메뉴 건너뛰기




Volumn 64, Issue 10, 2014, Pages 482-489

Dissecting the molecular pathways of primary aldosteronism

Author keywords

Ca2+ signaling pathway; G protein coupled receptor; Primary aldosteronism; Somatic mutation; Steroidogenic enzymes

Indexed keywords

ALDOSTERONE; CALCIUM; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; MONOCLONAL ANTIBODY;

EID: 84937511257     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12200     Document Type: Article
Times cited : (19)

References (50)
  • 1
    • 17144421237 scopus 로고    scopus 로고
    • Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
    • Milliez P, Girerd X, Plouin PF etal. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol 2005; 45: 1243-1248.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1243-1248
    • Milliez, P.1    Girerd, X.2    Plouin, P.F.3
  • 3
    • 0013976493 scopus 로고
    • Pathology of primary aldosteronism
    • Neville AM, Symington T. Pathology of primary aldosteronism. Cancer 1966; 19: 1854-1868.
    • (1966) Cancer , vol.19 , pp. 1854-1868
    • Neville, A.M.1    Symington, T.2
  • 5
    • 84898923510 scopus 로고    scopus 로고
    • GATA6, SF1, NGFIB and DAX1 in the remodeled subcapsular zones in primary aldosteronism
    • Nakamura Y, Kurotaki Y, Ise K etal. GATA6, SF1, NGFIB and DAX1 in the remodeled subcapsular zones in primary aldosteronism. Endocr J 2014; 61: 393-401.
    • (2014) Endocr J , vol.61 , pp. 393-401
    • Nakamura, Y.1    Kurotaki, Y.2    Ise, K.3
  • 6
    • 84891638064 scopus 로고    scopus 로고
    • Development of monoclonal antibodies against human CYP11B1 and CYP11B2
    • Gomez-Sanchez CE, Qi X, Velarde-Miranda C etal. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Mol Cell Endocrinol 2014; 383: 111-117.
    • (2014) Mol Cell Endocrinol , vol.383 , pp. 111-117
    • Gomez-Sanchez, C.E.1    Qi, X.2    Velarde-Miranda, C.3
  • 7
    • 84901687899 scopus 로고    scopus 로고
    • Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies
    • Nakamura Y, Maekawa T, Felizola SJ etal. Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies. Mol Cell Endocrinol 2014; 392: 73-79.
    • (2014) Mol Cell Endocrinol , vol.392 , pp. 73-79
    • Nakamura, Y.1    Maekawa, T.2    Felizola, S.J.3
  • 8
    • 0028116118 scopus 로고
    • Localization of steroidogenic enzymes in adrenal cortex and its disorders
    • Sasano H. Localization of steroidogenic enzymes in adrenal cortex and its disorders. Endocrine J 1994; 41: 471-482.
    • (1994) Endocrine J , vol.41 , pp. 471-482
    • Sasano, H.1
  • 9
    • 84937421307 scopus 로고    scopus 로고
    • Diagram of the pathways of human steroidogenesis
    • doi:10.15347/wjm/2014.005.
    • Häggström M, Richfield D. Diagram of the pathways of human steroidogenesis. Wikiversity J Med 2014. doi:10.15347/wjm/2014.005.
    • (2014) Wikiversity J Med
    • Häggström, M.1    Richfield, D.2
  • 11
    • 0031656580 scopus 로고    scopus 로고
    • Mitochondrial regulation of mineralocorticoid biosynthesis by calcium and the StAR protein
    • Cherradi N, Brandenburger Y, Capponi AM. Mitochondrial regulation of mineralocorticoid biosynthesis by calcium and the StAR protein. Eur J Endocrinol 1998; 139: 249-256.
    • (1998) Eur J Endocrinol , vol.139 , pp. 249-256
    • Cherradi, N.1    Brandenburger, Y.2    Capponi, A.M.3
  • 12
    • 24344483486 scopus 로고    scopus 로고
    • Expression profiles for steroidogenic enzymes in adrenocortical disease
    • Bassett MH, Mayhew B, Rehman K etal. Expression profiles for steroidogenic enzymes in adrenocortical disease. J Clin Endocrinol Metab 2005; 90: 5446-5455.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5446-5455
    • Bassett, M.H.1    Mayhew, B.2    Rehman, K.3
  • 13
    • 0028907678 scopus 로고
    • Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma
    • Wu KD, Chen YM, Chu JS etal. Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma. J Clin Endocrinol Metab 1995; 80: 783-789.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 783-789
    • Wu, K.D.1    Chen, Y.M.2    Chu, J.S.3
  • 14
    • 0033602859 scopus 로고    scopus 로고
    • Adrenal zonation: clues from 11beta-hydroxylase and aldosterone synthase
