메뉴 건너뛰기




Volumn 68, Issue 2, 2015, Pages 267-279

A Systematic Review of Immunotherapy in Urologic Cancer: Evolving Roles for Targeting of CTLA-4, PD-1/PD-L1, and HLA-G

Author keywords

Cancer immunotherapy; Checkpoint; CTLA 4; HLA G; Monoclonal antibodies; PD 1

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA G ANTIGEN; IPILIMUMAB; NIVOLUMAB; PLACEBO; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; SUNITINIB; TICILIMUMAB; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN;

EID: 84937516588     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2015.02.032     Document Type: Review
Times cited : (198)

References (75)
  • 1
    • 0036669785 scopus 로고    scopus 로고
    • The interaction properties of costimulatory molecules revisited
    • A.V. Collins, D.W. Brodie, R.J.C. Gilbert, and et al. The interaction properties of costimulatory molecules revisited Immunity 17 2002 201 210
    • (2002) Immunity , vol.17 , pp. 201-210
    • Collins, A.V.1    Brodie, D.W.2    Gilbert, R.J.C.3
  • 2
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • C.E. Rudd, A. Taylor, and H. Schneider CD28 and CTLA-4 coreceptor expression and signal transduction Immunol Rev 229 2009 12 26
    • (2009) Immunol Rev , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 6
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • A.A. Hurwitz, B.A. Foster, E.D. Kwon, and et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade Cancer Res 60 2000 2444 2448
    • (2000) Cancer Res , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1    Foster, B.A.2    Kwon, E.D.3
  • 7
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • S. Demaria, N. Kawashima, A.M. Yang, and et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer Clin Cancer Res 11 2005 728 734
    • (2005) Clin Cancer Res , vol.11 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 8
    • 84875689651 scopus 로고    scopus 로고
    • Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer
    • S. Wada, C.M. Jackson, K. Yoshimura, and et al. Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer J Transl Med 11 2013 89
    • (2013) J Transl Med , vol.11 , pp. 89
    • Wada, S.1    Jackson, C.M.2    Yoshimura, K.3
  • 9
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase I/II study
    • S.F. Slovin, C.S. Higano, O. Hamid, and et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study Ann Oncol 24 2013 1813 1821
    • (2013) Ann Oncol , vol.24 , pp. 1813-1821
    • Slovin, S.F.1    Higano, C.S.2    Hamid, O.3
  • 10
    • 34250223096 scopus 로고    scopus 로고
    • A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
    • E.J. Small, N.S. Tchekmedyian, B.I. Rini, L. Fong, I. Lowy, and J.P. Allison A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer Clin Cancer Res 13 2007 1810 1815
    • (2007) Clin Cancer Res , vol.13 , pp. 1810-1815
    • Small, E.J.1    Tchekmedyian, N.S.2    Rini, B.I.3    Fong, L.4    Lowy, I.5    Allison, J.P.6
  • 11
    • 58349090027 scopus 로고    scopus 로고
    • Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
    • L. Fong, S.S. Kwek, S. O'Brien, and et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF Cancer Res 69 2009 609 615
    • (2009) Cancer Res , vol.69 , pp. 609-615
    • Fong, L.1    Kwek, S.S.2    O'Brien, S.3
  • 12
    • 84860455345 scopus 로고    scopus 로고
    • Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
    • R.A. Madan, M. Mohebtash, P.M. Arlen, and et al. Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial Lancet Oncol 13 2012 501 508
    • (2012) Lancet Oncol , vol.13 , pp. 501-508
    • Madan, R.A.1    Mohebtash, M.2    Arlen, P.M.3
  • 13
    • 84896489380 scopus 로고    scopus 로고
    • A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: Immune correlates
    • C. Jochems, J.A. Tucker, K.Y. Tsang, and et al. A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates Cancer Immunol Immunother 63 2014 407 418
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 407-418
    • Jochems, C.1    Tucker, J.A.2    Tsang, K.Y.3
  • 14
    • 84860436621 scopus 로고    scopus 로고
    • Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
    • A.J.M. van den Eertwegh, J. Versluis, H.P. van den Berg, and et al. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial Lancet Oncol 13 2012 509 517
    • (2012) Lancet Oncol , vol.13 , pp. 509-517
    • Van Den Eertwegh, A.J.M.1    Versluis, J.2    Van Den Berg, H.P.3
  • 15
    • 84874116175 scopus 로고    scopus 로고
    • + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment
    • + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment Cancer Immunol Immunother 62 2013 245 256
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 245-256
    • Santegoets, S.A.M.1    Stam, A.M.2    Lougheed, S.3
  • 16
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
    • E.D. Kwon, C.G. Drake, H.I. Scher, and et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial Lancet Oncol 15 2014 700 712
    • (2014) Lancet Oncol , vol.15 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3
  • 17
    • 84862754605 scopus 로고    scopus 로고
    • Phase i trial of tremelimumab in combination with short-term androgen deprivation in patients with PSA-recurrent prostate cancer
    • D.G. McNeel, H.A. Smith, J.C. Eickhoff, and et al. Phase I trial of tremelimumab in combination with short-term androgen deprivation in patients with PSA-recurrent prostate cancer Cancer Immunol Immunother 61 2012 1137 1147
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1137-1147
    • McNeel, D.G.1    Smith, H.A.2    Eickhoff, J.C.3
  • 18
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • J.C. Yang, M. Hughes, U. Kammula, and et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis J Immunother 30 2007 825 830
    • (2007) J Immunother , vol.30 , pp. 825-830
    • Yang, J.C.1    Hughes, M.2    Kammula, U.3
  • 19
    • 27444440093 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
    • J.A. Blansfield, K.E. Beck, K. Tran, and et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer J Immunother 28 2005 593 598
    • (2005) J Immunother , vol.28 , pp. 593-598
    • Blansfield, J.A.1    Beck, K.E.2    Tran, K.3
  • 20
    • 79551717184 scopus 로고    scopus 로고
    • Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
    • B.I. Rini, M. Stein, P. Shannon, and et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma Cancer 117 2011 758 767
    • (2011) Cancer , vol.117 , pp. 758-767
    • Rini, B.I.1    Stein, M.2    Shannon, P.3
  • 21
    • 84899091409 scopus 로고    scopus 로고
    • Association between the cytotoxic T-lymphocyte antigen 4 +49A/G polymorphism and bladder cancer risk
    • L. Wang, G. Su, X. Zhao, and et al. Association between the cytotoxic T-lymphocyte antigen 4 +49A/G polymorphism and bladder cancer risk Tumour Biol 35 2014 1139 1142
    • (2014) Tumour Biol , vol.35 , pp. 1139-1142
    • Wang, L.1    Su, G.2    Zhao, X.3
  • 22
    • 77952337834 scopus 로고    scopus 로고
    • Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
    • B.C. Carthon, J.D. Wolchok, J. Yuan, and et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial Clin Cancer Res 16 2010 2861 2871
    • (2010) Clin Cancer Res , vol.16 , pp. 2861-2871
    • Carthon, B.C.1    Wolchok, J.D.2    Yuan, J.3
  • 23
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • G.J. Freeman, A.J. Long, Y. Iwai, and et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation J Exp Med 192 2000 1027 1034
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 24
    • 0035794314 scopus 로고    scopus 로고
    • B7-Dc, a New dendritic cell molecule with potent costimulatory properties for T cells
    • S.-Y. Tseng, M. Otsuji, K. Gorski, and et al. B7-Dc, a New dendritic cell molecule with potent costimulatory properties for T cells J Exp Med 193 2001 839 846
    • (2001) J Exp Med , vol.193 , pp. 839-846
    • Tseng, S.-Y.1    Otsuji, M.2    Gorski, K.3
  • 25
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Y. Ishida, Y. Agata, K. Shibahara, and T. Honjo Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death EMBO J 11 1992 3887 3895
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 27
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • H. Dong, S.E. Strome, D.R. Salomao, and et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion Nat Med 8 2002 793 800
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 28
    • 84887862839 scopus 로고    scopus 로고
    • A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
    • T. Okazaki, S. Chikuma, Y. Iwai, S. Fagarasan, and T. Honjo A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application Nat Immunol 14 2013 1212 1218
    • (2013) Nat Immunol , vol.14 , pp. 1212-1218
    • Okazaki, T.1    Chikuma, S.2    Iwai, Y.3    Fagarasan, S.4    Honjo, T.5
  • 29
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • S.L. Topalian, F.S. Hodi, J.R. Brahmer, and et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N Engl J Med 366 2012 2443 2454
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 31
    • 0029788698 scopus 로고    scopus 로고
    • Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10
    • I. Roth, D.B. Corry, R.M. Locksley, J.S. Abrams, M.J. Litton, and S.J. Fisher Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10 J Exp Med 184 1996 539 548
    • (1996) J Exp Med , vol.184 , pp. 539-548
    • Roth, I.1    Corry, D.B.2    Locksley, R.M.3    Abrams, J.S.4    Litton, M.J.5    Fisher, S.J.6
  • 32
    • 84879601217 scopus 로고    scopus 로고
    • Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer
    • P.A. Tang, and D.Y. Heng Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer Curr Oncol Rep 15 2013 98 104
    • (2013) Curr Oncol Rep , vol.15 , pp. 98-104
    • Tang, P.A.1    Heng, D.Y.2
  • 33
    • 33846852187 scopus 로고    scopus 로고
    • Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy
    • 709s-15s
    • R.H. Thompson, H. Dong, and E.D. Kwon Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy Clin Cancer Res 13 2007 709s-15s
    • (2007) Clin Cancer Res , vol.13
    • Thompson, R.H.1    Dong, H.2    Kwon, E.D.3
  • 34
    • 34250209885 scopus 로고    scopus 로고
    • Survivin and B7-H1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma
    • A.E. Krambeck, H. Dong, R.H. Thompson, and et al. Survivin and B7-H1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma Clin Cancer Res 13 2007 1749 1756
    • (2007) Clin Cancer Res , vol.13 , pp. 1749-1756
    • Krambeck, A.E.1    Dong, H.2    Thompson, R.H.3
  • 35
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • J.R. Brahmer, C.G. Drake, I. Wollner, and et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates J Clin Oncol 28 2010 3167 3175
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 36
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • J.R. Brahmer, S.S. Tykodi, L.Q. Chow, and et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer N Engl J Med 366 2012 2455 2465
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 37
    • 84880264878 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC)
    • D.C. Cho, J.A. Sosman, M. Sznol, and et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC) ASCO Meeting Abstr 31 2013 4505
    • (2013) ASCO Meeting Abstr , vol.31 , pp. 4505
    • Cho, D.C.1    Sosman, J.A.2    Sznol, M.3
  • 38
    • 84963672325 scopus 로고    scopus 로고
    • Randomized, dose-ranging phase II trial of nivolumab for metastatic renal cell carcinoma
    • R.J. Motzer, B.I. Rini, D.F. McDermott, and et al. Randomized, dose-ranging phase II trial of nivolumab for metastatic renal cell carcinoma Ann Oncol 25 Suppl 4 2014 iv281
    • (2014) Ann Oncol , vol.25 , pp. iv281
    • Motzer, R.J.1    Rini, B.I.2    McDermott, D.F.3
  • 39
    • 85019463007 scopus 로고    scopus 로고
    • Nivolumab in combination with sunitinib or pazopanib in patients with metastatic renal cell carcinoma
    • iv362-3
    • A. Amin, E.R. Plimack, J.R. Infante, and et al. Nivolumab in combination with sunitinib or pazopanib in patients with metastatic renal cell carcinoma Ann Oncol 25 Suppl 4 2014 iv362-3
    • (2014) Ann Oncol , vol.25
    • Amin, A.1    Plimack, E.R.2    Infante, J.R.3
  • 40
    • 84925969185 scopus 로고    scopus 로고
    • Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib: Results from COMPARZ, a randomized controlled trial
    • T.K. Choueiri, D.J. Figueroa, A.P. Fay, and et al. Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib: results from COMPARZ, a randomized controlled trial Clin Cancer Res 21 2015 1071 1077
    • (2015) Clin Cancer Res , vol.21 , pp. 1071-1077
    • Choueiri, T.K.1    Figueroa, D.J.2    Fay, A.P.3
  • 41
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • R.S. Herbst, J.-C. Soria, M. Kowanetz, and et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature 515 2014 563 567
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.-C.2    Kowanetz, M.3
  • 42
    • 34248586083 scopus 로고    scopus 로고
    • Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
    • J. Nakanishi, Y. Wada, K. Matsumoto, M. Azuma, K. Kikuchi, and S. Ueda Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers Cancer Immunol Immunother 56 2007 1173 1182
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1173-1182
    • Nakanishi, J.1    Wada, Y.2    Matsumoto, K.3    Azuma, M.4    Kikuchi, K.5    Ueda, S.6
  • 43
    • 34247113727 scopus 로고    scopus 로고
    • PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: Associations with localized stage progression
    • B.A. Inman, T.J. Sebo, X. Frigola, and et al. PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression Cancer 109 2007 1499 1505
