Is weaning failure caused by low-frequency fatigue of the diaphragm?

American Journal of Respiratory and Critical Care Medicine

Volumn 167, Issue 2, 2003, Pages 120-127

  Laghi, Franco ^a   Cattapan, Steven E ^a   Jubran, Amal ^a   Parthasarathy, Sairam ^a   Warshawsky, Paul ^a   Choi, Yoon Sub A ^a   Tobin, Martin J ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Muscle fatigue; Phrenic nerve; Respiratory insufficiency; Respiratory muscles; Ventilator weaning

Indexed keywords

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; BREATHING MUSCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAPHRAGM; FEMALE; HUMAN; HYPOTHESIS; MALE; MUSCLE FATIGUE; MUSCLE TWITCH; MUSCLE WEAKNESS; NERVE STIMULATION; PHRENIC NERVE; PRESSURE; PRIORITY JOURNAL; THORAX; TREATMENT FAILURE;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; COHORT STUDIES; DIAPHRAGM; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MANOMETRY; MIDDLE AGED; MUSCLE FATIGUE; PHRENIC NERVE; PROBABILITY; RESPIRATION, ARTIFICIAL; RESPIRATORY INSUFFICIENCY; RESPIRATORY MECHANICS; RISK ASSESSMENT; SAMPLING STUDIES; SURVIVAL ANALYSIS; VENTILATOR WEANING; WORK OF BREATHING;

EID: 0037438557     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200210-1246OC     Document Type: Article

References (66)

