Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats

Biochemical and Biophysical Research Communications

Volumn 378, Issue 3, 2009, Pages 424-427

  Yamada, Takanori ^a   Obo, Yumi ^a   Furukawa, Mami ^a   Hotta, Mayuko ^a   Yamasaki, Ayako ^a   Honoki, Kanya ^b   Fukushima, Nobuyuki ^c   Tsujiuchi, Toshifumi ^a  

^a Faculty of Science and Engineering   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c KINKI UNIVERSITY   (Japan)

Author keywords

Lung tumor; Lysophosphatidic acid receptor 1; Mutation; Nitrosamine; Rat

Indexed keywords

BIS(2 HYDROXYPROPYL)NITROSAMINE; DRINKING WATER; GENOMIC DNA; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HYPERPLASIA; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG CARCINOGENESIS; LUNG LESION; LUNG TUMOR; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR GROWTH; WISTAR RAT;

ADENOCARCINOMA; ADENOMA; ANIMALS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; LUNG NEOPLASMS; MALE; MUTATION; NITROSAMINES; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RATS; RATS, WISTAR; RECEPTORS, LYSOPHOSPHATIDIC ACID;

RATTUS; RATTUS NORVEGICUS;

EID: 57749169050     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.044     Document Type: Article

References (34)

1. Konishi Y., Denda A., Kondo H., and Takahashi S. Lung carcinomas induced by oral administration of N-bis(2-hydroxypropyl)nitrosamine in rats. Jpn. J. Cancer Res. 67 (1976) 773-780
2. Y. Konishi, H. Kondoh, A. Denda, S. Takahashi, S. Inui, Lung carcinomas induced by oral administration of N-bis(2-hydroxypropyl)nitrosamine in rats, in: I. Severi, (Ed.), Tumors of Early Life in Man and Animals. Perugia Quadrennaial International Conference of Cancer, Division of Cancer Research, Perugia University, Perugia, 1978, pp. 637-649.
3. Kitada H., Tsutsumi M., Tsujiuchi T., Takahama M., Fukuda T., Narita N., and Konishi Y. Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced N-nitrosobis(2-hydroxypropyl) amine by in rat. Mol. Carcinog. 115 (1996) 276-283
4. Tsujiuchi T., Sasaki Y., Tsutsumi M., and Konishi Y. Mutations and reduced expression of the transforming growth factor-βreceptor II gene in rat lung adenocarcinomas induced N-nitrosobis(2-hydroxypropyl) amine. Jpn. J. Cancer Res. 91 (2000) 1090-1095
5. Tsujiuchi T., Sasaki Y., Tsutsumi M., and Konishi Y. Mutations of the smad2 and smad4 genes in lung adenocarcinomas induced N-nitrosobis(2-hydroxypropyl) amine in rats. Mol. Carcinog. 29 (2000) 87-91
6. Tsujiuchi T., Sasaki Y., Tsutsumi M., and Konishi Y. Alterations of the M6p/lgf2 receptor gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl) amine in rat. Mol. Carcinog. 36 (2003) 32-37
7. Tsujiuchi T., Sasaki Y., Murata N., Tsutsumi M., Konishi Y., and Nakae D. FHIT alterations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Carcinogenesis 22 (2001) 2017-2022
8. Tsujiuchi T., Sasaki Y., Oka Y., Kuniyasu H., and Tsutsumi M. Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Mol. Carcinog. 40 (2004) 241-246
9. Shimizu K., Kato A., Hinotsume D., Shigemura M., Hanaoka M., Shimoichi Y., Honoki K., and Tsujiuchi T. Reduced expressions of Foxp1 and Rassf1a genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Cancer Lett. 236 (2006) 186-190
10. Ishii I., Fukushima N., Ye X., and Chun J. Lysophospholipid receptors: signaling and biology. Annu. Rev. Biochem. 73 (2004) 321-354
11. Furui T., LaPushin R., Mao M., Khan H., Watt S.R., and Watt M.A.V. Overexpression of Edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophatidic acid-independent manner. Clin. Cancer Res. 5 (1999) 4308-4318
12. Goetzl E.J., Dolezalova H., Kong Y., Hu Y.L., Jaffe R.B., Kalli K.R., and Conover C.A. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res. 59 (1999) 5370-5375
13. Contos J.J.A., Fukushima N., Weiner J.A., Kaushal D., and Chun J. Requirement for the lpA1 lysophosohatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. USA 97 (2000) 13383-13389
14. Contos J.J.A., Ishii I., Fukushima N., Kingsbury M.A., Ye X., Kawamura S., Brown J.H., and Chun J. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysopfosphatidic acid receptor knockout mice. signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol. Cell. Biol. 22 (2002) 6921-6929