    • Rainey WE. Adrenal zonation: clues from 11beta-hydroxylase and aldosterone synthase. Mol Cell Endocrinol 1999; 151: 151-160.
    • (1999) Mol Cell Endocrinol , vol.151 , pp. 151-160
    • Rainey, W.E.1
  • 15
    • 0025999564 scopus 로고
    • The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex
    • Curnow KM, Tusie-Lunaf MT, Pascoe L etal. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol Endocr 1991; 5: 1513-1522.
    • (1991) Mol Endocr , vol.5 , pp. 1513-1522
    • Curnow, K.M.1    Tusie-Lunaf, M.T.2    Pascoe, L.3
  • 16
    • 21244452625 scopus 로고    scopus 로고
    • Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family
    • Simard J, Ricketts ML, Gingras S etal. Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. Endocrine Rev 2005; 26: 525-582.
    • (2005) Endocrine Rev , vol.26 , pp. 525-582
    • Simard, J.1    Ricketts, M.L.2    Gingras, S.3
  • 17
    • 73849110168 scopus 로고    scopus 로고
    • Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6
    • Doi M, Takahashi Y, Komatsu R etal. Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med 2010; 16: 67-74.
    • (2010) Nat Med , vol.16 , pp. 67-74
    • Doi, M.1    Takahashi, Y.2    Komatsu, R.3
  • 18
    • 84896731223 scopus 로고    scopus 로고
    • Isoform-specific monoclonal antibodies against 3beta-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism
    • Doi M, Satoh F, Maekawa T etal. Isoform-specific monoclonal antibodies against 3beta-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism. J Clin Endocrinol Metab 2014; 99: E257-262.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. E257-E262
    • Doi, M.1    Satoh, F.2    Maekawa, T.3
  • 19
    • 77149141395 scopus 로고    scopus 로고
    • Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members
    • Nogueira EF, Rainey WE. Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members. Endocrinology 2010; 151: 1060-1070.
    • (2010) Endocrinology , vol.151 , pp. 1060-1070
    • Nogueira, E.F.1    Rainey, W.E.2
  • 20
    • 35848946407 scopus 로고    scopus 로고
    • G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism
    • Ye P, Mariniello B, Mantero F, Shibata H, Rainey WE. G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. J Endocrinol 2007; 195: 39-48.
    • (2007) J Endocrinol , vol.195 , pp. 39-48
    • Ye, P.1    Mariniello, B.2    Mantero, F.3    Shibata, H.4    Rainey, W.E.5
  • 21
    • 0035072954 scopus 로고    scopus 로고
    • G-protein-mediated signaling and its control in macrophages and mammalian cells
    • Chakraborty P. G-protein-mediated signaling and its control in macrophages and mammalian cells. Crit Rev Microbiol 2001; 27: 1-8.
    • (2001) Crit Rev Microbiol , vol.27 , pp. 1-8
    • Chakraborty, P.1
  • 22
    • 85047689001 scopus 로고    scopus 로고
    • Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies
    • Lefebvre H, Cartier D, Duparc C etal. Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies. J Clin Endocrinol Metab 2002; 87: 1211-1216.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1211-1216
    • Lefebvre, H.1    Cartier, D.2    Duparc, C.3
  • 23
    • 84897892857 scopus 로고    scopus 로고
    • PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues
    • Felizola SJA, Nakamura Y, Ono Y etal. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. J Mol Endocrinol 2014; 52: 159-167.
    • (2014) J Mol Endocrinol , vol.52 , pp. 159-167
    • Felizola, S.J.A.1    Nakamura, Y.2    Ono, Y.3
  • 24
    • 67449158981 scopus 로고    scopus 로고
    • Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis
    • Nogueira EF, Xing Y, Morris CA, Rainey WE. Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis. J Mol Endocrinol 2009; 42: 319-330.
    • (2009) J Mol Endocrinol , vol.42 , pp. 319-330
    • Nogueira, E.F.1    Xing, Y.2    Morris, C.A.3    Rainey, W.E.4
  • 25
    • 78049241143 scopus 로고    scopus 로고
    • Protein kinase Cμ mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells
    • Chen YC, Chen Y, Huang SH, Wang SM. Protein kinase Cμ mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. FEBS Lett 2010; 584: 4442-4448.
    • (2010) FEBS Lett , vol.584 , pp. 4442-4448
    • Chen, Y.C.1    Chen, Y.2    Huang, S.H.3    Wang, S.M.4
  • 26
    • 84885409364 scopus 로고    scopus 로고
    • Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway
    • Felizola SJA, Nakamura Y, Satoh F etal. Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway. Mol Cell Endocrinol 2014; 382: 170-177.
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 170-177
    • Felizola, S.J.A.1    Nakamura, Y.2    Satoh, F.3
  • 27
    • 0032817288 scopus 로고    scopus 로고
    • Pharmacological and molecular characterization of 5-hydroxytryptamine (7) receptors in the rat adrenal gland
    • Contesse V, Lenglet S, Grumolato L etal. Pharmacological and molecular characterization of 5-hydroxytryptamine (7) receptors in the rat adrenal gland. Mol Pharmacol 1999; 56: 552-561.
    • (1999) Mol Pharmacol , vol.56 , pp. 552-561
    • Contesse, V.1    Lenglet, S.2    Grumolato, L.3
  • 29
    • 29644433074 scopus 로고    scopus 로고
    • Expression profile of serotonin4 (5-HT4) receptors in adrenocortical aldosterone-producing adenomas
    • Cartier D, Jégou S, Parmentier F etal. Expression profile of serotonin4 (5-HT4) receptors in adrenocortical aldosterone-producing adenomas. Eur J Endocrinol 2005; 153: 939-947.
    • (2005) Eur J Endocrinol , vol.153 , pp. 939-947
    • Cartier, D.1    Jégou, S.2    Parmentier, F.3
  • 30
    • 33644831806 scopus 로고    scopus 로고
    • Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas
    • Saner-Amigh K, Mayhew BA, Mantero F etal. Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas. J Clin Endocrinol Metab 2006; 91: 1136-1142.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1136-1142
    • Saner-Amigh, K.1    Mayhew, B.A.2    Mantero, F.3
  • 31
    • 0034724508 scopus 로고    scopus 로고
    • Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes
    • Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. DNA Res 2000; 7: 111-120.
    • (2000) DNA Res , vol.7 , pp. 111-120
    • Hurowitz, E.H.1    Melnyk, J.M.2    Chen, Y.J.3    Kouros-Mehr, H.4    Simon, M.I.5    Shizuya, H.6
  • 32
    • 84893331711 scopus 로고    scopus 로고
    • G protein-coupled receptor
    • Hille B. G protein-coupled receptor. Scholarpedia 2009; 4: 8214.
    • (2009) Scholarpedia , vol.4 , pp. 8214
    • Hille, B.1
  • 33
    • 0037199927 scopus 로고    scopus 로고
    • Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells
    • Liu F, Usui I, Evans LG, Austin DA etal. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem 2002; 277: 32099-32108.
    • (2002) J Biol Chem , vol.277 , pp. 32099-32108
    • Liu, F.1    Usui, I.2    Evans, L.G.3    Austin, D.A.4
  • 36
    • 14244265833 scopus 로고    scopus 로고
    • Cyclic adenosine 3′,5′-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter
    • Clem BF, Hudson EA, Clark BJ. Cyclic adenosine 3′, 5′-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter. Endocrinology 2005; 146: 1348-1356.
    • (2005) Endocrinology , vol.146 , pp. 1348-1356
    • Clem, B.F.1    Hudson, E.A.2    Clark, B.J.3
  • 37
    • 0033305264 scopus 로고    scopus 로고
    • Angiotensin II and cyclic adenosine 3′,5′-monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element
    • Clark BJ, Combs R. Angiotensin II and cyclic adenosine 3′, 5′-monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element. Endocrinology 1999; 140: 4390-4398.
    • (1999) Endocrinology , vol.140 , pp. 4390-4398
    • Clark, B.J.1    Combs, R.2
  • 38
    • 0032475883 scopus 로고    scopus 로고
    • Mediation of cyclic AMP signaling by the first intracellular loop of the gonadotropin-releasing hormone receptor
    • Arora KK, Krsmanovic LZ, Mores N, O'Farrell H, Catt KJ. Mediation of cyclic AMP signaling by the first intracellular loop of the gonadotropin-releasing hormone receptor. J Biol Chem 1998; 273: 25581-25586.
    • (1998) J Biol Chem , vol.273 , pp. 25581-25586
    • Arora, K.K.1    Krsmanovic, L.Z.2    Mores, N.3    O'Farrell, H.4    Catt, K.J.5
  • 39
    • 33947415606 scopus 로고    scopus 로고
    • Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)
    • Rorick-Kehn LM, Johnson BG, Burkey JL etal. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R, 4S, 5S, 6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4, 6-dicarboxylic acid (LY404039). J Pharmacol Exp Ther 2007; 321: 308-317.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 308-317
