-
1
-
-
40949149451
-
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells
-
Akao Y, Itoh T, Ohguchi K, Iinuma M, Nozawa Y, (2008). Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. Bioorg Med Chem 16: 2803-2810.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 2803-2810
-
-
Akao, Y.1
Itoh, T.2
Ohguchi, K.3
Iinuma, M.4
Nozawa, Y.5
-
2
-
-
84890540333
-
The Concise Guide to PHARMACOLOGY 2013/14: Catalytic receptors
-
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013a). The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors. Br J Pharmacol 170: 1676-1705.
-
(2013)
Br J Pharmacol
, vol.170
, pp. 1676-1705
-
-
Alexander, S.P.H.1
Benson, H.E.2
Faccenda, E.3
Pawson, A.J.4
Sharman, J.L.5
Spedding, M.6
-
3
-
-
84890472386
-
The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
-
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013b). The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol 170: 1797-1867.
-
(2013)
Br J Pharmacol
, vol.170
, pp. 1797-1867
-
-
Alexander, S.P.H.1
Benson, H.E.2
Faccenda, E.3
Pawson, A.J.4
Sharman, J.L.5
Spedding, M.6
-
4
-
-
46249128327
-
Future innovations in anti-platelet therapies
-
Barrett NE, Holbrook L, Jones S, Kaiser WJ, Moraes LA, Rana R, et al. (2008). Future innovations in anti-platelet therapies. Br J Pharmacol 154: 918-939.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 918-939
-
-
Barrett, N.E.1
Holbrook, L.2
Jones, S.3
Kaiser, W.J.4
Moraes, L.A.5
Rana, R.6
-
5
-
-
50449111165
-
Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity
-
Benavente-Garcia O, Castillo J, (2008). Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 56: 6185-6205.
-
(2008)
J Agric Food Chem
, vol.56
, pp. 6185-6205
-
-
Benavente-Garcia, O.1
Castillo, J.2
-
6
-
-
0642363623
-
Uses and properties of citrus flavonoids
-
Benavente-Garcbox drawings light down and left'a OCJ, Marin FR, Ortun A, Del Rbox drawings light down and left'o JA, (1997). Uses and properties of citrus flavonoids. J Agric Food Chem 45: 4505-4515.
-
(1997)
J Agric Food Chem
, vol.45
, pp. 4505-4515
-
-
Marin, F.R.1
Ortun, A.2
-
7
-
-
0028303913
-
CAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets
-
Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, et al. (1994). cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. J Biol Chem 269: 14509-14517.
-
(1994)
J Biol Chem
, vol.269
, pp. 14509-14517
-
-
Butt, E.1
Abel, K.2
Krieger, M.3
Palm, D.4
Hoppe, V.5
Hoppe, J.6
-
8
-
-
1442331993
-
Integrin activation
-
Calderwood DA, (2004). Integrin activation. J Cell Sci 117: 657-666.
-
(2004)
J Cell Sci
, vol.117
, pp. 657-666
-
-
Calderwood, D.A.1
-
9
-
-
84902243803
-
Antiproliferative and apoptosis-inducing activity of nobiletin against three subtypes of human breast cancer cell lines
-
Chen C, Ono M, Takeshima M, Nakano S, (2014). Antiproliferative and apoptosis-inducing activity of nobiletin against three subtypes of human breast cancer cell lines. Anticancer Res 34: 1785-1792.
-
(2014)
Anticancer Res
, vol.34
, pp. 1785-1792
-
-
Chen, C.1
Ono, M.2
Takeshima, M.3
Nakano, S.4
-
10
-
-
79955664087
-
Mammalian cyclic nucleotide phosphodiesterases: Molecular mechanisms and physiological functions
-
Francis SH, Blount MA, Corbin JD, (2011). Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. Physiol Rev 91: 651-690.
-
(2011)
Physiol Rev
, vol.91
, pp. 651-690
-
-
Francis, S.H.1
Blount, M.A.2
Corbin, J.D.3
-
11
-
-
0035849516
-
Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release
-
Freedman JE, Parker C 3rd, Li L, Perlman JA, Frei B, Ivanov V, et al. (2001). Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103: 2792-2798.