15. Fang X., Schummer M., Mao M., Yu S., Tabassam F.H., Swaby R., Hasegawa Y., Tanyi J.L., LaPushin R., Eder A., Jaffe R., Erickson J., and Mills G.B. Lysophosphatidic acid is a bioactive mediator in ovarian cancer. Biochim. Biophys. Acta 1582 (2002) 257-264
16. Fujita T., Miyamoto S., Onoyama I., Sonoda K., Mekada E., and Mekada H. Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. Cancer Lett. 192 (2003) 161-169
17. An S., Bleu T., Halmark O.G., and Goetzl E.J. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273 (1998) 7906-7910
18. Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., Murakami-Murofushi K., Tsujimoto M., Arai H., and Inoue K. Molecular cloning, characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274 (1999) 27776-27785
19. Noguchi K., Ishii S., and Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278 (2003) 25600-25606
20. Lee C.W., Rivera R., Gardell S., Dubin A.E., and Chun J. GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5. J. Biol. Chem. 281 (2006) 23589-23597
21. Shida D., Watanabe T., Aoki J., Hama K., Kitayama J., Sonoda H., Kishi Y., Yamaguchi H., Sasaki S., Sako A., Konishi T., Arai H., and Nagawa H. Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer. Lab. Invest. 84 (2004) 1352-1362
22. Tsujiuchi T., Shimizu K., Onishi M., Shigemura M., Shano S., Honoki K., and Fukushima N. Aberrant expressions of lysophosphatidic acid receptor genes in lung, liver tumors of rats. J. Toxicol. Pathol. 19 (2006) 137-141
23. Tsujiuchi T., Shimizu K., Onishi M., Sugata E., Fujii H., Mori T., Honoki K., and Fukushima N. Involvement of aberrant DNA methylation on reduced expression of lysophosphatidic acid receptor-1 gene in rat tumor cell lines. Biochem. Biophys. Res. Commun. 349 (2006) 1151-1155
24. Shano S., Hatanaka K., Ninose S., Moriyama R., Tsujiuchi T., and Fukushima N. A Lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation. Biochim. Biophys. Acta 1783 (2008) 748-759
25. Jiao J., Pienkowska M., Glickman B.W., and Zielenska M. Molecular analysis of mutations induced by ethylating N-nitroso compounds in the lacI gene of Escherichia coli. Mutat. Res. 352 (1996) 39-45
26. Tsutsumi M., Murakami Y., Kondoh S., Tsujiuchi T., Honoki K., Horiguchi K., Noguchi O., Kobayashi E., Okita S., Sekiya T., and Konishi Y. Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-oxopropyl)amine. Jpn. J. Cancer Res. 84 (1993) 956-960
27. Nakae D., Yoshiji H., Maruyama H., Kinugasa T., Denda A., and Konishi Y. Production of both 8-hydroxydeoxyguanosine in liver DNA and γ-glutamyltransferase-positive hepatocellular lesions in rat given a choline-deficient, l-amino acid-defined diet. Jpn. J. Cancer Res. 81 (1990) 1081-1084
28. Moriya M., Ou C., Bodepudi V., Johnson F., Takeshita M., and Grollma A.P. Site-specific mutagenesis using a gapped duplex vector: a study of translation synthesis past 8-oxodeoxyguanosine in E. coli. Mutat. Res. 254 (1991) 281-288
29. Malins D.C., and Haimanot R. 4, 6-Diamino-5-formamidopyrimidine, 8-hydroxyguanine and 8-hydroxyadenine in DNA from neoplastic liver of English sole exposed to carcinogens. Biochem. Biophys. Res. Commun. 173 (1990) 614-619
30. Kamiya H., Miura H., Murata-Kamiya N., Ishikawa H., Sakaguchi T., Inoue H., Sasaki T., Masutani C., Hanaoka F., and Nishimura S. 8-Hydroxyadenine (7, 8-dihydro-8-oxoadenine) induces misincorporation in invitro DNA synthesis and mutations in NIH3T3 cells. Nucleic Acids Res. 23 (1995) 2893-2899
31. Wang D., Kreutzer D.A., and Essigmann J.M. Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions. Mutat. Res. 400 (1998) 99-115
32. Y. Obo, T. Yamada, M. Furukawa, M. Hotta, K. Honoki, N. Fukushima, T. Tsujiuchi, Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors, Mutat. Res., in press.
33. Sardar V.M., Bautista D.L., Fischer D.J., Yokoyama K., Nusser N., Viraq T., Wang D.A., Baker D.L., Tiqyi G., and Parrill A.L. Molecular basis for lysophosphatidic acid receptor antagonist selectivity. Biochim. Biophys. Acta 1582 (2002) 309-317
34. Valentine W.J., Fells J.I., Perygin D.H., Mujahid S., Yokoyama K., Fujiwara Y., Tsukahara R., Van Brocklyn J.R., Parrill A.L., and Tiqyi G. Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. J. Biol. Chem. 283 (2008) 12175-12187