New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4815-4823

  Zhang, Yu ^a   Liu, Bin ^b   Wu, Xingyu ^a   Lei, Ridong ^a,b   Ning, Xianling ^a   Liu, Yu ^a   Liu, Zhenming ^b   Ge, Zemei ^b   Li, Runtao ^b   Yin, Yuxin ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Anti proliferation; Dithiocarbamic acid ester; Docking; Pyruvate kinase M2; Structure activity relationship

Indexed keywords

3 (1H INDOL 3 YL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (2 CHLOROPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (2 METHOXYPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (3,4 DICHLOROPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (3,4 DIFLUOROPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 (BENZYLOXY)PHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 (DIMETHYLAMINO)PHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 CHLOROPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 CYANOPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 FLUOROPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 HYDROXYPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 METHOXYPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (4 NITROPHENYL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (FURAN 2 YL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (NAPHTHALEN 1 YL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 (NAPHTHALEN 2 YL) 3 OXOPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 ((1H PYRROLO[2,3 B]PYRIDIN 3 YL)PROPYLPYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (1H PYRROL 2 YL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (2 OXO 2H CHROMEN 3 YL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (3,4,5 TRIMETHOXYPHENYL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (4 (TRIFLUOROMETHYL)PHENYL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (PYRIDIN 3 YL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (THIAZOL 2 YL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 (THIOPHEN 2 YL)PROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; 3 OXO 3 PHENYLPROPYL(PYRIDIN 3 YLMETHYL)CARBAMODITHIOATE; ANTINEOPLASTIC AGENT; ENZYME ACTIVATOR; PYRUVATE KINASE; PYRUVATE KINASE M2; UNCLASSIFIED DRUG; UNINDEXED DRUG; ESTER; ISOPROTEIN; THIOCARBAMIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; H1299 CELL LINE; HCT116 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER CELL LINE; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; ESTERS; G2 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MOLECULAR DOCKING SIMULATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PYRUVATE KINASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

EID: 84937516660     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.05.041     Document Type: Article

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