1. Bellemare F, Grassino A. Effect of pressure and timing of contraction on human diaphragm fatigue. J Appl Physiol 1982;53:1190-1195.
2. Dahlstedt AJ, Katz A, Westerblad H. Role of myoplasmic phosphate in contractile function of skeletal muscle: Studies on creatine kinase-deficient mice. J Physiol 2001;533:379-388.
3. Westerblad H, Lee JA, Lannergren J, Allen DG. Cellular mechanisms of fatigue in skeletal muscle. Am J Physiol 1991;261:C195-C209.
4. Westerblad H, Bruton JD, Lannergren J. The effect of intracellular pH on contractile function of intact, single fibres of mouse muscle declines with increasing temperature. J Physiol 1997;500:193-204.
5. Laghi F, D'Alfonso N, Tobin MJ. Pattern of recovery from diaphragmatic fatigue over 24 hours. J Appl Physiol 1995;79:539-546.
6. Zhu E, Comtois AS, Fang L, Comtois NR, Grassino AE. Influence of tension time on muscle fiber sarcolemmal injury in rat diaphragm. J Appl Physiol 2000;88:135-141.
7. Jiang TX, Reid WD, Road JD. Delayed diaphragm injury and diaphragm force production. Am J Respir Crit Care Med 1998;157:736-742.
8. Mador JM, Rodis A, Diaz J. Diaphragmatic fatigue following voluntary hyperpnea. Am J Respir Crit Care Med 1996;154:63-67.
9. McKenzie DK, Bigland-Ritchie B, Gorman RB, Gandevia SC. Central and peripheral fatigue of human diaphragm and limb muscles assessed by twitch interpolation. J Physiol 1992;454:643-656.
10. Cohen CA, Zagelbaum G, Gross D, Roussos C, Macklem PT. Clinical manifestations of inspiratory muscle fatigue. Am J Med 1982;73:308-316.
11. Brochard L, Harf A, Lorino H, Lemaire F. Inspiratory pressure support prevents diaphragmatic fatigue during weaning from mechanical ventilation. Am Rev Respir Dis 1989;139:513-521.
12. Goldstone JC, Green M, Moxham J. Maximum relaxation rate of the diaphragm during weaning from mechanical ventilation. Thorax 1994;49:54-60.
13. Jubran A, Tobin MJ. Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation. Am J Respir Crit Care Med 1997;155:906-915.
14. Purro A, Appendini L, De Gaetano A, Gudjonsdottir M, Donner CF, Rossi A. Physiologic determinants of ventilator dependence in long-term mechanically ventilated patients. Am J Respir Crit Care Med 2000;161:1115-1123.
15. Vassilakopoulos T, Zakynthinos S, Roussos C. The tension-time index and the frequency/tidal volume ratio are the major pathophysiologic determinants of weaning failure and success. Am J Respir Crit Care Med 1998;158:378-385.
16. Laghi F, Jubran A, Parthasarathy S, Choe W, Segal JM, Tobin MJ. Can patients who fail a trial of weaning develop diaphragmatic fatigue [abstract]? Am J Respir Crit Care Med 2000;161:A790.
17. Cattapan SE, Laghi F, Jubran A, Parthasarathy S, Warshawsky PJ, Tobin MJ. Does respiratory muscle recruitment differ among patients who succeed or fail a trial of weaning from mechanical ventilation [abstract]? Am J Respir Crit Care Med 2002;165:A164.
18. Mador MJ, Magalang UJ, Kufel TJ. Twitch potentiation following voluntary diaphragmatic contraction. Am J Respir Crit Care Med 1994;149:739-743.
19. Marini JJ, Smith TC, Lamb V. Estimation of inspiratory muscle strength in mechanically ventilated patients: The measurement of maximal inspiratory pressure. J Crit Care 1986;1:32-38.
20. Jubran A, Mathru M, Dries D, Tobin MJ. Continuous recordings of mixed venous oxygen saturation during weaning from mechanical ventilation and the ramifications thereof. Am J Respir Crit Care Med 1998;158:1763-1769.
21. Yang KL, Tobin MJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med 1991;324:1445-1450.
22. Topeli A, Laghi F, Tobin MJ. The voluntary drive to breathe is not decreased in hypercapnic patients with severe COPD. Eur Respir J 2001;18:53-60.
23. Laghi F, Harrison MJ, Tobin MJ. Comparison of magnetic and electrical phrenic nerve stimulation in assessment of diaphragmatic contractility. J Appl Physiol 1996;80:1731-1742.
24. Frank NR, Mead J, Ferris BG Jr. The mechanical behavior of the lungs in healthy elderly persons. J Clin Invest 1957;36:1680-1687.
25. Petrol BJ, Legare M, Goldberg P, Milic-Emili J, Gottfried SB. Continuous positive airway pressure reduces work of breathing and dyspnea during weaning from mechanical ventilation in severe chronic obstructive pulmonary disease. Am Rev Respir Dis 1990;141:281-289.
26. Lessard MR, Lofaso F, Brochard L. Expiratory muscle activity increases intrinsic positive end-expiratory pressure independently of dynamic hyperinflation in mechanically ventilated patients. Am J Respir Crit Care Med 1995;151:562-569.
27. Parthasarathy S, Jubran A, Tobin MJ. Cycling of inspiratory and expiratory muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med 1998;158:1471-1478.
28. Barnard PA, Levine S. Critique on application of diaphragmatic time-tension index to spontaneously breathing humans. J Appl Physiol 1986;60:1067-1072.
29. Cattapan SE, Laghi F, Astor TL, Tobin MJ. Can diaphragmatic contractility be assessed by airway twitch pressure in mechanically ventilated patients [abstract]? Am J Respir Crit Care Med 2001;163:A754.
30. Hart N, Nickol AH, Cramer D, Ward SP, Lofaso F, Pride NB, Moxham J, Polkey MI. Effect of severe isolated unilateral and bilateral diaphragm weakness on exercise performance. Am J Respir Crit Care Med 2002;165:1265-1270.
31. Tobin MJ, Laghi F. Monitoring respiratory muscle function. In: Tobin MJ, editor. Principles and Practice of Intensive Care Monitoring. New York: McGraw-Hill; 1998. p. 497-544.
32. Aubier M, Murciano D, Lecocguic Y, Viires N, Pariente R. Bilateral phrenic stimulation: A simple technique to assess diaphragmatic fatigue in humans. J Appl Physiol 1985;58:58-64.
33. Yan S, Similowski T, Gauthier AP, Macklem PT, Bellemare F. Effect of fatigue on diaphragmatic function at different lung volumes. J Appl Physiol 1992;72:1064-1067.
