-
2
-
-
0033376891
-
Overexpression of Edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner
-
Furui T, LaPushin R, Mao M, Khan H, Watt SR, Watt MAV. Overexpression of Edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. Clin Cancer Res 1999; 5: 4308-4318.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 4308-4318
-
-
Furui, T.1
LaPushin, R.2
Mao, M.3
Khan, H.4
Watt, S.R.5
Watt, M.A.V.6
-
3
-
-
0032697808
-
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer
-
Goetzl EJ, Dolezalova H, Kong Y, Hu YL, Jaffe RB, Kalli KR, Conover CA. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res 1999; 59: 5370-5375.
-
(1999)
Cancer Res
, vol.59
, pp. 5370-5375
-
-
Goetzl, E.J.1
Dolezalova, H.2
Kong, Y.3
Hu, Y.L.4
Jaffe, R.B.5
Kalli, K.R.6
Conover, C.A.7
-
4
-
-
0034700050
-
Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
-
Contos JJA, Fukushima N, Weiner JA, Kaushal D, Chun J. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci USA 2000; 97: 13383-13389.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13383-13389
-
-
Contos, J.J.A.1
Fukushima, N.2
Weiner, J.A.3
Kaushal, D.4
Chun, J.5
-
5
-
-
0036786445
-
Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to lpa(2)
-
Contos JJA, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol 2002; 22: 6921-6929.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6921-6929
-
-
Contos, J.J.A.1
Ishii, I.2
Fukushima, N.3
Kingsbury, M.A.4
Ye, X.5
Kawamura, S.6
Brown, J.H.7
Chun, J.8
-
6
-
-
0242339246
-
Lysophosphatidic acid is a bioactive mediator in ovarian cancer
-
Fang X, Schummer M, Mao M, Yu S, Tabassam FH, Swaby R, Hasegawa Y, Tanyi JL, LaPushin R, Eder A, Jaffe R, Erickson J, Mills GB. Lysophosphatidic acid is a bioactive mediator in ovarian cancer. Biochim Biophys Acta 2002; 1582: 257-264.
-
(2002)
Biochim Biophys Acta
, vol.1582
, pp. 257-264
-
-
Fang, X.1
Schummer, M.2
Mao, M.3
Yu, S.4
Tabassam, F.H.5
Swaby, R.6
Hasegawa, Y.7
Tanyi, J.L.8
LaPushin, R.9
Eder, A.10
Jaffe, R.11
Erickson, J.12
Mills, G.B.13
-
7
-
-
0037474724
-
Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer
-
Fujita T, Miyamoto S, Onoyama I, Sonoda K, Mekada E, Nakano H. Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. Cancer Lett 2003; 192: 161-169.
-
(2003)
Cancer Lett
, vol.192
, pp. 161-169
-
-
Fujita, T.1
Miyamoto, S.2
Onoyama, I.3
Sonoda, K.4
Mekada, E.5
Nakano, H.6
-
8
-
-
0032478615
-
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
-
An S, Bleu T, Halmark OG, Goetzl EJ. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 1998; 273: 7906-7910.
-
(1998)
J Biol Chem
, vol.273
, pp. 7906-7910
-
-
An, S.1
Bleu, T.2
Halmark, O.G.3
Goetzl, E.J.4
-
9
-
-
0033600761
-
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
-
Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 1999; 274: 27776-27785.
-
(1999)
J Biol Chem
, vol.274
, pp. 27776-27785
-
-
Bandoh, K.1
Aoki, J.2
Hosono, H.3
Kobayashi, S.4
Kobayashi, T.5
Murakami-Murofushi, K.6
Tsujimoto, M.7
Arai, H.8
Inoue, K.9
-
10
-
-
0038152846
-
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
-
Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 2003; 278: 25600-25606.
-
(2003)
J Biol Chem
, vol.278
, pp. 25600-25606
-
-
Noguchi, K.1
Ishii, S.2
Shimizu, T.3
-
11
-
-
33747685338
-
GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5
-
Lee CW, Rivera R, Gardell S, Dubin AE, Chun J. GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5. J Biol Chem 2006; 281: 23589-23597.
