Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells

Biochemical and Biophysical Research Communications

Volumn 461, Issue 1, 2015, Pages 59-64

  Ishii, Shuhei ^a   Hirane, Miku ^a   Fukushima, Kaori ^a   Tomimatsu, Ayaka ^a   Fukushima, Nobuyuki ^a   Tsujiuchi, Toshifumi ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

LPA; LPA receptor; Pancreatic cancer cells; Tumor progression

Indexed keywords

LPAR4 PROTEIN, HUMAN; LPAR5 PROTEIN, HUMAN; LPAR6 PROTEIN, HUMAN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHOLIPID; P2RY9 RECEPTOR, HUMAN; PURINERGIC P2 RECEPTOR; PURINERGIC RECEPTOR;

CELL MOTION; HUMAN; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; LYSOPHOSPHOLIPIDS; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, PURINERGIC; RECEPTORS, PURINERGIC P2;

EID: 84937511071     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.169     Document Type: Article

References (24)

1. Y.C. Yung, N.C. Stoddard, and J. Chun LPA receptor signaling: pharmacology, physiology, and pathophysiology J. Lipid Res. 55 2014 1192 1214
2. N.C. Stoddard, and J. Chun Promising pharmacological directions in the world of lysophosphatidic acid signaling Biomol. Ther. 23 2015 1 11
3. T. Tsujiuchi, M. Araki, M. Hirane, Y. Dong, and N. Fukushima Lysophosphatidic acid receptors in cancer pathobiology Histol. Histopathol. 29 2014 313 321
4. K. Okabe, M. Hayashi, K. Kato, M. Okumura, R. Fukui, K. Honoki, N. Fukushima, and T. Tsujiuchi Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells Mol. Carcinog. 52 2013 247 254
5. M. Hayashi, K. Okabe, K. Kato, M. Okumura, R. Fukui, N. Fukushima, and T. Tsujiuchi Differential function of lysophosphatidic acid receptors in cell proliferation and migration of neuroblastoma cells Cancer Lett. 316 2012 91 96
6. K. Kato, R. Fukui, K. Okabe, E. Tanabe, M. Kitayoshi, N. Fukushima, and T. Tsujiuchi Constitutively active lysophosphatidic acid receptor-1 enhances the induction of matrix metalloproteinase-2 Biochem. Biophys. Res. Commun. 417 2012 790 793
7. M. Hayashi, K. Okabe, Y. Yamawaki, M. Teranishi, K. Honoki, T. Mori, N. Fukushima, and T. Tsujiuchi Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells Biochem. Biophys. Res. Commun. 405 2011 450 454
8. S.M. Pasternack, I. von Kügelgen, K. Al Aboud, Y.A. Lee, F. Rüschendorf, K. Voss, A.M. Hillmer, G.J. Molderings, T. Franz, A. Ramirez, P. Nürnberg, M.M. Nöthen, and R.C. Betz G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth Nat. Genet. 40 2008 329 334
9. Z. Lee, C.T. Cheng, H. Zhang, M.A. Subler, J. Wu, A. Mukherjee, J.J. Windle, C.K. Chen, and X. Fang Role of LPA4/p2y9/GPR23 in negative regulation of cell motility Mol. Biol. Cell. 19 2008 5435 5445
10. M. Jongsma, E. Matas-Rico, A. Rzadkowski, K. Jalink, and W.H. Moolenaar LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor PLoS One 6 2011 e29260
11. S. Shano, K. Hatanaka, S. Ninose, R. Moriyama, T. Tsujiuchi, and N. Fukushima A Lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation Biochim. Biophys. Acta 1783 2008 748 759
12. T. Yamada, M. Furukawa, M. Hotta, A. Yamasaki, K. Honoki, N. Fukushima, and T. Tsujiuchi Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats Biochem. Biophys. Res. Commun. 378 2009 424 427
13. Y. Obo, T. Yamada, M. Furukawa, M. Hotta, K. Honoki, N. Fukishima, and T. Tsujiuchi Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors Mutat. Res. 660 2009 47 50
14. M. Tsujino, M. Fujii, K. Okabe, T. Mori, N. Fukushima, and T. Tsujiuchi Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells Virchows Arch. 457 2010 669 676
15. Y. Dong, M. Hirane, M. Araki, N. Fukushima, and T. Tsujiuchi Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells Biochem. Biophys. Res. Commun. 446 2014 585 589
16. Y. Dong, M. Hirane, M. Araki, N. Fukushima, K. Honoki, and T. Tsujiuchi Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines Mol. Cell. Biochem. 393 2014 17 22
17. K. Okabe, M. Hayashi, Y. Yamawaki, M. Teranishi, K. Honoki, T. Mori, N. Fukushima, and T. Tsujiuchi Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells Mol. Carcinog. 50 2011 635 642
18. J. Folkman Tumor angiogenesis: therapeutic implications N. Engl. J. Med. 285 1971 1182 1186
19. G.M. Tozer, C. Kanthou, and B.C. Baguley Disrupting tumor blood vessels Nat. Rev. Cancer 5 2005 423 435
20. M.-E. Lin, D.R. Herr, and J. Chun Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance Prostagl. Other Lipid Mediat 91 2010 130 138
21. S. Aikawa, T. Hashimoto, K. Kano, and J. Aoki Lysophosphatidic acid as a lipid mediator with multiple biological actions J. Biochem. 157 2015 81 89
22. Y.-L. Hu, M.-K. Tee, E.J. Goetzl, N. Auersperg, G.B. Mills, N. Ferrara, and R.B. Jaffe Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells J. Natl. Cancer Inst. 93 2001 762 768
23. D. Shida, J. Kitayama, H. Yanaguchi, Y. Okaji, N.H. Tsuno, T. Watanabe, Y. Takuwa, and H. Nagawa Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1 Cancer Res. 63 2003 1706 1711
24. 1-expressing tumor cells Biochem. Biophys. Res. Commun. 422 2012 339 343