Inhibition of forkhead BoxO-specific transcription prevents mechanical ventilation-induced diaphragm dysfunction

Critical Care Medicine

Volumn 43, Issue 5, 2015, Pages e133-e142

  Smuder, Ashley J ^a   Sollanek, Kurt J ^a   Min, Kisuk ^b   Nelson, W Bradley ^c   Powers, Scott K ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OHIO DOMINICAN UNIVERSITY   (United States)

Author keywords

atrophy; forkhead boxO; proteolysis; respiratory muscles; transcription factor; weaning

Indexed keywords

CASPASE 3; FORKHEAD BOXO PROTEIN; MUSCLE PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR; UBIQUITIN; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, RAT; NERVE PROTEIN;

ADENO ASSOCIATED VIRUS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; AUTOPHAGY; CONTROLLED STUDY; DIAPHRAGM; DIAPHRAGM DISEASE; DIAPHRAGM DYSFUNCTION; DIAPHRAGM MUSCLE; ELECTRON MICROSCOPY; FEMALE; HEART RATE; LYSOSOME; MUSCLE CONTRACTILITY; MUSCLE STRENGTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SYSTOLIC BLOOD PRESSURE; TRANSCRIPTION REGULATION; ULTRASTRUCTURE; YOUNG ADULT; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; HEMODYNAMICS; MUSCLE ATROPHY; MUSCLE CONTRACTION; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; DIAPHRAGM; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HEMODYNAMICS; MUSCLE CONTRACTION; MUSCULAR ATROPHY; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION, ARTIFICIAL; SIGNAL TRANSDUCTION;

EID: 84937560314     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000928     Document Type: Article

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