HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-α and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2

Journal of Innate Immunity

Volumn 7, Issue 4, 2015, Pages 405-416

  Kwak, Man Sup ^a   Lim, Mihwa ^a,b   Lee, Yong Joon ^a,b   Lee, Hyun Sook ^a,b   Kim, Young Hun ^a,b   Youn, Ju Ho ^a,b   Choi, Ji Eun ^c   Shin, Jeon Soo ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Brain Korea 21 Plus Project for Medical Science   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Gram positive bacteria; HMGB1; Inflammation; Lipoteichoic acid; TLR2

Indexed keywords

CD14 ANTIGEN; HIGH MOBILITY GROUP B1 PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOTEICHOIC ACID; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA; HMGB1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; PROTEIN BINDING; TEICHOIC ACID; TLR2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BACTERIAL CELL WALL; CATALYSIS; CONFOCAL MICROSCOPY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; HEK293 CELL LINE; HUMAN; HUMAN CELL; INFLAMMATION; LUCIFERASE ASSAY; MACROPHAGE; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LIPID INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; UPREGULATION; GENETICS; IMMUNOLOGY; METABOLISM;

ANTIGENS, CD14; HEK293 CELLS; HMGB1 PROTEIN; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; PROTEIN BINDING; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84937525964     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000369972     Document Type: Article

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