Adenosine A2A receptors are necessary and sufficient to trigger memory impairment in adult mice

British Journal of Pharmacology

Volumn 172, Issue 15, 2015, Pages 3831-3845

  Pagnussat, N ^a   Almeida, A S ^a   Marques, D M ^a   Nunes, F ^a   Chenet, G C ^a   Botton, P H S ^a   Mioranzza, S ^a   Loss, C M ^a   Cunha, R A ^b,c   Porciuncula L O ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2A RECEPTOR; SCOPOLAMINE; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 2-(4-(2-CARBOXYETHYL)PHENETHYLAMINO)-5'-N-ETHYLCARBOXAMIDOADENOSINE; 5-AMINO-7-(2-PHENYLETHYL)-2-(2-FURYL)PYRAZOLO(4,3-E)-1,2,4-TRIAZOLO(1,5-C)PYRIMIDINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; PHENETHYLAMINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SCOPOLAMINE BROMIDE; TRIAZOLE DERIVATIVE; XANTHINE DERIVATIVE;

ADULT; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVATION; LEARNING AND MEMORY TEST; LOCOMOTION; MALE; MODIFIED Y MAZE TEST; MOUSE; NONHUMAN; OBJECT RECOGNITION TASK; PASSIVE AVOIDANCE TEST; PRIORITY JOURNAL; SHORT TERM MEMORY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; AVOIDANCE BEHAVIOR; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MAZE TEST; MEMORY DISORDER; PATHOPHYSIOLOGY; PHYSIOLOGY; RECOGNITION;

ADENOSINE; ANIMALS; AVOIDANCE LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRAVENTRICULAR; LOCOMOTION; MALE; MAZE LEARNING; MEMORY DISORDERS; MEMORY, SHORT-TERM; MICE; PHENETHYLAMINES; PURINERGIC P1 RECEPTOR AGONISTS; PURINERGIC P1 RECEPTOR ANTAGONISTS; PYRIMIDINES; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECOGNITION (PSYCHOLOGY); SCOPOLAMINE HYDROBROMIDE; TRIAZOLES; XANTHINES;

EID: 84937424234     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13180     Document Type: Article

References (66)

