In vivo kinetic and steady-state quantification of 18F-CPFPX binding to rat cerebral A1 adenosine receptors: Validation by displacement and autoradiographic experiments

Journal of Nuclear Medicine

Volumn 54, Issue 8, 2013, Pages 1411-1419

  Elmenhorst, David ^a   Kroll, Tina ^a   Wedekind, Franziska ^a   Weisshaupt, Angela ^a   Beer, Simone ^a   Bauer, Andreas ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

18F CPFPX; Adenosine A1 receptor; Autoradiography; Blocking experiment; Kinetic modeling; Positron emission tomography

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 3 (3 FLUOROPROPYL) 1 PROPYLXANTHINE F 18; ADENOSINE A1 RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BLOOD SAMPLING; BODY TEMPERATURE; BOLUS INJECTION; BRAIN CORTEX; BREATHING RATE; CAUDATE NUCLEUS; CEREBELLUM; CINGULATE GYRUS; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG METABOLISM; ENTORHINAL CORTEX; GRAY MATTER; HEART RATE; HIPPOCAMPUS; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; IN VIVO STUDY; LIGAND BINDING; MALE; NEUROIMAGING; NONHUMAN; OLFACTORY BULB; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RADIOACTIVITY; RAT; RIGHT HEMISPHERE; STEADY STATE;

18F-CPFPX; ADENOSINE A1 RECEPTOR; AUTORADIOGRAPHY; BLOCKING EXPERIMENT; KINETIC MODELING; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; AUTORADIOGRAPHY; BRAIN; KINETICS; MALE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; REPRODUCIBILITY OF RESULTS; XANTHINES;

EID: 84881472529     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.115576     Document Type: Article

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