34. Laghi F, Topeli A, Tobin MJ. Does resistive loading decrease diaphragmatic contractility before task failure? J Appl Physiol 1998;85:1103-1112.
35. Mador MJ, Kufel TJ, Pineda LA, Steinwald A, Aggarwal A, Upadhyay AM, Khan MA. Effect of pulmonary rehabilitation on quadriceps fatigability during exercise. Am J Respir Crit Care Med 2001;163:930-935.
36. Nava S, Rubini F, Zanotti E, Caldiroli D. The tension-time index of the diaphragm revisited in quadriplegic patients with diaphragm pacing. Am J Respir Crit Care Med 1996;153:1322-1327.
37. Gauthier GF, Hobbs AW. Effects of denervation on the distribution of myosin isozymes in skeletal muscle fibers. Exp Nettrol 1982;76:331-346.
38. Gandevia SC, Gorman RB, McKenzie DK, Southon FC. Dynamic changes in human diaphragm length: Maximal inspiratory and expulsive efforts studied with sequential radiography. J Physiol 1992;457:167-176.
39. De Troyer A, Peche R, Yernault JC, Estenne M. Neck muscle activity in patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994;150:41-47.
40. Ninane V, Yernault JC, De Troyer A. Intrinsic PEEP in patients with chronic obstructive pulmonary disease: Role of expiratory muscles. Am Rev Respir Dis 1993;148:1037-1042.
41. Laghi F, Jubran A, Topeli A, Fahey PJ, Garrity ER Jr, Arcidi JM, de Pinto DJ, Edwards LC, Tobin MJ. Effect of lung volume reduction surgery on neuromechanical coupling of the diaphragm. Am J Respir Crit Care Med 1998;157:475-483.
42. Estenne M, Derom E, De Troyer A. Neck and abdominal muscle activity in patients with severe thoracic scoliosis. Am J Respir Crit Care Med 1998;158:452-457.
43. Yan S, Sliwinski P, Gauthier AP, Lichros I, Zakynthinos S, Macklem PT. Effect of global inspiratory muscle fatigue on ventilatory and respiratory muscle responses to CO2. J Appl Physiol 1993;75:1371-1377.
44. Celli B, Criner G, Rassulo J. Ventilatory muscle recruitment during unsupported arm exercise in normal subjects. J Appl Physiol 1988;64:1936-1941.
45. Tobin MJ, Perez W, Guenther SM, Semmes BJ, Mador MJ, Allen SJ, Lodato RF, Dantzker DR. The pattern of breathing during successful and unsuccessful trials of weaning from mechanical ventilation. Am Rev Respir Dis 1986;134:1111-1118.
46. Sassoon CS, Mahutte CK. Airway occlusion pressure and breathing pattern as predictors of weaning outcome. Am Rev Respir Dis 1993;148:860-866.
47. Ferguson GT. Effects of oxygenation and hypercapnia on diaphragmatic function and central drive during respiratory failure. J Appl Physiol 1995;78:1764-1771.
48. Sassoon CS, Gruer SE, Sieck GC. Temporal relationships of ventilatory failure, pump failure, and diaphragm fatigue. J Appl Physiol 1996;81:238-245.
49. Davenport PW, Reep RRL. Cerebral cortex and respiration. In: Dempsey JA, Pack AI, editors. Regulation of Breathing. New York: Marcel Dekker; 1995. p. 365-388.
50. Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 2001;81:1725-1789.
51. Scardella AT, Parisi RA, Phair DK, Santiago TV, Edelman NH. The role of endogenous opioids in the ventilatory response to acute flow-resistive loads. Am Rev Respir Dis 1986;133:26-31.
52. Attali V, Mehiri S, Straus C, Salachas F, Arnulf I, Meininger V, Derenne JP, Similowski T. Influence of neck muscles on mouth pressure response to cervical magnetic stimulation. Am J Respir Crit Care Med 1997;156:509-514.
53. 31P-NMR spectroscopy. J Appl Physiol 2000;88:933-938.
54. Topeli A, Laghi F, Tobin MJ. Can diaphragmatic contractility be assessed by twitch airway pressures in patients with chronic obstructive pulmonary disease? Am J Respir Crit Care Med 1999;160:1369-1374.
55. Boczkowski J, Lisdero CL, Lanone S, Samb A, Carreras MC, Boveris A, Aubier M, Poderoso JJ. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia. FASEB J 1999;13:1637-1646.
56. Tawa NE Jr, Odessey R, Goldberg AL. Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles. J Clin Invest 1997;100:197-203.
57. Ebihara S, Hussain SN, Danialou G, Cho WK, Gottfried SB, Petrof BJ. Mechanical ventilation protects against diaphragm injury in sepsis: Interaction of oxidative and mechanical stresses. Am J Respir Crit Care Med 2002;165:221-228.
58. Sassoon CS, Ciaozzo VJ, Manka A, Sieck GC. Altered diaphragm contractile properties with controlled mechanical ventilation. J Appl Physiol 2002;92:2585-2595.
59. Laaban JP, Kouchakji B, Dore MF, Orvoen-Frija E, David P, Rochemaure J. Nutritional status of patients with chronic obstructive pulmonary disease and acute respiratory failure. Chest 1993;103:1362-1368.
60. Ameredes BT, Watchko JF, Daood MJ, Rosas JF, Donahoe MP, Rogers RM. Growth hormone restores aged diaphragm myosin composition and performance after chronic undernutrition. J Appl Physiol 1999;87:1253-1259.
61. Lewis MI, Lorusso TJ, Zhan WZ, Sieck GC. Interactive effects of denervation and malnutrition on diaphragm structure and function. J Appl Physiol 1996;81:2165-2172.
62. Lewis MI, Monn SA, Zhan WZ, Sieck GC. Interactive effects of emphysema and malnutrition on diaphragm structure and function. J Appl Physiol 1994;77:947-955.
63. Aldrich TK, Karpel JP, Uhrlass RM, Sparapani MA, Eramo D, Ferranti R. Weaning from mechanical ventilation: Adjunctive use of inspiratory muscle resistive training. Crit Care Med 1989;17:143-147.
64. Johnson PH, Cowley AJ, Kinnear WJ. A randomized controlled trial of inspiratory muscle training in stable chronic heart failure. Eur Heart J 1998;19:1249-1253.
65. Larson JL, Covey MK, Wirtz SE, Berry JK, Alex CG, Langbein WE, Edwards L. Cycle ergometer and inspiratory muscle training in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;160:500-507.
66. Braun NM, Arora NS, Rochester DF. Respiratory muscle and pulmonary function in polymyositis and other proximal myopathies. Thorax 1983;38:616-623.