1. Albasanz JL, Perez S, Barrachina M, Ferrer I, Martín M, (2008). Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease. Brain Pathol 18: 211-219.
2. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013). The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol 170: 1459-1581.
3. Angelucci ME, Vital MA, Cesário C, Zadusky CR, Rosalen PL, Da Cunha C, (1999). The effect of caffeine in animal models of learning and memory. Eur J Pharmacol 373: 135-140.
4. Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, et al. (2006). Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience 142: 941-952.
5. 2A receptor functions. J Neurosci 33: 11390-11399.
6. Bartus RT, (2000). On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 163: 495-529.
7. 2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation. Mol Psychiatry 18: 320-331.
8. Borota D, Murray E, Keceli G, Chang A, Watabe JM, Ly M, et al. (2014). Post-study caffeine administration enhances memory consolidation in humans. Nat Neurosci 17: 201-203.
9. Botton PH, Costa MS, Ardais AP, Mioranzza S, Souza DO, da Rocha JB, et al. (2010). Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice. Behav Brain Res 214: 254-259.
10. Bruns RF, Katims JJ, Annau Z, Snyder SH, Daly JW, (1983). Adenosine receptor interactions and anxiolytics. Neuropharmacology 22: 1523-1529.
11. 2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci 29: 14741-14751.
12. Cao C, Loewenstein DA, Lin X, Zhang C, Wang L, Duara R, et al. (2012). High Blood caffeine levels in MCI linked to lack of progression to dementia. J Alzheimers Dis 30: 559-572.
13. Chen JF, Eltzschig HK, Fredholm BB, (2013). Adenosine receptors as drug targets-what are the challenges? Nat Rev Drug Discov 12: 265-286.
14. Cognato GP, Agostinho PM, Hockemeyer J, Müller CE, Souza DO, Cunha RA, (2010). Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life. J Neurochem 112: 453-462.
15. Costa MS, Botton PH, Mioranzza S, Ardais AP, Moreira JD, Souza DO, et al. (2008). Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochem Int 53: 89-94.
16. 2A receptors in the modulation of LTP in the rat hippocampus upon ageing. Eur J Neurosci 34: 12-21.
17. 2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Exp Neurol 210: 776-781.
18. 2A receptor-mediated facilitation of plasticity. Neurochem Int 52: 65-72.
19. Cunha RA, Agostinho PM, (2010). Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline. J Alzheimers Dis 20 (Suppl. 1): S95-S116.
20. 3H]acetylcholine release from different areas of the rat hippocampus. J Neurochem 63: 207-214.
21. 2A receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Exp Neurol 203: 241-245.
22. 2A receptor. Eur J Pharmacol 401: 63-77.
23. 2A receptors. Br J Pharmacol 129: 1465-1473.
24. 1 adenosine receptors: validation by displacement and autoradiographic experiments. J Nucl Med 54: 1411-1419.
25. Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M, (2009). Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis 16: 85-91.
26. 2A receptors upregulation in the hippocampus of a rat model of sporadic dementia. J Alzheimers Dis 34: 509-518.
27. Fisher A, (2012). Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease. J Neurochem 120 (Suppl. 1): 22-33.
28. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE, (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51: 83-133.
29. Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM, (2005). Adenosine and brain function. Int Rev Neurobiol 63: 191-270.
30. 2A signaling. Prog Neurobiol 83: 263-276.
31. 1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. Eur J Neurosci 16: 547-550.
32. 2A receptors in the brain. Neurobiol Learn Mem 87: 42-56.
33. 1 receptors and enhances consolidation of step-down avoidance. Behav Brain Res 234: 184-191.
34. Hirotsu I, Hori N, Katsuda N, Ishihara T, (1989). Effect of anticholinergic drug on long-term potentiation in rat hippocampal slices. Brain Res 482: 194-197.
35. Jackisch R, Strittmatter H, Kasakov L, Hertting G, (1984). Endogenous adenosine as a modulator of hippocampal acetylcholine release. Naunyn Schmiedebergs Arch Pharmacol 327: 319-325.
36. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). Animal research: Reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
37. Klinkenberg I, Blokland A, (2010). The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 34: 1307-1350.
38. 2 receptor antagonists. Psychopharmacology (Berl) 146: 214-219.
39. Laurent C, Eddarkaoui S, Derisbourg M, Leboucher A, Demeyer D, Carrier S, et al. (2014). Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiol Aging 35: 2079-2090.
40. 2A adenosine receptor subtypes with a differential sensitivity to atropine. Neuroscience 116: 913-920.
41. Martin SJ, Grimwood PD, Morris RG, (2000). Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23: 649-711.
42. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
43. 1 receptors prevents methylphenidate-induced impairment of object recognition task in adult mice. Prog Neuropsychopharmacol Biol Psychiatry 35: 169-176.
44. Nikodijevic O, Jacobson KA, Daly JW, (1993). Locomotor activity in mice during chronic treatment with caffeine and withdrawal. Pharmacol Biochem Behav 44: 199-216.
45. 3H]-acetylcholine release from the rat motor nerve terminals. Eur J Neurosci 15: 1728-1736.
46. Pandolfo P, Machado NJ, Köfalvi A, Takahashi RN, Cunha RA,. (2013). Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. Eur Neuropsychopharmacol 23: 317-328.
47. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al.; NC-IUPHAR. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-D1106.
48. Pedata F, Giovannelli L, De Sarno P, Pepeu G, (1986). Effect of adenosine, adenosine derivatives, and caffeine on acetylcholine release from brain synaptosomes: interaction with muscarinic autoregulatory mechanisms. J Neurochem 46: 1593-1598.
49. 1 receptors in the posterior cingulate cortex facilitates memory in rats. Eur J Pharmacol 437: 151-154.
50. Pereira GS, Rossato JI, Sarkis JJ, Cammarota M, Bonan CD, Izquierdo I, (2005). Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat. Neurobiol Learn Mem 83: 217-223.
51. 2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats. Behav Brain Res 159: 197-205.
52. 2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57: 121-134.
53. Riedel W, Hogervorst E, Leboux R, Verhey F, van Praag H, Jolles J, (1995). Caffeine attenuates scopolamine-induced memory impairment in humans. Psychopharmacology (Berl) 122: 158-168.
54. Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA, (2008). Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats. Neurobiol Aging 29: 1597-1601.
55. 2A antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor. Eur Neuropsychopharmacol 23: 972-977.
56. Snyder SH, Katims JJ, Annau Z, Bruns RF, Daly JW, (1981). Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A 78: 3260-3264.
57. 1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl) adenosine-induced cognitive disturbance. J Med Chem 36: 2508-2518.
58. Tanaka Y, Sakurai M, Hayashi S, (1989). Effect of scopolamine and HP 029, a cholinesterase inhibitor, on long-term potentiation in hippocampal slices of the Guinea Pig. Neurosci Lett 98: 179-183.
59. Vannucchi MG, Scali C, Kopf SR, Pepeu G, Casamenti F, (1997). Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience 79: 837-846.
60. 1 antagonist, worsens long-term memory. Neurosci Lett 548: 296-300.
61. 2A receptors. Exp Neurol 199: 438-445.
62. Warburton EC, Koder T, Cho K, Massey PV, Duguid G, Barker GR, et al. (2003). Cholinergic neurotransmission is essential for perirhinal cortical plasticity and recognition memory. Neuron 38: 987-996.
63. Winters BD, Bartko SJ, Saksida LM, Bussey TJ, (2007). Scopolamine infused into perirhinal cortex improves object recognition memory by blocking the acquisition of interfering object information. Learn Mem 14: 590-596.
64. 2A receptor antagonists. Naunyn Schmiedebergs Arch Pharmacol 375: 133-144.
65. 2A-adenosine receptor: a GPCR with unique features? Br J Pharmacol 153 (Suppl. 1): S184-S190.
66. 2A receptors. Brain Res 1303: 74-83.