran S., Ali Seyed M., Scharer C.D., Laycock N., Dalton W.B., Williams H., Karanam S., Datta M.W., Jaye D.L., and Moreno C.S. Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Res. 66 (2006) 4011-4019
3. Shin M.S., Fredrickson T.N., Hartley J.W., Suzuki T., Akagi K., and Morse III H.C. High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Cancer Res. 64 (2004) 4419-4427
4. Li Z., Kustikova O.S., Kamino K., Neumann T., Rhein M., Grassman E., Fehse B., and Baum C. Insertional mutagenesis by replication-deficient retroviral vectors encoding the large T oncogene. Ann. NY Acad. Sci. 1106 (2007) 95-113
5. Du Y., Spence S.E., Jenkins N.A., and Copeland N.G. Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. Blood 106 (2005) 2498-2505
6. Graham J.D., Hunt S.M., Tran N., and Clarke C.L. Regulation of the expression and activity by progestins of a member of the SOX gene family of transcriptional modulators. J. Mol. Endocrinol. 22 (1999) 295-304
7. Ahn S.G., Cho G.H., Jeong S.Y., Rhim H., Choi J.Y., and Kim I.K. Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells. Biochem. Biophys. Res. Commun. 260 (1999) 216-221
8. Lee C.J., Appleby V.J., Orme A.T., Chan W.I., and Scotting P.J. Differential expression of SOX4 and SOX11 in medulloblastoma. J. Neurooncol. 57 (2002) 201-214
9. Liao Y.L., Sun Y.M., Chau G.Y., Chau Y.P., Lai T.C., Wang J.L., Horng J.T., Hsiao M., and Tsou A.P. Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma. Oncogene 27 (2008) 5578-5589
10. Frierson Jr. H.F., El-Naggar A.K., Welsh J.B., Sapinoso L.M., Su A.I., Cheng J., Saku T., Moskaluk C.A., and Hampton G.M. Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am. J. Pathol. 161 (2002) 1315-1323
11. Aaboe M., Birkenkamp-Demtroder K., Wiuf C., Sorensen F.B., Thykjaer T., Sauter G., Jensen K.M., Dyrskjot L., and Orntoft T. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Cancer Res. 66 (2006) 3434-3442
12. Wang L.H., Kim S.H., Lee J.H., Choi Y.L., Kim Y.C., Park T.S., Hong Y.C., Wu C.F., and Shin Y.K. Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression. Clin. Cancer Res. 13 (2007) 102-110
13. Chern C.J., and Beutler E. Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans. Am. J. Hum. Genet. 28 (1976) 9-17
14. Huang Y.W., Liu J.C., Deatherage D.E., Luo J., Mutch D.G., Goodfellow P.J., Miller D.S., and Huang T.H. Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer Res. 69 (2009) 9038-9046
15. Dyrskjot L., Ostenfeld M.S., Bramsen J.B., Silahtaroglu A.N., Lamy P., Ramanathan R., Fristrup N., Jensen J.L., Andersen C.L., Zieger K., Kauppinen S., Ulhoi B.P., Kjems J., Borre M., and Orntoft T.F. Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Res. 69 (2009) 4851-4860
16. Mavropoulos A., Devos N., Biemar F., Zecchin E., Argenton F., Edlund H., Motte P., Martial J.A., and Peers B. Sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Dev. Biol. 285 (2005) 211-223
17. Andersen C.L., Christensen L.L., Thorsen K., Schepeler T., Sorensen F.B., Verspaget H.W., Simon R., Kruhoffer M., Aaltonen L.A., Laurberg S., and Orntoft T.F. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br. J. Cancer 100 (2009) 511-523
18. Schilham M.W., Oosterwegel M.A., Moerer P., Ya J., de Boer P.A., van de Wetering M., Verbeek S., Lamers W.H., Kruisbeek A.M., Cumano A., and Clevers H. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature 380 (1996) 711-714
19. Cheung M., Abu-Elmagd M., Clevers H., and Scotting P.J. Roles of Sox4 in central nervous system development. Brain Res. Mol. Brain Res. 79 (2000) 180-191
20. van de Wetering M., Oosterwegel M., van Norren K., and Clevers H. Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J. 12 (1993) 3847-3854