    • Rorick-Kehn, L.M.1    Johnson, B.G.2    Burkey, J.L.3
  • 40
    • 0031055985 scopus 로고    scopus 로고
    • LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors
    • Schoepp DD, Johnson BG, Wright RA etal. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 1997; 36: 1-11.
    • (1997) Neuropharmacology , vol.36 , pp. 1-11
    • Schoepp, D.D.1    Johnson, B.G.2    Wright, R.A.3
  • 41
    • 33746090892 scopus 로고    scopus 로고
    • RGS2 is regulated by angiotensin II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells
    • Romero DG, Plonczynski MW, Gomez-Sanchez EP, Yanes LL, Gomez-Sanchez CE. RGS2 is regulated by angiotensin II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells. Endocrinology 2007; 147: 3889-3897.
    • (2007) Endocrinology , vol.147 , pp. 3889-3897
    • Romero, D.G.1    Plonczynski, M.W.2    Gomez-Sanchez, E.P.3    Yanes, L.L.4    Gomez-Sanchez, C.E.5
  • 42
    • 0036721321 scopus 로고    scopus 로고
    • Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase
    • Condon JC, Pezzi V, Drummond BM, Yin S, Rainey WE. Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. Endocrinology 2002; 143: 3651-3657.
    • (2002) Endocrinology , vol.143 , pp. 3651-3657
    • Condon, J.C.1    Pezzi, V.2    Drummond, B.M.3    Yin, S.4    Rainey, W.E.5
  • 43
    • 79951506090 scopus 로고    scopus 로고
    • K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension
    • Choi M, Scholl UI, Yue P etal. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 2011; 331: 768-772.
    • (2011) Science , vol.331 , pp. 768-772
    • Choi, M.1    Scholl, U.I.2    Yue, P.3
  • 44
    • 65549129174 scopus 로고    scopus 로고
    • PEP-19, an intrinsically disordered regulator of calmodulin signaling
    • Kleerekoper QK, Putkey JA. PEP-19, an intrinsically disordered regulator of calmodulin signaling. J Biol Chem 2009; 284: 7455-7464.
    • (2009) J Biol Chem , vol.284 , pp. 7455-7464
    • Kleerekoper, Q.K.1    Putkey, J.A.2
  • 45
    • 0032510478 scopus 로고    scopus 로고
    • Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
    • Deisseroth K, Heist EK, Tsien RW. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 1998; 392: 198-202.
    • (1998) Nature , vol.392 , pp. 198-202
    • Deisseroth, K.1    Heist, E.K.2    Tsien, R.W.3
  • 46
    • 79960361662 scopus 로고    scopus 로고
    • Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/pcp4-null mice
    • Wei P, Blundon JA, Rong Y, Zakharenko SS, Morgan JI. Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/pcp4-null mice. Mol Cell Biol 2011; 31: 2838-2844.
    • (2011) Mol Cell Biol , vol.31 , pp. 2838-2844
    • Wei, P.1    Blundon, J.A.2    Rong, Y.3    Zakharenko, S.S.4    Morgan, J.I.5
  • 47
    • 41149181485 scopus 로고    scopus 로고
    • Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R
    • Akizuki O, Inayoshi A, Kitayama T etal. Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R. Eur J Pharmacol 2008; 584: 424-434.
    • (2008) Eur J Pharmacol , vol.584 , pp. 424-434
    • Akizuki, O.1    Inayoshi, A.2    Kitayama, T.3
  • 48
    • 84861799719 scopus 로고    scopus 로고
    • Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators
    • Hu C, Rusin CG, Tan Z, Guagliardo NA, Barrett PQ. Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators. J Clin Invest 2012; 122: 2046-2053.
    • (2012) J Clin Invest , vol.122 , pp. 2046-2053
    • Hu, C.1    Rusin, C.G.2    Tan, Z.3    Guagliardo, N.A.4    Barrett, P.Q.5
  • 49
    • 84883464824 scopus 로고    scopus 로고
    • Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism
    • Scholl UI, Goh G, Stölting G etal. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet 2013; 45: 1050-1054.
    • (2013) Nat Genet , vol.45 , pp. 1050-1054
    • Scholl, U.I.1    Goh, G.2    Stölting, G.3
  • 50
    • 84875737352 scopus 로고    scopus 로고
    • Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension
    • Beuschlein F, Boulkroun S, Osswald A etal. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet 2013; 45: 440-444.
    • (2013) Nat Genet , vol.45 , pp. 440-444
    • Beuschlein, F.1    Boulkroun, S.2    Osswald, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.