Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3472-3480

  Pingaew, Ratchanok ^a   Prachayasittikul, Veda ^b   Mandi, Prasit ^b   Nantasenamat, Chanin ^b   Prachayasittikul, Supaluk ^b   Ruchirawat, Somsak ^c,d   Prachayasittikul, Virapong ^b  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c CHULABHORN RESEARCH INSTITUTE   (Thailand)

^d Ministry of Education   (Thailand)

Author keywords

Anti aromatase activity; Molecular docking; Structure activity relationships; Sulfonamide; Tetrahydroisoquinoline; Triazole

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 1,2,3 TRIAZOLE SULFONAMIDE DERIVATIVE; 4 [[1 [3 [(3,4 DIHYDROISOQUINOLIN 2 (1H)YL)SULFONYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 4 [[1 [3 [(6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2 (1H)YL)SULFONYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [3 [(3,4 DIHYDROISOQUINOLIN 2 (1H)YL)SULFONYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [3 [(6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2 (1H)YL)SULFONYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; AROMATASE INHIBITOR; COUMARIN OXYMETHYL; FUNCTIONAL GROUP; KETOCONAZOLE; LETROZOLE; NAPHTHALENE OXYMETHYL; PHENOXYMETHYL; PHENYL GROUP; SULFONAMIDE; SULFONYL GROUP; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; AROMATASE; CYP19A1 PROTEIN, HUMAN; ISOQUINOLINE DERIVATIVE; PROTEIN BINDING; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL INTERACTION; CHEMICAL REACTION; CLICK REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IC50; MASS SPECTROMETRY; MOLECULAR DOCKING; NONHUMAN; PI PI STACKING INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VERO CELL LINE; ANIMAL; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; HUMAN; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; AROMATASE; AROMATASE INHIBITORS; CATALYTIC DOMAIN; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISOQUINOLINES; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRIAZOLES; VERO CELLS;

EID: 84937425435     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.036     Document Type: Article

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