-
(2001)
Circulation
, vol.103
, pp. 2792-2798
-
-
Freedman, J.E.1
Parker, C.2
Li, L.3
Perlman, J.A.4
Frei, B.5
Ivanov, V.6
-
12
-
-
0035011368
-
Inhibitors of platelet signal transduction as anti-aggregatory drugs
-
Geiger J, (2001). Inhibitors of platelet signal transduction as anti-aggregatory drugs. Expert Opin Investig Drugs 10: 865-890.
-
(2001)
Expert Opin Investig Drugs
, vol.10
, pp. 865-890
-
-
Geiger, J.1
-
13
-
-
4444260266
-
Platelet adhesion signalling and the regulation of thrombus formation
-
Gibbins JM, (2004). Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci 117: 3415-3425.
-
(2004)
J Cell Sci
, vol.117
, pp. 3415-3425
-
-
Gibbins, J.M.1
-
14
-
-
0018376096
-
Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity
-
Hathaway DR, Adelstein RS, (1979). Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity. Proc Natl Acad Sci U S A 76: 1653-1657.
-
(1979)
Proc Natl Acad Sci U S A
, vol.76
, pp. 1653-1657
-
-
Hathaway, D.R.1
Adelstein, R.S.2
-
15
-
-
84857892715
-
Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: A systematic review and meta-analysis of randomized trials
-
Hooper L, Kay C, Abdelhamid A, Kroon PA, Cohn JS, Rimm EB, et al. (2012). Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 95: 740-751.
-
(2012)
Am J Clin Nutr
, vol.95
, pp. 740-751
-
-
Hooper, L.1
Kay, C.2
Abdelhamid, A.3
Kroon, P.A.4
Cohn, J.S.5
Rimm, E.B.6
-
16
-
-
2442543550
-
Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway
-
Hubbard GP, Stevens JM, Cicmil M, Sage T, Jordan PA, Williams CM, et al. (2003). Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. J Thromb Haemost 1: 1079-1088.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1079-1088
-
-
Hubbard, G.P.1
Stevens, J.M.2
Cicmil, M.3
Sage, T.4
Jordan, P.A.5
Williams, C.M.6
-
17
-
-
13244275108
-
Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans
-
Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM, (2004). Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. J Thromb Haemost 2: 2138-2145.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 2138-2145
-
-
Hubbard, G.P.1
Wolffram, S.2
Lovegrove, J.A.3
Gibbins, J.M.4
-
18
-
-
33750096668
-
Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: A pilot study
-
Hubbard GP, Wolffram S, de Vos R, Bovy A, Gibbins JM, Lovegrove JA, (2006). Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. Br J Nutr 96: 482-488.
-
(2006)
Br J Nutr
, vol.96
, pp. 482-488
-
-
Hubbard, G.P.1
Wolffram, S.2
De Vos, R.3
Bovy, A.4
Gibbins, J.M.5
Lovegrove, J.A.6
-
19
-
-
0035912775
-
The effect of fruit and vegetable intake on risk for coronary heart disease
-
Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, et al. (2001). The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134: 1106-1114.
-
(2001)
Ann Intern Med
, vol.134
, pp. 1106-1114
-
-
Joshipura, K.J.1
Hu, F.B.2
Manson, J.E.3
Stampfer, M.J.4
Rimm, E.B.5
Speizer, F.E.6
-
20
-
-
77954326944
-
Animal research: Reporting in vivo experiments: The ARRIVE guidelines
-
Group NCRRGW.
-
Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, Group NCRRGW (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1577-1579
-
-
Kilkenny, C.1
Browne, W.2
Cuthill, I.C.3
Emerson, M.4
Altman, D.G.5
-
21
-
-
0038142355
-
A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans
-
Li Z, Ajdic J, Eigenthaler M, Du X, (2003a). A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood 101: 4423-4429.
-
(2003)
Blood
, vol.101
, pp. 4423-4429
-
-
Li, Z.1
Ajdic, J.2
Eigenthaler, M.3
Du, X.4
-
22
-
-
0037428145
-
A stimulatory role for cGMP-dependent protein kinase in platelet activation
-
Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, et al. (2003b). A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 112: 77-86.
-
(2003)
Cell
, vol.112
, pp. 77-86
-
-
Li, Z.1
Xi, X.2
Gu, M.3
Feil, R.4
Ye, R.D.5
Eigenthaler, M.6
-
23
-
-
0037495020
-
Complex effects of different green tea catechins on human platelets
-
Lill G, Voit S, Schror K, Weber AA, (2003). Complex effects of different green tea catechins on human platelets. FEBS Lett 546: 265-270.
