2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6322-6327

  Walsh, Martin J ^a   Brimacombe, Kyle R ^a   Veith, Henrike ^a   Bougie, James M ^a   Daniel, Thomas ^a   Leister, William ^a   Cantley, Lewis C ^b,c   Israelsen, William J ^d   Vander Heiden, Matthew G ^d,e   Shen, Min ^a   Auld, Douglas S ^a,f   Thomas, Craig J ^a   Boxer, Matthew B ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Anti cancer strategies; Cellular metabolism; PKM2; Pyruvate kinase; Small molecule activators

Indexed keywords

1,2,3,4 TETRAHYDROQUINOLINE DERIVATIVE; 2 OXO N ARYL 1,2,3,4 TETRAHYDROQUINOLINE 6 SULFONAMIDE DERIVATIVE; 3 OXO 3,4 DIHYDRO 2H BENZ[B][1,4]OXAZINE 7 SULFONAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; ISOPROTEIN; NCGC 00185916; NCGC 00185939; NCGC 00186527; PYRUVATE KINASE; PYRUVATE KINASE M2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIVER MICROSOME; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUZUKI REACTION; TUMOR CELL DESTRUCTION;

EID: 80054781436     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.114     Document Type: Article

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