    • (2007) Cancer , vol.109 , pp. 1499-1505
    • Inman, B.A.1    Sebo, T.J.2    Frigola, X.3
  • 44
    • 84892544676 scopus 로고    scopus 로고
    • Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder
    • E. Xylinas, B.D. Robinson, L.A. Kluth, and et al. Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder Eur J Surg Oncol 40 2014 121 127
    • (2014) Eur J Surg Oncol , vol.40 , pp. 121-127
    • Xylinas, E.1    Robinson, B.D.2    Kluth, L.A.3
  • 45
    • 51049096135 scopus 로고    scopus 로고
    • T-cell coregulatory molecule expression in urothelial cell carcinoma: Clinicopathologic correlations and association with survival
    • S.A. Boorjian, Y. Sheinin, P.L. Crispen, and et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival Clin Cancer Res 14 2008 4800 4808
    • (2008) Clin Cancer Res , vol.14 , pp. 4800-4808
    • Boorjian, S.A.1    Sheinin, Y.2    Crispen, P.L.3
  • 46
    • 84928637112 scopus 로고    scopus 로고
    • A phase Ib study of pembrolizumab in patients with advanced urothelial tract cancer
    • E.R. Plimack, S. Gupta, J. Bellmunt, and et al. A phase Ib study of pembrolizumab in patients with advanced urothelial tract cancer Ann Oncol 25 Suppl 4 2014 mdu438.24
    • (2014) Ann Oncol , vol.25 , pp. mdu43824
    • Plimack, E.R.1    Gupta, S.2    Bellmunt, J.3
  • 47
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3208a leads to clinical activity in patients with metastatic urothelial bladder cancer
    • J. Bellmunt, D.P. Petrylak, T. Powles, and et al. Inhibition of PD-L1 by MPDL3208a leads to clinical activity in patients with metastatic urothelial bladder cancer Ann Oncol 25 Suppl 4 2014 iv280
    • (2014) Ann Oncol , vol.25 , pp. iv280
    • Bellmunt, J.1    Petrylak, D.P.2    Powles, T.3
  • 48
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • T. Powles, J.P. Eder, G.D. Fine, and et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer Nature 515 2014 558 562
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 49
    • 46749123555 scopus 로고    scopus 로고
    • Beyond the increasing complexity of the immunomodulatory HLA-G molecule
    • E.D. Carosella, B. Favier, N. Rouas-Freiss, P. Moreau, and J. Lemaoult Beyond the increasing complexity of the immunomodulatory HLA-G molecule Blood 111 2008 4862 4870
    • (2008) Blood , vol.111 , pp. 4862-4870
    • Carosella, E.D.1    Favier, B.2    Rouas-Freiss, N.3    Moreau, P.4    LeMaoult, J.5
  • 50
    • 84055218980 scopus 로고    scopus 로고
    • The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells
    • E.D. Carosella, S. Gregori, and J. LeMaoult The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells Blood 118 2011 6499 6505
    • (2011) Blood , vol.118 , pp. 6499-6505
    • Carosella, E.D.1    Gregori, S.2    LeMaoult, J.3
  • 53
    • 84860223684 scopus 로고    scopus 로고
    • HLA-G expression is associated with metastasis and poor survival in the Balb/c nu/nu murine tumor model with ovarian cancer
    • A. Lin, X. Zhang, H.H. Xu, D.P. Xu, Y.Y. Ruan, and W.H. Yan HLA-G expression is associated with metastasis and poor survival in the Balb/c nu/nu murine tumor model with ovarian cancer Int J Cancer 131 2012 150 157
    • (2012) Int J Cancer , vol.131 , pp. 150-157
    • Lin, A.1    Zhang, X.2    Xu, H.H.3    Xu, D.P.4    Ruan, Y.Y.5    Yan, W.H.6
  • 54
    • 68249127418 scopus 로고    scopus 로고
    • Characterization of HLA-G expression in renal cell carcinoma
    • B.L. Li, A. Lin, X.J. Zhang, and et al. Characterization of HLA-G expression in renal cell carcinoma Tissue Antigens 74 2009 213 221
    • (2009) Tissue Antigens , vol.74 , pp. 213-221
    • Li, B.L.1    Lin, A.2    Zhang, X.J.3
  • 55
    • 0043175315 scopus 로고    scopus 로고
    • Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma
    • J. Bukur, V. Rebmann, H. Grosse-Wilde, and et al. Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma Cancer Res 63 2003 4107 4111
    • (2003) Cancer Res , vol.63 , pp. 4107-4111
    • Bukur, J.1    Rebmann, V.2    Grosse-Wilde, H.3
  • 57
    • 77956010189 scopus 로고    scopus 로고
    • Tumor-specific upregulation of human leukocyte antigen-G expression in bladder transitional cell carcinoma
    • L.H. Gan, L.F. Huang, X. Zhang, and et al. Tumor-specific upregulation of human leukocyte antigen-G expression in bladder transitional cell carcinoma Hum Immunol 71 2010 899 904
    • (2010) Hum Immunol , vol.71 , pp. 899-904
    • Gan, L.H.1    Huang, L.F.2    Zhang, X.3
  • 58
    • 84898001946 scopus 로고    scopus 로고
    • B7-H3-mediated tumor immunology: Friend or foe?