-
(2003)
FEBS Lett
, vol.546
, pp. 265-270
-
-
Lill, G.1
Voit, S.2
Schror, K.3
Weber, A.A.4
-
24
-
-
39749109478
-
Triggers, targets and treatments for thrombosis
-
Mackman N, (2008). Triggers, targets and treatments for thrombosis. Nature 451: 914-918.
-
(2008)
Nature
, vol.451
, pp. 914-918
-
-
Mackman, N.1
-
25
-
-
78651098102
-
Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry
-
Manthey JA, Cesar TB, Jackson E, Mertens-Talcott S, (2011). Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. J Agric Food Chem 59: 145-151.
-
(2011)
J Agric Food Chem
, vol.59
, pp. 145-151
-
-
Manthey, J.A.1
Cesar, T.B.2
Jackson, E.3
Mertens-Talcott, S.4
-
26
-
-
0026726483
-
The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
-
Matter WF, Brown RF, Vlahos CJ, (1992). The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun 186: 624-631.
-
(1992)
Biochem Biophys Res Commun
, vol.186
, pp. 624-631
-
-
Matter, W.F.1
Brown, R.F.2
Vlahos, C.J.3
-
27
-
-
77954331629
-
Guidelines for reporting experiments involving animals: The ARRIVE guidelines
-
McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1573-1576
-
-
McGrath, J.C.1
Drummond, G.B.2
McLachlan, E.M.3
Kilkenny, C.4
Wainwright, C.L.5
-
28
-
-
40749148947
-
P2Y12 antagonism: Promises and challenges
-
Michelson AD, (2008). P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol 28: s33-s38.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. s33-s38
-
-
Michelson, A.D.1
-
29
-
-
0033637140
-
The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
-
Middleton E Jr, Kandaswami C, Theoharides TC, (2000). The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 673-751
-
-
Middleton, Jr.E.1
Kandaswami, C.2
Theoharides, T.C.3
-
30
-
-
84860343177
-
Epigallocatechin-3-gallate has an anti-platelet effect in a cyclic AMP-dependent manner
-
Ok WJ, Cho HJ, Kim HH, Lee DH, Kang HY, Kwon HW, et al. (2012). Epigallocatechin-3-gallate has an anti-platelet effect in a cyclic AMP-dependent manner. J Atheroscler Thromb 19: 337-348.
-
(2012)
J Atheroscler Thromb
, vol.19
, pp. 337-348
-
-
Ok, W.J.1
Cho, H.J.2
Kim, H.H.3
Lee, D.H.4
Kang, H.Y.5
Kwon, H.W.6
-
31
-
-
84902076187
-
The Ca(2+) /calmodulin-dependent kinase kinase beta-AMP-activated protein kinase-alpha1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets
-
Onselaer MB, Oury C, Hunter RW, Eeckhoudt S, Barile N, Lecut C, et al. (2014). The Ca(2+) /calmodulin-dependent kinase kinase beta-AMP-activated protein kinase-alpha1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets. J Thromb Haemost 12: 973-986.
-
(2014)
J Thromb Haemost
, vol.12
, pp. 973-986
-
-
Onselaer, M.B.1
Oury, C.2
Hunter, R.W.3
Eeckhoudt, S.4
Barile, N.5
Lecut, C.6
-
32
-
-
84891791940
-
The IUPHAR/BPS Guide to PHARMACOLOGY: An expert-driven knowledgebase of drug targets and their ligands
-
NC-IUPHAR.
-
Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl Acids Res 42: D1098-106.
-
(2014)
Nucl Acids Res
, vol.42
, pp. D1098-D1106
-
-
Pawson, A.J.1
Sharman, J.L.2
Benson, H.E.3
Faccenda, E.4
Alexander, S.P.5
Buneman, O.P.6
-
33
-
-
0015796787
-
Antithrombogenic properties of a hexamethoxylated flavonoid. Reduction of deaths in rats due to intravascular infusion of adenosine diphosphate (ADP)
-
Robbins RC, (1973). Antithrombogenic properties of a hexamethoxylated flavonoid. Reduction of deaths in rats due to intravascular infusion of adenosine diphosphate (ADP). Atherosclerosis 18: 73-82.
