Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 2, 2015, Pages L139-L146

  Sun, Xue Jiao ^a   Li, Zhan Hua ^a   Zhang, Yang ^a   Zhou, Guang ^a   Zhang, Jian Quan ^a   Deng, Jing Min ^a   Bai, Jing ^a   Liu, Guang Nan ^a   Li, Mei Hua ^a   MacNee, William ^b   Zhong, Xiao Ning ^a   He, Zhi Yi ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chronic obstructive pulmonary disease; Corticosteroid insensitivity; Erythromycin; Glucocorticoid receptor; Histone deacetylase 2

Indexed keywords

CIGARETTE SMOKE; CORTICOSTEROID; DEXAMETHASONE; ERYTHROMYCIN; GLUCOCORTICOID RECEPTOR; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ANTIINFLAMMATORY AGENT; GASTROINTESTINAL AGENT; GLUCOCORTICOID RECEPTOR ALPHA; INTERLEUKIN 8;

ADULT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ADVERSE EFFECTS; CASE CONTROL STUDY; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG COMBINATION; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; OXIDATIVE STRESS; PATHOLOGY; SMOKING; U937 CELL LINE; WESTERN BLOTTING;

ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; DEXAMETHASONE; DRUG THERAPY, COMBINATION; ERYTHROMYCIN; GASTROINTESTINAL AGENTS; HISTONE DEACETYLASE 2; HUMANS; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, GLUCOCORTICOID; SMOKING; U937 CELLS;

EID: 84937408527     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00292.2014     Document Type: Article

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