    • L. Wang, F.-B. Kang, and B.-E. Shan B7-H3-mediated tumor immunology: friend or foe? Int J Cancer 134 2014 2764 2771
    • (2014) Int J Cancer , vol.134 , pp. 2764-2771
    • Wang, L.1    Kang, F.-B.2    Shan, B.-E.3
  • 59
    • 84886948036 scopus 로고    scopus 로고
    • B7 family checkpoint regulators in immune regulation and disease
    • S. Ceeraz, E.C. Nowak, and R.J. Noelle B7 family checkpoint regulators in immune regulation and disease Trends Immunol 34 2013 556 563
    • (2013) Trends Immunol , vol.34 , pp. 556-563
    • Ceeraz, S.1    Nowak, E.C.2    Noelle, R.J.3
  • 60
    • 77958067744 scopus 로고    scopus 로고
    • Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
    • J. Jiang, Y. Zhu, C. Wu, and et al. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer Cancer Immunol Immunother 59 2010 1707 1714
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1707-1714
    • Jiang, J.1    Zhu, Y.2    Wu, C.3
  • 61
    • 33745886516 scopus 로고    scopus 로고
    • B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival
    • A.E. Krambeck, R.H. Thompson, H. Dong, and et al. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival Proc Natl Acad Sci U S A 103 2006 10391 10396
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10391-10396
    • Krambeck, A.E.1    Thompson, R.H.2    Dong, H.3
  • 62
    • 16344391363 scopus 로고    scopus 로고
    • B7-H4 is highly expressed in ductal and lobular breast cancer
    • B. Tringler, S. Zhuo, G. Pilkington, and et al. B7-H4 is highly expressed in ductal and lobular breast cancer Clin Cancer Res 11 2005 1842 1848
    • (2005) Clin Cancer Res , vol.11 , pp. 1842-1848
    • Tringler, B.1    Zhuo, S.2    Pilkington, G.3
  • 63
    • 84864458660 scopus 로고    scopus 로고
    • Coinhibitory molecules in hematologic malignancies: Targets for therapeutic intervention
    • W.J. Norde, W. Hobo, R. van der Voort, and H. Dolstra Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention Blood 120 2012 728 736
    • (2012) Blood , vol.120 , pp. 728-736
    • Norde, W.J.1    Hobo, W.2    Van Der Voort, R.3    Dolstra, H.4
  • 64
    • 80155127321 scopus 로고    scopus 로고
    • Prospects for TIM3-targeted antitumor immunotherapy
    • S.F. Ngiow, M.W.L. Teng, and M.J. Smyth Prospects for TIM3-targeted antitumor immunotherapy Cancer Res 71 2011 6567 6571
    • (2011) Cancer Res , vol.71 , pp. 6567-6571
    • Ngiow, S.F.1    Teng, M.W.L.2    Smyth, M.J.3
  • 65
    • 84864299061 scopus 로고    scopus 로고
    • Is the clinical malignant phenotype of prostate cancer a result of a highly proliferative immune-evasive B7-H3-expressing cell population?