-
(2006)
J Biol Chem
, vol.281
, pp. 23589-23597
-
-
Lee, C.W.1
Rivera, R.2
Gardell, S.3
Dubin, A.E.4
Chun, J.5
-
12
-
-
39749127777
-
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
-
Pasternack SM, von Kügelgen I, Aboud KAJ, Lee Y-A, Rüschendorf F, Voss K, AHillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Berz RC. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet 2008; 40: 329-334.
-
(2008)
Nat Genet
, vol.40
, pp. 329-334
-
-
Pasternack, S.M.1
von Kügelgen, I.2
Aboud, K.A.J.3
Lee, Y.-A.4
Rüschendorf, F.5
Voss, K.6
AHillmer, A.M.7
Molderings, G.J.8
Franz, T.9
Ramirez, A.10
Nürnberg, P.11
Nöthen, M.M.12
Berz, R.C.13
-
13
-
-
39749127117
-
Disruption of P2Y5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair
-
Shimomura Y, Wajid M, Ishii Y, Shapiro L, Petukhowa L, Gordon D, Christiano AM. Disruption of P2Y5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet 2008; 40: 335-339.
-
(2008)
Nat Genet
, vol.40
, pp. 335-339
-
-
Shimomura, Y.1
Wajid, M.2
Ishii, Y.3
Shapiro, L.4
Petukhowa, L.5
Gordon, D.6
Christiano, A.M.7
-
14
-
-
4944255719
-
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer
-
Shida D, Watanabe T, Aoki J, Hama K, Kitayama J, Sonoda H, Kishi Y, Yamaguchi H, Sasaki S, Sako A, Konishi T, Arai H, Nagawa H. Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer. Lab Investig 2004; 84: 1352-1362.
-
(2004)
Lab Investig
, vol.84
, pp. 1352-1362
-
-
Shida, D.1
Watanabe, T.2
Aoki, J.3
Hama, K.4
Kitayama, J.5
Sonoda, H.6
Kishi, Y.7
Yamaguchi, H.8
Sasaki, S.9
Sako, A.10
Konishi, T.11
Arai, H.12
Nagawa, H.13
-
15
-
-
33749988274
-
Aberrant expressions of lysophosphatidic acid receptor genes in lung and liver tumors of rats
-
Tsujiuchi T, Shimizu K, Onishi M, Shigemura M, Shano S, Honoki K, Fukushima N. Aberrant expressions of lysophosphatidic acid receptor genes in lung and liver tumors of rats. J Toxicol Pathol 2006; 19: 137-141.
-
(2006)
J Toxicol Pathol
, vol.19
, pp. 137-141
-
-
Tsujiuchi, T.1
Shimizu, K.2
Onishi, M.3
Shigemura, M.4
Shano, S.5
Honoki, K.6
Fukushima, N.7
-
16
-
-
57749169050
-
Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats
-
Yamada T, Furukawa M, Hotta M, Yamasaki A, Honoki K, Fukushima N, Tsujiuchi T. Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats. Biochem Biophys Res Commun 2009; 378: 424-427.
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 424-427
-
-
Yamada, T.1
Furukawa, M.2
Hotta, M.3
Yamasaki, A.4
Honoki, K.5
Fukushima, N.6
Tsujiuchi, T.7
-
17
-
-
58149463915
-
Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors
-
Obo Y, Yamada T, Furukawa M, Hotta M, Honoki K, Fukushima N, Tsujiuchi T. Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors. Mutat Res 2009; 660: 47-50.
