The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets

Journal of Thrombosis and Haemostasis

Volumn 12, Issue 6, 2014, Pages 973-986

  Onselaer, M B ^a   Oury, C ^b   Hunter, R W ^c   Eeckhoudt, S ^d   Barile, N ^a   Lecut, C ^b   Morel, N ^a   Viollet, B ^e,f,g   Jacquet, L M ^d   Bertrand, L ^a   Sakamoto, K ^c   Vanoverschelde, J L ^a,d   Beauloye, C ^a,d   Horman, S ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c EPFL   (Switzerland)

^d CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^e INSTITUT COCHIN   (France)

^f CNRS   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

AMP activated protein kinase; Cytoskeleton; Platelet aggregation; Signal transduction; Thrombin

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 1; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; COFILIN; CYTOSKELETON PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MYOSIN LIGHT CHAIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN; ACTIN BINDING PROTEIN; ACTIN DEPOLYMERIZING FACTOR; AMPK ALPHA1 SUBUNIT, MOUSE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CELL ADHESION MOLECULE; HEPARIN; PHOSPHOPROTEIN; PRKAA1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; VASODILATOR-STIMULATED PHOSPHOPROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MAJOR SURGERY; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; PROTEIN SECRETION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; ACTIN FILAMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEART SURGERY; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; TIME;

ACTIN CYTOSKELETON; ACTIN DEPOLYMERIZING FACTORS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTICOAGULANTS; BLOOD PLATELETS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CARDIAC SURGICAL PROCEDURES; CELL ADHESION MOLECULES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HEPARIN; HUMANS; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MYOSIN LIGHT CHAINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; THROMBIN; TIME FACTORS;

EID: 84902076187     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12568     Document Type: Article

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