Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3420-3427

  Zhou, Wen ^a   Zhang, Xu ^a   Xiao, Ling ^b   Ding, Jing ^a   Liu, Quan Hua ^b   Li, Shao Shun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

Antitumor activity; Positional isomer; Semi synthesis; Shikonin derivatives; Structure activity relationship

Indexed keywords

1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 ETHYLPENT 3 ENYL ACETATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 2 (4 METHOXYPHENYL)ACETATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 2 HYDROXY 2 METHYLPROPANOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 2 METHOXYBENZOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 3 (3,4 DIMETHOXYPHENYL)ACRYLATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 3 PHENYLPROPANOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 4 METHOXYBENZOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL 4 NITROBENZOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL BENZOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL BUT 2 ENOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL BUTYRATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL CINNAMATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL FURAN 2 CARBOXYLATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL FURAN 3 CARBOXYLATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL ISOBUTYRATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL ISONICOTINATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL METHYLBUTANOATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL NICOTINATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL PROPIONATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL TETRAHYDROFURAN 2 CARBOXYLATE; 1 (1,4 DIHYDRO 5,8 DIMETHOXY 1,4 DIOXONAPHTHALEN 6 YL) 4 METHYLPENT 3 ENYL TETRAHYDROFURAN 3 CARBOXYLATE; 5, 8 O DIMETHYLACYLSHIKONIN DERIVATIVE; 5,8 DIMETHOXY 1,4 NAPHTHOQUINONE; ANTINEOPLASTIC AGENT; FLUOROURACIL; SHIKONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; MOUSE; NONHUMAN; SARCOMA; STRUCTURE ACTIVITY RELATION;

ACYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FIBROBLASTS; HUMANS; INHIBITORY CONCENTRATION 50; ISOMERISM; MALE; MICE; NAPHTHOQUINONES; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 80955179555     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.006     Document Type: Article

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