-
(2009)
Mutat Res
, vol.660
, pp. 47-50
-
-
Obo, Y.1
Yamada, T.2
Furukawa, M.3
Hotta, M.4
Honoki, K.5
Fukushima, N.6
Tsujiuchi, T.7
-
18
-
-
33748625994
-
Involvement of aberrant DNA methylation on reduced expression of lysophosphatidic acid receptor-1 gene in rat tumor cell lines
-
Tsujiuchi T, Shimizu K, Onishi M, Sugata E, Fujii H, Mori T, Honoki K, Fukushima N. Involvement of aberrant DNA methylation on reduced expression of lysophosphatidic acid receptor-1 gene in rat tumor cell lines. Biochem Biophys Res Commun 2006; 349: 1151-1155.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, pp. 1151-1155
-
-
Tsujiuchi, T.1
Shimizu, K.2
Onishi, M.3
Sugata, E.4
Fujii, H.5
Mori, T.6
Honoki, K.7
Fukushima, N.8
-
19
-
-
41949086804
-
A Lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation
-
Shano S, Hatanaka K, Ninose S, Moriyama R, Tsujiuchi T, Fukushima N. A Lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation. Biochim Biophys Acta 2008; 1783: 748-759.
-
(2008)
Biochim Biophys Acta
, vol.1783
, pp. 748-759
-
-
Shano, S.1
Hatanaka, K.2
Ninose, S.3
Moriyama, R.4
Tsujiuchi, T.5
Fukushima, N.6
-
20
-
-
0035328785
-
Metastasis-associated differences in gene expression in a murine model of osteosarcoma
-
Khanna C, Khan J, Nguyen P, Prehn J, Caylor J, Yeung C, Trepel J, Meltzer P, Helman L. Metastasis-associated differences in gene expression in a murine model of osteosarcoma. Cancer Res 2001; 61: 3750-3759.
-
(2001)
Cancer Res
, vol.61
, pp. 3750-3759
-
-
Khanna, C.1
Khan, J.2
Nguyen, P.3
Prehn, J.4
Caylor, J.5
Yeung, C.6
Trepel, J.7
Meltzer, P.8
Helman, L.9
-
21
-
-
0037379768
-
Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1
-
Shida D, Kitayama J, Yanaguchi H, Okaji Y, Tsuno NH, Watanabe T, Takuwa Y, Nagawa H. Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. Cancer Res 2003; 63: 1706-1711.
-
(2003)
Cancer Res
, vol.63
, pp. 1706-1711
-
-
Shida, D.1
Kitayama, J.2
Yanaguchi, H.3
Okaji, Y.4
Tsuno, N.H.5
Watanabe, T.6
Takuwa, Y.7
Nagawa, H.8
-
22
-
-
56749151299
-
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells
-
Yu S, Murph MM, Lu Y, liu S, Hall HS, Liu J, Stephens C, Fang X, Mills GB. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst 2008; 100: 1630-1642.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1630-1642
-
-
Yu, S.1
Murph, M.M.2
Lu, Y.3
liu, S.4
Hall, H.S.5
Liu, J.6
Stephens, C.7
Fang, X.8
Mills, G.B.9
-
23
-
-
8044219690
-
Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicines-induced cell cycle disturbance in partially hepatecomized rats
-
Ohashi K, Tsutsumi M, Tsujiuchi T, Kobitsu K, Okajima E, Nakajima Y, Nakano H, Takahama M, Mori Y, Konishi Y. Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicines-induced cell cycle disturbance in partially hepatecomized rats. Cancer Res 1996; 56: 3473-3479.
-
(1996)
Cancer Res
, vol.56
, pp. 3473-3479
-
-
Ohashi, K.1
Tsutsumi, M.2
Tsujiuchi, T.3
Kobitsu, K.4
Okajima, E.5
Nakajima, Y.6
Nakano, H.7
Takahama, M.8
Mori, Y.9
Konishi, Y.10
-
24
-
-
0017049599
-
Lung carcinomas induced by oral administration of N-bis(2-hydroxypropyl)nitrosamine in rats
-
Konishi Y, Denda A, Kondo H, Takahashi S. Lung carcinomas induced by oral administration of N-bis(2-hydroxypropyl)nitrosamine in rats. Jpn J Cancer Res 1976; 67: 773-780.
-
(1976)
Jpn J Cancer Res
, vol.67
, pp. 773-780
-
-
Konishi, Y.1
Denda, A.2
Kondo, H.3
Takahashi, S.4
-
25
-
-
0035895989
-
Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent
-
Hooks SB, Santos WL, Im D-S, Heise CE, Macdonald TL, Lynch KR. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. J Biol Chem 2001; 276: 4611-4621.