-
(1973)
Atherosclerosis
, vol.18
, pp. 73-82
-
-
Robbins, R.C.1
-
34
-
-
0024232126
-
Flavones in citrus exhibit antiadhesive action on platelets
-
Robbins RC, (1988). Flavones in citrus exhibit antiadhesive action on platelets. Int J Vitam Nutr Res 58: 418-421.
-
(1988)
Int J Vitam Nutr Res
, vol.58
, pp. 418-421
-
-
Robbins, R.C.1
-
35
-
-
0017616677
-
Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats
-
Sempinska E, Kostka B, Krolikowska M, Kalisiak E, (1977). Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats. Pol J Pharmacol Pharm 29: 7-10.
-
(1977)
Pol J Pharmacol Pharm
, vol.29
, pp. 7-10
-
-
Sempinska, E.1
Kostka, B.2
Krolikowska, M.3
Kalisiak, E.4
-
36
-
-
0023110249
-
Induction of the fibrinogen receptor on human platelets by intracellular mediators
-
Shattil SJ, Brass LF, (1987). Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem 262: 992-1000.
-
(1987)
J Biol Chem
, vol.262
, pp. 992-1000
-
-
Shattil, S.J.1
Brass, L.F.2
-
37
-
-
84878063767
-
Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells
-
Shi MD, Liao YC, Shih YW, Tsai LY, (2013). Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. Phytomedicine 20: 743-752.
-
(2013)
Phytomedicine
, vol.20
, pp. 743-752
-
-
Shi, M.D.1
Liao, Y.C.2
Shih, Y.W.3
Tsai, L.Y.4
-
38
-
-
84888200706
-
Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling
-
Vaiyapuri S, Ali MS, Moraes LA, Sage T, Lewis KR, Jones CI, et al. (2013). Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. Arterioscler Thromb Vasc Biol 33: 2740-2749.
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 2740-2749
-
-
Vaiyapuri, S.1
Ali, M.S.2
Moraes, L.A.3
Sage, T.4
Lewis, K.R.5
Jones, C.I.6
-
39
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF, (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269: 5241-5248.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
40
-
-
34548423695
-
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
-
Walle T, (2007). Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? Semin Cancer Biol 17: 354-362.
-
(2007)
Semin Cancer Biol
, vol.17
, pp. 354-362
-
-
Walle, T.1
-
41
-
-
77949389166
-
A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids
-
Wright B, Moraes LA, Kemp CF, Mullen W, Crozier A, Lovegrove JA, et al. (2010). A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. Br J Pharmacol 159: 1312-1325.
-
(2010)
Br J Pharmacol
, vol.159
, pp. 1312-1325
-
-
Wright, B.1
Moraes, L.A.2
Kemp, C.F.3
Mullen, W.4
Crozier, A.5
Lovegrove, J.A.6
-
42
-
-
84871746740
-
Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs
-
Wright B, Spencer JP, Lovegrove JA, Gibbins JM, (2012). Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs. Cardiovasc Res 97: 13-22.
-
(2012)
Cardiovasc Res
, vol.97
, pp. 13-22
-
-
Wright, B.1
Spencer, J.P.2
Lovegrove, J.A.3
Gibbins, J.M.4
-
43
-
-
33646040117
-
Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms
-
Wu YQ, Zhou CH, Tao J, Li SN, (2006). Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. Life Sci 78: 2689-2696.
-
(2006)
Life Sci
, vol.78
, pp. 2689-2696
-
-
Wu, Y.Q.1
Zhou, C.H.2
Tao, J.3
Li, S.N.4
-
44
-
-
3142717728
-
Urinary metabolites of nobiletin orally administered to rats
-
Yasuda T, Yoshimura Y, Yabuki H, Nakazawa T, Ohsawa K, Mimaki Y, et al. (2003). Urinary metabolites of nobiletin orally administered to rats. Chem Pharm Bull (Tokyo) 51: 1426-1428.
-
(2003)
Chem Pharm Bull (Tokyo)
, vol.51
, pp. 1426-1428
-
-
Yasuda, T.1
Yoshimura, Y.2
Yabuki, H.3
Nakazawa, T.4
Ohsawa, K.5
Mimaki, Y.6
|