    • Y. Liu, L. Vlatkovic, T. Saeter, and et al. Is the clinical malignant phenotype of prostate cancer a result of a highly proliferative immune-evasive B7-H3-expressing cell population? Int J Urol 19 2012 749 756
    • (2012) Int J Urol , vol.19 , pp. 749-756
    • Liu, Y.1    Vlatkovic, L.2    Saeter, T.3
  • 66
    • 80051550965 scopus 로고    scopus 로고
    • B7-H3 over expression in prostate cancer promotes tumor cell progression
    • H. Yuan, X. Wei, G. Zhang, C. Li, X. Zhang, and J. Hou B7-H3 over expression in prostate cancer promotes tumor cell progression J Urol 186 2011 1093 1099
    • (2011) J Urol , vol.186 , pp. 1093-1099
    • Yuan, H.1    Wei, X.2    Zhang, G.3    Li, C.4    Zhang, X.5    Hou, J.6
  • 67
    • 79952703623 scopus 로고    scopus 로고
    • Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer
    • A.S. Parker, M.G. Heckman, Y. Sheinin, and et al. Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer Int J Radiat Oncol Biol Phys 79 2011 1343 1349
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 1343-1349
    • Parker, A.S.1    Heckman, M.G.2    Sheinin, Y.3
  • 68
    • 34548046956 scopus 로고    scopus 로고
    • B7-H3 ligand expression by prostate cancer: A novel marker of prognosis and potential target for therapy
    • T.J. Roth, Y. Sheinin, C.M. Lohse, and et al. B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy Cancer Res 67 2007 7893 7900
    • (2007) Cancer Res , vol.67 , pp. 7893-7900
    • Roth, T.J.1    Sheinin, Y.2    Lohse, C.M.3
  • 69
    • 70349669259 scopus 로고    scopus 로고
    • A phase i pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
    • C. Brignone, B. Escudier, C. Grygar, M. Marcu, and F. Triebel A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma Clin Cancer Res 15 2009 6225 6231
    • (2009) Clin Cancer Res , vol.15 , pp. 6225-6231
    • Brignone, C.1    Escudier, B.2    Grygar, C.3    Marcu, M.4    Triebel, F.5
  • 70
    • 84888164273 scopus 로고    scopus 로고
    • B7-H3 is a new cancer-specific endothelial marker in clear cell renal cell carcinoma
    • X. Qin, H. Zhang, D. Ye, B. Dai, Y. Zhu, and G. Shi B7-H3 is a new cancer-specific endothelial marker in clear cell renal cell carcinoma Onco Targets Ther 6 2013 1667 1673
    • (2013) Onco Targets Ther , vol.6 , pp. 1667-1673
    • Qin, X.1    Zhang, H.2    Ye, D.3    Dai, B.4    Zhu, Y.5    Shi, G.6
  • 71
    • 52649160243 scopus 로고    scopus 로고
    • Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma
    • P.L. Crispen, Y. Sheinin, T.J. Roth, and et al. Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma Clin Cancer Res 14 2008 5150 5157
    • (2008) Clin Cancer Res , vol.14 , pp. 5150-5157
    • Crispen, P.L.1    Sheinin, Y.2    Roth, T.J.3
  • 72
    • 33744792341 scopus 로고    scopus 로고
    • Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    • K.E. Beck, J.A. Blansfield, K.Q. Tran, and et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4 J Clin Oncol 24 2006 2283 2289
    • (2006) J Clin Oncol , vol.24 , pp. 2283-2289
    • Beck, K.E.1    Blansfield, J.A.2    Tran, K.Q.3
  • 73
    • 84903208336 scopus 로고    scopus 로고
    • PD-1 pathway inhibitors: Changing the landscape of cancer immunotherapy
    • D.E. Dolan, and S. Gupta PD-1 pathway inhibitors: changing the landscape of cancer immunotherapy Cancer Control 21 2014 231 237
    • (2014) Cancer Control , vol.21 , pp. 231-237
    • Dolan, D.E.1    Gupta, S.2
  • 74
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • J.D. Wolchok, H. Kluger, M.K. Callahan, and et al. Nivolumab plus ipilimumab in advanced melanoma N Engl J Med 369 2013 122 133
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 75
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • M.A. Curran, W. Montalvo, H. Yagita, and J.P. Allison PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors Proc Natl Acad Sci U S A 107 2010 4275 4280
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.