-
(2001)
J Biol Chem
, vol.276
, pp. 4611-4621
-
-
Hooks, S.B.1
Santos, W.L.2
Im, D.-S.3
Heise, C.E.4
Macdonald, T.L.5
Lynch, K.R.6
-
26
-
-
77949526409
-
LPA receptors: Subtypes and biological actions
-
Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J. LPA receptors: Subtypes and biological actions. Annu Rev Pharmacol Toxicol 2010; 50: 157-186.
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 157-186
-
-
Choi, J.W.1
Herr, D.R.2
Noguchi, K.3
Yung, Y.C.4
Lee, C.W.5
Mutoh, T.6
Lin, M.E.7
Teo, S.T.8
Park, K.E.9
Mosley, A.N.10
Chun, J.11
-
27
-
-
0037068378
-
DNA methylation and cancer
-
Jones PA. DNA methylation and cancer. Oncogene 2002; 21: 5358-5360.
-
(2002)
Oncogene
, vol.21
, pp. 5358-5360
-
-
Jones, P.A.1
-
28
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-428.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
29
-
-
34247173599
-
LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neural cell line
-
Yanagida K, Ishii S, Hamano F, Noguchi K, Shimizu T. LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neural cell line. J Biol Chem 2007; 282: 5814-5824.
-
(2007)
J Biol Chem
, vol.282
, pp. 5814-5824
-
-
Yanagida, K.1
Ishii, S.2
Hamano, F.3
Noguchi, K.4
Shimizu, T.5
-
30
-
-
47249103800
-
Orphan G protein-coupled receptor GRP56 regulates neural progenitor cell migration via a Gα12/13 and Rho pathway
-
Iguchi T, Sakata K, Yoshizaki K, Tago K, Mizuno N, Itoh H. Orphan G protein-coupled receptor GRP56 regulates neural progenitor cell migration via a Gα12/13 and Rho pathway. J Biol Chem 2008; 283: 14469-14478.
-
(2008)
J Biol Chem
, vol.283
, pp. 14469-14478
-
-
Iguchi, T.1
Sakata, K.2
Yoshizaki, K.3
Tago, K.4
Mizuno, N.5
Itoh, H.6
-
31
-
-
67650533801
-
The action and mode of binding of thiazolidine ligands at free fatty acid receptor 1
-
Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G. The action and mode of binding of thiazolidine ligands at free fatty acid receptor 1. J Biol Chem 2009; 284: 17527-17539.
-
(2009)
J Biol Chem
, vol.284
, pp. 17527-17539
-
-
Smith, N.J.1
Stoddart, L.A.2
Devine, N.M.3
Jenkins, L.4
Milligan, G.5
-
32
-
-
77956373483
-
Structure basis for the specific inhibition of heterotrimetric Gq protein by a small molecule
-
Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H. Structure basis for the specific inhibition of heterotrimetric Gq protein by a small molecule. Proc Natl Axad Sci USA 2010; 107: 13666-13671.
-
(2010)
Proc Natl Axad Sci USA
, vol.107
, pp. 13666-13671
-
-
Nishimura, A.1
Kitano, K.2
Takasaki, J.3
Taniguchi, M.4
Mizuno, N.5
Tago, K.6
Hakoshima, T.7
Itoh, H.8
-
33
-
-
77953656293
-
No mutations of lysophosphatidic acid receptor genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
-
Wakabayashi N, Tsujino M, Tajiri M, Taki M, Koshino A, Ikeda H, Fukushima N, Tsujiuchi T. No mutations of lysophosphatidic acid receptor genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. J Toxicol Pathol 2010; 3: 63-66.
-
(2010)
J Toxicol Pathol
, vol.3
, pp. 63-66
-
-
Wakabayashi, N.1
Tsujino, M.2
Tajiri, M.3
Taki, M.4
Koshino, A.5
Ikeda, H.6
Fukushima, N.7
Tsujiuchi, T.8
|